LOCUS       NM_015238               7136 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens WW and C2 domain containing 1 (WWC1), transcript
            variant 3, mRNA.
ACCESSION   NM_015238
VERSION     NM_015238.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7136)
  AUTHORS   Papenberg,G., Karalija,N., Johansson,J., Andersson,M., Axelsson,J.,
            Riklund,K., Lindenberger,U., Nyberg,L. and Backman,L.
  TITLE     The influence of hippocampal dopamine D2 receptor losses on
            episodic-memory decline across 5 years is moderated by BDNF and
            KIBRA polymorphisms
  JOURNAL   Cortex 176, 53-61 (2024)
   PUBMED   38749085
  REMARK    GeneRIF: The influence of hippocampal dopamine D2 receptor losses
            on episodic-memory decline across 5 years is moderated by BDNF and
            KIBRA polymorphisms.
REFERENCE   2  (bases 1 to 7136)
  AUTHORS   Zhang,S., Zhang,B., Liao,Z., Chen,Y., Guo,W., Wu,J., Liu,H.,
            Weng,R., Su,D., Chen,G., Zhang,Z., Li,C., Long,J., Xiao,Y., Ma,Y.,
            Zhou,T., Xu,C. and Su,P.
  TITLE     Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA
            and inhibiting Hippo signaling pathway
  JOURNAL   Mol Ther 32 (5), 1461-1478 (2024)
   PUBMED   38414246
  REMARK    GeneRIF: Hnrnpk protects against osteoarthritis through targeting
            WWC1 mRNA and inhibiting Hippo signaling pathway.
REFERENCE   3  (bases 1 to 7136)
  AUTHORS   Homayouni,R., Daugherty,A.M., Yu,Q., Raz,N. and Ofen,N.
  TITLE     KIBRA single nucleotide polymorphism is associated with hippocampal
            subfield volumes and cognition across development
  JOURNAL   Brain Struct Funct 229 (1), 223-230 (2024)
   PUBMED   37853296
  REMARK    GeneRIF: KIBRA single nucleotide polymorphism is associated with
            hippocampal subfield volumes and cognition across development.
REFERENCE   4  (bases 1 to 7136)
  AUTHORS   Meliambro,K., Yang,Y., de Cos,M., Rodriguez Ballestas,E.,
            Malkin,C., Haydak,J., Lee,J.R., Salem,F., Mariani,L.H.,
            Gordon,R.E., Basgen,J.M., Wen,H.H., Fu,J., Azeloglu,E.U., He,J.C.,
            Wong,J.S. and Campbell,K.N.
  TITLE     KIBRA upregulation increases susceptibility to podocyte injury and
            glomerular disease progression
  JOURNAL   JCI Insight 8 (7), e165002 (2023)
   PUBMED   36853804
  REMARK    GeneRIF: KIBRA upregulation increases susceptibility to podocyte
            injury and glomerular disease progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7136)
  AUTHORS   Ahmetov,I.I., Valeeva,E.V., Yerdenova,M.B., Datkhabayeva,G.K.,
            Bouzid,A., Bhamidimarri,P.M., Sharafetdinova,L.M., Egorova,E.S.,
            Semenova,E.A., Gabdrakhmanova,L.J., Yusupov,R.A., Larin,A.K.,
            Kulemin,N.A., Generozov,E.V., Hamoudi,R., Kustubayeva,A.M. and
            Rees,T.
  TITLE     KIBRA Gene Variant Is Associated with Ability in Chess and Science
  JOURNAL   Genes (Basel) 14 (1), 204 (2023)
   PUBMED   36672945
  REMARK    GeneRIF: KIBRA Gene Variant Is Associated with Ability in Chess and
            Science.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7136)
  AUTHORS   Schaper,K., Kolsch,H., Popp,J., Wagner,M. and Jessen,F.
  TITLE     KIBRA gene variants are associated with episodic memory in healthy
            elderly
  JOURNAL   Neurobiol Aging 29 (7), 1123-1125 (2008)
   PUBMED   17353070
  REMARK    GeneRIF: The impact of KIBRA on memory is most likely of high
            relevance in elderly subjects as it is in young.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7136)
  AUTHORS   Papassotiropoulos,A., Stephan,D.A., Huentelman,M.J., Hoerndli,F.J.,
            Craig,D.W., Pearson,J.V., Huynh,K.D., Brunner,F., Corneveaux,J.,
            Osborne,D., Wollmer,M.A., Aerni,A., Coluccia,D., Hanggi,J.,
            Mondadori,C.R., Buchmann,A., Reiman,E.M., Caselli,R.J., Henke,K.
            and de Quervain,D.J.
  TITLE     Common Kibra alleles are associated with human memory performance
  JOURNAL   Science 314 (5798), 475-478 (2006)
   PUBMED   17053149
  REMARK    GeneRIF: gene expression studies showed that KIBRA was expressed in
            memory-related brain structures; KIBRA allele-dependent differences
            in hippocampal activations during memory retrieval were detected
            GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 7136)
  AUTHORS   Rayala,S.K., den Hollander,P., Manavathi,B., Talukder,A.H.,
            Song,C., Peng,S., Barnekow,A., Kremerskothen,J. and Kumar,R.
  TITLE     Essential role of KIBRA in co-activator function of dynein light
            chain 1 in mammalian cells
  JOURNAL   J Biol Chem 281 (28), 19092-19099 (2006)
   PUBMED   16684779
  REMARK    GeneRIF: the DLC1-KIBRA interaction is essential for ER
            transactivation in breast cancer cells
REFERENCE   9  (bases 1 to 7136)
  AUTHORS   Buther,K., Plaas,C., Barnekow,A. and Kremerskothen,J.
  TITLE     KIBRA is a novel substrate for protein kinase Czeta
  JOURNAL   Biochem Biophys Res Commun 317 (3), 703-707 (2004)
   PUBMED   15081397
  REMARK    GeneRIF: identification as novel substrate for protein kinase C
            zeta and regulation of cellular function by same enzyme
REFERENCE   10 (bases 1 to 7136)
  AUTHORS   Kremerskothen,J., Plaas,C., Buther,K., Finger,I., Veltel,S.,
            Matanis,T., Liedtke,T. and Barnekow,A.
  TITLE     Characterization of KIBRA, a novel WW domain-containing protein
  JOURNAL   Biochem Biophys Res Commun 300 (4), 862-867 (2003)
   PUBMED   12559952
  REMARK    GeneRIF: Data describe the isolation of a cDNA coding for a novel
            protein, KIBRA, possessing two amino-terminal WW domains, an
            internal C2-like domain and a carboxy-terminal glutamic acid-rich
            stretch
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026689.6, DR001014.1,
            AF506799.1, BC004394.1, AC020894.5 and CA313640.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_015238.2.
            
            Summary: The protein encoded by this gene is a cytoplasmic
            phosphoprotein that interacts with PRKC-zeta and dynein light
            chain-1. Alleles of this gene have been found that enhance memory
            in some individuals. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2010].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. This
            results in a shorter protein (isoform 3) compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF506799.1, SRR14038191.2493354.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265293.9/ ENSP00000265293.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               AC026689.6         58779-59193
            416-442             DR001014.1         410-436
            443-2880            AF506799.1         1-2438
            2881-4022           BC004394.1         31-1172
            4023-4592           AF506799.1         3581-4150
            4593-6483           AC020894.5         25695-27585
            6484-7136           CA313640.1         15-667              c
FEATURES             Location/Qualifiers
     source          1..7136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     gene            1..7136
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="WW and C2 domain containing 1"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
     exon            1..627
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     CDS             509..3850
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="isoform 3 is encoded by transcript variant 3; WW,
                     C2 and coiled-coil domain containing 1; kidney and brain
                     protein; HBeAg-binding protein 3; protein WWC1; protein
                     KIBRA; protein phosphatase 1, regulatory subunit 168"
                     /codon_start=1
                     /product="protein KIBRA isoform 3"
                     /protein_id="NP_056053.1"
                     /db_xref="CCDS:CCDS4366.1"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
                     /translation="MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKP
                     LTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVV
                     AQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEIL
                     KAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVL
                     RETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQ
                     YLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVL
                     DSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARDTQSKAL
                     TERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLV
                     ASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIHEDEVAK
                     TQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSPLMADPLLAGDAFLNSLE
                     FEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLGQAVNTAQGCGLKVACVSAAVSD
                     ESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQL
                     SNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALH
                     QKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKP
                     VGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENEAVAEE
                     EEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRRVGTPS
                     QGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKR
                     PSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLEQAKSHGEKEL
                     PQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRGQSCKEPPEV
                     QSFREKMAFFTRPRMNIPALSADDV"
     exon            628..737
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            738..941
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1018
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1098
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1228
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1375
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1449
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1692
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1782
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2318
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2427
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2508
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2595
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2788
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2941
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3033
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3166
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3331
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3424
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3658
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3783
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..7136
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4569..4574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="hexamer: AATAAA"
     polyA_site      4592
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="major polyA site"
     regulatory      6757..6762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="hexamer: AATAAA"
     polyA_site      6776
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
     regulatory      7114..7119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="hexamer: AATAAA"
     regulatory      7118..7123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="hexamer: AATAAA"
     polyA_site      7133
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
     polyA_site      7136
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
ORIGIN      
        1 gtttccgggg cagcgcggtt acctgcaccg cccgagccgc acctggcgga ggcagaagtc
       61 acaaacccgg cgagctcaga gcggtggagc ggagaggagg gacggcaccc ggctgcaggg
      121 aggagggagg cggcagcggc agcggcggcg tggagggcgc agcgcgccgc gcggcggagg
      181 agggcagacg gcggcggcgg cggcgctcgg ctcgctctgc ccggccggct gggcgcgcac
      241 ccgggctcgc accgcgccgc tgcggacgca catggcagcg tgagaggccg gcggcgggag
      301 gagcgggcgg cgccgggtcg gggctgcagg gccgcatgga cagcggcgcc accccggccg
      361 gcccctacta gggcccccca tctgcgggcg ccaccccccg gatcatggtg cctcggcggc
      421 cgcccgggct aagagcggcc ggctggagcc gctgagcccc cgctgcggcc gggagctgca
      481 tgggggagcg ccggcagcgc ttgggaagat gccccggccg gagctgcccc tgccggaggg
      541 ctgggaggag gcgcgcgact tcgacggcaa ggtctactac atagaccaca cgaaccgcac
      601 caccagctgg atcgacccgc gggacaggta caccaaaccg ctcacctttg ctgactgcat
      661 tagtgatgag ttgccgctag gatgggaaga ggcatatgac ccacaggttg gagattactt
      721 catagaccac aacaccaaaa ccactcagat tgaggatcct cgagtacaat ggcggcggga
      781 gcaggaacat atgctgaagg attacctggt ggtggcccag gaggctctga gtgcacaaaa
      841 ggagatctac caggtgaagc agcagcgcct ggagcttgca cagcaggagt accagcaact
      901 gcatgccgtc tgggagcata agctgggctc ccaggtcagc ttggtctctg gttcatcatc
      961 cagctccaag tatgaccctg agatcctgaa agctgaaatt gccactgcaa aatcccgggt
     1021 caacaagctg aagagagaga tggttcacct ccagcacgag ctgcagttca aagagcgtgg
     1081 ctttcagacc ctgaagaaaa tcgataagaa aatgtctgat gctcagggca gctacaaact
     1141 ggatgaagct caggctgtct tgagagaaac aaaagccatc aaaaaggcta ttacctgtgg
     1201 ggaaaaggaa aagcaagatc tcattaagag ccttgccatg ttgaaggacg gcttccgcac
     1261 tgacaggggg tctcactcag acctgtggtc cagcagcagc tctctggaga gttcgagttt
     1321 cccgctaccg aaacagtacc tggatgtgag ctcccagaca gacatctcgg gaagcttcgg
     1381 catcaacagc aacaatcagt tggcagagaa ggtcagattg cgccttcgat atgaagaggc
     1441 taagagaagg atcgccaacc tgaagatcca gctggccaag cttgacagtg aggcctggcc
     1501 tggggtgctg gactcagaga gggaccggct gatccttatc aacgagaagg aggagctgct
     1561 gaaggagatg cgcttcatca gcccccgcaa gtggacccag ggggaggtgg agcagctgga
     1621 gatggcccgg aagcggctgg aaaaggacct gcaggcagcc cgggacaccc agagcaaggc
     1681 gctgacggag aggttaaagt taaacagtaa gaggaaccag cttgtgagag aactggagga
     1741 agccacccgg caggtggcaa ctctgcactc ccagctgaaa agtctctcaa gcagcatgca
     1801 gtccctgtcc tcaggcagca gccccggatc cctcacgtcc agccggggct ccctggttgc
     1861 atccagcctg gactcctcca cttcagccag cttcactgac ctctactatg acccctttga
     1921 gcagctggac tcagagctgc agagcaaggt ggagttcctg ctcctggagg gggccaccgg
     1981 cttccggccc tcaggctgca tcaccaccat ccacgaggat gaggtggcca agacccagaa
     2041 ggcagaggga ggtggccgcc tgcaggctct gcgttccctg tctggcaccc caaagtccat
     2101 gacctcccta tccccacgtt cctctctctc ctccccctcc ccaccctgtt cccctctcat
     2161 ggctgacccc ctcctggctg gtgatgcctt cctcaactcc ttggagtttg aagacccgga
     2221 gctgagtgcc actctttgtg aactgagcct tggtaacagc gcccaggaaa gataccggct
     2281 ggaggaacca ggaacggagg gcaagcagct gggccaagct gtgaatacgg cccaggggtg
     2341 tggcctgaaa gtggcctgtg tctcagccgc cgtatcggac gagtcagtgg ctggagacag
     2401 tggtgtgtac gaggcttccg tgcagagact gggtgcttca gaagctgctg catttgacag
     2461 tgacgaatcg gaagcagtgg gtgcgacccg aattcagatt gccctgaagt atgatgagaa
     2521 gaataagcaa tttgcaatat taatcatcca gctgagtaac ctttctgctc tgttgcagca
     2581 acaagaccag aaagtgaata tccgcgtggc tgtccttcct tgctctgaaa gcacaacctg
     2641 cctgttccgg acccggcctc tggacgcctc agacactcta gtgttcaatg aggtgttctg
     2701 ggtatccatg tcctatccag cccttcacca gaagacctta agagtcgatg tctgtaccac
     2761 cgacaggagc catctggaag agtgcctggg aggcgcccag atcagcctgg cggaggtctg
     2821 ccggtctggg gagaggtcga ctcgctggta caaccttctc agctacaaat acttgaagaa
     2881 acagagcagg gagctcaagc cagtgggagt catggcccct gcctcagggc ctgccagcac
     2941 ggacgctgtg tctgctctgt tggaacagac agcagtggag ctggagaaga ggcaggaggg
     3001 caggagcagc acacagacac tggaagacag ctggaggtat gaggagacca gtgagaatga
     3061 ggcagtagcc gaggaagagg aggaggaggt ggaggaggag gagggagaag aggatgtttt
     3121 caccgagaaa gcctcacctg atatggatgg gtacccagca ttaaaggtgg acaaagagac
     3181 caacacggag accccggccc catcccccac agtggtgcga cctaaggacc ggagagtggg
     3241 caccccgtcc caggggccat ttcttcgagg gagcaccatc atccgctcta agaccttctc
     3301 cccaggaccc cagagccagt acgtgtgccg gctgaatcgg agtgatagtg acagctccac
     3361 tctgtccaaa aagccacctt ttgttcgaaa ctccctggag cgacgcagcg tccggatgaa
     3421 gcggccttcc tcggtcaagt cgctgcgctc cgagcgtctg atccgtacct cgctggacct
     3481 ggagttagac ctgcaggcga caagaacctg gcacagccaa ttgacccagg agatctcggt
     3541 gctgaaggag ctcaaggagc agctggaaca agccaagagc cacggggaga aggagctgcc
     3601 acagtggttg cgtgaggacg agcgtttccg cctgctgctg aggatgctgg agaagcggca
     3661 gatggaccga gcggagcaca agggtgagct tcagacagac aagatgatga gggcagctgc
     3721 caaggatgtg cacaggctcc gaggccagag ctgtaaggaa cccccagaag ttcagtcttt
     3781 cagggagaag atggcatttt tcacccggcc tcggatgaat atcccagctc tctctgcaga
     3841 tgacgtctaa tcgccagaaa agtatttcct ttgttccact gaccaggctg tgaacattga
     3901 ctgtggctaa agttatttat gtggtgttat atgaaggtac tgagtcacaa gtcctctagt
     3961 gctcttgttg gtttgaagat gaaccgactt tttagtttgg gtcctactgt tgttattaaa
     4021 aacagaacaa aaacaaaaca cacacacaca caaaaacaga aacaaaaaaa accagcatta
     4081 aaataataag attgtatagt ttgtatattt aggagtgtat ttttgggaaa gaaaatttaa
     4141 atgaactaaa gcagtattga gttgctgctc ttcttaaaat cgtttagatt ttttttggtt
     4201 tgtacagctc caccttttag aggtcttact gcaataagaa gtaatgcctg ggggacggta
     4261 atcctaatag gacgtcccgc acttgtcaca gtacagctaa tttttcctag ttaacatatt
     4321 ttgtacaata ttaaaaaaat gcacagaaac cattgggggg gattcagagg tgcatccacg
     4381 gatcttcttg agctgtgacg tgtttttatg tggctgccca acgtggagcg ggcagtgtga
     4441 taggctgggt gggctaagca gcctagtcta tgtgggtgac aggccacgct ggtctcagat
     4501 gcccagtgaa gccactaaca tgagtgaggg gagggctgtg gggaactcca ttcagtttta
     4561 tctccatcaa taaagtggcc tttcaaaaag aatcttcctc ttgctctctt tttctttcct
     4621 acccctcact tcatctgttt ccctgatttt tgactctccc ctttccagtc atttctttcc
     4681 cacccatccg cagtcctgga aacatttatt ttttcttttg cccactgttt tcatttgctc
     4741 attaaattaa aatgactgct cggctcattg ggaatccaca tccccaagtt agactgggga
     4801 tatgctctct gtactgtctc cttctatgga attccacccc acccagagag agatgacttc
     4861 acagtttgtt catatgagca tcatcccatg tcgtccccaa cccaggggct ggtaggtgct
     4921 acagcttgtg cttcatgctg ctcctgtggc ccctattcct acccagctca gagctttgca
     4981 gggtctactg cagacaatca gaagtcagtt tctaacaaat agcaacagcc acaaatctct
     5041 tcctccttcc tctctgacat taccctgtgc aacttttctc aaagtctgtt gcaccactca
     5101 gcaaagcaag ttgcaccagc tatatcagaa tcacctgggg cagcctatta aaaatgcaga
     5161 ctgttgagac catcctggct aacacggtga aaccctgtct ctactaaaaa tacaaaaaat
     5221 tagccggccg tggtggcggg cagctactcg ggaggctgag gcaggagaat gacctgaacc
     5281 tgggaggcag agcttgcagt gagctgagat tgtgccactg cactccagcc tgggtgacag
     5341 agcaagactc cgtctcaaaa aaaaaaaaaa aagaaaaatg cagactggct ggcgcggtgg
     5401 ctcatgcttg taatcccagc actttgggag gctgaggcgg gcagatcaac tgagatcggg
     5461 ggttcgagac cagcctgatc aacatggaga aacctggtct ctactaaaaa tacataatta
     5521 gctgggcgta gtggcgcata cctgtaatcc cagctacttg ggtggccaag gcttgaaccc
     5581 aggaggcgga ggttgcggtg agccgagatg gcgccattga ctccagcctg ggcaacaaga
     5641 gcgtaactcc atctcaaaaa aataataata ataaaaataa aatgcagact gtcaggtcct
     5701 ctctagaccc actgaactat cccgcccacc ctgggacggt ccccagtgcc agtgttttac
     5761 ccatgttccc tctgtaagtc ttatgcacac cgcaatttga gagccccact ggtataaagt
     5821 gagtgaaacc caggcagaga caggcaaaat ggtgaggccc gcatcctatt ggtgagtcac
     5881 acagggaacg ctgaaattca tggccttctc caggctactg ggaacccatg ggcggtgatg
     5941 gagggagtgg tgccaccttc acttgctgct gaggctcttc cccctctccc cagcatactc
     6001 cttacctggc tgtctctcct catgtataag gaacctatag tggtgtagaa tctactcttc
     6061 ttccccctgt ggcttccagg cccccctgta tagctgctat ccagcccgat ttctcaccac
     6121 tggcccaggg cttcctcctg ccccgtggct tcacgtctct gaacacatca atctctgatg
     6181 ttctctctcc ttccattgaa ttccaccaga cacattcagg gtttacttcg taatgtcttc
     6241 atatgagtat caatcaacac cttccccaac tcaattgtac taggttgtag agcacaagga
     6301 tggtctcgtg ctgctctgtg gcacctgtgc ctacactcct ctgagctttg aggaggctgc
     6361 tctctttgct gaccccatga tcttttctgc ccttctgtta agggcattgg ccacagcaac
     6421 ggggcaaatg ccccaagctg gctgtaagtg acccatccct ttggctccca tgattagacc
     6481 aaggagaggc atggggtcca gctgagccat tcagaaccat tccttagcat tttccactca
     6541 aaggttagag atgagatttt ctcttcccaa ggctacctct ggccatggtt ccagcttcat
     6601 gggggcaatg ggattaggaa aatgaggtca acctgcaaag gaaagcagat gcaagagatg
     6661 gagacagaat gggggtgtcc tggggatctt ggagcctgaa ttcattggca caaaaggcag
     6721 cagcatcctc actgtatctg cagtccattt ggactcaata aaaactttga aagtcacatg
     6781 tgttatggaa ttccttctca gtgacacatt catctgtgct cagttgtccc agcaagggtc
     6841 agcccctcat acccctgcag catccgctgc tatgaagcag agctgtaaac gccctccctg
     6901 tgtataggaa aagctacatg gagcaaatcc tcctgcctga agaagtgcat ctcagcatca
     6961 cttcagctgt cggggcattt gtggggagaa ccagaccacc tctgcggaag gcagcagacc
     7021 ctcttccagc catggatgga gttgaattct ctataaacgg ttcaccagca aaccaccaat
     7081 acattccatt gtttgcctag agagaaattt aaaaataaat aaatgttcac ttataa
//
