LOCUS       NP_056053               1113 aa            linear   PRI 24-JUN-2024
DEFINITION  protein KIBRA isoform 3 [Homo sapiens].
ACCESSION   NP_056053
VERSION     NP_056053.1
DBSOURCE    REFSEQ: accession NM_015238.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1113)
  AUTHORS   Papenberg,G., Karalija,N., Johansson,J., Andersson,M., Axelsson,J.,
            Riklund,K., Lindenberger,U., Nyberg,L. and Backman,L.
  TITLE     The influence of hippocampal dopamine D2 receptor losses on
            episodic-memory decline across 5 years is moderated by BDNF and
            KIBRA polymorphisms
  JOURNAL   Cortex 176, 53-61 (2024)
   PUBMED   38749085
  REMARK    GeneRIF: The influence of hippocampal dopamine D2 receptor losses
            on episodic-memory decline across 5 years is moderated by BDNF and
            KIBRA polymorphisms.
REFERENCE   2  (residues 1 to 1113)
  AUTHORS   Zhang,S., Zhang,B., Liao,Z., Chen,Y., Guo,W., Wu,J., Liu,H.,
            Weng,R., Su,D., Chen,G., Zhang,Z., Li,C., Long,J., Xiao,Y., Ma,Y.,
            Zhou,T., Xu,C. and Su,P.
  TITLE     Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA
            and inhibiting Hippo signaling pathway
  JOURNAL   Mol Ther 32 (5), 1461-1478 (2024)
   PUBMED   38414246
  REMARK    GeneRIF: Hnrnpk protects against osteoarthritis through targeting
            WWC1 mRNA and inhibiting Hippo signaling pathway.
REFERENCE   3  (residues 1 to 1113)
  AUTHORS   Homayouni,R., Daugherty,A.M., Yu,Q., Raz,N. and Ofen,N.
  TITLE     KIBRA single nucleotide polymorphism is associated with hippocampal
            subfield volumes and cognition across development
  JOURNAL   Brain Struct Funct 229 (1), 223-230 (2024)
   PUBMED   37853296
  REMARK    GeneRIF: KIBRA single nucleotide polymorphism is associated with
            hippocampal subfield volumes and cognition across development.
REFERENCE   4  (residues 1 to 1113)
  AUTHORS   Meliambro,K., Yang,Y., de Cos,M., Rodriguez Ballestas,E.,
            Malkin,C., Haydak,J., Lee,J.R., Salem,F., Mariani,L.H.,
            Gordon,R.E., Basgen,J.M., Wen,H.H., Fu,J., Azeloglu,E.U., He,J.C.,
            Wong,J.S. and Campbell,K.N.
  TITLE     KIBRA upregulation increases susceptibility to podocyte injury and
            glomerular disease progression
  JOURNAL   JCI Insight 8 (7), e165002 (2023)
   PUBMED   36853804
  REMARK    GeneRIF: KIBRA upregulation increases susceptibility to podocyte
            injury and glomerular disease progression.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1113)
  AUTHORS   Ahmetov,I.I., Valeeva,E.V., Yerdenova,M.B., Datkhabayeva,G.K.,
            Bouzid,A., Bhamidimarri,P.M., Sharafetdinova,L.M., Egorova,E.S.,
            Semenova,E.A., Gabdrakhmanova,L.J., Yusupov,R.A., Larin,A.K.,
            Kulemin,N.A., Generozov,E.V., Hamoudi,R., Kustubayeva,A.M. and
            Rees,T.
  TITLE     KIBRA Gene Variant Is Associated with Ability in Chess and Science
  JOURNAL   Genes (Basel) 14 (1), 204 (2023)
   PUBMED   36672945
  REMARK    GeneRIF: KIBRA Gene Variant Is Associated with Ability in Chess and
            Science.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1113)
  AUTHORS   Schaper,K., Kolsch,H., Popp,J., Wagner,M. and Jessen,F.
  TITLE     KIBRA gene variants are associated with episodic memory in healthy
            elderly
  JOURNAL   Neurobiol Aging 29 (7), 1123-1125 (2008)
   PUBMED   17353070
  REMARK    GeneRIF: The impact of KIBRA on memory is most likely of high
            relevance in elderly subjects as it is in young.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (residues 1 to 1113)
  AUTHORS   Papassotiropoulos,A., Stephan,D.A., Huentelman,M.J., Hoerndli,F.J.,
            Craig,D.W., Pearson,J.V., Huynh,K.D., Brunner,F., Corneveaux,J.,
            Osborne,D., Wollmer,M.A., Aerni,A., Coluccia,D., Hanggi,J.,
            Mondadori,C.R., Buchmann,A., Reiman,E.M., Caselli,R.J., Henke,K.
            and de Quervain,D.J.
  TITLE     Common Kibra alleles are associated with human memory performance
  JOURNAL   Science 314 (5798), 475-478 (2006)
   PUBMED   17053149
  REMARK    GeneRIF: gene expression studies showed that KIBRA was expressed in
            memory-related brain structures; KIBRA allele-dependent differences
            in hippocampal activations during memory retrieval were detected
            GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
REFERENCE   8  (residues 1 to 1113)
  AUTHORS   Rayala,S.K., den Hollander,P., Manavathi,B., Talukder,A.H.,
            Song,C., Peng,S., Barnekow,A., Kremerskothen,J. and Kumar,R.
  TITLE     Essential role of KIBRA in co-activator function of dynein light
            chain 1 in mammalian cells
  JOURNAL   J Biol Chem 281 (28), 19092-19099 (2006)
   PUBMED   16684779
  REMARK    GeneRIF: the DLC1-KIBRA interaction is essential for ER
            transactivation in breast cancer cells
REFERENCE   9  (residues 1 to 1113)
  AUTHORS   Buther,K., Plaas,C., Barnekow,A. and Kremerskothen,J.
  TITLE     KIBRA is a novel substrate for protein kinase Czeta
  JOURNAL   Biochem Biophys Res Commun 317 (3), 703-707 (2004)
   PUBMED   15081397
  REMARK    GeneRIF: identification as novel substrate for protein kinase C
            zeta and regulation of cellular function by same enzyme
REFERENCE   10 (residues 1 to 1113)
  AUTHORS   Kremerskothen,J., Plaas,C., Buther,K., Finger,I., Veltel,S.,
            Matanis,T., Liedtke,T. and Barnekow,A.
  TITLE     Characterization of KIBRA, a novel WW domain-containing protein
  JOURNAL   Biochem Biophys Res Commun 300 (4), 862-867 (2003)
   PUBMED   12559952
  REMARK    GeneRIF: Data describe the isolation of a cDNA coding for a novel
            protein, KIBRA, possessing two amino-terminal WW domains, an
            internal C2-like domain and a carboxy-terminal glutamic acid-rich
            stretch
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026689.6, DR001014.1,
            AF506799.1, BC004394.1, AC020894.5 and CA313640.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a cytoplasmic
            phosphoprotein that interacts with PRKC-zeta and dynein light
            chain-1. Alleles of this gene have been found that enhance memory
            in some individuals. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2010].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. This
            results in a shorter protein (isoform 3) compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF506799.1, SRR14038191.2493354.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265293.9/ ENSP00000265293.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1113
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     Protein         1..1113
                     /product="protein KIBRA isoform 3"
                     /note="WW, C2 and coiled-coil domain containing 1; kidney
                     and brain protein; HBeAg-binding protein 3; protein WWC1;
                     protein KIBRA; protein phosphatase 1, regulatory subunit
                     168"
                     /calculated_mol_wt=125170
     Region          9..39
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(23,34)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          56..85
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(70,81)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SXA9; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Region          <162..>422
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <311..>422
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          429..448
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX03.1)"
     Region          522..547
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            535
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            542
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000269|PubMed:22784093; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Region          660..783
                     /region_name="C2_Kibra"
                     /note="C2 domain found in Human protein Kibra; cd08680"
                     /db_xref="CDD:176062"
     Region          825..975
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX03.1)"
     Region          839..1113
                     /region_name="Interaction with histone H3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            899
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            912
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            927
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SXA9; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            929
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            931
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000269|PubMed:22784093,
                     ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            947
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Region          953..996
                     /region_name="Interaction with PRKCZ"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX03.1)"
     Region          956..975
                     /region_name="Interaction with PRKCZ.
                     /evidence=ECO:0000269|PubMed:24682284"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            975
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCZ.
                     /evidence=ECO:0000269|PubMed:15081397; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Site            978
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCZ.
                     /evidence=ECO:0000269|PubMed:15081397; propagated from
                     UniProtKB/Swiss-Prot (Q8IX03.1)"
     Region          1111..1113
                     /region_name="ADDV motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX03.1)"
     CDS             1..1113
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /coded_by="NM_015238.3:509..3850"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS4366.1"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
ORIGIN      
        1 mprpelplpe gweeardfdg kvyyidhtnr ttswidprdr ytkpltfadc isdelplgwe
       61 eaydpqvgdy fidhntkttq iedprvqwrr eqehmlkdyl vvaqealsaq keiyqvkqqr
      121 lelaqqeyqq lhavwehklg sqvslvsgss ssskydpeil kaeiataksr vnklkremvh
      181 lqhelqfker gfqtlkkidk kmsdaqgsyk ldeaqavlre tkaikkaitc gekekqdlik
      241 slamlkdgfr tdrgshsdlw ssssslesss fplpkqyldv ssqtdisgsf ginsnnqlae
      301 kvrlrlryee akrrianlki qlakldseaw pgvldserdr lilinekeel lkemrfispr
      361 kwtqgeveql emarkrlekd lqaardtqsk alterlklns krnqlvrele eatrqvatlh
      421 sqlkslsssm qslssgsspg sltssrgslv assldsstsa sftdlyydpf eqldselqsk
      481 veflllegat gfrpsgcitt ihedevaktq kaegggrlqa lrslsgtpks mtslsprssl
      541 sspsppcspl madpllagda flnslefedp elsatlcels lgnsaqeryr leepgtegkq
      601 lgqavntaqg cglkvacvsa avsdesvagd sgvyeasvqr lgaseaaafd sdeseavgat
      661 riqialkyde knkqfailii qlsnlsallq qqdqkvnirv avlpcsestt clfrtrplda
      721 sdtlvfnevf wvsmsypalh qktlrvdvct tdrshleecl ggaqislaev crsgerstrw
      781 ynllsykylk kqsrelkpvg vmapasgpas tdavsalleq tavelekrqe grsstqtled
      841 swryeetsen eavaeeeeee veeeegeedv ftekaspdmd gypalkvdke tntetpapsp
      901 tvvrpkdrrv gtpsqgpflr gstiirsktf spgpqsqyvc rlnrsdsdss tlskkppfvr
      961 nslerrsvrm krpssvkslr serlirtsld leldlqatrt whsqltqeis vlkelkeqle
     1021 qakshgekel pqwlrederf rlllrmlekr qmdraehkge lqtdkmmraa akdvhrlrgq
     1081 sckeppevqs frekmafftr prmnipalsa ddv
//
