LOCUS       NM_001161662            7151 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens WW and C2 domain containing 1 (WWC1), transcript
            variant 2, mRNA.
ACCESSION   NM_001161662
VERSION     NM_001161662.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7151)
  AUTHORS   Papenberg,G., Karalija,N., Johansson,J., Andersson,M., Axelsson,J.,
            Riklund,K., Lindenberger,U., Nyberg,L. and Backman,L.
  TITLE     The influence of hippocampal dopamine D2 receptor losses on
            episodic-memory decline across 5 years is moderated by BDNF and
            KIBRA polymorphisms
  JOURNAL   Cortex 176, 53-61 (2024)
   PUBMED   38749085
  REMARK    GeneRIF: The influence of hippocampal dopamine D2 receptor losses
            on episodic-memory decline across 5 years is moderated by BDNF and
            KIBRA polymorphisms.
REFERENCE   2  (bases 1 to 7151)
  AUTHORS   Zhang,S., Zhang,B., Liao,Z., Chen,Y., Guo,W., Wu,J., Liu,H.,
            Weng,R., Su,D., Chen,G., Zhang,Z., Li,C., Long,J., Xiao,Y., Ma,Y.,
            Zhou,T., Xu,C. and Su,P.
  TITLE     Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA
            and inhibiting Hippo signaling pathway
  JOURNAL   Mol Ther 32 (5), 1461-1478 (2024)
   PUBMED   38414246
  REMARK    GeneRIF: Hnrnpk protects against osteoarthritis through targeting
            WWC1 mRNA and inhibiting Hippo signaling pathway.
REFERENCE   3  (bases 1 to 7151)
  AUTHORS   Homayouni,R., Daugherty,A.M., Yu,Q., Raz,N. and Ofen,N.
  TITLE     KIBRA single nucleotide polymorphism is associated with hippocampal
            subfield volumes and cognition across development
  JOURNAL   Brain Struct Funct 229 (1), 223-230 (2024)
   PUBMED   37853296
  REMARK    GeneRIF: KIBRA single nucleotide polymorphism is associated with
            hippocampal subfield volumes and cognition across development.
REFERENCE   4  (bases 1 to 7151)
  AUTHORS   Meliambro,K., Yang,Y., de Cos,M., Rodriguez Ballestas,E.,
            Malkin,C., Haydak,J., Lee,J.R., Salem,F., Mariani,L.H.,
            Gordon,R.E., Basgen,J.M., Wen,H.H., Fu,J., Azeloglu,E.U., He,J.C.,
            Wong,J.S. and Campbell,K.N.
  TITLE     KIBRA upregulation increases susceptibility to podocyte injury and
            glomerular disease progression
  JOURNAL   JCI Insight 8 (7), e165002 (2023)
   PUBMED   36853804
  REMARK    GeneRIF: KIBRA upregulation increases susceptibility to podocyte
            injury and glomerular disease progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7151)
  AUTHORS   Ahmetov,I.I., Valeeva,E.V., Yerdenova,M.B., Datkhabayeva,G.K.,
            Bouzid,A., Bhamidimarri,P.M., Sharafetdinova,L.M., Egorova,E.S.,
            Semenova,E.A., Gabdrakhmanova,L.J., Yusupov,R.A., Larin,A.K.,
            Kulemin,N.A., Generozov,E.V., Hamoudi,R., Kustubayeva,A.M. and
            Rees,T.
  TITLE     KIBRA Gene Variant Is Associated with Ability in Chess and Science
  JOURNAL   Genes (Basel) 14 (1), 204 (2023)
   PUBMED   36672945
  REMARK    GeneRIF: KIBRA Gene Variant Is Associated with Ability in Chess and
            Science.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7151)
  AUTHORS   Schaper,K., Kolsch,H., Popp,J., Wagner,M. and Jessen,F.
  TITLE     KIBRA gene variants are associated with episodic memory in healthy
            elderly
  JOURNAL   Neurobiol Aging 29 (7), 1123-1125 (2008)
   PUBMED   17353070
  REMARK    GeneRIF: The impact of KIBRA on memory is most likely of high
            relevance in elderly subjects as it is in young.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7151)
  AUTHORS   Papassotiropoulos,A., Stephan,D.A., Huentelman,M.J., Hoerndli,F.J.,
            Craig,D.W., Pearson,J.V., Huynh,K.D., Brunner,F., Corneveaux,J.,
            Osborne,D., Wollmer,M.A., Aerni,A., Coluccia,D., Hanggi,J.,
            Mondadori,C.R., Buchmann,A., Reiman,E.M., Caselli,R.J., Henke,K.
            and de Quervain,D.J.
  TITLE     Common Kibra alleles are associated with human memory performance
  JOURNAL   Science 314 (5798), 475-478 (2006)
   PUBMED   17053149
  REMARK    GeneRIF: gene expression studies showed that KIBRA was expressed in
            memory-related brain structures; KIBRA allele-dependent differences
            in hippocampal activations during memory retrieval were detected
            GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 7151)
  AUTHORS   Rayala,S.K., den Hollander,P., Manavathi,B., Talukder,A.H.,
            Song,C., Peng,S., Barnekow,A., Kremerskothen,J. and Kumar,R.
  TITLE     Essential role of KIBRA in co-activator function of dynein light
            chain 1 in mammalian cells
  JOURNAL   J Biol Chem 281 (28), 19092-19099 (2006)
   PUBMED   16684779
  REMARK    GeneRIF: the DLC1-KIBRA interaction is essential for ER
            transactivation in breast cancer cells
REFERENCE   9  (bases 1 to 7151)
  AUTHORS   Buther,K., Plaas,C., Barnekow,A. and Kremerskothen,J.
  TITLE     KIBRA is a novel substrate for protein kinase Czeta
  JOURNAL   Biochem Biophys Res Commun 317 (3), 703-707 (2004)
   PUBMED   15081397
  REMARK    GeneRIF: identification as novel substrate for protein kinase C
            zeta and regulation of cellular function by same enzyme
REFERENCE   10 (bases 1 to 7151)
  AUTHORS   Kremerskothen,J., Plaas,C., Buther,K., Finger,I., Veltel,S.,
            Matanis,T., Liedtke,T. and Barnekow,A.
  TITLE     Characterization of KIBRA, a novel WW domain-containing protein
  JOURNAL   Biochem Biophys Res Commun 300 (4), 862-867 (2003)
   PUBMED   12559952
  REMARK    GeneRIF: Data describe the isolation of a cDNA coding for a novel
            protein, KIBRA, possessing two amino-terminal WW domains, an
            internal C2-like domain and a carboxy-terminal glutamic acid-rich
            stretch
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026689.6, DR001014.1,
            BX640827.1, AK296323.1, AC020894.5 and CA313640.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001161662.1.
            
            Summary: The protein encoded by this gene is a cytoplasmic
            phosphoprotein that interacts with PRKC-zeta and dynein light
            chain-1. Alleles of this gene have been found that enhance memory
            in some individuals. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2010].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. This
            results in a shorter protein (isoform 2) compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               AC026689.6         58779-59193
            416-611             DR001014.1         410-605
            612-2188            BX640827.1         1-1577
            2189-3676           AK296323.1         1684-3171
            3677-4306           BX640827.1         3066-3695
            4307-6498           AC020894.5         25394-27585
            6499-7151           CA313640.1         15-667              c
FEATURES             Location/Qualifiers
     source          1..7151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     gene            1..7151
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="WW and C2 domain containing 1"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
     exon            1..627
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     CDS             509..3865
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="isoform 2 is encoded by transcript variant 2; WW,
                     C2 and coiled-coil domain containing 1; kidney and brain
                     protein; HBeAg-binding protein 3; protein WWC1; protein
                     KIBRA; protein phosphatase 1, regulatory subunit 168"
                     /codon_start=1
                     /product="protein KIBRA isoform 2"
                     /protein_id="NP_001155134.1"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
                     /translation="MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKP
                     LTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVV
                     AQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEIL
                     KAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVL
                     RETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQ
                     YLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVL
                     DSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARDTQSKAL
                     TERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLV
                     ASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIHEDEVAK
                     TQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSPLMADPLLAGDAFLNSLE
                     FEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLGQAVNTAQGCGLKVACVSAAVSD
                     ESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQL
                     SNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALH
                     QKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKP
                     VGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENEAVAEE
                     EEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRRVGTPS
                     QGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKR
                     PSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLEQAKS
                     HGEKELPQWLREDERFRLLLRMLEKRMDRAEHKGELQTDKMMRAAAKDVHRLRGQSCK
                     EPPEVQSFREKMAFFTRPRMNIPALSADDV"
     exon            628..737
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            738..941
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1018
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1098
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1228
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1375
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1449
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1692
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1782
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2318
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2427
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2508
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2595
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2788
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2941
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3033
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3166
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3331
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3424
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3676
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3798
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..7151
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4584..4589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="hexamer: AATAAA"
     polyA_site      4607
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="major polyA site"
     regulatory      6772..6777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="hexamer: AATAAA"
     polyA_site      6791
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
     regulatory      7129..7134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="hexamer: AATAAA"
     regulatory      7133..7138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="hexamer: AATAAA"
     polyA_site      7148
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
     polyA_site      7151
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
ORIGIN      
        1 gtttccgggg cagcgcggtt acctgcaccg cccgagccgc acctggcgga ggcagaagtc
       61 acaaacccgg cgagctcaga gcggtggagc ggagaggagg gacggcaccc ggctgcaggg
      121 aggagggagg cggcagcggc agcggcggcg tggagggcgc agcgcgccgc gcggcggagg
      181 agggcagacg gcggcggcgg cggcgctcgg ctcgctctgc ccggccggct gggcgcgcac
      241 ccgggctcgc accgcgccgc tgcggacgca catggcagcg tgagaggccg gcggcgggag
      301 gagcgggcgg cgccgggtcg gggctgcagg gccgcatgga cagcggcgcc accccggccg
      361 gcccctacta gggcccccca tctgcgggcg ccaccccccg gatcatggtg cctcggcggc
      421 cgcccgggct aagagcggcc ggctggagcc gctgagcccc cgctgcggcc gggagctgca
      481 tgggggagcg ccggcagcgc ttgggaagat gccccggccg gagctgcccc tgccggaggg
      541 ctgggaggag gcgcgcgact tcgacggcaa ggtctactac atagaccaca cgaaccgcac
      601 caccagctgg atcgacccgc gggacaggta caccaaaccg ctcacctttg ctgactgcat
      661 tagtgatgag ttgccgctag gatgggaaga ggcatatgac ccacaggttg gagattactt
      721 catagaccac aacaccaaaa ccactcagat tgaggatcct cgagtacaat ggcggcggga
      781 gcaggaacat atgctgaagg attacctggt ggtggcccag gaggctctga gtgcacaaaa
      841 ggagatctac caggtgaagc agcagcgcct ggagcttgca cagcaggagt accagcaact
      901 gcatgccgtc tgggagcata agctgggctc ccaggtcagc ttggtctctg gttcatcatc
      961 cagctccaag tatgaccctg agatcctgaa agctgaaatt gccactgcaa aatcccgggt
     1021 caacaagctg aagagagaga tggttcacct ccagcacgag ctgcagttca aagagcgtgg
     1081 ctttcagacc ctgaagaaaa tcgataagaa aatgtctgat gctcagggca gctacaaact
     1141 ggatgaagct caggctgtct tgagagaaac aaaagccatc aaaaaggcta ttacctgtgg
     1201 ggaaaaggaa aagcaagatc tcattaagag ccttgccatg ttgaaggacg gcttccgcac
     1261 tgacaggggg tctcactcag acctgtggtc cagcagcagc tctctggaga gttcgagttt
     1321 cccgctaccg aaacagtacc tggatgtgag ctcccagaca gacatctcgg gaagcttcgg
     1381 catcaacagc aacaatcagt tggcagagaa ggtcagattg cgccttcgat atgaagaggc
     1441 taagagaagg atcgccaacc tgaagatcca gctggccaag cttgacagtg aggcctggcc
     1501 tggggtgctg gactcagaga gggaccggct gatccttatc aacgagaagg aggagctgct
     1561 gaaggagatg cgcttcatca gcccccgcaa gtggacccag ggggaggtgg agcagctgga
     1621 gatggcccgg aagcggctgg aaaaggacct gcaggcagcc cgggacaccc agagcaaggc
     1681 gctgacggag aggttaaagt taaacagtaa gaggaaccag cttgtgagag aactggagga
     1741 agccacccgg caggtggcaa ctctgcactc ccagctgaaa agtctctcaa gcagcatgca
     1801 gtccctgtcc tcaggcagca gccccggatc cctcacgtcc agccggggct ccctggttgc
     1861 atccagcctg gactcctcca cttcagccag cttcactgac ctctactatg acccctttga
     1921 gcagctggac tcagagctgc agagcaaggt ggagttcctg ctcctggagg gggccaccgg
     1981 cttccggccc tcaggctgca tcaccaccat ccacgaggat gaggtggcca agacccagaa
     2041 ggcagaggga ggtggccgcc tgcaggctct gcgttccctg tctggcaccc caaagtccat
     2101 gacctcccta tccccacgtt cctctctctc ctccccctcc ccaccctgtt cccctctcat
     2161 ggctgacccc ctcctggctg gtgatgcctt cctcaactcc ttggagtttg aagacccgga
     2221 gctgagtgcc actctttgtg aactgagcct tggtaacagc gcccaggaaa gataccggct
     2281 ggaggaacca ggaacggagg gcaagcagct gggccaagct gtgaatacgg cccaggggtg
     2341 tggcctgaaa gtggcctgtg tctcagccgc cgtatcggac gagtcagtgg ctggagacag
     2401 tggtgtgtac gaggcttccg tgcagagact gggtgcttca gaagctgctg catttgacag
     2461 tgacgaatcg gaagcagtgg gtgcgacccg aattcagatt gccctgaagt atgatgagaa
     2521 gaataagcaa tttgcaatat taatcatcca gctgagtaac ctttctgctc tgttgcagca
     2581 acaagaccag aaagtgaata tccgcgtggc tgtccttcct tgctctgaaa gcacaacctg
     2641 cctgttccgg acccggcctc tggacgcctc agacactcta gtgttcaatg aggtgttctg
     2701 ggtatccatg tcctatccag cccttcacca gaagacctta agagtcgatg tctgtaccac
     2761 cgacaggagc catctggaag agtgcctggg aggcgcccag atcagcctgg cggaggtctg
     2821 ccggtctggg gagaggtcga ctcgctggta caaccttctc agctacaaat acttgaagaa
     2881 acagagcagg gagctcaagc cagtgggagt catggcccct gcctcagggc ctgccagcac
     2941 ggacgctgtg tctgctctgt tggaacagac agcagtggag ctggagaaga ggcaggaggg
     3001 caggagcagc acacagacac tggaagacag ctggaggtat gaggagacca gtgagaatga
     3061 ggcagtagcc gaggaagagg aggaggaggt ggaggaggag gagggagaag aggatgtttt
     3121 caccgagaaa gcctcacctg atatggatgg gtacccagca ttaaaggtgg acaaagagac
     3181 caacacggag accccggccc catcccccac agtggtgcga cctaaggacc ggagagtggg
     3241 caccccgtcc caggggccat ttcttcgagg gagcaccatc atccgctcta agaccttctc
     3301 cccaggaccc cagagccagt acgtgtgccg gctgaatcgg agtgatagtg acagctccac
     3361 tctgtccaaa aagccacctt ttgttcgaaa ctccctggag cgacgcagcg tccggatgaa
     3421 gcggccgtcc ccacccccac agccttcctc ggtcaagtcg ctgcgctccg agcgtctgat
     3481 ccgtacctcg ctggacctgg agttagacct gcaggcgaca agaacctggc acagccaatt
     3541 gacccaggag atctcggtgc tgaaggagct caaggagcag ctggaacaag ccaagagcca
     3601 cggggagaag gagctgccac agtggttgcg tgaggacgag cgtttccgcc tgctgctgag
     3661 gatgctggag aagcggatgg accgagcgga gcacaagggt gagcttcaga cagacaagat
     3721 gatgagggca gctgccaagg atgtgcacag gctccgaggc cagagctgta aggaaccccc
     3781 agaagttcag tctttcaggg agaagatggc atttttcacc cggcctcgga tgaatatccc
     3841 agctctctct gcagatgacg tctaatcgcc agaaaagtat ttcctttgtt ccactgacca
     3901 ggctgtgaac attgactgtg gctaaagtta tttatgtggt gttatatgaa ggtactgagt
     3961 cacaagtcct ctagtgctct tgttggtttg aagatgaacc gactttttag tttgggtcct
     4021 actgttgtta ttaaaaacag aacaaaaaca aaacacacac acacacaaaa acagaaacaa
     4081 aaaaaaccag cattaaaata ataagattgt atagtttgta tatttaggag tgtatttttg
     4141 ggaaagaaaa tttaaatgaa ctaaagcagt attgagttgc tgctcttctt aaaatcgttt
     4201 agattttttt tggtttgtac agctccacct tttagaggtc ttactgcaat aagaagtaat
     4261 gcctggggga cggtaatcct aataggacgt cccgcacttg tcacagtaca gctaattttt
     4321 cctagttaac atattttgta caatattaaa aaaatgcaca gaaaccattg ggggggattc
     4381 agaggtgcat ccacggatct tcttgagctg tgacgtgttt ttatgtggct gcccaacgtg
     4441 gagcgggcag tgtgataggc tgggtgggct aagcagccta gtctatgtgg gtgacaggcc
     4501 acgctggtct cagatgccca gtgaagccac taacatgagt gaggggaggg ctgtggggaa
     4561 ctccattcag ttttatctcc atcaataaag tggcctttca aaaagaatct tcctcttgct
     4621 ctctttttct ttcctacccc tcacttcatc tgtttccctg atttttgact ctcccctttc
     4681 cagtcatttc tttcccaccc atccgcagtc ctggaaacat ttattttttc ttttgcccac
     4741 tgttttcatt tgctcattaa attaaaatga ctgctcggct cattgggaat ccacatcccc
     4801 aagttagact ggggatatgc tctctgtact gtctccttct atggaattcc accccaccca
     4861 gagagagatg acttcacagt ttgttcatat gagcatcatc ccatgtcgtc cccaacccag
     4921 gggctggtag gtgctacagc ttgtgcttca tgctgctcct gtggccccta ttcctaccca
     4981 gctcagagct ttgcagggtc tactgcagac aatcagaagt cagtttctaa caaatagcaa
     5041 cagccacaaa tctcttcctc cttcctctct gacattaccc tgtgcaactt ttctcaaagt
     5101 ctgttgcacc actcagcaaa gcaagttgca ccagctatat cagaatcacc tggggcagcc
     5161 tattaaaaat gcagactgtt gagaccatcc tggctaacac ggtgaaaccc tgtctctact
     5221 aaaaatacaa aaaattagcc ggccgtggtg gcgggcagct actcgggagg ctgaggcagg
     5281 agaatgacct gaacctggga ggcagagctt gcagtgagct gagattgtgc cactgcactc
     5341 cagcctgggt gacagagcaa gactccgtct caaaaaaaaa aaaaaaagaa aaatgcagac
     5401 tggctggcgc ggtggctcat gcttgtaatc ccagcacttt gggaggctga ggcgggcaga
     5461 tcaactgaga tcgggggttc gagaccagcc tgatcaacat ggagaaacct ggtctctact
     5521 aaaaatacat aattagctgg gcgtagtggc gcatacctgt aatcccagct acttgggtgg
     5581 ccaaggcttg aacccaggag gcggaggttg cggtgagccg agatggcgcc attgactcca
     5641 gcctgggcaa caagagcgta actccatctc aaaaaaataa taataataaa aataaaatgc
     5701 agactgtcag gtcctctcta gacccactga actatcccgc ccaccctggg acggtcccca
     5761 gtgccagtgt tttacccatg ttccctctgt aagtcttatg cacaccgcaa tttgagagcc
     5821 ccactggtat aaagtgagtg aaacccaggc agagacaggc aaaatggtga ggcccgcatc
     5881 ctattggtga gtcacacagg gaacgctgaa attcatggcc ttctccaggc tactgggaac
     5941 ccatgggcgg tgatggaggg agtggtgcca ccttcacttg ctgctgaggc tcttccccct
     6001 ctccccagca tactccttac ctggctgtct ctcctcatgt ataaggaacc tatagtggtg
     6061 tagaatctac tcttcttccc cctgtggctt ccaggccccc ctgtatagct gctatccagc
     6121 ccgatttctc accactggcc cagggcttcc tcctgccccg tggcttcacg tctctgaaca
     6181 catcaatctc tgatgttctc tctccttcca ttgaattcca ccagacacat tcagggttta
     6241 cttcgtaatg tcttcatatg agtatcaatc aacaccttcc ccaactcaat tgtactaggt
     6301 tgtagagcac aaggatggtc tcgtgctgct ctgtggcacc tgtgcctaca ctcctctgag
     6361 ctttgaggag gctgctctct ttgctgaccc catgatcttt tctgcccttc tgttaagggc
     6421 attggccaca gcaacggggc aaatgcccca agctggctgt aagtgaccca tccctttggc
     6481 tcccatgatt agaccaagga gaggcatggg gtccagctga gccattcaga accattcctt
     6541 agcattttcc actcaaaggt tagagatgag attttctctt cccaaggcta cctctggcca
     6601 tggttccagc ttcatggggg caatgggatt aggaaaatga ggtcaacctg caaaggaaag
     6661 cagatgcaag agatggagac agaatggggg tgtcctgggg atcttggagc ctgaattcat
     6721 tggcacaaaa ggcagcagca tcctcactgt atctgcagtc catttggact caataaaaac
     6781 tttgaaagtc acatgtgtta tggaattcct tctcagtgac acattcatct gtgctcagtt
     6841 gtcccagcaa gggtcagccc ctcatacccc tgcagcatcc gctgctatga agcagagctg
     6901 taaacgccct ccctgtgtat aggaaaagct acatggagca aatcctcctg cctgaagaag
     6961 tgcatctcag catcacttca gctgtcgggg catttgtggg gagaaccaga ccacctctgc
     7021 ggaaggcagc agaccctctt ccagccatgg atggagttga attctctata aacggttcac
     7081 cagcaaacca ccaatacatt ccattgtttg cctagagaga aatttaaaaa taaataaatg
     7141 ttcacttata a
//
