LOCUS       NM_001080436           13545 bp    mRNA    linear   PRI 28-AUG-2022
DEFINITION  Homo sapiens WT1 interacting protein (WTIP), mRNA.
ACCESSION   NM_001080436 XM_059037
VERSION     NM_001080436.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13545)
  AUTHORS   De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y,
            Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Liu WR, Erbilgin
            A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Bos
            JM, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez
            V, Snyder M, Parikh VN and Ashley EA.
  TITLE     Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein)
            Underlies Novel Mechanism for Cardiac Hypertrophy
  JOURNAL   Circ Genom Precis Med 15 (4), e003563 (2022)
   PUBMED   35671065
  REMARK    GeneRIF: Wnt Signaling Interactor WTIP (Wilms Tumor Interacting
            Protein) Underlies Novel Mechanism for Cardiac Hypertrophy.
REFERENCE   2  (bases 1 to 13545)
  AUTHORS   Zhu Y, Tong X, Wang Y and Lu X.
  TITLE     WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute
            myeloid leukemia
  JOURNAL   Cell Death Dis 13 (1), 18 (2021)
   PUBMED   34930905
  REMARK    GeneRIF: WTIP upregulates FOXO3a and induces apoptosis through PUMA
            in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13545)
  AUTHORS   Hao Q, Zong X, Sun Q, Lin YC, Song YJ, Hashemikhabir S, Hsu RY,
            Kamran M, Chaudhary R, Tripathi V, Singh DK, Chakraborty A, Li XL,
            Kim YJ, Orjalo AV, Polycarpou-Schwarz M, Moriarity BS, Jenkins LM,
            Johansson HE, Zhu YJ, Diederichs S, Bagchi A, Kim TH, Janga SC, Lal
            A, Prasanth SG and Prasanth KV.
  TITLE     The S-phase-induced lncRNA SUNO1 promotes cell proliferation by
            controlling YAP1/Hippo signaling pathway
  JOURNAL   Elife 9, e55102 (2020)
   PUBMED   33108271
  REMARK    GeneRIF: The S-phase-induced lncRNA SUNO1 promotes cell
            proliferation by controlling YAP1/Hippo signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13545)
  AUTHORS   Wu Z, Qiu M, Mi Z, Meng M, Guo Y, Jiang X, Fang J, Wang H, Zhao J,
            Liu Z, Qian D and Yuan Z.
  TITLE     WT1-interacting protein inhibits cell proliferation and
            tumorigenicity in non-small-cell lung cancer via the AKT/FOXO1 axis
  JOURNAL   Mol Oncol 13 (5), 1059-1074 (2019)
   PUBMED   30690883
  REMARK    GeneRIF: WTIP impairs AKT phosphorylation and activation, leading
            to enhanced expression and transcriptional activity of FOXO1, which
            further increases p21Cip1 and p27Kip1, and decreases cyclin D1,
            which consequently results in cell cycle arrest.
REFERENCE   5  (bases 1 to 13545)
  AUTHORS   Lu X, Zhuang H, Yu Q, Zhang X, Wu Z, Zhang L, Xu Y, Wu B, Yang L,
            Ma A, Gan X, Yu X, Shen J and Xu R.
  TITLE     Identification of the UBA2-WTIP fusion gene in acute myeloid
            leukemia
  JOURNAL   Exp Cell Res 371 (2), 409-416 (2018)
   PUBMED   30179602
  REMARK    GeneRIF: The findings suggest that the UBA2-WTIP fusion is an
            oncogenic fusion gene, as well as a promising therapeutic target
            for the treatment of acute myeloid leukemia.
REFERENCE   6  (bases 1 to 13545)
  AUTHORS   Das Thakur M, Feng Y, Jagannathan R, Seppa MJ, Skeath JB and
            Longmore GD.
  TITLE     Ajuba LIM proteins are negative regulators of the Hippo signaling
            pathway
  JOURNAL   Curr Biol 20 (7), 657-662 (2010)
   PUBMED   20303269
REFERENCE   7  (bases 1 to 13545)
  AUTHORS   Kim JH, Konieczkowski M, Mukherjee A, Schechtman S, Khan S,
            Schelling JR, Ross MD, Bruggeman LA and Sedor JR.
  TITLE     Podocyte injury induces nuclear translocation of WTIP via
            microtubule-dependent transport
  JOURNAL   J Biol Chem 285 (13), 9995-10004 (2010)
   PUBMED   20086015
  REMARK    GeneRIF: Stress signaling pathways initiate WTIP nuclear
            translocation, and the concomitant loss of WTIP from cell contacts
            changes podocyte morphology and dynamic actin assembly, suggesting
            a mechanism that transmits changes in podocyte morphology to the
            nucleus.
REFERENCE   8  (bases 1 to 13545)
  AUTHORS   van Wijk NV, Witte F, Feike AC, Schambony A, Birchmeier W, Mundlos
            S and Stricker S.
  TITLE     The LIM domain protein Wtip interacts with the receptor tyrosine
            kinase Ror2 and inhibits canonical Wnt signalling
  JOURNAL   Biochem Biophys Res Commun 390 (2), 211-216 (2009)
   PUBMED   19785987
  REMARK    GeneRIF: Full-length Ror2 recruits Wtip to the cell membrane, a
            mutant involved in human disease fails to do so. Both genes and
            proteins show overlapping expression in the mouse embryo.
REFERENCE   9  (bases 1 to 13545)
  AUTHORS   Langer EM, Feng Y, Zhaoyuan H, Rauscher FJ 3rd, Kroll KL and
            Longmore GD.
  TITLE     Ajuba LIM proteins are snail/slug corepressors required for neural
            crest development in Xenopus
  JOURNAL   Dev Cell 14 (3), 424-436 (2008)
   PUBMED   18331720
  REMARK    GeneRIF: WTIP is a member of the Ajuba family of LIM-domain
            containing proteins. Ajuba LIM proteins co-repress E-cadherin
            expression through interaction with the SNAG domain of Snail/Slug
            and promote epithelial to mesenchymal differentiation in a Xenopus
            model.
REFERENCE   10 (bases 1 to 13545)
  AUTHORS   Srichai MB, Konieczkowski M, Padiyar A, Konieczkowski DJ, Mukherjee
            A, Hayden PS, Kamat S, El-Meanawy MA, Khan S, Mundel P, Lee SB,
            Bruggeman LA, Schelling JR and Sedor JR.
  TITLE     A WT1 co-regulator controls podocyte phenotype by shuttling between
            adhesion structures and nucleus
  JOURNAL   J Biol Chem 279 (14), 14398-14408 (2004)
   PUBMED   14736876
  REMARK    GeneRIF: WTIP monitors slit diaphragm protein assembly as part of a
            multiple protein complex, linking this specialized adhesion
            junction to the actin cytoskeleton, and shuttles into the nucleus
            after podocyte injury
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008747.5.
            
            On May 17, 2019 this sequence version replaced NM_001080436.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4195099.1,
                                           ERR279843.10033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590071.7/ ENSP00000466953.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC008747.5         80209-80425
            218-884             AC008747.5         80426-81092
            885-986             AC008747.5         88827-88928
            987-1054            AC008747.5         91488-91555
            1055-1117           AC008747.5         91714-91776
            1118-1248           AC008747.5         91943-92073
            1249-1300           AC008747.5         93037-93088
            1301-1369           AC008747.5         94154-94222
            1370-2421           AC008747.5         98580-99631
            2422-13545          AC008747.5         99632-110755
FEATURES             Location/Qualifiers
     source          1..13545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..13545
                     /gene="WTIP"
                     /note="WT1 interacting protein"
                     /db_xref="GeneID:126374"
                     /db_xref="HGNC:HGNC:20964"
                     /db_xref="MIM:614790"
     exon            1..884
                     /gene="WTIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1510
                     /gene="WTIP"
                     /note="Wilms tumor 1 interacting protein"
                     /codon_start=1
                     /product="Wilms tumor protein 1-interacting protein"
                     /protein_id="NP_001073905.1"
                     /db_xref="CCDS:CCDS59375.1"
                     /db_xref="GeneID:126374"
                     /db_xref="HGNC:HGNC:20964"
                     /db_xref="MIM:614790"
                     /translation="MQRSRAGADEAALLLAGLALRELEPGCGSPGRGRRGPRPGPGDE
                     AAPALGRRGKGSGGPEAGADGLSRGERGPRRAAVPELSAQPAGSPRASLAGSDGGGGG
                     GSARSSGISLGYDQRHGSPRSGRSDPRPGPGPPSVGSARSSVSSLGSRGSAGAYADFL
                     PPGACPAPARSPEPAGPAPFPLPALPLPPGREGGPSAAERRLEALTRELERALEARTA
                     RDYFGICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRRLRGKAFYNVGEKVYCQE
                     DFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVEN
                     NIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSG
                     EEGRRCYPLAGHLLCRRCHLRRLQPGPLPSPTVHVTEL"
     exon            885..986
                     /gene="WTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1054
                     /gene="WTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1117
                     /gene="WTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1248
                     /gene="WTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1300
                     /gene="WTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1369
                     /gene="WTIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..13545
                     /gene="WTIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WTIP"
                     /note="hexamer: AATATA"
     polyA_site      2414
                     /gene="WTIP"
                     /note="major polyA site"
     polyA_site      2460
                     /gene="WTIP"
     regulatory      13519..13524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WTIP"
                     /note="hexamer: AATAAA"
     polyA_site      13545
                     /gene="WTIP"
ORIGIN      
        1 cattcctccg ccgcgcgcgc cgccgagcag ggcgccgcgt cccccggccc gcgcgtggcc
       61 gccggaacga ccccggcccg gcgccggccc cgccccgccc cgcgcccagg ggtcccgggg
      121 cgggctccgg gcttcgggcg gacgatgcgg cggcccggcc ggagcggcgg cgggaagcgg
      181 aggcggaggt gacgcgccag ggccggcggg ccgggccatg cagcgctcca gggcgggcgc
      241 ggacgaggcg gccctactcc tggccgggct ggccctgcgg gagctggagc ccgggtgcgg
      301 ctctcccggt cgggggcggc gggggccgcg gcctgggcct ggagacgagg cggcgcccgc
      361 gctgggccgc agagggaagg gcagcggcgg ccccgaggcc ggggcggacg gactgagccg
      421 cggggagcgg ggtccccggc gcgcggcggt tccggagctc agcgcgcagc ctgcgggcag
      481 cccacgggcc agcctggcgg ggtccgacgg cggcggcggt ggcggcagcg cccgatccag
      541 cggcatcagc ctgggctacg accagcgcca cggcagcccg cgctccggtc gctcggaccc
      601 gcgtcccggt cccgggccgc cttcggtggg cagcgcccgc tccagcgttt ccagcctcgg
      661 ctcccggggc tcggccggcg cctacgctga cttcctcccg cccggcgcct gccccgcgcc
      721 cgctcgctcc ccggagcctg cggggccggc tcccttcccg ctgcctgcac tcccgctgcc
      781 ccctggccgg gagggcggcc caagcgcggc cgagcggcgg ctggaggcgc tcacccggga
      841 gctggagcgg gcgctcgagg cgcgcacggc gcgggactac ttcggcattt gcatcaagtg
      901 tgggcttggc atctacggag cccagcaggc gtgccaggca atggggagtc tttatcacac
      961 tgactgcttc acctgcgact cgtgtgggag acgactccgt gggaaggcgt tctacaacgt
     1021 gggtgagaaa gtgtactgcc aggaggactt cctgtactcc gggttccagc agacggccga
     1081 caaatgcagc gtgtgtggac atctcatcat ggaaatgatc ctgcaggccc tgggcaagtc
     1141 ctaccaccca ggctgcttcc ggtgctccgt gtgcaatgag tgcctggacg gggttccctt
     1201 caccgtggac gtggagaaca acatctactg cgtgcgagac tatcacacgg tttttgcacc
     1261 aaaatgcgcc tcctgtgccc gtcctatcct ccctgcacag ggctgcgaga caaccatccg
     1321 tgtggtgtcc atggacagag actaccacgt ggcatgttac cactgtgagg actgcgggct
     1381 gcagctgagc ggggaggagg gacgccgttg ctatcccctg gcgggccacc tactgtgtcg
     1441 tcgttgccac ctgcggcgcc tccaacctgg gcctcttccc tcacccactg tgcacgtcac
     1501 tgagctctga gcaggggaaa acccgtccct gggccggggt gggtgtgggt gtggagggag
     1561 ggcccgcgtg ggtggccctg gtcagcgtca ggggagctcc ctccaatcag tttcccaccg
     1621 agctgctgtc tgcaggggcc ggacccccgc gtggaagctt ctatttattc accgtctgtg
     1681 cctgctcaag tcacttccct gcgggccctg cctcccaccc accccatcac cagctttcca
     1741 cttggaggcc ccctgtgccc tgcagcctca gggtaggccg tgggtcacca ggctggagag
     1801 ggcccctgcc ttggccaggg gtgcgaggtg acccggctgc attgctgggt gggagctgct
     1861 gtctgttgtt caggggcctg gcccccgccc tcccccccga ccccgacctc gcaaagcgca
     1921 ctcccgggca gggtgtggtc tggaaggcgg ggctggcggg gacatgggtg ttcctgcatc
     1981 tcctagcgca gttcctgctg gtgggtggaa gggtgcctgg tttaggcggg gtcccaggag
     2041 ggggtgaggg gtgacaccct tggggagggg gcctgcaaag ggcactgcct gtggccacgt
     2101 ggtgtctgtg ggaattggtc ctggggactt tgatgggtgt ttgcggcccc agttgccgcc
     2161 ctgctccctc ttccagggct cctggcttgg gccccccgac ccccctgctc agctcgggaa
     2221 aatccccgtg cggctccagc cccgggtcac gctcaggagc gatgagaggg gcgccctggc
     2281 cacgcttcag gaaagcctgt gtctgcgcgc ggggcaaggg gctccacgac aaaaggacaa
     2341 gatttgactt aaattaagtt tttcccttga ggatattttc attttcttta aaagaatata
     2401 attttcttct aagatcttgg accagccttg ttatttttaa agcaaatgcc ggcaaactca
     2461 caagtgtcta gtttgtctgt tacggagctg gttttcaggt ggtaagaacc ttgtggtttc
     2521 aggacttttg tcctgaaatt cctctaaaac ttcgccacgc gtgtccacct ttcagacttt
     2581 agggtagtgt ggggttccgt gtgtgtccgg gtgttaaggg cggtcgcccc atgaaatgca
     2641 gtgtggaggt ccctccgtgc tccccgggac acactgacgg gaatgtgggg tctggacatg
     2701 ggaggccctg gtcctgatgc ggaatcccca ggggttcagg ggacatctgg actgaagtca
     2761 ctcgcccctg ggagagcctg gacccacctc ttggctgctg ctctcccctt cctcccccac
     2821 cgtcaggtgt gagttctgtg aatcactcgc ggggctgggc taggctccgg gaaccagcag
     2881 ggctgtccag gccgagccca agggaacaaa caccaggagg cgcccgcagg gaagtggcgg
     2941 cttcggagtc cagcagggcc gaggcatggc gcgggcgcca cctggtgggc tgagccggca
     3001 agtacagggg tggtcaggga gccttagcca gggacttaca cagcgtggag agcgctgcat
     3061 cttagagtgg ggccttcagc aggaccaggg gccacttctt ggaggaggtg atcccactgg
     3121 ggccagagag taaagtccag gcgtggaggc tccggtgctg gctctctcct gctagctgag
     3181 ctgctttttc ttttcttttc tttttttttt tttgagacgg agtgtcattg tgtcacccag
     3241 gctggagtgc agtggcacaa tcttggctca ctgcagcctc cgcctcccgg gttcaagcaa
     3301 ttctcctgct ttagtctccc gagtagctgg gactacaggc gcacgccacc acgcccggct
     3361 aattttgtat ttttagtaga gatggggttt caccatgttg gtcaggctgg tctccaactg
     3421 ctgacctcag gggcgatcca cccacctcag cctcccaaag tgctgggatt acaggtgtgt
     3481 accactgtgc ccggcttttt tttttttttt ttttgagaca gggtctcgtt ctgtcgccca
     3541 ggctggagtg cgttggcaca atctgggcct actgcaacct ctgcctccag ggttcaagta
     3601 attctcatgc ctcagcctcc ccagtagctg agactacagg tgtgccccat gacgcccagc
     3661 tatttttttt tttttttttt ttaaagacag agtctagctc tgtcgcccag gctggagtgc
     3721 agtggcgtga tctgggctga ctgcaacctc tgcctcccac gttcaagcat tctgcctcag
     3781 ccttccaagt gctgggatta caagtgtgcg ccaccaggcc tggctaattt ttgtattttt
     3841 agtagagtcg gggtttcacc atgttggcca gactggtctg gaactcctgg cctcaagcga
     3901 tccatccgcc ttgaccttcc aaagttctgg gattacaggc gtgagccact gtgcctggcc
     3961 ttactttttg tatttttagt tgagaggggg tttcagcatg ttggccaggt tggtgtcaaa
     4021 ctcctgacct caagcgagcc caccttggcc tcccagagtg ttgggattac aggcttgagc
     4081 caccgtgcct ggcctgggct cctttgcctt ctaactggtc agttgcaaag ctgtcctctg
     4141 aactgtcctc tctgcttcct ccctcaaacc tgctttgagc cgggtttctc cttgttgcca
     4201 acccggtcct tctcctcccc ttcctttgca tgtgccatgg tgggccctgt gcttatatcc
     4261 atggggttgc ttcactgaac cctgctccat cccggtcacc atgcacgctc ctgccagctg
     4321 gcctgagtca tcacagcttg gagtcccccc aaccccaccc aagtaacaca ctttgtcaaa
     4381 ggtcgcagtc aagggactgc ataggccctt ggggcagtgg cctcaccagg ccacactctg
     4441 ccctttcttt ctgggcccct gggccccgca ttgccttctg tcagggctgg tggccactgc
     4501 tccacctcct cccccggagc tgtgcatggc agttccctcc gtgggagcca ctctcccggg
     4561 gtttcttcct ctatgaagaa accttggcct ctatgaagtc aggccccagt tgtgacacct
     4621 cacttgacac ccagaagtct tggcctctgc tctccaagct catttgccaa cagcagtatc
     4681 tccatttcat gcccaggggt gacactgacc ccatgattat agagatggag gatgctgtgt
     4741 gagaactggg ctgagccatg ccagtggcct gtgaccctcc agccctggat gccacccccc
     4801 acctgcccaa ggggaccccc actgatgtgg tctctgctga cacctgtgcc tgtgcctggg
     4861 gtccctgtca tccttccctg gtctgagtgg caagtctcct gccatccctg tccccgctat
     4921 gcggtgagct cttcagcttg ggcccgcctg gtggctcacg ctactctcca ccgtgcctgg
     4981 attagggcga gtgctgaggc tggagctgac cctgccctgg ccttcagggt cttggcttag
     5041 ttccacctgc actggtccaa gtccagcctg gttgcctagt gaaggatcca cagtgggtac
     5101 ataaagggcc aagcgctgtc cacgtggaca catcctatgt gggcgtgagt gctccctgca
     5161 atccccagac aagcctgcct ctcagcgggg ctcagctcag agacatagac cctggagggc
     5221 tgagtctgcc tgtgtgcgtg tgtgtgtgca tgtgtgtgtg tgtgagagag agacagggat
     5281 ggggggagag tgtgtgtatc aatgagagag acggagaaag tcgtgtgtga aagggattga
     5341 atatttcaga aaatgaatga gagagattgg gagagatggt gggaggtgga gtgggagaga
     5401 gacctgttgt ttaagaggga gactgagtga ctccgagaat gagggggaaa gatacggaga
     5461 caggataagc tgcagagaga gagggagaga gggattgaac tggagcgaga ccaacagagc
     5521 cctgacgctg ggatttggga ggatttggtg ggttctcagt gaccccactg aggcctgacc
     5581 caccagtgga aaaggctcac ctcctgtaag tgaccacact gtggggtgta attgtgtgtt
     5641 tgtttgtgtg tgtgtgtgtg tgtctgtgtg tgtgttggcg tcgccctgat ggcctcttgg
     5701 agggtcctgg ggtgggtggg tcttgggcat ggggtgccct ctgccctcat tctttcttca
     5761 tccgggctcc ctgcccctgt tggggtggga agcacagatg tcagcttgct gagctgcagg
     5821 taccatgaca atcccaagtg gaactgctct tggggggctg tgtggggagg ggccactggg
     5881 caggatttat gagacctggg cagaggtgtg gggagcagtg tgggccagag ggtgactggg
     5941 ggttggggtg agttgggtag ggtgcagctg tgctcatccc tcccacccag ccccaccctg
     6001 aggctggtct ctagctcgtg agcagaggcc gagagaaggc ccttccccat cacggggtcc
     6061 tgtctcgtcc ggtctggcag ccctcatctg gccaggaggc cagcaaggac ttccggtgcc
     6121 acactcggga ggggtgaggg ctttgctggc tgcagggtta ggagtaggcg cagcctgtgg
     6181 ggcccaggag aaccttgggg tggggatcaa gaacaggtct gggagagggg ggagcatcag
     6241 ggccacctgc agcctccacc cagcccagct ctggaggctt tgcccccacc ccgcccccat
     6301 ggtaggcgtg ttccctagag gctggtgggg acctgggaga ggggcatgtg cacacatttc
     6361 atggggatga tgggggactc tgggagccag cctgggtggg ggctcagagg tgggaggggc
     6421 cctgaggcct gaggtggtgg aaggagctca cctatctcag gcccaggccc ttgccaggtt
     6481 cctagtccct ggccggatac cccagggtgg cctgggatcc tggagagtgc tcaggaaact
     6541 caggaggagt gtggacgcgg ctcctctcct tccacccact tccctggccc tgagggcatt
     6601 gctgggccac catcccagac ctggggcatg tgtcacaggg ctgccaggag ggcatagggc
     6661 ccaaggattc cccagggatg ccagcccccc tgtgggccct caggactggt agccctgggc
     6721 cccctggcgc tttgtaggga ggtgctcagc agtgatggtt gtgtgcctgt cacacccacc
     6781 cacctgtgcc tccccccacc tgccacgccc attgtcctac acccagcgca cactcctctc
     6841 cacgctgcgc acgtgaaccc gcccgggtca cacacctgcc ctgccatggt gacaggactg
     6901 tgtgggatct ctgcctccct gcctgaagtt cctgccattg ggacctgtca caggcacaca
     6961 ggacacagct ggctcaccct cttctctgac agcacctggg ccatccctga tagtgatcag
     7021 ccctgctgag gaagggttag ggtgggctgc aggctggagg ccagggagag gccctggacc
     7081 gggcctggca tttactcacc ctcctcccat cccacactgt cccggagcct ccatctccac
     7141 ctgagccagc tgggttgatg cggatttcca ggcatcctca gcgggaccca tggcctgggg
     7201 tcaccacctt cctgagctgc gtggatctca gccaggactt ctcgtccctg agaacagatt
     7261 ggggctggga gtcccagccc gtccctggac cagccctgcc atcagcttgc ccagcctagt
     7321 tccctttctc ttctgcgctc tgaatgtgca ctccgcgtgt tcagatgctc atggtttctg
     7381 atgagaagtt ggctgtgtct ctcacggagc ctctctcgga ggtgatgagt gacttttctc
     7441 ttgctgccgt caagattcct ggctgtggat tggatggatg ggaagctctg tccctgaaca
     7501 gcccttgtga ctatggggct gtccttccac agtgtgcact gagggtgcag gccaaacctt
     7561 ttaaagaata aacagaaaga aatcggctct ttcacttctt gcaagttggt gaaaacagac
     7621 tcttccaggg aattttaact ttttatcatc ctatttactc tggaaagcct tgtctcgtgt
     7681 tttagagctt gtagggttta ataaaactag ttaacagcca ggcacggtgg ttcacgcctg
     7741 taatcccagc actttgggag gccgtggcgg ataggtcact tgaggtcagg agttcgagac
     7801 aatcctggcc aacatggcga aaccccgtct ctactaaaat tacaaaaact agccaggtgt
     7861 ggtggtgggc acctgtagtc ccagctactg gggaggaggc tgaggcacga gaatcgcttg
     7921 aactggggag actgaggttg cagtgagccg agttcacacc actgcactcc agcctgggtg
     7981 acagagctag acgctatctc aaaaataaat aaataaataa ataaataaat aaataaatga
     8041 atataaataa aactggttaa aaattgagtc tccctgaagt aggtgctctt tcccgtgaaa
     8101 actacttttt tggtttggtt tgaaggtaag aaagagcggg agaaactttg ctcttttcat
     8161 ttaataattg tgttcagcct ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt
     8221 gggaggccga ggtgggcgga tcacctgagg tcgggagttt gagaccaacc tgaccaatat
     8281 ggagaaaccc tgtctctact aaaaatacaa aatttttagc cgggcatggt ggcgcatgcc
     8341 tgtaatccca gctactcggg aggctgaggc agaagaagcg cttgaacccg ggaggcggag
     8401 gttgcagtca gccgagatcg tgccattgca ctccagcctg ggcaacaaga gtgaactccg
     8461 tctcaaaaaa aaaaaaaaaa aaaaaaattg tattcggcct atgatgaaat attttattat
     8521 tagatagcag tgtcactaat aagttttaag ttgtccagag ttaattgtga atatcagaac
     8581 aggattctta taacaaaagc agttgtctta agatgaatgg ctcatatttg ggtgcagtat
     8641 ttgatgccca aaagaacaaa cataaaccaa aaaaaaaaaa aaaaaaattc cagactgtcc
     8701 cctttggatg ccagttgaat ctgtgtcttg tgccccctga gggtctgccc ggtcacatcc
     8761 ccttgtcttc tctagggttc acggggatcc ttctcatcct cttctaggta ccaggttcca
     8821 ttagttttgt ctgtcagtct tgtcaccagg gagctggaga cctggagggg agccctgatg
     8881 tctgggacag tgcttgtcag tggatgggct tttgcatagg gggatggggt agggagtgag
     8941 tcattgcatt atagacttgg actaggtgga tgctattttt catggtggtg gtgatgggag
     9001 aagctgttgg gttatttcac agaggaagcc cgagctccct gctgaagatg ataaatgatg
     9061 cacagatttc aatccatcct acggcttcag cctccagtcc tggtcccaca catctcctgg
     9121 agcagagcct gattcccagc ctctgtagct ggttgaggag caaataggtt tccctgtcct
     9181 gactccacct tggagcacct tcccttgaga cccaccaggc tctctttcag tcacagcatc
     9241 ttcctcctgc tccatgtggt tgaaatctca ggtcctctaa ggatccctcc tcattctctg
     9301 ttagtgtgag gtgggacttt tttttttgtt ttgagatgga gtcttgctct gtcgcccagg
     9361 ctggagttca gtggcaggat ttcagctcag tacagcctcg gcctcccggg ttcaagtgac
     9421 tctccggcct cagcctccca agtagctggg attacaggca cctgccatca ctcccagcta
     9481 attttttata tttttagtga atacagggtt tcatcatgtt ggccaggctg gtctctaact
     9541 cctgacctta agtgatctac ccgcctcagc ctcctaaagt gctaggatta taggtgtgag
     9601 ccactgcacc tggcctgtga ggtgggaagt ttcaatactc ccttagcctt ggtttggtca
     9661 ccagaaggag gggacatgag tgaaggtccc agtccaccct atgcaagcag aagcctcttt
     9721 ggttttagtt ttaaaggtgc attgacccat gtacctttgc atggacatgt tcttatttgg
     9781 ggttaccttt gtgttgactt tgtgtggcca ggaccctgga gatgaggcca ggatggccga
     9841 ctccaacccc ttagctgctt ccttgccctg tatggagcag ctcagcctgg gatgcaggag
     9901 cagctgtgtc cctccgctcc cgccaggcct ctccccctgc cttctgggac tggaagttcc
     9961 taggagtccg gaagtgctga gctgcaggag gcttctcatg gccccaggac acacccatca
    10021 ccccatctat attgagatgt tatctagaga gacgcctgta gtaaaatccg ctctgtgacg
    10081 gtggtgtata aacattttct gtgcaaggac cttgccctcc ttttcaaaaa agtaagtatg
    10141 actcccacat gaaaattttc ttctacaaca cgacatacgt tcattgtggt acatttagga
    10201 aatttaaatg atttatttct tataaaacat catctgtttt tctactggac ctggctttta
    10261 taaatcatgc ggtgataaat aatatggcag ttagagctgg gtgcacttgg ctcctgcctg
    10321 tggtcccagc tggctgggag gcagaggcag gaggattgct tgaggccagg attccaggct
    10381 gcagggagct atgactgcca gtgcactcca gccagggtaa cacagcgaga ccctgtgtta
    10441 gcctgttttc acgctgctga taaagacatc cccaagactg ggaagaaaaa gaggtttaat
    10501 tggatttaca gttccacatg gctggggagg cctcagcctc ccacatggct ggggaggcct
    10561 cccaccaaaa ggcactttca tggtggcggc aagagaaaaa tgacagagat gcaaaagcag
    10621 aaacccccga taaaaccatc agatcttgtg agacttattc actaccatga gaacagtgtg
    10681 ggggaaactg cccccatgat tcagattctc tcccactggg tccctcccac aaaatgtggg
    10741 aattaaggga gtacagttca agatgagatt tgggtggaga cacagagcca aacgatatca
    10801 ttctgcccct ggccccttca aatctcatgt cctcacattt caaaaccaat catgacttcc
    10861 caacagtccc ccaaattctt aactcatttc agcattaacc caaatccaga gtccaaagtc
    10921 taatctgaga caaggcaagg cccttccacc tatgagcctg taaaatcaaa agcaagttag
    10981 ttacttccta gatacaatgg gggtacaggt attgggtgaa tacggccatt ccaaatggga
    11041 gaaattggcc aaaacaaagg ggttacagga cccatgcaag tccaaaatcc agcggggcag
    11101 tcaaattttg aagctccaaa gtgatttcct ttgactccat gtctcatatc caagtcacag
    11161 tgatgcaaga ggtgtgttcc catagtcgta ggcagctcca cccctgtggc tttgcagggc
    11221 atagctcccc tgctggcttc tttcatgggc tggcattgag tgtctgcggc ttttccaggc
    11281 accttgtaca agctgtcagt gtatctacca ttctgatgtt tggaggatgg tggccttctt
    11341 cttacagctc tactaggcag taccccagta gggatactgt gtttgggctc tgaccccaca
    11401 tttcccttct gcactgccct agcagaggtt ctccaagagg gcccctcccc tgcagcaaac
    11461 ttttgcctgg gcatccaggc attttcatac atcttctgaa atctagatgg aggttcccaa
    11521 acctcaattc ttgacttctg tacacccgca ggctcaacac cacatggtag ctgccaaggt
    11581 tggggtttgc actctctgaa accatgggct gagctgtacc ttggcccctt ttagcaatgg
    11641 ctggagtggc tgggacacaa ggcagcaagt cctaggctgc acacaacatg gggactttgg
    11701 gtccagccca caaaaccatt ttttgctcct aggcttctgg gtctgtgatg ggaagaccaa
    11761 tgacatgccc tggagacatt ttccccattg tcttggggtt aaacattccc ctccttgtta
    11821 cttatgcaaa tttctgcagc cagcttgaat ttcttctaaa aaaatgggtg tttctttact
    11881 gcatcgtcag gctgcaaatt ttccaatttt ttatgctctg tttccctttt aaaatggaat
    11941 gtttttaaac ccaagtcacc tcttgaacgc ttttctgctt agaaatttct tctgccagat
    12001 accctaaatt atctctctca agttcaaagt tccacaaatc tctagggcag gggcaaaatg
    12061 ccgccaatct ctttgcttaa acataacaag aatcaccttt gctccagttc ccaacaagtt
    12121 cctcatctcc atctgagacc acatcagcct ggaccttagt attcatatca ctatcagcat
    12181 ttttatcaaa tattaaacaa atttctagga ggttccaaac tttcccacat tttcctatat
    12241 tcttctgagc cctccaaact gttccaacct ctgcctgtta cccagttcca aagttgcttc
    12301 cacattttcg ggtatgtttt cagcaacacc ccactcccag taccaattta ctgtattagt
    12361 ttgttttcat gctgctgata aagacatacc tgtgactggg aagaaaaaga ggtttaatgg
    12421 gacttgtagc tccacatggc tgggaggcct cagaatcatg gcctgaggca aaagttatgt
    12481 ggtagcggca agagaaaatg aagggtgcaa aagcggaaac cctcgataaa accatgagat
    12541 ctcgtgagac atattcacta ccatgagaac aatatggggg aaactgcccc catgattcaa
    12601 aatatttccc attgggtccc tcccacaaca cgtgagaatt atgggagtac aattcaagat
    12661 gagatttcgg tggggacaca gagccaaacc gtatcagacc ccgtctctac aaaaacaaaa
    12721 acaaaataaa aaaaagtagc tacgtgtttg ggcctggctt tcattattta ccaaggatca
    12781 agacctgaac atgaaaatgg caggccaagg gttcctgcct ttggatgcac atggccacct
    12841 tgcccactag aacatctgtg ccaagcagtg ttcccatcaa tcataggaaa ataccatttc
    12901 ccgcatcctt accaacccta ggtattgcca ataagaaaac aaagtctgta tcaatttgat
    12961 gaaaataatt tgaatgtgtg catttgatga gctgtgagaa tgagaatctt ttgcatgcat
    13021 tggccatggg cttccctttt gtgagttgcc tgtgaatgtc cttttcccag tttactagtt
    13081 tgggattgaa tattcttaca catttatttg gtgaagaact tttatttcaa attatgaaag
    13141 aaaaaaatac ttgctagaat tctgatttga agtgctttca aattctgtgt taatttggag
    13201 ctgacaccct ttaatattga gtcctggctt tgagggtctg gtgcgtttcc tccattcact
    13261 gaagttttat tttacatctc tcagtaaagc tttatggatt agggtcttca gaagccttac
    13321 ttgtttttct ggctctattt tcttgtccag aaactccacc actgtgctaa agagacagtg
    13381 gtggaggtgc tgggcgtgct gcttttctcc tggctctaat gggaaggcca agaggcaggt
    13441 cagggtcaga ctccaccttg agtctggcat tggctgttgg catcatgagg accccacgta
    13501 ttgtactttg ataaagttaa taaatggaat tctcctttac ctcaa
//
