LOCUS       NP_001073905             430 aa            linear   PRI 28-AUG-2022
DEFINITION  Wilms tumor protein 1-interacting protein [Homo sapiens].
ACCESSION   NP_001073905 XP_059037
VERSION     NP_001073905.1
DBSOURCE    REFSEQ: accession NM_001080436.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y,
            Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Liu WR, Erbilgin
            A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Bos
            JM, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez
            V, Snyder M, Parikh VN and Ashley EA.
  TITLE     Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein)
            Underlies Novel Mechanism for Cardiac Hypertrophy
  JOURNAL   Circ Genom Precis Med 15 (4), e003563 (2022)
   PUBMED   35671065
  REMARK    GeneRIF: Wnt Signaling Interactor WTIP (Wilms Tumor Interacting
            Protein) Underlies Novel Mechanism for Cardiac Hypertrophy.
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Zhu Y, Tong X, Wang Y and Lu X.
  TITLE     WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute
            myeloid leukemia
  JOURNAL   Cell Death Dis 13 (1), 18 (2021)
   PUBMED   34930905
  REMARK    GeneRIF: WTIP upregulates FOXO3a and induces apoptosis through PUMA
            in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Hao Q, Zong X, Sun Q, Lin YC, Song YJ, Hashemikhabir S, Hsu RY,
            Kamran M, Chaudhary R, Tripathi V, Singh DK, Chakraborty A, Li XL,
            Kim YJ, Orjalo AV, Polycarpou-Schwarz M, Moriarity BS, Jenkins LM,
            Johansson HE, Zhu YJ, Diederichs S, Bagchi A, Kim TH, Janga SC, Lal
            A, Prasanth SG and Prasanth KV.
  TITLE     The S-phase-induced lncRNA SUNO1 promotes cell proliferation by
            controlling YAP1/Hippo signaling pathway
  JOURNAL   Elife 9, e55102 (2020)
   PUBMED   33108271
  REMARK    GeneRIF: The S-phase-induced lncRNA SUNO1 promotes cell
            proliferation by controlling YAP1/Hippo signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 430)
  AUTHORS   Wu Z, Qiu M, Mi Z, Meng M, Guo Y, Jiang X, Fang J, Wang H, Zhao J,
            Liu Z, Qian D and Yuan Z.
  TITLE     WT1-interacting protein inhibits cell proliferation and
            tumorigenicity in non-small-cell lung cancer via the AKT/FOXO1 axis
  JOURNAL   Mol Oncol 13 (5), 1059-1074 (2019)
   PUBMED   30690883
  REMARK    GeneRIF: WTIP impairs AKT phosphorylation and activation, leading
            to enhanced expression and transcriptional activity of FOXO1, which
            further increases p21Cip1 and p27Kip1, and decreases cyclin D1,
            which consequently results in cell cycle arrest.
REFERENCE   5  (residues 1 to 430)
  AUTHORS   Lu X, Zhuang H, Yu Q, Zhang X, Wu Z, Zhang L, Xu Y, Wu B, Yang L,
            Ma A, Gan X, Yu X, Shen J and Xu R.
  TITLE     Identification of the UBA2-WTIP fusion gene in acute myeloid
            leukemia
  JOURNAL   Exp Cell Res 371 (2), 409-416 (2018)
   PUBMED   30179602
  REMARK    GeneRIF: The findings suggest that the UBA2-WTIP fusion is an
            oncogenic fusion gene, as well as a promising therapeutic target
            for the treatment of acute myeloid leukemia.
REFERENCE   6  (residues 1 to 430)
  AUTHORS   Das Thakur M, Feng Y, Jagannathan R, Seppa MJ, Skeath JB and
            Longmore GD.
  TITLE     Ajuba LIM proteins are negative regulators of the Hippo signaling
            pathway
  JOURNAL   Curr Biol 20 (7), 657-662 (2010)
   PUBMED   20303269
REFERENCE   7  (residues 1 to 430)
  AUTHORS   Kim JH, Konieczkowski M, Mukherjee A, Schechtman S, Khan S,
            Schelling JR, Ross MD, Bruggeman LA and Sedor JR.
  TITLE     Podocyte injury induces nuclear translocation of WTIP via
            microtubule-dependent transport
  JOURNAL   J Biol Chem 285 (13), 9995-10004 (2010)
   PUBMED   20086015
  REMARK    GeneRIF: Stress signaling pathways initiate WTIP nuclear
            translocation, and the concomitant loss of WTIP from cell contacts
            changes podocyte morphology and dynamic actin assembly, suggesting
            a mechanism that transmits changes in podocyte morphology to the
            nucleus.
REFERENCE   8  (residues 1 to 430)
  AUTHORS   van Wijk NV, Witte F, Feike AC, Schambony A, Birchmeier W, Mundlos
            S and Stricker S.
  TITLE     The LIM domain protein Wtip interacts with the receptor tyrosine
            kinase Ror2 and inhibits canonical Wnt signalling
  JOURNAL   Biochem Biophys Res Commun 390 (2), 211-216 (2009)
   PUBMED   19785987
  REMARK    GeneRIF: Full-length Ror2 recruits Wtip to the cell membrane, a
            mutant involved in human disease fails to do so. Both genes and
            proteins show overlapping expression in the mouse embryo.
REFERENCE   9  (residues 1 to 430)
  AUTHORS   Langer EM, Feng Y, Zhaoyuan H, Rauscher FJ 3rd, Kroll KL and
            Longmore GD.
  TITLE     Ajuba LIM proteins are snail/slug corepressors required for neural
            crest development in Xenopus
  JOURNAL   Dev Cell 14 (3), 424-436 (2008)
   PUBMED   18331720
  REMARK    GeneRIF: WTIP is a member of the Ajuba family of LIM-domain
            containing proteins. Ajuba LIM proteins co-repress E-cadherin
            expression through interaction with the SNAG domain of Snail/Slug
            and promote epithelial to mesenchymal differentiation in a Xenopus
            model.
REFERENCE   10 (residues 1 to 430)
  AUTHORS   Srichai MB, Konieczkowski M, Padiyar A, Konieczkowski DJ, Mukherjee
            A, Hayden PS, Kamat S, El-Meanawy MA, Khan S, Mundel P, Lee SB,
            Bruggeman LA, Schelling JR and Sedor JR.
  TITLE     A WT1 co-regulator controls podocyte phenotype by shuttling between
            adhesion structures and nucleus
  JOURNAL   J Biol Chem 279 (14), 14398-14408 (2004)
   PUBMED   14736876
  REMARK    GeneRIF: WTIP monitors slit diaphragm protein assembly as part of a
            multiple protein complex, linking this specialized adhesion
            junction to the actin cytoskeleton, and shuttles into the nucleus
            after podocyte injury
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008747.5.
            
            On Jan 18, 2007 this sequence version replaced XP_059037.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4195099.1,
                                           ERR279843.10033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590071.7/ ENSP00000466953.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     Protein         1..430
                     /product="Wilms tumor protein 1-interacting protein"
                     /note="Wilms tumor 1 interacting protein"
                     /calculated_mol_wt=44993
     Region          <44..220
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     Region          225..278
                     /region_name="LIM1_Ajuba_like"
                     /note="The first LIM domain of Ajuba-like proteins;
                     cd09352"
                     /db_xref="CDD:188738"
     Site            order(225,228,247,250,253,256,274,277)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188738"
     Region          290..342
                     /region_name="LIM2_Ajuba_like"
                     /note="The second LIM domain of Ajuba-like proteins;
                     cd09355"
                     /db_xref="CDD:188741"
     Site            order(290,293,310,313,316,319,338,341)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188741"
     Region          350..411
                     /region_name="LIM3_Ajuba_like"
                     /note="The third LIM domain of Ajuba-like proteins;
                     cd09438"
                     /db_xref="CDD:188822"
     Site            order(350,353,377,380,383,386,407,410)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188822"
     CDS             1..430
                     /gene="WTIP"
                     /coded_by="NM_001080436.2:218..1510"
                     /db_xref="CCDS:CCDS59375.1"
                     /db_xref="GeneID:126374"
                     /db_xref="HGNC:HGNC:20964"
                     /db_xref="MIM:614790"
ORIGIN      
        1 mqrsragade aalllaglal relepgcgsp grgrrgprpg pgdeaapalg rrgkgsggpe
       61 agadglsrge rgprraavpe lsaqpagspr aslagsdggg gggsarssgi slgydqrhgs
      121 prsgrsdprp gpgppsvgsa rssvsslgsr gsagayadfl ppgacpapar spepagpapf
      181 plpalplppg reggpsaaer rlealtrele raleartard yfgicikcgl giygaqqacq
      241 amgslyhtdc ftcdscgrrl rgkafynvge kvycqedfly sgfqqtadkc svcghlimem
      301 ilqalgksyh pgcfrcsvcn ecldgvpftv dvenniycvr dyhtvfapkc ascarpilpa
      361 qgcettirvv smdrdyhvac yhcedcglql sgeegrrcyp laghllcrrc hlrrlqpgpl
      421 psptvhvtel
//
