LOCUS       NM_001270531            2105 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens WT1 associated protein (WTAP), transcript variant 4,
            mRNA.
ACCESSION   NM_001270531
VERSION     NM_001270531.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Zhou,Z., Chen,X., Wang,H., Ding,L., Wang,M., Li,G. and Xia,L.
  TITLE     WTAP-dependent N6-methyladenosine methylation of lncRNA TEX41
            promotes renal cell carcinoma progression
  JOURNAL   Sci Rep 14 (1), 24742 (2024)
   PUBMED   39433619
  REMARK    GeneRIF: WTAP-dependent N6-methyladenosine methylation of lncRNA
            TEX41 promotes renal cell carcinoma progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2105)
  AUTHORS   Fang,M., Li,T. and Wu,Z.
  TITLE     WTAP-MEDIATED M6A MODIFICATION OF KLF6 AGGRAVATES
            HYPOXIA/REOXYGENATION-INDUCED HUMAN CARDIOMYOCYTE INJURY
  JOURNAL   Shock 62 (2), 201-207 (2024)
   PUBMED   38662610
  REMARK    GeneRIF: WTAP-MEDIATED M6A MODIFICATION OF KLF6 AGGRAVATES
            HYPOXIA/REOXYGENATION-INDUCED HUMAN CARDIOMYOCYTE INJURY.
REFERENCE   3  (bases 1 to 2105)
  AUTHORS   Zou,J., Ma,Q., Gao,C., Yang,M., Wen,J., Xu,L., Guo,X., Zhong,X. and
            Duan,Y.
  TITLE     WTAP promotes proliferation of esophageal squamous cell carcinoma
            via m6A-dependent epigenetic promoting of PTP4A1
  JOURNAL   Cancer Sci 115 (7), 2254-2268 (2024)
   PUBMED   38746998
  REMARK    GeneRIF: WTAP promotes proliferation of esophageal squamous cell
            carcinoma via m[6]A-dependent epigenetic promoting of PTP4A1.
REFERENCE   4  (bases 1 to 2105)
  AUTHORS   Du,X., Shi,L., Wang,B. and Zhang,G.
  TITLE     WTAP mediated m6A-modified circ_0056856 contributes to the
            proliferation, migration, and invasion of IL-22-stimulated human
            keratinocyte by miR-197-3p/CDK1 axis
  JOURNAL   Arch Dermatol Res 316 (6), 208 (2024)
   PUBMED   38787443
  REMARK    GeneRIF: WTAP mediated m6A-modified circ_0056856 contributes to the
            proliferation, migration, and invasion of IL-22-stimulated human
            keratinocyte by miR-197-3p/CDK1 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2105)
  AUTHORS   Ge,Y., Chen,R., Ling,T., Liu,B., Huang,J., Cheng,Y., Lin,Y.,
            Chen,H., Xie,X., Xia,G., Luo,G., Yuan,S. and Xu,A.
  TITLE     Elevated WTAP promotes hyperinflammation by increasing m6A
            modification in inflammatory disease models
  JOURNAL   J Clin Invest 134 (14), e177932 (2024)
   PUBMED   39007267
  REMARK    GeneRIF: Elevated WTAP promotes hyperinflammation by increasing m6A
            modification in inflammatory disease models.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2105)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   7  (bases 1 to 2105)
  AUTHORS   Ortega,A., Niksic,M., Bachi,A., Wilm,M., Sanchez,L., Hastie,N. and
            Valcarcel,J.
  TITLE     Biochemical function of female-lethal (2)D/Wilms' tumor
            suppressor-1-associated proteins in alternative pre-mRNA splicing
  JOURNAL   J Biol Chem 278 (5), 3040-3047 (2003)
   PUBMED   12444081
REFERENCE   8  (bases 1 to 2105)
  AUTHORS   Utsch,B., Kaya,A., Ozburun,A., Lentze,M.J., Albers,N. and Ludwig,M.
  TITLE     Exclusion of WTAP and HOXA13 as candidate genes for isolated
            hypospadias
  JOURNAL   Scand J Urol Nephrol 37 (6), 498-501 (2003)
   PUBMED   14675924
  REMARK    GeneRIF: WTAP protein involved in the morphogenesis of the
            genitourinaty tract and in the etiology of isolated hypospadias.
REFERENCE   9  (bases 1 to 2105)
  AUTHORS   Little,N.A., Hastie,N.D. and Davies,R.C.
  TITLE     Identification of WTAP, a novel Wilms' tumour 1-associating protein
  JOURNAL   Hum Mol Genet 9 (15), 2231-2239 (2000)
   PUBMED   11001926
REFERENCE   10 (bases 1 to 2105)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG702882.1, BX387163.2,
            AF374416.1 and BC069192.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001270531.1.
            
            Summary: The Wilms tumor suppressor gene WT1 appears to play a role
            in both transcriptional and posttranscriptional regulation of
            certain cellular genes. This gene encodes a WT1-associating
            protein, which is a ubiquitously expressed nuclear protein. Like
            WT1 protein, this protein is localized throughout the nucleoplasm
            as well as in speckles and partially colocalizes with splicing
            factors. Alternative splicing of this gene results in several
            transcript variants encoding three different isoforms. [provided by
            RefSeq, Jul 2012].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1 and 4 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.160528.1, ERR279855.238.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621533.5/ ENSP00000479438.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               BG702882.1         11-160
            151-868             BX387163.2         139-856
            869-1540            AF374416.1         888-1559
            1541-1576           BC069192.1         1515-1550
            1577-2101           BC069192.1         1552-2076
            2102-2105           AF374416.1         2109-2112
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..2105
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /note="WT1 associated protein"
                     /db_xref="GeneID:9589"
                     /db_xref="HGNC:HGNC:16846"
                     /db_xref="MIM:605442"
     exon            1..198
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..236
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1397
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     Wilms' tumour 1-associating protein; PNAS-132; putative
                     pre-mRNA splicing regulator female-lethal(2D);
                     pre-mRNA-splicing regulator WTAP; hFL(2)D;
                     female-lethal(2)D homolog; wilms tumor 1-associating
                     protein; Wilms tumor 1 associated protein"
                     /codon_start=1
                     /product="pre-mRNA-splicing regulator WTAP isoform 1"
                     /protein_id="NP_001257460.1"
                     /db_xref="CCDS:CCDS5266.1"
                     /db_xref="GeneID:9589"
                     /db_xref="HGNC:HGNC:16846"
                     /db_xref="MIM:605442"
                     /translation="MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKY
                     TDLNSNDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQ
                     PSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAK
                     CRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGM
                     QSTILVLQQQLKETRQQLAQYQQQQSQASAPSTSRTTASEPVEQSEATSKDCSRLTNG
                     PSNGSSSRQRTSGSGFHREGNTTEDDFPSSPGNGNKSSNSSEERTGRGGSGYVNQLSA
                     GYESVDSPTGSENSLTHQSNDTDSSHDPQEEKAVSGKGNRTVGSRHVQNGLDSSVNVQ
                     GSVL"
     exon            237..292
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..351
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..479
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..658
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..813
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..2105
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2078..2083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /note="hexamer: AATAAA"
     polyA_site      2105
                     /gene="WTAP"
                     /gene_synonym="Mum2"
                     /note="major polyA site"
ORIGIN      
        1 ctccctcagc gccattttgt ggcagcgaga cccacaaata aaggggagcg caggggttgc
       61 ggcgggacta ggagcgcggc ggggccggcg gcagagctgt ccggctgcgc ggtggcccgg
      121 ggggcccggg cggcagggca agcagcgcgg cctcggccta tgcgaccggt ggcgccggcg
      181 cggcttctgc ctggagagga ttcaagatga ccaacgaaga acctcttccc aagaaggttc
      241 gattgagtga aacagacttc aaagttatgg caagagatga gttaattcta agatggaaac
      301 aatatgaagc atatgtacaa gctttggagg gcaagtacac agatcttaac tctaatgatg
      361 taactggcct aagagagtct gaagaaaaac taaagcaaca acagcaggag tctgcacgca
      421 gggaaaacat ccttgtaatg cgactagcaa ccaaggaaca agagatgcaa gagtgtacta
      481 ctcaaatcca gtacctcaag caagtccagc agccgagcgt tgcccaactg agatcaacaa
      541 tggtagaccc agcgatcaac ttgtttttcc taaaaatgaa aggtgaactg gaacagacta
      601 aagacaaact ggaacaagcc caaaatgaac tgagtgcctg gaagtttacg cctgatagcc
      661 aaacagggaa aaagttaatg gcgaagtgtc gaatgcttat ccaggagaat caagagcttg
      721 gaaggcagct gtcccaggga cgtattgcac aacttgaagc agagttggct ttacagaaga
      781 aatacagtga ggagcttaaa agcagtcagg atgaactgaa tgacttcatc atccagcttg
      841 atgaagaagt agagggtatg cagagtacca ttctagttct gcagcagcag ctgaaggaga
      901 cacgccagca gttggctcag taccagcagc agcagtctca ggcctctgcc ccaagtacca
      961 gcaggactac agcttctgaa cctgtagaac agtcagaggc cacaagtaaa gactgcagtc
     1021 gtctgacaaa cggaccaagt aatggtagct cctcccgcca gaggacgtct gggtctggat
     1081 ttcacaggga gggcaacaca accgaagatg actttccttc ttctccaggg aatggtaata
     1141 agtcctccaa cagctcagag gagagaactg gcagaggagg tagtggttac gtaaatcaac
     1201 tcagtgcggg gtatgaaagt gtagactctc ccacgggcag tgaaaactct ctcacacacc
     1261 aatcaaatga cacagactcc agtcatgacc ctcaagagga gaaagcagtg agtgggaaag
     1321 gtaatcgaac tgtgggttcc cgccacgttc agaatggctt ggactcaagt gtaaatgtac
     1381 agggttcagt tttgtaatat tttttcagca aatttttata cagtgtcatt taatttggga
     1441 gaggatactg tccagaaaat taatgcatac ttttgtcaca atttgccttt ttgtgggtgt
     1501 acgttttggt ttttttttgt tgtttttttt ctttgttttt tttttctttt cttttttttt
     1561 tttttttttt ttttttgctt caatacttct gccgctttgg aaattgtaac agttaattac
     1621 tttgaatgtt gctaaaagga cattttgtgt agggtcaagt tatttttata tgagttaatg
     1681 tgaaattgta aatggaaatt tttccttaaa atacaacaca atgatgtctg tataaatctg
     1741 tctgtttaga atctgtgctg tgtaagggca ttcgtactca tgctgttact gtacttatgc
     1801 accattcaga cttgttagag tagatgtggg tttatgactg ccaagtttgc ccagtacagt
     1861 agttttttat cactaaaagt tggactcatt gatggagtcc tgtagtagtt tcagtgttag
     1921 atacagtttt ttccaccata catctgtgca ttttctcttt aggtgactgt ttaagaaatt
     1981 tgtgtgcata gttactcagt ttttatgaac tgttgtatcc tgttaatgca tattgctctg
     2041 tgactccagt atatcttacc tgtactgacc aaacctaaat aaagattttt attgtaactc
     2101 cttaa
//
