LOCUS       NM_014653               5082 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens WSC domain containing 2 (WSCD2), transcript variant 1,
            mRNA.
ACCESSION   NM_014653 XM_033113
VERSION     NM_014653.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5082)
  AUTHORS   Lo,M.T., Hinds,D.A., Tung,J.Y., Franz,C., Fan,C.C., Wang,Y.,
            Smeland,O.B., Schork,A., Holland,D., Kauppi,K., Sanyal,N.,
            Escott-Price,V., Smith,D.J., O'Donovan,M., Stefansson,H.,
            Bjornsdottir,G., Thorgeirsson,T.E., Stefansson,K., McEvoy,L.K.,
            Dale,A.M., Andreassen,O.A. and Chen,C.H.
  TITLE     Genome-wide analyses for personality traits identify six genomic
            loci and show correlations with psychiatric disorders
  JOURNAL   Nat Genet 49 (1), 152-156 (2017)
   PUBMED   27918536
  REMARK    GeneRIF: WSCD2 polymorphism is associated with extraversion.
REFERENCE   2  (bases 1 to 5082)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5082)
  AUTHORS   Greenwood,T.A., Akiskal,H.S., Akiskal,K.K. and Kelsoe,J.R.
  CONSRTM   Bipolar Genome Study
  TITLE     Genome-wide association study of temperament in bipolar disorder
            reveals significant associations with three novel Loci
  JOURNAL   Biol Psychiatry 72 (4), 303-310 (2012)
   PUBMED   22365631
REFERENCE   4  (bases 1 to 5082)
  AUTHORS   Kato,N., Miyata,T., Tabara,Y., Katsuya,T., Yanai,K., Hanada,H.,
            Kamide,K., Nakura,J., Kohara,K., Takeuchi,F., Mano,H., Yasunami,M.,
            Kimura,A., Kita,Y., Ueshima,H., Nakayama,T., Soma,M., Hata,A.,
            Fujioka,A., Kawano,Y., Nakao,K., Sekine,A., Yoshida,T.,
            Nakamura,Y., Saruta,T., Ogihara,T., Sugano,S., Miki,T. and
            Tomoike,H.
  TITLE     High-density association study and nomination of susceptibility
            genes for hypertension in the Japanese National Project
  JOURNAL   Hum Mol Genet 17 (4), 617-627 (2008)
   PUBMED   18003638
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009729.14, DA095713.1, BC110330.1 and BX647283.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014653.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.233484.1,
                                           SRR1803612.86103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2144335
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000547525.6/ ENSP00000448047.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AC009729.14        4943-5125
            184-400             DA095713.1         1-217
            401-1986            BC110330.1         1-1586
            1987-1987           AC009729.14        100508-100508
            1988-4664           BC110330.1         1588-4264
            4665-4743           BX647283.1         4264-4342
            4744-4746           AC009729.14        125854-125856
            4747-4956           BX647283.1         4352-4561
            4957-4957           AC009729.14        126067-126067
            4958-5082           BX647283.1         4563-4687
FEATURES             Location/Qualifiers
     source          1..5082
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..5082
                     /gene="WSCD2"
                     /note="WSC domain containing 2"
                     /db_xref="GeneID:9671"
                     /db_xref="HGNC:HGNC:29117"
                     /db_xref="MIM:619253"
     exon            1..639
                     /gene="WSCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1572
                     /gene="WSCD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1191..2888
                     /gene="WSCD2"
                     /note="WSC domain-containing protein 2"
                     /codon_start=1
                     /product="sialate:O-sulfotransferase 2"
                     /protein_id="NP_055468.2"
                     /db_xref="CCDS:CCDS41828.1"
                     /db_xref="GeneID:9671"
                     /db_xref="HGNC:HGNC:29117"
                     /db_xref="MIM:619253"
                     /translation="MAKLWFKFQRYFRRKPVRFFTFLALYLTAGSLVFLHSGFVGQPA
                     VSGNQANPAAAGGPAEGAELSFLGDMHLGRGFRDTGEASSIARRYGPWFKGKDGNERA
                     KLGDYGGAWSRALKGRVVREKEEERAKYIGCYLDDTQSRALRGVSFFDYKKMTIFRCQ
                     DNCAERGYLYGGLEFGAECYCGHKIQATNVSEAECDMECKGERGSVCGGANRLSVYRL
                     QLAQESARRYGSAVFRGCFRRPDNLSLALPVTAAMLNMSVDKCVDFCTEKEYPLAALA
                     GTACHCGFPTTRFPLHDREDEQLCAQKCSAEEFESCGTPSYFIVYQTQVQDNRCMDRR
                     FLPGKSKQLIALASFPGAGNTWARHLIELATGFYTGSYYFDGSLYNKGFKGERDHWRS
                     GRTICIKTHESGQKEIEAFDAAILLIRNPYKALMAEFNRKYGGHIGFAAHAHWKGKEW
                     PEFVRNYAPWWATHTLDWLKFGKKVLVVHFEDLKQDLFVQLGRMVSLLGVAVREDRLL
                     CVESQKDGNFKRSGLRKLEYDPYTADMQKTISAYIKMVDAALKGRNLTGVPDDYYPR"
     exon            1573..1687
                     /gene="WSCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1872
                     /gene="WSCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1994
                     /gene="WSCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2169
                     /gene="WSCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2334
                     /gene="WSCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2535
                     /gene="WSCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..5082
                     /gene="WSCD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4636..4641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WSCD2"
                     /note="hexamer: ATTAAA"
     polyA_site      4664
                     /gene="WSCD2"
                     /note="major polyA site"
     polyA_site      5082
                     /gene="WSCD2"
ORIGIN      
        1 gaggcgcgct gctggtggcg gcggcggcag cggcgcggga gctagggctg gagacgtgaa
       61 gtccagggga gcgagcaagg cagccaagga ggcagcggcg aggcagcgag agagagccag
      121 gcggccggag ctccgcgccg agccgcagcc ggtgccctgc gcgcaccggg cccgggcatc
      181 tccatccccg gggcgggtgc ccgcgcgggg cctcgccgcg gctcggggca cccgcagtgc
      241 cgcccgcccg agcgccaggc tcacaggagc ccggctttca cttcctctcg cttccgcccg
      301 cctccctggc tcgccggctg gcgtcgccac cgcctcctcg tccccggcca ccgctgtcgc
      361 cgctgctgca attcaaggcg cacactatcc cactttcccg ctggaggcgc agaggatgcc
      421 ccttgagcca gacctggaga aatagcccca gggcccggca ggaggagcct tggtggcgag
      481 aaaggaaatc caggctcccc tttccttaaa gccactgcag cagctgggaa ggcgcccaca
      541 gagcgggcgc gccaagcggg acgcgggagt cgcagagagg gaccccgggc gcctgctgag
      601 ctcagctggc agagtttgca agtggcggag acccttcagg tggcatccct gagtcctgat
      661 gcctgactgg atggaggccc accagcttct gttcccatga ggtagaaagg ccaagcttgg
      721 tcttcagctg gggaagaggc cagaaacaag gcccccagtg aaataaccca gatccattgg
      781 cctgaggagc agagaaaggg caagaagtga actgcagctg ctggtaaccc tcagaaacct
      841 tctccaagtg ctattctcac agttctttag gaacactctg aagtgaagaa caatatgtag
      901 gaaaatggga ccaacttatg tgtgttctga gcctcaaaac ccccttgttg gcccaaagaa
      961 gctcaccttc agtttgggag ggctggtaag ctccatcctt tctcatggcc tcagccaagc
     1021 attgaacttg ccctcccctt ctggccttgg tgatcacttt ttcaggaaga gtgagactga
     1081 ggacccccaa gtgttccatc cctaaggaaa gcttgggaaa ccaagcccct tccatcctct
     1141 cccaagcacc ccagccaagc cccagagagc cagtccggaa tgatcccact atggccaagc
     1201 tctggttcaa attccagcgg tacttccgcc ggaaacctgt gcgcttcttt accttcctgg
     1261 cactctacct gactgctggg agccttgtct tccttcactc tggctttgtg ggccagcccg
     1321 ctgtctcggg gaaccaggcg aaccccgctg ctgcaggagg cccagctgag ggtgctgagc
     1381 tgtccttctt gggtgacatg catctgggca gaggtttccg ggacacaggt gaagcctcaa
     1441 gcattgctcg caggtacgga ccctggttca agggcaagga tgggaatgag agagccaagc
     1501 ttggcgacta cggtggagcc tggagccgag ccctcaaggg gagggttgtc cgggagaagg
     1561 aggaagagcg agccaagtac atcggctgct acctggatga cacccagagt cgggcccttc
     1621 gaggagtgtc cttttttgac tacaaaaaga tgaccatctt ccgttgccag gacaactgtg
     1681 ctgaacgggg ttacctgtat ggcgggctgg agttcggcgc cgagtgctac tgcggccaca
     1741 agatccaggc gacgaacgtg agcgaggcag agtgcgacat ggagtgcaag ggcgagcgag
     1801 gcagcgtgtg cggcggcgcc aaccgcctct ctgtctaccg gctgcagctg gcccaggagt
     1861 cggcccgcag gtatggaagt gcagtgttcc ggggctgctt ccgcaggccc gacaaccttt
     1921 ccctggcctt acccgtgaca gctgccatgc tgaacatgtc tgtggacaaa tgcgtggact
     1981 tctgcactga gaaggagtac ccgctggcag ctcttgcagg caccgcctgc cactgtgggt
     2041 ttcccaccac ccgattcccg ctccatgaca gagaggatga gcagctctgt gcccagaagt
     2101 gcagcgcgga ggagtttgag agctgcggga ctcctagtta cttcattgtg taccagacac
     2161 aagtccaaga caaccgttgc atggacagaa ggttcctgcc aggcaagtcc aagcagctca
     2221 ttgctttggc cagcttccca ggtgctggca acacgtgggc tcgccacctc attgaattgg
     2281 ccacaggctt ctacactggc agctactact tcgatggctc cctctacaac aaagggttta
     2341 aaggtgagcg ggaccactgg cgcagcggac ggaccatctg catcaagacg cacgaaagcg
     2401 gccagaaaga gatcgaggcc ttcgacgccg ccatcctgct catccgcaac ccctacaaag
     2461 ccctcatggc tgagttcaac cgcaagtacg gcggccacat aggctttgct gcgcatgccc
     2521 actggaaggg caaagagtgg ccagagttcg tgaggaacta tgccccgtgg tgggccactc
     2581 acacactgga ctggctcaag tttggcaaga aggtgctggt ggtgcacttt gaggacctga
     2641 agcaggacct ctttgtccag ctgggccgga tggtcagcct gctgggcgtg gctgtcaggg
     2701 aggaccggct gctctgtgtg gagagccaga aggatggcaa cttcaagcgc tcagggctcc
     2761 ggaagctcga gtatgacccc tatactgcgg acatgcagaa gaccatctct gcctacatca
     2821 agatggtgga tgcagccctc aaagggcgga acctaacggg tgtccccgat gactactacc
     2881 caagatgatg cgtccacaca gggggagggt agactgggag tcctgaccac gcaggccctg
     2941 gggactcaag acccctggtt acccccactc atctgtcctc tctttggtct ggggacaatc
     3001 cccttggctg ctctttgcct tcaatgagtt tcctgcatga cagaggaggc tcaagggaag
     3061 agattgccca ggcactacca ctctgctcac atgttccccc cttggcaatg tggggcatct
     3121 tgtttagggg gttctagtta catggactct tttctgtctc ctgggtccct gcccccacca
     3181 ctctgggttc catttgtggg agggagggct catccacatc atggagactt gctggatgcc
     3241 ccatggcaat tgtcaaggct cttgatgcaa gagcccaggg ggctattgta aaaacttggc
     3301 cccagatgct tgtcccttct gggctgagat ttcgcagccc ccttctcatc tccacccaag
     3361 aagtgctggc accgatgttt aactcaggcc accttctgtt ctaaagaaag attgctggga
     3421 agtttctccg tggccttagg tttctgacat cctggatagt gtggggaggt aatggtgctc
     3481 acagtaggtt aattggagac accatgtggg gccattggtg ttatgagccc cccaggccac
     3541 actgcttctc agaaatgagc tgcttgcctt tccacctcca gggcatgaac cctgcccctt
     3601 tctatccatg ctgtgtccag gaggtgacct tgagatcctg ataccacctt caaggaacct
     3661 caggcaccaa cagtgagccc acgaggatgg tcacatgcca tgtgcagaat ttgacttaag
     3721 agagagcccc agtgacacat ctctccatgg tgggctccag tcagtcttac actgcccttc
     3781 tgacccctac aaatgggtcc tttgctatcc aggtgagaca gcaagagtgt tcttaatcag
     3841 atggaaccac acccaaaatg gacccccact accttcccag accatatatc tccccttgat
     3901 catagtccaa cagggccagc ttcccttggg ggccctttaa ggaatggggt gaatgaaatt
     3961 gtgtcatttc tatacaaaca ctgctctctt gatgctgaaa tgccaaaccg aaggatttct
     4021 gaggacctaa atcacggagc atcaatctta caaagtgttg gtccagagtc ccatctcttc
     4081 cccaaccctg gataccagta gcttcccacc cagtccaaac ctgcaccatc catcattatg
     4141 tagatgaaaa agccataggt catagcctct ttgctattct attggagtag cctccctagg
     4201 cagtccctct gaagccttgg agtgcaggta aatgctcatt cccaagtagc aaagagacca
     4261 tggagaaggt gcgtgtaaag agatatattt ttgtaagagg aatatgatta atacattccg
     4321 ccccttggaa cctggccatg caaagcaagg gcacagggat tagacctgtg gcacacttcc
     4381 ccaattccct catctgtagg atttgggctg ccccaggccc acccaggggg ctctgaatgt
     4441 attttgtacc gtgtttcttt cccccaggag aatttttagt cttctttcat gaagcagtgg
     4501 aggggttggc ctcccttcta ctgggaggtt gactctctct gggagactct tggtccaaga
     4561 cctgggtcag ttctttgctg gtggtcccct ctgaccacaa gcttctgcct gaagattcct
     4621 caggtcaaca ccatcattaa atgcgagttt tgttgatgat tctaccatgt ggtagagtgt
     4681 tgtgtaagac aggttcacaa atgggatgtt ttcctagtgt gtgtgtgtgt gtgtgtgtgt
     4741 gtgtatgaga gagagagaga gagacaacag agacagagag aggcagagag gcatagagag
     4801 acagagagag agacaagaaa cagagataga cagaaaatgt tcggggtggc aggcgggttg
     4861 gtgtataact gctttgtgcc tgtgtgactc tggcatagct gctcagggag aattacgtgc
     4921 ctctgtgtgt aaaattgcct ttgtgttctc ctgcctttct atgttttgaa actgtatccc
     4981 acaagttgcc ggtatgacca tcttatttgt aatgagtctg tgcaggtcct tgtgtatgga
     5041 attgcacccg tgtaaaggag gaaatggtca gtgtgcatga aa
//
