LOCUS       NM_015253               6056 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens WSC domain containing 1 (WSCD1), transcript variant 1,
            mRNA.
ACCESSION   NM_015253 XM_041964
VERSION     NM_015253.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6056)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   2  (bases 1 to 6056)
  AUTHORS   Xie,G., Roshandel,D., Sherva,R., Monach,P.A., Lu,E.Y., Kung,T.,
            Carrington,K., Zhang,S.S., Pulit,S.L., Ripke,S., Carette,S.,
            Dellaripa,P.F., Edberg,J.C., Hoffman,G.S., Khalidi,N.,
            Langford,C.A., Mahr,A.D., St Clair,E.W., Seo,P., Specks,U.,
            Spiera,R.F., Stone,J.H., Ytterberg,S.R., Raychaudhuri,S., de
            Bakker,P.I., Farrer,L.A., Amos,C.I., Merkel,P.A. and
            Siminovitch,K.A.
  TITLE     Association of granulomatosis with polyangiitis (Wegener's) with
            HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide
            analysis
  JOURNAL   Arthritis Rheum 65 (9), 2457-2468 (2013)
   PUBMED   23740775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC001231.3, AL833730.1, BC009975.2, AC104770.10 and BE504506.1.
            
            On Aug 13, 2020 this sequence version replaced NM_015253.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833730.1, SRR18074967.296444.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317744.10/ ENSP00000323087.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AC001231.3         1873-2107           c
            236-2927            AL833730.1         1-2692
            2928-2930           BC009975.2         2656-2658
            2931-6042           AC104770.10        55515-58626
            6043-6056           BE504506.1         7-20                c
FEATURES             Location/Qualifiers
     source          1..6056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..6056
                     /gene="WSCD1"
                     /note="WSC domain containing 1"
                     /db_xref="GeneID:23302"
                     /db_xref="HGNC:HGNC:29060"
                     /db_xref="MIM:619584"
     exon            1..274
                     /gene="WSCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..989
                     /gene="WSCD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             563..2290
                     /gene="WSCD1"
                     /note="isoform 1 is encoded by transcript variant 1; WSC
                     domain-containing protein 1; sialate:O-sulfotransferase 1"
                     /codon_start=1
                     /product="sialate:O-sulfotransferase 1 isoform 1"
                     /protein_id="NP_056068.1"
                     /db_xref="CCDS:CCDS32538.1"
                     /db_xref="GeneID:23302"
                     /db_xref="HGNC:HGNC:29060"
                     /db_xref="MIM:619584"
                     /translation="MAKPFFRLQKFLRRTQFLLFFLTAAYLMTGSLLLLQRVRVALPQ
                     GPRAPGPLQTLPVAAVALGVGLLDSRALHDPRVSPELLLGVDMLQSPLTRPRPGPRWL
                     RSRNSELRQLRRRWFHHFMSDSQGPPALGPEAARPAIHSRGTYIGCFSDDGHERTLKG
                     AVFYDLRKMTVSHCQDACAERSYVYAGLEAGAECYCGNRLPAVSVGLEECNHECKGEK
                     GSVCGAVDRLSVYRVDELQPGSRKRRTATYRGCFRLPENITHAFPSSLIQANVTVGTC
                     SGFCSQKEFPLAILRGWECYCAYPTPRFNLRDAMDSSVCGQDPEAQRLAEYCEVYQTP
                     VQDTRCTDRRFLPNKSKVFVALSSFPGAGNTWARHLIEHATGFYTGSYYFDGTLYNKG
                     FKGEKDHWRSRRTICVKTHESGRREIEMFDSAILLIRNPYRSLVAEFNRKCAGHLGYA
                     ADRNWKSKEWPDFVNSYASWWSSHVLDWLKYGKRLLVVHYEELRRSLVPTLREMVAFL
                     NVSVSEERLLCVENNKEGSFRRRGRRSHDPEPFTPEMKDLINGYIRTVDQALRDHNWT
                     GLPREYVPR"
     exon            990..1104
                     /gene="WSCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1289
                     /gene="WSCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1411
                     /gene="WSCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1571
                     /gene="WSCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1736
                     /gene="WSCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1937
                     /gene="WSCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..6056
                     /gene="WSCD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2886..2891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WSCD1"
                     /note="hexamer: CATAAA"
     polyA_site      2930
                     /gene="WSCD1"
                     /note="major polyA site"
     regulatory      6034..6039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WSCD1"
                     /note="hexamer: AATAAA"
     polyA_site      6056
                     /gene="WSCD1"
                     /note="major polyA site"
ORIGIN      
        1 gcagagcccg gcgcccgctc gcccgcccgc tgcccgcccc ggctccgcgc ccgcccgccc
       61 gccccgccgt tcagcccgga cgccagcagc cccggggagc caggcggcgg cgccctgtgc
      121 ccgggcgcgt gggtccgctt gccgcgggcg gccggagacg tgcgggcgcc ggggcttctg
      181 ggctccgggc actgcggggg gctgcgggct cggcgcccgg ggaaggcggg ccatgggcgc
      241 gggtgcgggc gccccagccg gccgcgatcg cgggatttct gcgccaggag atgaggggcg
      301 gtagagccct ggaatggaga tgtccttgac gcctgggcag aggctgcagc tgcaggaccc
      361 tgtggccact ggagataagt aatggtgcca tttgaacacc tactggaaac ggggcaggaa
      421 cagtgagtga ccccaggcga gcacaggcag gtgccaggag ccaggatgca aggatgacgc
      481 ctccggaggc cctggcctca ctcccacctg ggcgctagga gccatcccgg ggctccagcc
      541 aggagccctg ctgcccaggg gcatggccaa acctttcttc cgactccaga agtttctccg
      601 ccgaacacag ttcctgctgt tcttcctcac ggctgcctac ctgatgaccg gcagcctgct
      661 gctgctgcag cgggtccgcg tggctctccc acagggcccc cgggcacccg gccccctgca
      721 gaccttgcca gtggccgccg tggcgctggg cgtgggcttg ctggacagca gagccctgca
      781 cgaccctcga gtcagcccag agctgctgct gggtgtggac atgctgcaga gccccctgac
      841 ccggccccgg cccggccccc gctggctccg gagccgcaac tcggagctgc gtcagttgcg
      901 tcgccgctgg ttccaccact tcatgagtga ctcccaggga ccgcccgccc tgggccccga
      961 ggctgccagg cccgccatcc acagccgagg cacctacatt ggatgcttca gtgacgatgg
     1021 ccacgagagg actctgaaag gagctgtgtt ttatgacttg agaaagatga ctgtctccca
     1081 ctgccaggat gcgtgtgctg agcggtccta tgtctacgcc ggcttggagg ccggggcgga
     1141 gtgttactgc gggaaccggc tgccagcggt gagcgtgggg ctggaagagt gtaaccatga
     1201 gtgcaaaggc gagaagggct ctgtgtgcgg ggctgtggac cggctctccg tgtaccgtgt
     1261 ggacgagctg cagccgggct ccaggaagcg gcggaccgcc acctaccgcg gatgcttccg
     1321 actgccagag aacatcacac atgccttccc cagctccctg atacaggcca atgtgaccgt
     1381 ggggacttgc tcgggctttt gttcccagaa agagttcccc ttggccattc tcaggggctg
     1441 ggaatgctac tgtgcttacc ctaccccccg gttcaacctg cgggatgcca tggacagctc
     1501 agtatgtggc caggaccctg aggcacagag gctggcagaa tactgtgagg tctaccagac
     1561 acctgtgcaa gacactcgtt gtacagacag gaggttcctg cctaacaaat ccaaagtgtt
     1621 tgtggctttg tcaagcttcc caggagccgg gaacacatgg gcacggcacc tcattgagca
     1681 tgccactggc ttctatacag ggagctacta ctttgatgga accctctaca acaaagggtt
     1741 caagggcgaa aaggaccact ggcggagccg acgcaccatc tgtgtcaaaa cccacgagag
     1801 tggcaggagg gagattgaga tgtttgattc agccatcctg ctaatccgga acccatacag
     1861 gtccctggtg gcagaattca acagaaaatg tgccgggcac ctgggatatg cagctgaccg
     1921 caactggaag agcaaagagt ggccggactt tgtcaacagc tacgcctcgt ggtggtcctc
     1981 gcacgtcctg gactggctca agtacgggaa gcggctgctg gtggtgcact acgaggagct
     2041 gcggcgcagc ctggtgccca cgttacggga gatggtggcc ttcctcaacg tgtctgtgag
     2101 cgaggagcgg ctgctctgcg tggagaacaa caaggagggc agcttccggc ggcgcggccg
     2161 gcgctcccac gaccctgagc ccttcacccc ggagatgaaa gacttgatca atggctacat
     2221 ccggacggtg gaccaagccc tgcgtgacca caactggacg gggctgccca gggagtatgt
     2281 gcccagatga taggcctggc ccacgccgcc gcccccgctg agtgacgcaa tcgcaccacg
     2341 gggctgcgct ccccactctg atgctcaggc ccgtggcctc actgggacga acggtgggtg
     2401 gggggctcac cctggtgctg cctcccgcac aaggagacct ggacacaaca gacacacatc
     2461 acaaggcgaa cacaaatgga cacacatacc tggccacgaa cccacacctc ctcagacact
     2521 cagacaccac tccaggctca tagccccgtc ttgatgcaga gaagccaccc acgtggggtg
     2581 tgccaggcac ccccagatac aaatgcagcc acgcacagac gtaacacaca ggtgccaggc
     2641 cgtgtgctcc tggaggctgg ctggctgtct ctctcacaca gatacacgtg cgctccctgg
     2701 gatccgggag gccctgggct tcctgtgtgt agccctggca tagacttgct cgtcagggtg
     2761 ttcgactctg ggatgctggg ccgggcagac atttatgctc tgagcagcaa ggaccattgg
     2821 gatggaggtg ggcacaaaga ctgctgcttc cagggtgtgc ggccctggcc gtgtgtctga
     2881 catcccataa atgtgtgtgt ggtgtgacta cgggcaccac aaactccgca gccttgcctc
     2941 tcttttctct gtggctgggc tggctgcacc atgggcaggg ttgaggactg ccccccaccc
     3001 cgcccaagcc aatgcagaca ctgacctcaa gaccagccac accaagtctg tgcactgccc
     3061 accaccccct tcaacccctc ctacaccatg ctccggggcc tggggcctcc ttgcctggct
     3121 tcttcctcca gctatcctca gggaagctgg agattcaagt catgccccag aagcaaggtg
     3181 taagcatggg ggcgtgggga agagggcagg agctgaagtt ccaggggagc ccaggacccc
     3241 tggggacctg tacactagca ggatgggtct tgggagttgg catggggaga ttgtaagggc
     3301 tgtatctccg cgattactgg tactggtgct ccacccatag gggccctgtt ctctctgggg
     3361 tcccacactg gggtcatgag agctagttag tactcagcct gacccctagg tctggtcctg
     3421 ccagcctggg atgggggtca atgtatgcta cacatcttgg gctcacaagt gaggctgtgg
     3481 aggccaggag gttcaagtat ggagggtagg agtgcaaccc aggagcaacg ctcaaggtgg
     3541 ccgagatgca gggaggattg tggcgatccg gttgcacact ggcctctgtg gaggtcaggg
     3601 aggtgggaag gtgggtgggc ctgaactcag gcagcccttc agtggcttct tcaggcctag
     3661 gataaccctg gccaggcccc atggtcctgc tctgggtcag ctgtcaggga gacctccctt
     3721 cagcctgagc caagctgcat tgggaggaga aggcagggtg agggatctgg gagagcagga
     3781 cgttgagata tcctgaccct ctgcttccta gcctgatgat ggggaaccca gagccacccg
     3841 ctatgagcac aggccggggg tggaaggccc agtagagctg cccttcccca gatggaagct
     3901 tcctccaacc ttcagtttgg ccagtgggtg ggtttgggca tctgtgcccc tggtggcctc
     3961 caaatccttc ctgggattcc cccaaaccca cactgatgcg aagctgttct tgaccctccc
     4021 atagcatcaa ctcagttcag ctcaaagcta gaaacaccaa ggtctttgaa aatgtttatt
     4081 ggctcaggat agcttcggca tccaatctgc gaaggcccct gatggagcta tttcttccta
     4141 gtatcaggag caattgagac ccctcaggag tttccacact gctgtggacg ggatagccag
     4201 ggcagacctg catcccagag caagcctaga tccttgaaag caatgtcagg cgtggcagtg
     4261 gggaagccat ggaggctggg aagggcaaag tgtggagaga ggagtgaccg ggactggagc
     4321 cagggtctgg ggagagcaac agcaccaggc ttttcctggt agttggattg gtacattcac
     4381 tgctgccagg tacccagaga tgtcatctct ctccaggtag agcatcacca gctcctgtgg
     4441 ccttgtagat gactctgtac ctcagtgaag agtgcaggca agtagagtga tggggtcagt
     4501 gtccatccag tttacgctga gtcagtccat acagcaagac acctggcact tggcaggtac
     4561 tcctggatgt tgatgagcaa ggaagagcaa cggccctgtc agctggcagt ggtcctcaca
     4621 gccttcatcc caggtctgcc tacgtgggag atctcatcag aaacaggaac ggggatctgt
     4681 ctgtgcttgc aggaaagtcc atttgttttt ctccaagtta ggtctcatct acagctctta
     4741 gcttctcagt aaagaggata ctctcccaac cagccaagga ataaaagctg atctgtatgt
     4801 agggcagaag tgtggcaaat gcatcaggaa ccggttagaa cagaacagag aaaccctgac
     4861 tgtctacaga ttccaacttt aatagcaagc ctgtggagtt acacaaacct gtgttaaaac
     4921 atgtaatttt tatggatttc atctcccgtt gtggatcaat ttggaaaaac caaaatatgt
     4981 aattttaaaa aactaaaaca catcctggta gtcccagtga tgtgtaaatg agagagaaga
     5041 atagacaggc ttccaaaccc tgggaagaaa gctgcttaat tatgtgaaca tcttataatg
     5101 aagtctcttg cagctaaaat tagattttga gtgcatgaat ctgtgataat gtttgcatat
     5161 cagaatgcat tctcccctta aaagtagcag tagccacttg gttcttaggg ggccccaaga
     5221 ggagaggaga agtgctgagg ttgatgttac gactgcaaga attcttggga cacaggtttg
     5281 ttttctgctg acttgctcgg aaacccattg gaggtatctg aaatgtgatg actccaaagg
     5341 ggttcatttc actataggga gaaattgatt cgtctgactt cctatttatc accactcaat
     5401 attgggtgag ttggtctgaa caaggtgggg ataaagtaga gtggaaataa tgtagagtcg
     5461 tcagactgaa aggccaggtt gtagtcccag ctcttatctg ccatcttgga caaagctttt
     5521 cccatctcca gtctcagttt cccatccata aaatggggga agtggtaggt cttgctgatt
     5581 gcatccacat tcattcctcc atttcctttc ccagcaaccc cccatttctg tttgggaatt
     5641 catatgatct gccagagcct ctccaggggt ggaatacatg tcctggacta agccaatgac
     5701 accttccatc tttccagcta tggtgactgg gttaggtatg atcttgtgag ttaagacaat
     5761 gaagccagag ggaatttcaa gacttatggg aatgctgggt agaagctgtt ttaattcccc
     5821 tgttgaatgt gaaaaaggta gtagtattcc tgggtcttta tgatgaccac cttgggcctt
     5881 gggatcatga ccaggaatca cgtgaagctg acaccactga agggagagtt gagaggcaga
     5941 aagagatcaa gtccttggtg aaattgttta agtacaggat caagccttgc ttgagattgg
     6001 ccttacctct ggactttttt tgttatatga gctaataaat tctgtttatt gtttaa
//
