LOCUS       NM_018639               2855 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens WD repeat and SOCS box containing 2 (WSB2), transcript
            variant 2, mRNA.
ACCESSION   NM_018639
VERSION     NM_018639.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Zhang,J., Yu,Y., Zou,X., Du,Y., Liang,Q., Gong,M., He,Y., Luo,J.,
            Wu,D., Jiang,X., Sinclair,M., Tajkhorshid,E., Chen,H.Z., Hou,Z.,
            Zheng,Y., Chen,L.F. and Yang,X.D.
  TITLE     WSB1/2 target chromatin-bound lysine-methylated RelA for
            proteasomal degradation and NF-kappaB termination
  JOURNAL   Nucleic Acids Res 52 (9), 4969-4984 (2024)
   PUBMED   38452206
  REMARK    GeneRIF: WSB1/2 target chromatin-bound lysine-methylated RelA for
            proteasomal degradation and NF-kappaB termination.
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Li,X., Zhang,C.C., Lin,X.T., Zhang,J., Zhang,Y.J., Yu,H.Q.,
            Liu,Z.Y., Gong,Y., Zhang,L.D. and Xie,C.M.
  TITLE     Elevated expression of WSB2 degrades p53 and activates the
            IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma
  JOURNAL   Exp Mol Med 56 (1), 177-191 (2024)
   PUBMED   38177295
  REMARK    GeneRIF: Elevated expression of WSB2 degrades p53 and activates the
            IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Ma,L., Zhang,Y. and Hu,F.
  TITLE     miR-28-5p inhibits the migration of breast cancer by regulating
            WSB2
  JOURNAL   Int J Mol Med 46 (4), 1562-1570 (2020)
   PUBMED   32945370
  REMARK    GeneRIF: miR285p inhibits the migration of breast cancer by
            regulating WSB2.
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Zhang,Y., Li,Z., Zhao,W., Hu,H., Zhao,L., Zhu,Y., Yang,X., Gao,B.,
            Yang,H., Huang,Y. and Song,X.
  TITLE     WD repeat and SOCS box containing protein 2 in the proliferation,
            cycle progression, and migration of melanoma cells
  JOURNAL   Biomed Pharmacother 116, 108974 (2019)
   PUBMED   31103822
  REMARK    GeneRIF: This is the first report to demonstrate the effects of
            WSB2 on melanoma cell function.
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Nara,H., Onoda,T., Rahman,M., Araki,A., Juliana,F.M., Tanaka,N. and
            Asao,H.
  TITLE     Regulation of interleukin-21 receptor expression and its signal
            transduction by WSB-2
  JOURNAL   Biochem Biophys Res Commun 392 (2), 171-177 (2010)
   PUBMED   20059963
  REMARK    GeneRIF: This report provides the first evidence that WSB-2 is a
            regulator of IL-21R expression and IL-21-induced signal
            transduction.
REFERENCE   8  (bases 1 to 2855)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   9  (bases 1 to 2855)
  AUTHORS   Li,X.G., Song,J.D. and Wang,Y.Q.
  TITLE     Differential expression of a novel colorectal cancer
            differentiation-related gene in colorectal cancer
  JOURNAL   World J Gastroenterol 7 (4), 551-554 (2001)
   PUBMED   11819827
  REMARK    GeneRIF: SBA2 gene might be a promising novel biomarker of cell
            differentiation in colorectal cancer and its biological features
            need further studies.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA772463.1, AF229181.1,
            AC131159.5 and CA443120.1.
            
            On Feb 27, 2020 this sequence version replaced NM_018639.4.
            
            Summary: This gene encodes a member of the WD-protein subfamily.
            The encoded protein contains five WD-repeats spanning most of the
            protein and an SOCS box in the C-terminus. The SOCS box may act as
            a bridge between specific substrate-binding domains and E3
            ubiquitin protein ligases. Three transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jun 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015887.2, AF229181.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315436.8/ ENSP00000319474.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA772463.1         33-65
            34-1755             AF229181.1         5-1726
            1756-1756           AC131159.5         30708-30708         c
            1757-2481           AF229181.1         1728-2452
            2482-2855           CA443120.1         12-385              c
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..2855
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /note="WD repeat and SOCS box containing 2"
                     /db_xref="GeneID:55884"
                     /db_xref="HGNC:HGNC:19222"
     exon            1..144
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1346
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /note="isoform 2 is encoded by transcript variant 2; CS
                     box-containing WD protein; WD repeat and SOCS
                     box-containing protein 2; WSB-2"
                     /codon_start=1
                     /product="WD repeat and SOCS box-containing protein 2
                     isoform 2"
                     /protein_id="NP_061109.1"
                     /db_xref="CCDS:CCDS9186.1"
                     /db_xref="GeneID:55884"
                     /db_xref="HGNC:HGNC:19222"
                     /translation="MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWS
                     QGHCIVKLIPWPLEEQFIPKGFEAKSRSSKNETKGRGSPKEKTLDCGQIVWGLAFSPW
                     PSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLS
                     FTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGE
                     KSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRS
                     LHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMT
                     NGLCCTFFPHGGVIATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLALPIP
                     KKMKEFLTYRTF"
     exon            145..313
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..558
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..690
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..791
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..964
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1075
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1183
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..2855
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2199
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /note="major polyA site"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /note="hexamer: AAGAAA"
     polyA_site      2636
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /note="major polyA site"
     regulatory      2838..2843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WSB2"
                     /gene_synonym="SBA2"
                     /note="hexamer: AATAAA"
     polyA_site      2855
                     /gene="WSB2"
                     /gene_synonym="SBA2"
ORIGIN      
        1 aagcagctga tggcctctcc gggcggcggc ggcggcctgg ccggggcggg cggcgcgggg
       61 gcggcatgag ggcccgcggc ccggggggct gaggcgcccg ccgcctgccg cgggggccgc
      121 tcgcgtcctc catggaggcc ggagaggaac cgctgctgct ggccgaactc aagcccgggc
      181 gcccccacca gtttgattgg aagtccagct gtgaaacctg gagcgtcgcc ttctccccag
      241 atggctcctg gtttgcttgg tctcaaggac actgcatcgt caaactgatc ccctggccgt
      301 tggaggagca gttcatccct aaagggtttg aagccaaaag ccgaagtagc aaaaatgaga
      361 cgaaagggcg gggcagccca aaagagaaga cgctggactg tggtcagatt gtctgggggc
      421 tggccttcag cccgtggcct tccccaccca gcaggaagct ctgggcacgc caccaccccc
      481 aagtgcccga tgtctcttgc ctggttcttg ctacgggact caacgatggg cagatcaaga
      541 tctgggaggt gcagacaggg ctcctgcttt tgaatctttc cggccaccaa gatgtcgtga
      601 gagatctgag cttcacaccc agtggcagtt tgattttggt ctccgcgtca cgggataaga
      661 ctcttcgcat ctgggacctg aataaacacg gtaaacagat tcaagtgtta tcgggccacc
      721 tgcagtgggt ttactgctgt tccatctccc cagactgcag catgctgtgc tctgcagctg
      781 gagagaagtc ggtctttcta tggagcatga ggtcctacac gttaattcgg aagctagagg
      841 gccatcaaag cagtgttgtc tcttgtgact tctcccccga ctctgccctg cttgtcacgg
      901 cttcttacga taccaatgtg attatgtggg acccctacac cggcgaaagg ctgaggtcac
      961 tccaccacac ccaggttgac cccgccatgg atgacagtga cgtccacatt agctcactga
     1021 gatctgtgtg cttctctcca gaaggcttgt accttgccac ggtggcagat gacagactcc
     1081 tcaggatctg ggccctggaa ctgaaaactc ccattgcatt tgctcctatg accaatgggc
     1141 tttgctgcac attttttcca catggtggag tcattgccac agggacaaga gatggccacg
     1201 tccagttctg gacagctcct agggtcctgt cctcactgaa gcacttatgc cggaaagccc
     1261 ttcgaagttt cctaacaact taccaagtcc tagcactgcc aatccccaag aaaatgaaag
     1321 agttcctcac atacaggact ttttaagcaa caccacatct tgtgcttctt tgtagcaggg
     1381 taaatcgtcc tgtcaaaggg agttgctgga ataatgggcc aaacatctgg tcttgcattg
     1441 aaatagcatt tctttgggat tgtgaataga atgtagcaaa accagattcc agtgtactag
     1501 tcatggatct ttctctccct ggcatgtgaa agtcagtctt agaggaagag attccacttg
     1561 cacggcaaca gagccttacg ttaaattttc agtccagtta tgaacagcaa gtgttgaact
     1621 ctttctgctt gttttgattc aaagtgcagt tactgatgtt gttttgatta tgcaactaag
     1681 taggcctcca gagcctctct agtggcagag cagctcacac tccctccgct gggaacgatg
     1741 gcttctgcct agtacctatc cttgtgtttc tgatgcagtg gtagcattgg ttcaagttct
     1801 ctcctgctgt ggtcagagtt gcttcgatgt tggccaagtg cttttcttct tgggctccct
     1861 tctgacctgc aggacagttt tcctggagcc atttggtatg aggtattaat ttagcttaac
     1921 taaattacag gggactcaga ggccgtgctc ctgaccgatc cagacactat tactggcttt
     1981 tttttttttt ttttaacaat ggtgtgcatg tgcaggaaat gacaaatttg tatgtcagat
     2041 tatacaagga tgtattctta aaccgcatga ctattcagat ggctactgag ttatcagtgg
     2101 ccatttatta gcatcatatt tatttgtatt ttctcaacag atgttaaggt acaactgtgt
     2161 ttttctcgat tatctaaaaa ccatagtact taaattgaac agttgcaaag atgtcttaat
     2221 tgtgtaaaga attggtgtag tcatgacttt agctgatact cttatgtacg agatctgtct
     2281 ctgctgttta acttcattgg attaatcagc tggtttcaac tctactgcga aacaaaaata
     2341 gctccttaaa agtactgttc tccttcagtg gcatgtagtt atctaatcaa gacacctcat
     2401 tcaaacaaaa cctgccttag gaaaatttaa tatattttaa attattttaa aagaaataca
     2461 acatcttatt ctttagcttt cttaatcggt gctttatgga ggccagtgta acgttacatg
     2521 actcgttgag aaagttgagg aatttcctct accacctttg ttgcttgaag aaaaacatgt
     2581 cttttcaaaa tgagaggctt tcattgaaga aaagaaaaaa acaacagtta aaagcttttg
     2641 gctctctgtt tcattttttt ccattaagaa aaaaaaaagt ccccttttaa aacaagcagg
     2701 gctgggtgtg acggcacatg cctgtaatcc cagcactttg ggaggctgag gtgggaggac
     2761 tgcttgagcc caggagttca agatcagcct gggcaacaga gtgagataag acccaatctt
     2821 tatttaaaaa ataaataaat aaatagccaa aaaaa
//
