LOCUS       NM_015626               5105 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens WD repeat and SOCS box containing 1 (WSB1), transcript
            variant 1, mRNA.
ACCESSION   NM_015626
VERSION     NM_015626.10
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5105)
  AUTHORS   Zhang,J., Yu,Y., Zou,X., Du,Y., Liang,Q., Gong,M., He,Y., Luo,J.,
            Wu,D., Jiang,X., Sinclair,M., Tajkhorshid,E., Chen,H.Z., Hou,Z.,
            Zheng,Y., Chen,L.F. and Yang,X.D.
  TITLE     WSB1/2 target chromatin-bound lysine-methylated RelA for
            proteasomal degradation and NF-kappaB termination
  JOURNAL   Nucleic Acids Res 52 (9), 4969-4984 (2024)
   PUBMED   38452206
  REMARK    GeneRIF: WSB1/2 target chromatin-bound lysine-methylated RelA for
            proteasomal degradation and NF-kappaB termination.
REFERENCE   2  (bases 1 to 5105)
  AUTHORS   Boldrini,L. and Bardi,M.
  TITLE     WSB1 Involvement in Prostate Cancer Progression
  JOURNAL   Genes (Basel) 14 (8), 1558 (2023)
   PUBMED   37628609
  REMARK    GeneRIF: WSB1 Involvement in Prostate Cancer Progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5105)
  AUTHORS   Carneiro,V.L., da Silva,H.B.F., Queiroz,G.A., Veiga,R.V.,
            Oliveira,P.R.S., Carneiro,N.V.Q., Pires,A.O., da Silva,R.R.,
            Sena,F., Belitardo,E., Nascimento,R., Silva,M., Marques,C.R.,
            Costa,R.D.S., Alcantra-Neves,N.M., Barreto,M.L., Cooper,P.J. and
            Figueiredo,C.A.
  TITLE     WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune
            Responses to Ascaris lumbricoides
  JOURNAL   Front Immunol 12, 622051 (2021)
   PUBMED   33692795
  REMARK    GeneRIF: WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune
            Responses to Ascaris lumbricoides.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5105)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 5105)
  AUTHORS   Xu,H., Han,H. and Tian,G.
  TITLE     High expression of WSB1 is associated with poor prognosis in
            hepatocellular carcinoma and affects epithelial-mesenchymal
            transition
  JOURNAL   J BUON 25 (4), 1890-1896 (2020)
   PUBMED   33099929
  REMARK    GeneRIF: High expression of WSB1 is associated with poor prognosis
            in hepatocellular carcinoma and affects epithelial-mesenchymal
            transition.
REFERENCE   6  (bases 1 to 5105)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   7  (bases 1 to 5105)
  AUTHORS   Kamura,T., Burian,D., Yan,Q., Schmidt,S.L., Lane,W.S., Querido,E.,
            Branton,P.E., Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Muf1, a novel Elongin BC-interacting leucine-rich repeat protein
            that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin
            ligase
  JOURNAL   J Biol Chem 276 (32), 29748-29753 (2001)
   PUBMED   11384984
REFERENCE   8  (bases 1 to 5105)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 5105)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 5105)
  AUTHORS   Vasiliauskas,D., Hancock,S. and Stern,C.D.
  TITLE     SWiP-1: novel SOCS box containing WD-protein regulated by
            signalling centres and by Shh during development
  JOURNAL   Mech Dev 82 (1-2), 79-94 (1999)
   PUBMED   10354473
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC308179.1, BC021110.1,
            BU189299.1, BC048007.1, AK074917.1 and AC026254.9.
            
            On Nov 22, 2018 this sequence version replaced NM_015626.9.
            
            Summary: This gene encodes a member of the WD-protein subfamily.
            This protein shares a high sequence identity to mouse and chick
            proteins. It contains several WD-repeats spanning most of the
            protein and an SOCS box in the C-terminus. Alternatively spliced
            transcript variants encoding distinct isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074917.1, SRR3476690.949922.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262394.7/ ENSP00000262394.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DC308179.1         94-112
            20-2069             BC021110.1         1-2050
            2070-2234           BU189299.1         337-501
            2235-2798           BC048007.1         3591-4154
            2799-2810           AK074917.1         2798-2809
            2811-5105           AC026254.9         84409-86703
FEATURES             Location/Qualifiers
     source          1..5105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.1"
     gene            1..5105
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /note="WD repeat and SOCS box containing 1"
                     /db_xref="GeneID:26118"
                     /db_xref="HGNC:HGNC:19221"
                     /db_xref="MIM:610091"
     exon            1..322
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1548
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /note="isoform 1 is encoded by transcript variant 1; SOCS
                     box-containing WD protein SWiP-1; WD repeat and SOCS
                     box-containing protein 1"
                     /codon_start=1
                     /product="WD repeat and SOCS box-containing protein 1
                     isoform 1"
                     /protein_id="NP_056441.6"
                     /db_xref="CCDS:CCDS11220.1"
                     /db_xref="GeneID:26118"
                     /db_xref="HGNC:HGNC:19221"
                     /db_xref="MIM:610091"
                     /translation="MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAP
                     DGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREH
                     IIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTG
                     KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVY
                     SCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY
                     DTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKM
                     VRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCR
                     MSIRRVMPTQEVQELPIPSKLLEFLSYRI"
     exon            323..491
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..760
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..892
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..993
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1166
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1280
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1388
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..5105
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3180..3185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3203
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /note="major polyA site"
     regulatory      4989..4994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /note="hexamer: GATAAA"
     polyA_site      5009
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /note="major polyA site"
     regulatory      5086..5091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
                     /note="hexamer: AATAAA"
     polyA_site      5105
                     /gene="WSB1"
                     /gene_synonym="SWIP1; WSB-1"
ORIGIN      
        1 agtgtctcgt ttgcagtcgg cgctttaggg gaactgtctt cctccgcagg cgcgaggctg
       61 ggtacagggt ctattgtctg tggttgactc cgtactttgg tctgaggcct tcgggagctt
      121 tcccgaggca gttagcagaa gccgcagcgg ccgcccccgc ccgtctcctc tgtccctggg
      181 cccgggaggg accaacttgg cgtcacgccc ctcagcggtc gccactctct tctctgttgt
      241 tgggtccgca tcgtattccc ggaatcagac ggtgccccat agatggccag ctttcccccg
      301 agggtcaacg agaaagagat cgtgagatta cgtactatag gtgaactttt agctcctgca
      361 gctccttttg acaagaaatg tggtcgtgaa aattggactg ttgcttttgc tccagatggt
      421 tcatactttg cttggtcaca aggacatcgc acagtaaagc ttgttccgtg gtcccagtgc
      481 cttcagaact ttctcttgca tggcaccaag aatgttacca attcaagcag tttaagattg
      541 ccaagacaaa atagtgatgg tggtcagaaa aataagcctc gtgaacatat tatagactgt
      601 ggagatatag tctggagtct tgcttttggg tcatcagttc cagaaaaaca gagtcgctgt
      661 gtaaatatag aatggcatcg cttcagattt ggacaagatc agctacttct tgctacaggg
      721 ttgaacaatg ggcgtatcaa aatatgggat gtatatacag gaaaactcct ccttaacttg
      781 gtagatcata ctgaagtggt cagagattta acttttgctc cagatggaag cttgatcctg
      841 gtgtcagctt caagagacaa aactctcaga gtatgggacc tgaaagatga tggaaacatg
      901 atgaaagtat tgagggggca tcagaattgg gtgtacagct gtgcattctc tcctgactct
      961 tctatgctgt gttcagtcgg agccagtaaa gcagttttcc tttggaatat ggataaatac
     1021 accatgatac ggaaactaga aggacatcac catgatgtgg tagcttgtga cttttctcct
     1081 gatggagcat tactggctac tgcatcttat gatactcgag tatatatctg ggatccacat
     1141 aatggagaca ttctgatgga atttgggcac ctgtttcccc cacctactcc aatatttgct
     1201 ggaggagcaa atgaccggtg ggtacgatct gtatctttta gccatgatgg actgcatgtt
     1261 gcaagccttg ctgatgataa aatggtgagg ttctggagaa ttgatgagga ttatccagtg
     1321 caagttgcac ctttgagcaa tggtctttgc tgtgccttct ctactgatgg cagtgtttta
     1381 gctgctggga cacatgacgg aagtgtgtat ttttgggcca ctccacggca ggtccctagc
     1441 ctgcaacatt tatgtcgcat gtcaatccga agagtgatgc ccacccaaga agttcaggag
     1501 ctgccgattc cttccaagct tttggagttt ctctcgtatc gtatttagaa gattctgcct
     1561 tccctagtag tagggactga cagaatacac ttaacacaaa cctcaagctt tactgacttc
     1621 aattatctgt ttttaaagac gtagaagatt tatttaattt gatatgttct tgtactgcat
     1681 tttgatcagt tgagctttta aaatattatt tatagacaat agaagtattt ctgaacatat
     1741 caaatataaa tttttttaaa gatctaactg tgaaaacata catacctgta catatttaga
     1801 tataagctgc tatatgttga atggaccctt ttgcttttct gatttttagt tctgacatgt
     1861 atatattgct tcagtagagc cacaatatgt atctttgctg taaagtgcaa ggaaatttta
     1921 aattctggga cactgagtta gatggtaaat actgacttac gaaagttgaa ttgggtgagg
     1981 cgggcaaatc acctgaggtc agcagtttga gactagcctg gcaaacatga tgaaaccctg
     2041 tctctactaa aaatacaaaa aaaaaaaaaa ttagccaggc gtggtggtgc acacctgtag
     2101 tcctagctac ttgggaggct gaggcaggag aattgcttga acccaggagg tggaggttgc
     2161 agtaagccaa gatcacacca ctgcactcca acctggacaa cagagcgaga ctccatctca
     2221 aaaaaaaaaa aaaattgtgt tgcctcatac gaaatgtatt tggttttgtt ggagagtgtc
     2281 agactgatct ggaagtgaaa cacagtttat gtacagggaa aaggatttta ttatccttag
     2341 gaatgtcatc caagacgtag agcttgaatg tgacgttatt taaaaacaac aacaaagaag
     2401 gcagagccag gatataacta gaaaaaggat gtcttttttt ttttttttac tccccctcta
     2461 aacactgctg ctgccttaat tttagaaagc agcttactag tttacccttg tggtataaag
     2521 tattataaat tgttgtgaat ttgaagaatc cgtctactgt attattgcta aatattttgt
     2581 ttatactaag ggacaattat tttaagacca tggatttaaa aaaaaaaaaa aaaactctgt
     2641 ttctgcaggg gatgatattg gtgagttgcc aaagaagcaa tacagcatat ctgcttttgc
     2701 cttctgttgt ttatcttacc tgcagatatt aagaatgtat gcattatgta aaatgctcaa
     2761 ttatatattt ttgttgagtt ttttaattaa agacttgtaa aaaaaaaaaa cagtatattg
     2821 caaatgtttc ttaaataggt taggtggagt actttctctc tgtctccatt gtaaggttga
     2881 tggtacacca caggcaaatt aagcaaaaag gacaatgaag aaagaatgca ggactcaggc
     2941 gctgctctag aattcattca gggctccccg agtgcagcag ctcttatggt ggttttgttt
     3001 ttaggagaac tgttgtaata atgcatattt taaaagcata gggaagctct agaacacagg
     3061 aaggtgacta ctaagcaaga gaaaagtatc ttttagtggg gaactaccag cctatagtaa
     3121 gtctatctgg ttaaagtagt tattatgaaa atctagcagt ctgggtcctt tgagaaggca
     3181 ttaaaaaagc aaaactctta tgagccatgt gtgattttga agactcattt ccactgagaa
     3241 attatttgga agttcctatg gttagctctg ttaaggaatg taaaaattta tagggggtgt
     3301 agggttatca atttgaaagc cagtagaaaa tctgctcaag ttacttcttg aggatcatct
     3361 gtattttaca aaaagaagca caagaagcat ctaatcttta tacttcttgt gacttttttt
     3421 cccctgcatt ttactttgta atatatcggc tttataattt taaaatacac tggccgggcg
     3481 cagtggccca cacctataat cccagcactt tgggaggcca aggcaggtgg gtcacttaag
     3541 gccgggagtt catgacaagc ctgaccaaca tagtgaaacc cctgtctcta ctaaaattac
     3601 aaaaattagc tgggcatggt ggtgggttcc tgtactccta gctacttagg aggctgaggc
     3661 aagagaattg cttgaactgg agaaatggag gttgcagtga gctgagatca cgcaactgca
     3721 ctccagcctg ggtgacagag taagactcta aataaataag ataccattac ttttcatatc
     3781 attgcattat ttttgctttc cacaccaaca tatccagtca agtaaaaaca gcttttttta
     3841 ttttttattt tttatttttt ttgagacgga gtctcacact gtcacctggg ctggagtgca
     3901 gtggtgcgat cttggctcac tgcagcctcc acctcctggg ttcaagcaat tctcctgcct
     3961 cagcctccca agcagctggg attacaggcg ctcccccacc acgcccagct aatttttgtt
     4021 gtatttttag gacagacggc gtttcactgt tggccagact ggtctcaaac tcctgacctc
     4081 gtgatccgcc cgcctcggcc tcccagagtg ctgggattat aggtgtgagc caccgaacct
     4141 ggcccaaaac agcatttttg gaagctacat tctgtgagat gttcacctgt ttgccacctc
     4201 ttctcgtgaa aaccatagtg agtgccagtg tgaaaggaag attgcagcgt atatgtcaag
     4261 tagaaacatg tttgaatttt ccatttgtct gtggggaaga aggtaataac agtaataaca
     4321 gactgaagga ccaaaggaaa atagggaaga cgttgattat ggacttggat cagattctag
     4381 ctacatgatt tgaaaatgac actgcctctc ctattttgcc acaagcctgt catttggaga
     4441 actggcagat catttatgtt cagatttaat tttctgtttt agaatcccat ggagtacatg
     4501 tgaacatagg aaaatcacac tcagcagcca agctatcctt ttgcgataat gaaatcactt
     4561 taaaacctat aacttgatct taggttggca aatcttaaac ttaacgatcc ttgaaatttc
     4621 ctgcctgctg tgactgtgat gcagttggat tcaactggtt tacactgctc ttgggtcggc
     4681 aagaccaaaa aaggttggac tgcactgtag catgcttatg ggttgaggca gtggcagagg
     4741 cagaggactt ggccgtcagc cagccagcac aggcgtaaga aaatagcatg agaagtttca
     4801 cgagcctgaa accattgaga cagtgattac aacctccata ttaatcagat gagggtttgt
     4861 aggtgacata gcattttacc caagtaattc tgaacagact gtggcttatg ataatacatt
     4921 ttaactagca agtgtgtgga ctataaaaca aatatctaga gttatatatg gatgtactat
     4981 catttggtga taaaagcata gaaaaagcat aagttggagt atactgggtt tttttgttgt
     5041 tgttaaattc ttttccatca gaagtaagag ctgttggcag caactaataa aatgcaacct
     5101 agtga
//
