LOCUS       NM_017818               1692 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WD repeat containing, antisense to TP73 (WRAP73),
            mRNA.
ACCESSION   NM_017818
VERSION     NM_017818.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1692)
  AUTHORS   Chu,Z. and Gruss,O.J.
  TITLE     Mitotic Maturation Compensates for Premature Centrosome Splitting
            and PCM Loss in Human cep135 Knockout Cells
  JOURNAL   Cells 11 (7), 1189 (2022)
   PUBMED   35406752
  REMARK    GeneRIF: Mitotic Maturation Compensates for Premature Centrosome
            Splitting and PCM Loss in Human cep135 Knockout Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1692)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1692)
  AUTHORS   Madhangi,M., Dutta,D., Show,S., Bhat,V.K., Rather,M.I., Tiwari,A.,
            Singh,N., Duvvari,M.R., Murthy,G.J., Kumar,A. and Nongthomba,U.
  TITLE     Exome sequencing and functional studies in zebrafish identify WDR8
            as the causative gene for isolated Microspherophakia in Indian
            families
  JOURNAL   Hum Mol Genet 30 (6), 467-484 (2021)
   PUBMED   33693649
  REMARK    GeneRIF: Exome sequencing and functional studies in zebrafish
            identify WDR8 as the causative gene for isolated Microspherophakia
            in Indian families.
REFERENCE   4  (bases 1 to 1692)
  AUTHORS   Kurtulmus,B., Wang,W., Ruppert,T., Neuner,A., Cerikan,B., Viol,L.,
            Duenas-Sanchez,R., Gruss,O.J. and Pereira,G.
  TITLE     WDR8 is a centriolar satellite and centriole-associated protein
            that promotes ciliary vesicle docking during ciliogenesis
  JOURNAL   J Cell Sci 129 (3), 621-636 (2016)
   PUBMED   26675238
  REMARK    GeneRIF: Cep135 is required for the recruitment of WDR8 to
            centrioles.
REFERENCE   5  (bases 1 to 1692)
  AUTHORS   Hori,A., Morand,A., Ikebe,C., Frith,D., Snijders,A.P. and Toda,T.
  TITLE     The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome
            and ensures proper spindle length and orientation
  JOURNAL   Biochem Biophys Res Commun 468 (1-2), 39-45 (2015)
   PUBMED   26545777
  REMARK    GeneRIF: Knockdown of Wdr8 or hMsd1/SSX2IP displayed very similar
            mitotic defects, in which spindle microtubules became shortened and
            misoriented.
REFERENCE   6  (bases 1 to 1692)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   7  (bases 1 to 1692)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   8  (bases 1 to 1692)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   9  (bases 1 to 1692)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   10 (bases 1 to 1692)
  AUTHORS   Koshizuka,Y., Ikegawa,S., Sano,M., Nakamura,K. and Nakamura,Y.
  TITLE     Isolation, characterization, and mapping of the mouse and human
            WDR8 genes, members of a novel WD-repeat gene family
  JOURNAL   Genomics 72 (3), 252-259 (2001)
   PUBMED   11401440
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC380547.1, BC086311.1 and
            AI376011.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017818.3.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. Studies of the
            related mouse protein suggest that the encoded protein may play a
            role in the process of ossification. [provided by RefSeq, Mar
            2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1061510.1,
                                           SRR3476690.439133.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270708.12/ ENSP00000270708.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DC380547.1         6-28
            24-1687             BC086311.1         1-1664
            1688-1692           AI376011.1         13-17               c
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..1692
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /note="WD repeat containing, antisense to TP73"
                     /db_xref="GeneID:49856"
                     /db_xref="HGNC:HGNC:12759"
                     /db_xref="MIM:606040"
     exon            1..173
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1487
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /note="WD repeat domain 8; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="WD repeat-containing protein WRAP73"
                     /protein_id="NP_060288.3"
                     /db_xref="CCDS:CCDS48.1"
                     /db_xref="GeneID:49856"
                     /db_xref="HGNC:HGNC:12759"
                     /db_xref="MIM:606040"
                     /translation="MNFSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQL
                     YTCLDQIQHIEWSADSLFILCAMYKRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPD
                     GRHILNTTEFHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDCKDYV
                     SIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAVWDTCLEYKILLYSLDGRLLSTYS
                     AYEWSLGIKSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITEFGHPAAINDPKIVVYK
                     EAEKSPQLGLGCLSFPPPRAGAGPLPSSESKYEIASVPVSLQTLKPVTDRANPKIGIG
                     MLAFSPDSYFLATRNDNIPNAVWVWDIQKLRLFAVLEQLSPVRAFQWDPQQPRLAICT
                     GGSRLYLWSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKDHFCLCFLETEAVVG
                     TACRQLGGHT"
     exon            174..326
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            327..443
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            444..516
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            517..620
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            621..707
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            708..842
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            843..920
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1026
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1152
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1344
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1692
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /note="hexamer: AATAAA"
     polyA_site      1692
                     /gene="WRAP73"
                     /gene_synonym="WDR8"
                     /note="major polyA site"
ORIGIN      
        1 gacttccggc ctcggaggcc ggcgtcggct gttgcagcct gctgcgcgcc caggggtccc
       61 gcgggttttc gggcgcaggg tggcgcccgc ggcaggcggc ggccatgaac ttctccgagg
      121 tattcaagct ctccagctta ctctgcaagt tctccccgga cggcaagtac ctggcttcct
      181 gtgtccagta ccggttagtg gtccgggatg tgaacaccct tcagatcctt cagctgtaca
      241 cgtgcctaga ccagatccag cacatcgagt ggtcggcaga ctcgctcttc atcctgtgcg
      301 ccatgtacaa gcgagggctg gtgcaggtct ggtctttaga gcagcccgaa tggcactgca
      361 aaatagacga gggctcagcc gggctggtgg cctcgtgctg gagcccggac gggcgccaca
      421 ttctcaacac cacggaattc catctgcgga taaccgtctg gtccttgtgc acaaaatccg
      481 tgtcttacat caaatacccg aaagcttgtc tgcagggaat caccttcacc agggacggcc
      541 gctacatggc gctggcagaa cggcgcgact gcaaagatta cgtgagcatc ttcgtctgca
      601 gtgattggca gctcctgcgg cattttgata cggacaccca ggatctcaca gggattgagt
      661 gggccccaaa cggctgtgtg ctggcagtgt gggacacctg cttggagtac aagattctgc
      721 tgtactcatt ggatggccgg ttgttgtcca cgtacagcgc ttacgagtgg tccctgggca
      781 tcaagtctgt ggcctggagc cccagcagtc agttcctggc agttgggagc tatgatggaa
      841 aggtgcgcat ccttaatcac gtgacttgga aaatgatcac ggagtttggg catcctgcag
      901 ccattaatga tcccaagata gtggtgtata aggaggccga gaagagccca cagctgggac
      961 tgggctgcct ctccttcccg ccgccccggg ccggggccgg ccctctcccg agctcagaga
     1021 gtaaatatga gatcgcctct gtcccagtct ccttacagac actgaaacct gttaccgaca
     1081 gagcaaaccc gaaaatcggc ataggaatgc tggcatttag tcctgacagc tacttcctgg
     1141 cgacaaggaa cgacaacatt cccaatgccg tctgggtctg ggacattcag aagctgaggc
     1201 tgttcgcggt gctcgagcag ctgtccccag tgcgcgcatt tcagtgggac ccgcagcagc
     1261 cgcggctggc catctgcacg ggaggcagca ggctctacct gtggtcccca gcgggctgca
     1321 tgtcggtgca ggtgcctggg gaaggcgact ttgcagtgct ctctctgtgc tggcatttaa
     1381 gcggagactc gatggccctc ctcagcaagg atcacttctg cctctgcttc ctggagacag
     1441 aggcagtggt cggcacagcc tgcagacagc tgggcggcca cacgtagcag cggtgcacta
     1501 acgtgtgcag aaacagggct actctgtgtt tccagtgtgg gaaaaaacac agcttcacca
     1561 ggaggttctc cactgtggtg gtctggattc agtgattgat tctatttttc tatagcaaag
     1621 catttttgta aatatgtatg gtataaaact gtagttttat tatttaaaat aaatacttgc
     1681 tgatttatac aa
//
