LOCUS       NM_001143992            1749 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens WD repeat containing antisense to TP53 (WRAP53),
            transcript variant 4, mRNA.
ACCESSION   NM_001143992
VERSION     NM_001143992.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Klump,B.M., Perez,G.I., Patrick,E.M., Adams-Boone,K., Cohen,S.B.,
            Han,L., Yu,K. and Schmidt,J.C.
  TITLE     TCAB1 prevents nucleolar accumulation of the telomerase RNA to
            facilitate telomerase assembly
  JOURNAL   Cell Rep 42 (6), 112577 (2023)
   PUBMED   37267110
  REMARK    GeneRIF: TCAB1 prevents nucleolar accumulation of the telomerase
            RNA to facilitate telomerase assembly.
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Zhu,Y., Sun,W., Jiang,X., Bai,R., Luo,Y., Gao,Y., Li,S., Huang,Z.,
            Gong,Y. and Xie,C.
  TITLE     Differential effects of WRAP53 transcript variants on non-small
            cell lung cancer cell behaviors
  JOURNAL   PLoS One 18 (1), e0281132 (2023)
   PUBMED   36706151
  REMARK    GeneRIF: Differential effects of WRAP53 transcript variants on
            non-small cell lung cancer cell behaviors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Savage,S.A., Jones,K., Teshome,K., Lori,A., McReynolds,L.J. and
            Niewisch,M.R.
  TITLE     Next-generation sequencing errors due to genetic variation in
            WRAP53 encoding TCAB1 on chromosome 17
  JOURNAL   Hum Mutat 43 (12), 1856-1859 (2022)
   PUBMED   36116037
  REMARK    GeneRIF: Next-generation sequencing errors due to genetic variation
            in WRAP53 encoding TCAB1 on chromosome 17.
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Yao,Y.F., Liu,W., Zhou,M.L., Qiu,T.L. and Wang,K.
  TITLE     [Effect of WRAP53 beta Targeted Co-Inhibitory Pathways Based on
            Comprehensive Bioinformatics Analysis in Treating Squamous Cell
            Carcinoma of the Head and Neck]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 53 (3), 457-465 (2022)
   PUBMED   35642155
  REMARK    GeneRIF: [Effect of WRAP53 beta Targeted Co-Inhibitory Pathways
            Based on Comprehensive Bioinformatics Analysis in Treating Squamous
            Cell Carcinoma of the Head and Neck].
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Sanchez-Moran,I., Rodriguez,C., Lapresa,R., Agulla,J., Sobrino,T.,
            Castillo,J., Bolanos,J.P. and Almeida,A.
  TITLE     Nuclear WRAP53 promotes neuronal survival and functional recovery
            after stroke
  JOURNAL   Sci Adv 6 (41) (2020)
   PUBMED   33028529
  REMARK    GeneRIF: Nuclear WRAP53 promotes neuronal survival and functional
            recovery after stroke.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Lan,Q., Zhang,L., Shen,M., Jo,W.J., Vermeulen,R., Li,G., Vulpe,C.,
            Lim,S., Ren,X., Rappaport,S.M., Berndt,S.I., Yeager,M., Yuenger,J.,
            Hayes,R.B., Linet,M., Yin,S., Chanock,S., Smith,M.T. and Rothman,N.
  TITLE     Large-scale evaluation of candidate genes identifies associations
            between DNA repair and genomic maintenance and development of
            benzene hematotoxicity
  JOURNAL   Carcinogenesis 30 (1), 50-58 (2009)
   PUBMED   18978339
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
            Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
            Chanock,S.J., Zheng,T. and Lan,Q.
  TITLE     Pathway-based evaluation of 380 candidate genes and lung cancer
            susceptibility suggests the importance of the cell cycle pathway
  JOURNAL   Carcinogenesis 29 (10), 1938-1943 (2008)
   PUBMED   18676680
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1749)
  AUTHORS   Garcia-Closas,M., Kristensen,V., Langerod,A., Qi,Y., Yeager,M.,
            Burdett,L., Welch,R., Lissowska,J., Peplonska,B., Brinton,L.,
            Gerhard,D.S., Gram,I.T., Perou,C.M., Borresen-Dale,A.L. and
            Chanock,S.
  TITLE     Common genetic variation in TP53 and its flanking genes, WDR79 and
            ATP1B2, and susceptibility to breast cancer
  JOURNAL   Int J Cancer 121 (11), 2532-2538 (2007)
   PUBMED   17683073
  REMARK    GeneRIF: Common variation in TP53 or WDR79 could be associated with
            ER negative breast cancers.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1749)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 1749)
  AUTHORS   Savage,S.A. and Niewisch,M.R.
  TITLE     Dyskeratosis Congenita and Related Telomere Biology Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ431240.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001143992.1.
            
            Summary: This gene encodes an essential component of the telomerase
            holoenzyme complex, a ribonucleoprotein complex required for
            telomere synthesis. This protein is enriched in Cajal bodies,
            nuclear sites of RNP processing that are important for telomerase
            function. It interacts with dyskerin, TERT and TERC, other
            components of active telomerase, and with small Cajal body RNAs
            (scaRNAs), which are involved in modifying splicing RNAs. This mRNA
            also functions as a p53 antisense transcript, that regulates
            endogenous p53 mRNA levels and further induction of p53 protein by
            targeting the 5' untranslated region of p53 mRNA. Alternatively
            spliced transcript variants which differ only in the 5' UTR have
            been found for this gene. [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (4, also known as WRAP53beta)
            differs in the 5' UTR compared to variant 1. Variants 1-4 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ431240.1, BC002336.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396463.7/ ENSP00000379727.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1749              DQ431240.1         129-1877
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1749
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /note="WD repeat containing antisense to TP53"
                     /db_xref="GeneID:55135"
                     /db_xref="HGNC:HGNC:25522"
                     /db_xref="MIM:612661"
     exon            1..85
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     exon            86..517
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1733
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /note="WD40 protein Wrap53; WD repeat-containing protein
                     79; WRAP53beta; WD repeat-containing protein WRAP53; WD40
                     repeat-containing protein antisense to TP53; WD40
                     repeat-containing protein encoding RNA antisense to p53"
                     /codon_start=1
                     /product="telomerase Cajal body protein 1"
                     /protein_id="NP_001137464.1"
                     /db_xref="CCDS:CCDS11119.1"
                     /db_xref="GeneID:55135"
                     /db_xref="HGNC:HGNC:25522"
                     /db_xref="MIM:612661"
                     /translation="MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPP
                     PERGDPPRLSPDPVAGSAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENT
                     SLPAEEANGSLSEEEANGPELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGS
                     WSEFSTQPENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVL
                     RMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDE
                     LTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFS
                     PAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAEL
                     LCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGK
                     PEPVLSFLPQKDCTNGVSLHPSLPLLATASGQRVFPEPTESGDEGEELGLPLLSTRHV
                     HLECRLQLWWCGGAPDSSIPDDHQGEKGQGGTEGGVGELI"
     exon            518..616
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     exon            617..728
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     exon            729..817
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     exon            818..908
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1041
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1250
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1354
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1489
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1749
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1729..1734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /note="hexamer: TATAAA"
     polyA_site      1749
                     /gene="WRAP53"
                     /gene_synonym="DKCB3; TCAB1; WDR79"
                     /note="major polyA site"
ORIGIN      
        1 agtgctttca aaagaattgg cgtccgctgt tcgcctctcc tcccgggagt cttctgccta
       61 ctcccagaag aggagggaag cacagtatga agactttgga gactcaaccg ttagctccgg
      121 actgctgtcc ttcagaccag gacccagctc cagcccatcc ttctccccac gcttccccga
      181 tgaataaaaa tgcggactct gaactgatgc caccgcctcc cgaaaggggg gatccgcccc
      241 ggttgtcccc agatcctgtg gctggctcag ctgtgtccca ggagctacgg gagggggacc
      301 cagtttctct ctccactccc ctggaaacag agtttggttc ccctagtgag ttgagtcctc
      361 gaatcgagga gcaagaactt tctgaaaata caagccttcc tgcagaagaa gcaaacggga
      421 gcctttctga agaagaagcg aacgggccag agttggggtc tggaaaagcc atggaagata
      481 cctctgggga acccgctgca gaggacgagg gagacaccgc ttggaactac agcttctccc
      541 agctgcctcg atttctcagt ggttcctggt cagagttcag cacccaacct gagaacttct
      601 tgaaaggctg taagtgggct cctgacggtt cctgcatctt gaccaatagt gctgataaca
      661 tcttgcgaat ttataacctg cccccagagc tgtaccatga gggggagcag gtggaatatg
      721 cagaaatggt ccctgtcctt cgaatggtgg aaggtgatac catctatgat tactgctggt
      781 attctctgat gtcctcagcc cagccagaca cctcctacgt ggccagcagc agccgggaga
      841 acccgattca tatctgggac gcattcactg gagagctccg ggcttccttt cgcgcctaca
      901 accacctgga tgagctgacg gcagcccatt cgctctgctt ctccccggat ggctcccagc
      961 tcttctgtgg cttcaaccgg actgtgcgtg ttttttccac ggcccggcct ggccgagact
     1021 gcgaggtccg agccacattt gcaaaaaagc agggccagag cggcatcatc tcctgcatag
     1081 ccttcagccc agcccagccc ctctatgcct gtggctccta cggccgctcc ctgggtctgt
     1141 atgcctggga tgatggctcc cctctcgcct tgctgggagg gcaccaaggg ggcatcaccc
     1201 acctctgctt tcatcccgat ggcaaccgct tcttctcagg agcccgcaag gatgctgagc
     1261 tcctgtgctg ggatctccgg cagtctggtt acccactgtg gtccctgggt cgagaggtga
     1321 ccaccaatca gcgcatctac ttcgatctgg acccgaccgg gcagttccta gtgagtggca
     1381 gcacgagcgg ggctgtctct gtgtgggaca cggacgggcc tggcaatgat gggaagccgg
     1441 agcccgtgtt gagttttctg ccccagaagg actgcaccaa tggcgtgagc ctgcacccta
     1501 gcctgcctct cctggccact gcctccggtc agcgtgtgtt tcctgagccc acagagagtg
     1561 gggacgaagg agaggagctg ggccttccct tgctctccac gcgccacgtc caccttgaat
     1621 gtcggcttca gctctggtgg tgtggggggg cgccagactc cagcatccct gatgatcacc
     1681 agggcgagaa agggcaggga ggaacggagg gaggtgtggg tgagctgata taaaaaggtt
     1741 tttatgata
//
