LOCUS       NM_003396               4972 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Wnt family member 9B (WNT9B), transcript variant 1,
            mRNA.
ACCESSION   NM_003396
VERSION     NM_003396.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4972)
  AUTHORS   Lu,S., Yakirevich,E., Yang,D., Xiao,Y., Wang,L.J. and Wang,Y.
  TITLE     Wnt Family Member 9b (Wnt9b) Is a New Sensitive and Specific Marker
            for Breast Cancer
  JOURNAL   Am J Surg Pathol 45 (12), 1633-1640 (2021)
   PUBMED   34324458
  REMARK    GeneRIF: Wnt Family Member 9b (Wnt9b) Is a New Sensitive and
            Specific Marker for Breast Cancer.
REFERENCE   2  (bases 1 to 4972)
  AUTHORS   Lemire,G., Zheng,B., Ediae,G.U., Zou,R., Bhola,P.T., Chisholm,C.,
            de Nanassy,J., Lo,B., Wang,C., Shril,S., El Desoky,S., Shalaby,M.,
            Kari,J.A., Wang,X., Kernohan,K.D., Boycott,K.M., Hildebrandt,F. and
            Sawyer,S.L.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     Homozygous WNT9B variants in two families with bilateral renal
            agenesis/hypoplasia/dysplasia
  JOURNAL   Am J Med Genet A 185 (10), 3005-3011 (2021)
   PUBMED   34145744
  REMARK    GeneRIF: Homozygous WNT9B variants in two families with bilateral
            renal agenesis/hypoplasia/dysplasia.
REFERENCE   3  (bases 1 to 4972)
  AUTHORS   Vandebergh,M., Andlauer,T.F.M., Zhou,Y., Mallants,K., Held,F.,
            Aly,L., Taylor,B.V., Hemmer,B., Dubois,B. and Goris,A.
  TITLE     Genetic Variation in WNT9B Increases Relapse Hazard in Multiple
            Sclerosis
  JOURNAL   Ann Neurol 89 (5), 884-894 (2021)
   PUBMED   33704824
  REMARK    GeneRIF: Genetic Variation in WNT9B Increases Relapse Hazard in
            Multiple Sclerosis.
REFERENCE   4  (bases 1 to 4972)
  AUTHORS   Wallace,J., Narasipura,S.D., Sha,B.E., French,A.L. and Al-Harthi,L.
  TITLE     Canonical Wnts Mediate CD8+ T Cell Noncytolytic Anti-HIV-1 Activity
            and Correlate with HIV-1 Clinical Status
  JOURNAL   J Immunol 205 (8), 2046-2055 (2020)
   PUBMED   32887752
  REMARK    GeneRIF: Canonical Wnts Mediate CD8(+) T Cell Noncytolytic
            Anti-HIV-1 Activity and Correlate with HIV-1 Clinical Status.
REFERENCE   5  (bases 1 to 4972)
  AUTHORS   Xiong,Y., Chen,L., Yan,C., Zhou,W., Endo,Y., Liu,J., Hu,L., Hu,Y.,
            Mi,B. and Liu,G.
  TITLE     Circulating Exosomal miR-20b-5p Inhibition Restores Wnt9b Signaling
            and Reverses Diabetes-Associated Impaired Wound Healing
  JOURNAL   Small 16 (3), e1904044 (2020)
   PUBMED   31867895
  REMARK    GeneRIF: Circulating Exosomal miR-20b-5p Inhibition Restores Wnt9b
            Signaling and Reverses Diabetes-Associated Impaired Wound Healing.
REFERENCE   6  (bases 1 to 4972)
  AUTHORS   Qian,J., Jiang,Z., Li,M., Heaphy,P., Liu,Y.H. and Shackleford,G.M.
  TITLE     Mouse Wnt9b transforming activity, tissue-specific expression, and
            evolution
  JOURNAL   Genomics 81 (1), 34-46 (2003)
   PUBMED   12573259
REFERENCE   7  (bases 1 to 4972)
  AUTHORS   Kirikoshi,H., Sekihara,H. and Katoh,M.
  TITLE     Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation
            of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol
  JOURNAL   Int J Oncol 19 (6), 1221-1225 (2001)
   PUBMED   11713592
REFERENCE   8  (bases 1 to 4972)
  AUTHORS   Kirikoshi,H., Sekihara,H. and Katoh,M.
  TITLE     Molecular cloning and characterization of WNT14B, a novel member of
            the WNT gene family
  JOURNAL   Int J Oncol 19 (5), 947-952 (2001)
   PUBMED   11604992
REFERENCE   9  (bases 1 to 4972)
  AUTHORS   Bergstein,I., Eisenberg,L.M., Bhalerao,J., Jenkins,N.A.,
            Copeland,N.G., Osborne,M.P., Bowcock,A.M. and Brown,A.M.
  TITLE     Isolation of two novel WNT genes, WNT14 and WNT15, one of which
            (WNT15) is closely linked to WNT3 on human chromosome 17q21
  JOURNAL   Genomics 46 (3), 450-458 (1997)
   PUBMED   9441749
REFERENCE   10 (bases 1 to 4972)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015855.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003396.2.
            
            Summary: The WNT gene family consists of structurally related genes
            that encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. Study
            of its expression in the teratocarcinoma cell line NT2 suggests
            that it may be implicated in the early process of neuronal
            differentiation of NT2 cells induced by retinoic acid. This gene is
            clustered with WNT3, another family member, in the chromosome 17q21
            region. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB063483.1, AY358217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290015.7/ ENSP00000290015.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC015855.13        44773-44905
            134-390             AC015855.13        65707-65963
            391-656             AC015855.13        68291-68556
            657-4972            AC015855.13        69435-73750
FEATURES             Location/Qualifiers
     source          1..4972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..4972
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /note="Wnt family member 9B"
                     /db_xref="GeneID:7484"
                     /db_xref="HGNC:HGNC:12779"
                     /db_xref="MIM:602864"
     exon            1..133
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1130
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; wingless-type MMTV integration site family,
                     member 15; protein Wnt-9b; protein Wnt-14b; wingless-type
                     MMTV integration site family member 9B"
                     /codon_start=1
                     /product="protein Wnt-9b isoform 1 precursor"
                     /protein_id="NP_003387.1"
                     /db_xref="CCDS:CCDS11506.1"
                     /db_xref="GeneID:7484"
                     /db_xref="HGNC:HGNC:12779"
                     /db_xref="MIM:602864"
                     /translation="MRPPPALALAGLCLLALPAAAASYFGLTGREVLTPFPGLGTAAA
                     PAQGGAHLKQCDLLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSL
                     EGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDSPGLESRQAWQWG
                     VCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGS
                     CAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAP
                     RSGDLVYMEDSPSFCRPSKYSPGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQ
                     VQWCCYVECQQCVQEELVYTCKH"
     exon            134..390
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            391..656
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /inference="alignment:Splign:2.1.0"
     exon            657..4972
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4939..4944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /note="hexamer: AATAAA"
     regulatory      4947..4952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /note="hexamer: AATAAA"
     polyA_site      4962
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /note="major polyA site"
     polyA_site      4972
                     /gene="WNT9B"
                     /gene_synonym="WNT14B; WNT15"
                     /note="major polyA site"
ORIGIN      
        1 agctgcgagc ttgagcggcg cgaggagatg ctagagggcg cagcgccgcc agcaccatgc
       61 gccccccgcc cgcgctggcc ctggccgggc tctgcctgct ggcgctgccc gccgccgccg
      121 cctcctactt cggcctgacc gggcgggaag tcctgacgcc cttcccagga ttgggcactg
      181 cggcagcccc ggcacagggc ggggcccacc tgaagcagtg tgacctgctg aagctgtccc
      241 ggcggcagaa gcagctctgc cggagggagc ccggcctggc tgagaccctg agggatgctg
      301 cgcacctcgg cctgcttgag tgccagtttc agttccggca tgagcgctgg aactgtagcc
      361 tggagggcag gatgggcctg ctcaagagag gcttcaaaga gacagctttc ctgtacgcgg
      421 tgtcctctgc cgccctcacc cacaccctgg cccgggcctg cagcgctggg cgcatggagc
      481 gctgcacctg tgatgactct ccggggctgg agagccggca ggcctggcag tggggcgtgt
      541 gcggtgacaa cctcaagtac agcaccaagt ttctgagcaa cttcctgggg tccaagagag
      601 gaaacaagga cctgcgggca cgggcagacg cccacaatac ccacgtgggc atcaaggctg
      661 tgaagagtgg cctcaggacc acgtgtaagt gccatggcgt atcaggctcc tgtgccgtgc
      721 gcacctgctg gaagcagctc tccccgttcc gtgagacggg ccaggtgctg aaactgcgct
      781 atgactcggc tgtcaaggtg tccagtgcca ccaatgaggc cttgggccgc ctagagctgt
      841 gggcccctgc caggcagggc agcctcacca aaggcctggc cccaaggtct ggggacctgg
      901 tgtacatgga ggactcaccc agcttctgcc ggcccagcaa gtactcacct ggcacagcag
      961 gtagggtgtg ctcccgggag gccagctgca gcagcctgtg ctgcgggcgg ggctatgaca
     1021 cccagagccg cctggtggcc ttctcctgcc actgccaggt gcagtggtgc tgctacgtgg
     1081 agtgccagca atgtgtgcag gaggagcttg tgtacacctg caagcactag gcctactgcc
     1141 cagcaagcca gtctggcact gccaggacct cctgtggcac ccttcaagct gcccagccgg
     1201 ccctctgggc agactgtcat cacatgcatg cataaaccgg catgtgtgcc aatgcacacg
     1261 agtgtgccac tcaccaccat tccttggcca gccttttgcc tccctcgata ctcaacaaag
     1321 agaagcaaag cctcctccct taacccaagc atccccaacc ttgttgagga cttggagagg
     1381 agggcagagt gagaaagaca tggagggaaa taagggagac caagagcaca gcaggactga
     1441 aattttggac gggagagagg ggctattcca tcttgcttcc tgggatgaat ggcttggagc
     1501 cagcatgttc ttgggaggtg aactgctggg ctaggaatgc caaggcaggc agtgccagct
     1561 ggaagtgaag gcgggagcct ggctgagatg ggtcaatcgg gtcctgtggc cctgctcagg
     1621 tgcagtgggc tccaggtgtc acacacctcc accactcccc tggttttgct gtgccagaga
     1681 tggggagaaa gcacaggtgg tagaagccat ccgttcagag aaaggagagc tttctgtgct
     1741 tgagtggacc cgagtgagat ctgtgccctg gagccctgtg tccttgattt ggcttttcaa
     1801 atatgcctcc gctgaggcct cattcttgtc tcgagagctg ggttatgcac actcacccag
     1861 ccgtgctcaa aactaccacc agtgcaggta agacaggtgg gagaactagc caccaaggcg
     1921 ggactcagtg cacctgaggt tgaacaggga gacaacggcc cctccctgtg ttccctgctg
     1981 gccaaaggaa tcttcactcc cagcgcagag gaggagggca acagcttcct ggtgcctggc
     2041 agtgacgtgg cgagctcagt ttctcagctg gctcttgagt gagctttggt gacttcctgt
     2101 ggctggggcc tgcctggtct gtgacacccc cataccagct gagttcacaa tactgaagaa
     2161 cagctggctc acgagctatg acttgaagtt acatttctat tcttgtggct gctcatctag
     2221 ttaaggcttt tgccctggct ggggttatag gtgcttgagt ccttgctaag cctggctcct
     2281 gggtagcctc cttcagttcc taatggcctc tcacttggcc ctcactttgg ctcttacttg
     2341 aggaggagac gtgactttga taatttcctc agatcctgtg gacattttca gcagcacctg
     2401 ccaaggccct ctgtgaaagg aggagagact ggtacctcca cacaggcaca catggatgca
     2461 cagcccctgg accaggctgg gggttcctgt tgcacatgcc tctcttgttc aggatgaaga
     2521 ccttgcaggg gtccccttgc tggaggcatt gtacttcccc agagtggggc ccgatgccac
     2581 ccaggaggaa gtgacttctt tcgggaagcc cttggccact ttgctggccc tgccacgccc
     2641 atctgtcagc ttcctttctc cctaaaccta gagttgctga cccttcacca acacaggaaa
     2701 tttcagaatc agctgaatgc tcagaaacct cgcctgtgcc agctccagga caaaggcccg
     2761 ctgactgtgc cctggccaac tccctgagac ctccaagggc gaggaggagc tgcccagtct
     2821 ccagtggatc agggcagtct gctggatgct ggaaggattt ttgactgcag aggcccggct
     2881 gagaagccaa actgacctga gcccctctcg ttaaaatgac attgctgacc caagcacctg
     2941 gcccacacct tggcagcagg agaaaaatgg ggagagggct ggttttctcc tttcttccac
     3001 ttccccacag catggagatt ttctctgcct tcccaatcca tcttgctcct ccgagacccc
     3061 aactctgcct ccacccaggc tcagtgctgg gcgtaaggca gcagggacct cactggcaga
     3121 gcagggggcc tgggagcaac gtggaggcca gagcaccctg atccaccaac atgccacctg
     3181 cattctgact tcatggctgg cagtgccagg gtcgtgggag ggcaaagggc aggctctaag
     3241 gcatctaggc agtggctggc tgctaacatg gacaccccaa gtcaatggca cagtgcaggt
     3301 tctgagggct ccttggcttg tggggtcttc tctgtctgtc tctctccctc tcttcttcct
     3361 tgctctcatc cctttctttt ccagttaccc ctgaagaccc acctcggccc tcttggggcc
     3421 cctggggact agagtgacca ctgacccctc attctacagc tttaagggaa atgctcacag
     3481 ggtatttttg tctacctcaa atatatagtt tttagagcaa aggagaataa tttatatagc
     3541 taagatatat gagaaagtat ttatattatt tatatagttg ctatatttca cagacagcac
     3601 aggtggggtt tgtgtatttt cccggaaacc ctctgtctgg ggagatacag cctgacctga
     3661 ccgggtcccc cactgagcag gaggccgggt cgctgggaag gaggacaaac ctgtattcca
     3721 tgactgggtc tgtctcggag ctggtaagca catgtccgct ctgtgatgag ccctggtggg
     3781 ctccatccag accctccttg tgatgttttt gtagattttc tgcccttctg ggtccaggcc
     3841 cccttcttct gctctggcaa aagtgtctta ctcataatga taatgacaac gagaattccc
     3901 acacctggca tttgtaaagc actttgctat ttagaaacaa aaacttttac ccctttcatc
     3961 tcacttgatt tctccgttat ctctgtgagg taggtggggc cacattactg tggccatttt
     4021 atagatgagg tccagagatg gagagctgtg ctcaaagtca cacctaagag acttgttcaa
     4081 tgaatattta ctgaacatct ccatagacca ggcactacgg gctgacctgc tctgagccca
     4141 ggagccccaa agcctggata ccactgtgag cccaagaact cagggaagca gttccttccc
     4201 aggctgtgat cccagccttt tggatctgga tggcatgttg gcacttcccc caagtggagt
     4261 cccatgtctc aggggctttg gctgcctgag aaggctggag agaccaggaa cccatggagg
     4321 ccactccaag gggtccttct gcccacactg cccaagaagc ttgggctaca ccactgggcc
     4381 cctcccaacc tacagatgaa ttttgattgc tctcatttgt gttttgcttg taaaaatgaa
     4441 ttgttttcca ctggatttct ggctgctttt gcaaaagtca gctgcgctgg cagactgggc
     4501 ctgcatgtcc tcctgcaggc agctagagtg agggagtcta atggacagga tgccccaagt
     4561 gcccccgttg ctcatggatg cccctgcctg cctctcatga gcacatagtc ctgtcccctg
     4621 gtctagataa gcccagcttt cctggtaccc ttcatcacct ggcagacaga cagccccatg
     4681 ccaaccctgg acattacttg cttttgaacc tttcctttct caacaaccat gaacttcaaa
     4741 tgctttctgt ctcaggacac tttagaataa caatggaagc catcacttat tgagcacccc
     4801 ttatgtccat ttattcaacc aatgattatt tagggatctc ttattgagca ccaggcagca
     4861 tcctgggtgc ttggtgcagc aaggaacagg accaagtctc tgcctcatgg ggctgacatc
     4921 ctagtgggtg agaaagacaa taaaccaata aatgacatgc cagttatttg ca
//
