LOCUS       NM_003395               4005 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Wnt family member 9A (WNT9A), mRNA.
ACCESSION   NM_003395
VERSION     NM_003395.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4005)
  AUTHORS   Dai,J., Jiang,H., Cheng,Z., Li,Y., Yang,Z., Cheng,C. and Tang,X.
  TITLE     Genetic polymorphism of WNT9A is functionally associated with thumb
            osteoarthritis in the Chinese population
  JOURNAL   Adv Rheumatol 64 (1), 12 (2024)
   PUBMED   38287451
  REMARK    GeneRIF: Genetic polymorphism of WNT9A is functionally associated
            with thumb osteoarthritis in the Chinese population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4005)
  AUTHORS   Chen,J., Tang,J., Nie,M., Li,Y., Wurfel,M.M., Meyer,N.J., Wei,Y.,
            Zhao,Y., Frank,A.J., Thompson,B.T., Christiani,D.C., Chen,F. and
            Zhang,R.
  TITLE     WNT9A Affects Late-Onset Acute Respiratory Distress Syndrome and
            28-Day Survival: Evidence from a Three-Step Multiomics Study
  JOURNAL   Am J Respir Cell Mol Biol 69 (2), 220-229 (2023)
   PUBMED   37094100
  REMARK    GeneRIF: WNT9A Affects Late-Onset Acute Respiratory Distress
            Syndrome and 28-Day Survival: Evidence from a Three-Step Multiomics
            Study.
REFERENCE   3  (bases 1 to 4005)
  AUTHORS   Teufel,S., Kockemann,P., Fabritius,C., Wolff,L.I., Bertrand,J.,
            Pap,T. and Hartmann,C.
  TITLE     Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like
            symptoms in hTNF transgenic mice
  JOURNAL   Cell Death Dis 12 (5), 494 (2021)
   PUBMED   33990546
  REMARK    GeneRIF: Loss of the WNT9a ligand aggravates the rheumatoid
            arthritis-like symptoms in hTNF transgenic mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4005)
  AUTHORS   Boer,C.G., Yau,M.S., Rice,S.J., Coutinho de Almeida,R., Cheung,K.,
            Styrkarsdottir,U., Southam,L., Broer,L., Wilkinson,J.M.,
            Uitterlinden,A.G., Zeggini,E., Felson,D., Loughlin,J., Young,M.,
            Capellini,T.D., Meulenbelt,I. and van Meurs,J.B.
  TITLE     Genome-wide association of phenotypes based on clustering patterns
            of hand osteoarthritis identify WNT9A as novel osteoarthritis gene
  JOURNAL   Ann Rheum Dis 80 (3), 367-375 (2021)
   PUBMED   33055079
  REMARK    GeneRIF: Genome-wide association of phenotypes based on clustering
            patterns of hand osteoarthritis identify WNT9A as novel
            osteoarthritis gene.
REFERENCE   5  (bases 1 to 4005)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4005)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and expression of mouse Wnt14, and structural
            comparison between mouse Wnt14-Wnt3a gene cluster and human
            WNT14-WNT3A gene cluster
  JOURNAL   Int J Mol Med 9 (3), 221-227 (2002)
   PUBMED   11836627
  REMARK    GeneRIF: Found clustered with WNT3A on 1q42.  .
REFERENCE   7  (bases 1 to 4005)
  AUTHORS   Saitoh,T., Hirai,M. and Katoh,M.
  TITLE     Molecular cloning and characterization of WNT3A and WNT14 clustered
            in human chromosome 1q42 region
  JOURNAL   Biochem Biophys Res Commun 284 (5), 1168-1175 (2001)
   PUBMED   11414706
REFERENCE   8  (bases 1 to 4005)
  AUTHORS   Hartmann,C. and Tabin,C.J.
  TITLE     Wnt-14 plays a pivotal role in inducing synovial joint formation in
            the developing appendicular skeleton
  JOURNAL   Cell 104 (3), 341-351 (2001)
   PUBMED   11239392
REFERENCE   9  (bases 1 to 4005)
  AUTHORS   Bergstein,I., Eisenberg,L.M., Bhalerao,J., Jenkins,N.A.,
            Copeland,N.G., Osborne,M.P., Bowcock,A.M. and Brown,A.M.
  TITLE     Isolation of two novel WNT genes, WNT14 and WNT15, one of which
            (WNT15) is closely linked to WNT3 on human chromosome 17q21
  JOURNAL   Genomics 46 (3), 450-458 (1997)
   PUBMED   9441749
REFERENCE   10 (bases 1 to 4005)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL360269.21, AK131041.1, AB060283.1 and AI280246.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003395.3.
            
            Summary: The WNT gene family consists of structurally related genes
            that encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. It is
            expressed in gastric cancer cell lines. The protein encoded by this
            gene shows 75% amino acid identity to chicken Wnt14, which has been
            shown to play a central role in initiating synovial joint formation
            in the chick limb. This gene is clustered with another family
            member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB060283.1, BC111960.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272164.6/ ENSP00000272164.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL360269.21        94522-94523         c
            3-197               AK131041.1         1-195
            198-198             AL360269.21        72053-72053         c
            199-1335            AB060283.1         165-1301
            1336-3775           AL360269.21        65477-67916         c
            3776-4005           AI280246.1         10-239              c
FEATURES             Location/Qualifiers
     source          1..4005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..4005
                     /gene="WNT9A"
                     /gene_synonym="WNT14"
                     /note="Wnt family member 9A"
                     /db_xref="GeneID:7483"
                     /db_xref="HGNC:HGNC:12778"
                     /db_xref="MIM:602863"
     exon            1..140
                     /gene="WNT9A"
                     /gene_synonym="WNT14"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1143
                     /gene="WNT9A"
                     /gene_synonym="WNT14"
                     /note="wingless-type MMTV integration site family, member
                     14; protein Wnt-9a; wingless-type MMTV integration site
                     family, member 9A"
                     /codon_start=1
                     /product="protein Wnt-9a precursor"
                     /protein_id="NP_003386.1"
                     /db_xref="CCDS:CCDS31045.1"
                     /db_xref="GeneID:7483"
                     /db_xref="HGNC:HGNC:12778"
                     /db_xref="MIM:602863"
                     /translation="MLDGSPLARWLAAAFGLTLLLAALRPSAAYFGLTGSEPLTILPL
                     TLEPEAAAQAHYKACDRLKLERKQRRMCRRDPGVAETLVEAVSMSALECQFQFRFERW
                     NCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLENR
                     EAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCH
                     GVSGSCTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAISPPRGRASG
                     AGGSDPLPRTPELVHLDDSPSFCLAGRFSPGTAGRRCHREKNCESICCGRGHNTQSRV
                     VTRPCQCQVRWCCYVECRQCTQREEVYTCKG"
     exon            141..397
                     /gene="WNT9A"
                     /gene_synonym="WNT14"
                     /inference="alignment:Splign:2.1.0"
     exon            398..660
                     /gene="WNT9A"
                     /gene_synonym="WNT14"
                     /inference="alignment:Splign:2.1.0"
     exon            661..4005
                     /gene="WNT9A"
                     /gene_synonym="WNT14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3984..3989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT9A"
                     /gene_synonym="WNT14"
                     /note="hexamer: AATAAA"
     polyA_site      4005
                     /gene="WNT9A"
                     /gene_synonym="WNT14"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggagct gggagcgcga tggtcggccg ccgaggcgcg gcaagatgct ggatgggtcc
       61 ccgctggcgc gctggctggc cgcggccttc gggctgacgc tgctgctcgc cgcgctgcgc
      121 ccttcggccg cctacttcgg gctgacgggc agcgagcccc tgaccatcct cccgctgacc
      181 ctggagccag aggcggctgc ccaggcgcac tacaaggcct gcgaccggct gaagctggag
      241 cggaagcagc ggcgcatgtg ccgccgggac ccgggcgtgg cagagacgct ggtggaggcc
      301 gtgagcatga gtgcgctcga gtgccagttc cagttccgct ttgagcgctg gaactgcacg
      361 ctggagggcc gctaccgggc cagcctgctc aagcgaggct tcaaggagac tgccttcctc
      421 tatgccatct cctcggctgg cctgacgcac gcactggcca aggcgtgcag cgcgggccgc
      481 atggagcgct gtacctgcga tgaggcaccc gacctggaga accgtgaggc ctggcagtgg
      541 gggggctgcg gagacaacct taagtacagc agcaagttcg tcaaggaatt cctgggcaga
      601 cggtcaagca aggatctgcg agcccgtgtg gacttccaca acaacctcgt gggtgtgaag
      661 gtgatcaagg ctggggtgga gaccacctgc aagtgccacg gcgtgtcagg ctcatgcacg
      721 gtgcggacct gctggcggca gttggcgcct ttccatgagg tgggcaagca tctgaagcac
      781 aagtatgaga cggcactcaa ggtgggcagc accaccaatg aagctgccgg cgaggcaggt
      841 gccatctccc caccacgggg ccgtgcctcg ggggcaggtg gcagcgaccc gctgccccgc
      901 actccagagc tggtgcacct ggatgactcg cctagcttct gcctggctgg ccgcttctcc
      961 ccgggcaccg ctggccgtag gtgccaccgt gagaagaact gcgagagcat ctgctgtggc
     1021 cgcggccata acacacagag ccgggtggtg acaaggccct gccagtgcca ggtgcgttgg
     1081 tgctgctatg tggagtgcag gcagtgcacg cagcgtgagg aggtctacac ctgcaagggc
     1141 tgagttccca ggccctgcca gccctgctgc acagggtgca ggcattgcac acggtgtgaa
     1201 gggtctacac ctgcacaggc tgagttcctg ggctcgacca gcccagctgc gtggggtaca
     1261 ggcattgcac acagtgtgaa tgggtctaca cctgcatggg ctgagtccct gggctcagac
     1321 ctagcagcgt ggggtgagtc cctgggctca gtcctagctg catggggtgc aggcattgca
     1381 cagagcatga atgggcctac acctgccaag gctgaatccc tgggcccagt cagccctgct
     1441 gcacatggca caggcattgc acacggtgtg aggagtgtac acctgcaagg gctgaggccc
     1501 tgggcccagt cagccctgct gctcagagtg caggcattgc acatggtgtg agaaggtcta
     1561 cacctgcaag ggacgagtcc ccgggcctgg ccaaccctgc tgtgcagggt gagggccatg
     1621 catgcagtat gaggggtcta cacctgcaag gactgagagg cttttctagc acgtcggggc
     1681 gtacagctgg agcagggtgc cgggggtcct ctgggttggc tgtccaagcc ctgtatctcc
     1741 ccctctccag gacccagagg cgggggttgg ctctggtctg gcgtatgcaa cctctctgct
     1801 tgtgccctgg gcctcagctt cctccctctg acccgagagc attgcaccaa tgctttctga
     1861 gctttctccc atccctaaca caccagtccc tgggaagcgg ctccccatgc cagtccattg
     1921 gctttccctc cccacctcct ctgaggcatg ggtggcaggt gcaccttggt gaccatgcgg
     1981 cctccgtgtg ggccacccgt tggggactgg cctggcccag gctgccccaa caccagcact
     2041 gtcttcagag actcaaacca ctagaagagg acgcagcctg ttctgcactc ccagggcccg
     2101 gccgtgcggg tgcccaggct cggggggaca ctgccgacct ctgacgttga gcacttctct
     2161 ttggagtaaa tatcagtgac ttttaaatta ttatgattat ttaactaata taataattat
     2221 tattttctcc atccctgcca cctccccggc tgcagctccc cgctctcggc caagccccag
     2281 tctgggaggg ccccgccttc cgtccctgac atattccctc ctaaccctgc ctctgatctg
     2341 cttagttgtt tgaaaccact aaatcgagat agatgtgtgt agttaaggaa atacagtgag
     2401 ctgcgtctgg ccacagccct tggggcttct ggaagccagc tcccccagcc ccatgccagc
     2461 cagccactgc cacgtggtgg gccagccggc ggcccctgcc ctgcaccctg tgggcagacg
     2521 cccggcctcc aggcagctca gtgcagattc tcgagctggg ggtggtggag aggggcgggc
     2581 atggtgaggg ggcagggcag ccctttgatt ggttcatgtc atgtcatgag gaagctgctt
     2641 gctttgtgtc actgggggac agattgggac agatgccggt ggaggcagtc ttgggctcgc
     2701 atctggccat ggaacgccat gctttatggc cctgctgttg tgtgtgctgg ggacagggtg
     2761 acctgcactg acctggcttg gtttgagggt gtagtgtgtg tgtgtgttgt gagagtgtgt
     2821 gtgctggcgt ggtcagtgtg catacgtgtg cgtatgttgt gagtgttgtg agtgcgtgtg
     2881 tgctggcgtg gtcaatgtgt gtaagcgtgt gttgtataaa tgcatgctgg catggtctgt
     2941 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatactg gcatggtcag cttggctgtg
     3001 ctgtgctgtc agtggcatgg cggtgcctta ggttcccaga gcctctcgcc ctgggctccg
     3061 tcttgtgggt gtcctgatgg ctgtgggctg ggttctgggc gggttgctgg tatggataca
     3121 ggaactactg agtgaatagg tgtctcagag ccctaagggt ctccagaaag ccggggtgtc
     3181 tgtgttttta aaagaaaacc tatttatgtt gctgtgggtc tctgccgtcc ctgtgttata
     3241 gtacataaga acctttattc tcctgtggtt cagagagcac cccgacatgt gcctgcagct
     3301 gcatccccgt accacagtgt gggtgcaaga cgctgggttt gtcctttgtc tggtgaagcc
     3361 tggctagaag gggtgggggt ggtagcccct gccctctgca gtgtccgcat ccactggtcc
     3421 ctgagcagca tagctggcca caccctcatg acatgacaag actgtcactc agtcactatt
     3481 gggtctatga agggcgtcaa gtcagaggaa ggtttttatt tttaatcaaa taccacattt
     3541 agctctatgt cataaatatt cagaaaacta tttttttaaa caaggcagac caaaaatgtc
     3601 tgctagctag ttggtttcta tacaaataca tattcgaatg tcttgctgga tgaagaggcc
     3661 gctcagccgg agcctcctgt ttcatgcgct tctcttctga ggggcagtag aggagaaagg
     3721 gctgttggga ggggttcagc ccgctccttg gccaggggat cccagccacc ttctctgcac
     3781 caggccctgc cttgagggac ctggaccccc aggtggcttc tggccaggtg tgggtgggtg
     3841 ggaggggccc tgtctgtgct ccgagtctcc gtgcgtgcaa tgatttctct acctcatctg
     3901 tgtggcccgt cccagaggga ctgtggagaa tgtatttatt taacagcttt gtgtcacaga
     3961 accagaaaca aatggaaaca ttaaataaat gtattttaaa ttata
//
