LOCUS       NM_003393               2144 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Wnt family member 8B (WNT8B), mRNA.
ACCESSION   NM_003393
VERSION     NM_003393.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2144)
  AUTHORS   Ngernsombat,C., Prattapong,P., Larbcharoensub,N., Khotthong,K. and
            Janvilisri,T.
  TITLE     WNT8B as an Independent Prognostic Marker for Nasopharyngeal
            Carcinoma
  JOURNAL   Curr Oncol 28 (4), 2529-2539 (2021)
   PUBMED   34287269
  REMARK    GeneRIF: WNT8B as an Independent Prognostic Marker for
            Nasopharyngeal Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2144)
  AUTHORS   Liu,Y., Wu,D., Cheng,H., Chen,L., Zhang,W., Zou,L., Gao,Q.,
            Zhao,Z., Chen,Q., Zeng,W., Zhang,Z., Jiang,W., Huang,C. and Liu,G.
  TITLE     Wnt8B, transcriptionally regulated by ZNF191, promotes cell
            proliferation of hepatocellular carcinoma via Wnt signaling
  JOURNAL   Cancer Sci 112 (2), 629-640 (2021)
   PUBMED   33197287
  REMARK    GeneRIF: Wnt8B, transcriptionally regulated by ZNF191, promotes
            cell proliferation of hepatocellular carcinoma via Wnt signaling.
REFERENCE   3  (bases 1 to 2144)
  AUTHORS   Voloshanenko,O., Gmach,P., Winter,J., Kranz,D. and Boutros,M.
  TITLE     Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting
            of receptor gene families
  JOURNAL   FASEB J 31 (11), 4832-4844 (2017)
   PUBMED   28733458
REFERENCE   4  (bases 1 to 2144)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   5  (bases 1 to 2144)
  AUTHORS   Gao,H., Zhang,Z.B., Jiang,Z.J., Wang,D.J., Huang,Y. and Wang,W.L.
  TITLE     [Mutation and expression of WNT8b gene and SHH gene in Hirschsprung
            disease]
  JOURNAL   Zhonghua Wei Chang Wai Ke Za Zhi 13 (10), 758-761 (2010)
   PUBMED   20972907
  REMARK    GeneRIF: WNT8b and SHH mutations and abnormal expressions are
            present in the peripheral blood of children with sporadic
            Hirschsprung disease.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2144)
  AUTHORS   Saitoh,T., Mine,T. and Katoh,M.
  TITLE     Up-regulation of WNT8B mRNA in human gastric cancer
  JOURNAL   Int J Oncol 20 (2), 343-348 (2002)
   PUBMED   11788899
  REMARK    GeneRIF: significantly up-regulated in gastric cancer cell lines
            KATO-III (signet-ring cell carcinoma) and MKN45 (poorly
            differentiated adenocarcinoma), and also in 5 out of 10 cases of
            primary gastric cancer
REFERENCE   7  (bases 1 to 2144)
  AUTHORS   Lako,M., Lindsay,S., Bullen,P., Wilson,D.I., Robson,S.C. and
            Strachan,T.
  TITLE     A novel mammalian wnt gene, WNT8B, shows brain-restricted
            expression in early development, with sharply delimited expression
            boundaries in the developing forebrain
  JOURNAL   Hum Mol Genet 7 (5), 813-822 (1998)
   PUBMED   9536085
REFERENCE   8  (bases 1 to 2144)
  AUTHORS   Lako,M., Strachan,T., Curtis,A.R. and Lindsay,S.
  TITLE     Isolation and characterization of WNT8B, a novel human Wnt gene
            that maps to 10q24
  JOURNAL   Genomics 35 (2), 386-388 (1996)
   PUBMED   8661156
REFERENCE   9  (bases 1 to 2144)
  AUTHORS   Cui,Y., Brown,J.D., Moon,R.T. and Christian,J.L.
  TITLE     Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential
            role in establishing the dorsoventral axis
  JOURNAL   Development 121 (7), 2177-2186 (1995)
   PUBMED   7635061
REFERENCE   10 (bases 1 to 2144)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359759.19, CN276452.1,
            AB073637.1 and AL133352.12.
            
            On May 17, 2019 this sequence version replaced NM_003393.3.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. It
            encodes a protein which shows 95%, 86% and 71% amino acid identity
            to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively.
            The expression patterns of the human and mouse genes appear
            identical and are restricted to the developing brain. The
            chromosomal location of this gene to 10q24 suggests it as a
            candidate gene for partial epilepsy. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11094.1, GQ891471.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148874
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343737.6/ ENSP00000340677.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AL359759.19        70917-70962
            47-62               CN276452.1         1-16
            63-2042             AB073637.1         15-1994
            2043-2144           AL133352.12        20573-20674
FEATURES             Location/Qualifiers
     source          1..2144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.31"
     gene            1..2144
                     /gene="WNT8B"
                     /note="Wnt family member 8B"
                     /db_xref="GeneID:7479"
                     /db_xref="HGNC:HGNC:12789"
                     /db_xref="MIM:601396"
     exon            1..228
                     /gene="WNT8B"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1216
                     /gene="WNT8B"
                     /note="protein Wnt-8b; wingless-type MMTV integration site
                     family, member 8B; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="protein Wnt-8b precursor"
                     /protein_id="NP_003384.2"
                     /db_xref="CCDS:CCDS7494.1"
                     /db_xref="GeneID:7479"
                     /db_xref="HGNC:HGNC:12789"
                     /db_xref="MIM:601396"
                     /translation="MFLSKPSVYICLFTCVLQLSHSWSVNNFLMTGPKAYLIYSSSVA
                     AGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTR
                     NCSLGDFDNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAM
                     NLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKV
                     DLLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRG
                     RALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS
                     RAERPRGGAAHKPGRKP"
     exon            229..262
                     /gene="WNT8B"
                     /inference="alignment:Splign:2.1.0"
     exon            263..401
                     /gene="WNT8B"
                     /inference="alignment:Splign:2.1.0"
     exon            402..527
                     /gene="WNT8B"
                     /inference="alignment:Splign:2.1.0"
     exon            528..670
                     /gene="WNT8B"
                     /inference="alignment:Splign:2.1.0"
     exon            671..2144
                     /gene="WNT8B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT8B"
                     /note="hexamer: AATAAA"
     polyA_site      2122
                     /gene="WNT8B"
                     /note="major polyA site"
ORIGIN      
        1 ccatttcacc tccccttaac tctgtttggg atcgcttaca caccaaggaa gttgggcttt
       61 gagaattcca tcccactggc actgaggaga atatttctcc gtcttgctta cccatctccc
      121 agttttttgg aattttctct agctgttact ccagaggatt atgtttcttt caaagccttc
      181 tgtgtacatc tgtcttttca cctgtgtcct ccaactcagc cacagctggt cggtgaacaa
      241 tttcctgatg actggtccaa aggcttacct gatttactcc agcagtgtgg cagctggtgc
      301 ccagagtggt attgaagaat gcaagtatca gtttgcctgg gaccgctgga actgccctga
      361 gagagccctg cagctgtcca gccatggtgg gcttcgcagt gccaatcggg agacagcatt
      421 tgtgcatgcc atcagttctg ctggagtcat gtacaccctg actagaaact gcagccttgg
      481 agattttgat aactgtggct gtgatgactc ccgcaacggg caactggggg gacaaggctg
      541 gctgtgggga ggctgcagtg acaatgtggg cttcggagag gcgatttcca agcagtttgt
      601 cgatgccctg gaaacaggac aggatgcacg ggcagccatg aacctgcaca acaacgaggc
      661 tggccgcaag gcggtgaagg gcaccatgaa acgcacgtgc aagtgccacg gcgtgtctgg
      721 cagctgcacc acgcagacct gttggctgca gctgcccgag ttccgcgagg tgggcgcgca
      781 cctgaaggag aagtaccacg cagcactcaa ggtggacctg ctgcagggtg ctggcaacag
      841 cgcggccggc cgcggcgcca tcgccgacac ctttcgctcc atctctaccc gggagctggt
      901 gcacctggag gactccccgg actactgcct ggagaacaaa acgctagggc tgctgggcac
      961 cgaaggccga gagtgcctaa ggcgcgggcg ggccctgggt cgctgggaac gccgcagctg
     1021 ccgccggctc tgcggggact gcgggctggc ggtggaggag cgccgggccg agaccgtgtc
     1081 cagctgcaac tgcaagttcc actggtgctg cgcagtccgc tgcgagcagt gccgccggag
     1141 ggtcaccaag tacttctgta gccgcgcaga gcggccgcgg gggggcgctg cgcacaaacc
     1201 cgggagaaaa ccctaagggt ttcctctgcc ccctcctttt cccactggtt cttggcttcc
     1261 tttagagacc ccggtaattg tggaacctag ggaatgggga acccgctctc ccagacctag
     1321 ggatcctgag agggagagac tgcaatttct ccaaagcttg ccactttcca gcctgtttcc
     1381 ccaattcctc tgtgctctcc tagagctctg tctgaatcct cgcagccaca cctaggtctg
     1441 agaactcagg ctttgagtta ctgatcttcc ttggattagg agaacaggtg ttcctcctcc
     1501 cctctcctag cagccctaat gtctgaccta gcctatcaag ccttaggcgc tggaagaacc
     1561 cttctcagac acgcaggacc caggtaaagt caaagctttg cccttttgcc cactgtctgc
     1621 taccagggct cacccactgc tgcacctctc ttctgcacag ctcctcccct gctacctgct
     1681 gagccagatt ccccaggaat cttgaatgct ttctctcctc ttctcccttt cctttcccag
     1741 aaaaactgag gaaactggcc ccggaaaagc atgtctttgg ggttggttcc tagaggcaga
     1801 ggttgaagat ggaagaggga gctctggagt gctaacttga acaccaaggg tgctactcat
     1861 ccctatggta tcatatcatg aatggacttt actagtgggg caatgacttt cctagacaat
     1921 aacccgaggg actccagata cataccccga aggtctagga aatacgttaa gggcagatta
     1981 cagtcatttc ctacccttta aaggtaactt ctcccttctc ctgacctact tcctcctagc
     2041 aaccaacttt acctcttctt ctccaaagga tctttgttcc tctgagccaa gactgaggta
     2101 aataaagcca ctttcctctt cagatcctgg tctgcacctc taga
//
