LOCUS       NM_058238               3948 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens Wnt family member 7B (WNT7B), transcript variant 2,
            mRNA.
ACCESSION   NM_058238 XM_001718758
VERSION     NM_058238.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3948)
  AUTHORS   Kong,X., Xiong,Y. and Li,L.
  TITLE     LINC01605 promotes malignant phenotypes of cervical cancer via
            miR-149-3p/WNT7B axis
  JOURNAL   Gene 921, 148518 (2024)
   PUBMED   38734188
  REMARK    GeneRIF: LINC01605 promotes malignant phenotypes of cervical cancer
            via miR-149-3p/WNT7B axis.
REFERENCE   2  (bases 1 to 3948)
  AUTHORS   AlAbdi,L., Rahbeeni,Z., Maddirevula,S., Helaby,R., Abdulwahab,F.,
            Khan,A.O., Riley,L.G., Alhashem,A., Chassaing,N., Jamieson,R.V. and
            Alkuraya,F.S.
  TITLE     A founder variant expands the phenotype of WNT7B-related PDAC
            syndrome
  JOURNAL   Clin Genet 106 (1), 66-71 (2024)
   PUBMED   38417950
  REMARK    GeneRIF: A founder variant expands the phenotype of WNT7B-related
            PDAC syndrome.
REFERENCE   3  (bases 1 to 3948)
  AUTHORS   Bouasker,S., Patel,N., Greenlees,R., Wellesley,D., Fares Taie,L.,
            Almontashiri,N.A., Baptista,J., Alghamdi,M.A., Boissel,S.,
            Martinovic,J., Prokudin,I., Holden,S., Mudhar,H.S., Riley,L.G.,
            Nassif,C., Attie-Bitach,T., Miguet,M., Delous,M., Ernest,S.,
            Plaisancie,J., Calvas,P., Rozet,J.M., Khan,A.O., Hamdan,F.F.,
            Jamieson,R.V., Alkuraya,F.S., Michaud,J.L. and Chassaing,N.
  TITLE     Bi-allelic variants in WNT7B disrupt the development of multiple
            organs in humans
  JOURNAL   J Med Genet 60 (3), 294-300 (2023)
   PUBMED   35790350
  REMARK    GeneRIF: Bi-allelic variants in WNT7B disrupt the development of
            multiple organs in humans.
REFERENCE   4  (bases 1 to 3948)
  AUTHORS   Yu,T., Zhou,F., Tian,W., Xu,R., Wang,B., Zeng,A., Zhou,Z., Li,M.,
            Wang,Y. and Zhang,J.
  TITLE     EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that
            promotes temozolomide resistance in glioblastoma
  JOURNAL   Oncogene 42 (6), 461-470 (2023)
   PUBMED   36517590
  REMARK    GeneRIF: EZH2 interacts with HP1BP3 to epigenetically activate
            WNT7B that promotes temozolomide resistance in glioblastoma.
REFERENCE   5  (bases 1 to 3948)
  AUTHORS   Chen,S., Ding,H., Wang,K. and Guo,K.
  TITLE     Inhibition of Wnt7b reduces the proliferation, invasion, and
            migration of colorectal cancer cells
  JOURNAL   Mol Biol Rep 50 (2), 1415-1424 (2023)
   PUBMED   36472725
  REMARK    GeneRIF: Inhibition of Wnt7b reduces the proliferation, invasion,
            and migration of colorectal cancer cells.
REFERENCE   6  (bases 1 to 3948)
  AUTHORS   Kirikoshi,H., Sekihara,H. and Katoh,M.
  TITLE     Molecular cloning and characterization of human WNT7B
  JOURNAL   Int J Oncol 19 (4), 779-783 (2001)
   PUBMED   11562755
REFERENCE   7  (bases 1 to 3948)
  AUTHORS   Tanaka,K., Okabayashi,K., Asashima,M., Perrimon,N. and Kadowaki,T.
  TITLE     The evolutionarily conserved porcupine gene family is involved in
            the processing of the Wnt family
  JOURNAL   Eur J Biochem 267 (13), 4300-4311 (2000)
   PUBMED   10866835
REFERENCE   8  (bases 1 to 3948)
  AUTHORS   van Bokhoven,H., Kissing,J., Schepens,M., van Beersum,S.,
            Simons,A., Riegman,P., McMahon,J.A., McMahon,A.P. and Brunner,H.G.
  TITLE     Assignment of WNT7B to human chromosome band 22q13 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 288-289 (1997)
   PUBMED   9284940
REFERENCE   9  (bases 1 to 3948)
  AUTHORS   Huguet,E.L., McMahon,J.A., McMahon,A.P., Bicknell,R. and
            Harris,A.L.
  TITLE     Differential expression of human Wnt genes 2, 3, 4, and 7B in human
            breast cell lines and normal and disease states of human breast
            tissue
  JOURNAL   Cancer Res 54 (10), 2615-2621 (1994)
   PUBMED   8168088
REFERENCE   10 (bases 1 to 3948)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR536603.4, AF416743.1,
            AB062766.1, BX511035.7 and CB853639.1.
            
            On Nov 22, 2018 this sequence version replaced NM_058238.2.
            
            Summary: This gene is a member of the WNT gene family, which
            consists of structurally related genes that encode secreted
            signaling proteins. These proteins have been implicated in
            oncogenesis and in several developmental processes, including
            regulation of cell fate and patterning during embryogenesis. Among
            members of the human WNT family, this gene product is most similar
            to WNT7A protein. [provided by RefSeq, Oct 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034923.1, AB062766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339464.9/ ENSP00000341032.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CR536603.4         7739-7772           c
            35-74               AF416743.1         1-40
            75-76               CR536603.4         7697-7698           c
            77-1474             AF416743.1         43-1440
            1475-2542           AB062766.1         1072-2139
            2543-3662           BX511035.7         20085-21204         c
            3663-3948           CB853639.1         15-300              c
FEATURES             Location/Qualifiers
     source          1..3948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..3948
                     /gene="WNT7B"
                     /note="Wnt family member 7B"
                     /db_xref="GeneID:7477"
                     /db_xref="HGNC:HGNC:12787"
                     /db_xref="MIM:601967"
     exon            1..479
                     /gene="WNT7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..1458
                     /gene="WNT7B"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; protein Wnt-7b; wingless-type MMTV integration
                     site family, member 7B"
                     /codon_start=1
                     /product="protein Wnt-7b isoform 2 precursor"
                     /protein_id="NP_478679.1"
                     /db_xref="CCDS:CCDS33667.1"
                     /db_xref="GeneID:7477"
                     /db_xref="HGNC:HGNC:12787"
                     /db_xref="MIM:601967"
                     /translation="MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGL
                     APRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSR
                     EAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGI
                     DFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTL
                     PKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPN
                     YCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFV
                     KCNTCSERTEVFTCK"
     exon            480..706
                     /gene="WNT7B"
                     /inference="alignment:Splign:2.1.0"
     exon            707..978
                     /gene="WNT7B"
                     /inference="alignment:Splign:2.1.0"
     exon            979..3948
                     /gene="WNT7B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3927..3932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT7B"
                     /note="hexamer: AATAAA"
     polyA_site      3948
                     /gene="WNT7B"
                     /note="major polyA site"
ORIGIN      
        1 gagtcacctg gggcggccga caagtgcgga cacattggcc gccgcggcgc tcggcgaggc
       61 gctcacggcc tcaggcggct gcgcctagtg caggctgcac ccgcccgcca gccgcgcccg
      121 ggcccccggc ccgcgcttgc aggggtccac ggtcgctcaa ccgggcttcg aggtcgcggc
      181 ccccagcctg ggtcaattcc ccgggctcac gcggcggtgg cggcggcggc atcccgggct
      241 caccatggtg gcagcgcgcg ccgagtgccc gcgcgtcgcc ggccgcccga gccgcagcgc
      301 gggctgagcg cagtctgccc gcagccccct ggcccctgcc cggccctgcc gggcccgcgc
      361 gtcccctccg gccgccgctg tctatggcgc agcccccctc cctggatcat gcacagaaac
      421 tttcgcaagt ggattttcta cgtgtttctc tgctttggcg tcctgtacgt gaagctcgga
      481 gcactgtcat ccgtggtggc cctgggagcc aacatcatct gcaacaagat tcctggccta
      541 gccccgcggc agcgtgccat ctgccagagt cggcccgatg ccatcattgt gattggggag
      601 ggggcgcaga tgggcatcaa cgagtgccag taccagttcc gcttcggacg ctggaactgc
      661 tctgccctcg gcgagaagac cgtcttcggg caagagctcc gagtagggag ccgtgaggct
      721 gccttcacgt acgccatcac cgcggctggc gtggcgcacg ccgtcaccgc tgcctgcagc
      781 caagggaacc tgagcaactg cggctgcgac cgcgagaagc agggctacta caaccaagcc
      841 gagggctgga agtggggcgg ctgctcggcc gacgtgcgtt acggcatcga cttctcccgg
      901 cgcttcgtgg acgctcggga gatcaagaag aacgcgcggc gcctcatgaa cctgcataac
      961 aatgaggccg gcaggaaggt tctagaggac cggatgcagc tggagtgcaa gtgccacggc
     1021 gtgtctggct cctgcaccac caaaacctgc tggaccacgc tgcccaagtt ccgagaggtg
     1081 ggccacctgc tgaaggagaa gtacaacgcg gccgtgcagg tggaggtggt gcgggccagc
     1141 cgtctgcggc agcccacctt cctgcgcatc aaacagctgc gcagctatca gaagcccatg
     1201 gagacagacc tggtgtacat tgagaagtcg cccaactact gcgaggagga cgcggccacg
     1261 ggcagcgtgg gcacgcaggg ccgtctctgc aaccgcacgt cgcccggcgc ggacggctgt
     1321 gacaccatgt gctgcggccg aggctacaac acccaccagt acaccaaggt gtggcagtgc
     1381 aactgcaaat tccactggtg ctgcttcgtc aagtgcaaca cctgcagcga gcgcaccgag
     1441 gtcttcacct gcaagtgagg ccaggcccgg aggcggccgc gggcaccctg gaacccggcg
     1501 gcattttgca catccactcc tcaccttccc tgccttggtg ctgccagcag cagacataga
     1561 cgggtgcaga agcggggagc tccaggtgca ggagggcacc ggccggggcc cacgccctct
     1621 gcccgcctcc ctggggctcc ttcctgccac ctcctcccat cacctcctgc ggcagaacag
     1681 cacccgtgac ccacccagag agcaaggcca ggggtcttgg tgctccccga cggggcccgg
     1741 caagttctct ttcttctctc tgggaaaatg aacgtccagg acacacctgt atcccagaga
     1801 gcaaagtgat gaggagactg agcgtcccca gccccacctg gcggcatgga cacagaaaag
     1861 ctacgccggc tggcctctcc agaccagttc ccaggctggg tctgccgctg ggccctgggg
     1921 cggtggggac agatgttgac acaaattatt tatgttttct tagtatcaga agaggattct
     1981 cggcactaac acatagccag tcctaactcc gtactctgtg tcagcccatc ccctagacac
     2041 cctctgtttc ctttcccggc cccacctggc cggccctctg cccctgcaga gctgaggcag
     2101 cctggggttg atggggacca cgcggtgcct gcaggtccta gaagtgagct gggcaggggc
     2161 tcttcagacc acacagccct gaccgggcct tggaggagag ccatggacag gctcctccat
     2221 gccgtctttc cttcttttga aaatcctatc aatggctggg cgcggtggct cacacctgta
     2281 atcccagcac tttgggagac cgaggcaggt ggatcacctg aggtcaggag ttcgagacca
     2341 gcctggccaa cgtggtgaaa ccctgtctct actaaaaata caaaaattag ctgggcgtgg
     2401 tggcgtgcac ctgtaatccc agctactcag gaggctgaga caggacactt gcttgaaccc
     2461 gggaggtgga ggttgcaatg agccaagatt gtgccactgt attccaactt gggtgacaga
     2521 gcacgactct gtctcaaaaa aagaaaagaa aataatatca agcaaatcaa aatatcaccc
     2581 acgtcaggtt ccaggagtcc ttcgttccct ccctcatcct gtcaccctcc cggcctggca
     2641 cctccagttt acagagaccc ccttccccct ggagccagcc tgacccctgg gacagtgctg
     2701 ccgcgggggt caggcaggtg gtgagtggtc agggatgttt gtcccacttg acagatggga
     2761 actctgaggc ccagagtggc acaaggacct accagagacc ctgcagctgt gactggaggc
     2821 ttccaccttt ctcctgccca gcctggggct ctggacctgg gagaacacat caggatgccc
     2881 ggggtggcag taggtagctc ccatgccttg aggcacttgg ctgctccctc caccccctga
     2941 cagcctcatt ggggcctgca ctcccctcgg tgcctttgag gcttcgccta gccctgtcct
     3001 ggtcctttta ccctgacccc agtgctgaga aaatctggat ccagagctgg acatgtcctt
     3061 tctggatgct cccacccctg tctctgagga gcatgagtga cagagggagg aacttgtccg
     3121 aggccagaga ggatggtctg cagctggctc ctggtgcacc cccactgccc acggcctggc
     3181 ccccatttag ggtgtgttct cttggaagcc cgtaggaatg tgttcttgag cagccgacaa
     3241 gccaagggcc tgggctcagc ctggggcaag tgggtccctc ctgggctctg gccctgtggt
     3301 ccagcccatg tgcctctaac catgcctgga cgctctgagt ctccgggcca ccgtgaatgc
     3361 cccaccctca gcctggcccc atccccttac cttccccaag tcccagaaca cacctgagtc
     3421 cataggcccg gcagcctctg caaggaacct ggttaactta tgttgttata tagcgtcgaa
     3481 atgtctatag tgtctttaaa ttattgtgac ctacactggg taccggagag ggggatggct
     3541 gcggccccca tccctcatcc cccatcccat cccatccctc atctcatccc tcatcccatc
     3601 ccccatccca tccctgaccc catcccccat cccatccctc atccctattc cccataccca
     3661 ccccccatcc catcccccat ctcccgaacc aggctcctcc tgcttcaaca gacccttggg
     3721 gcccctgatg ccaccgagac actcgcactg tcccttggct gccgggcacc ccactgagcc
     3781 cctgcccacc ccaaagtctg ccagcaacag gccctttgcc tgggtgagac gggggtcagg
     3841 gtggcccaga tgggggtgat ggcgaccaag gtgctgcgtc cccacccttc tgacggcagc
     3901 ctcccctgga ggggagtgct cggcccaata aaagctggaa tcggaaaa
//
