LOCUS       NM_004625               3991 bp    mRNA    linear   PRI 22-DEC-2024
DEFINITION  Homo sapiens Wnt family member 7A (WNT7A), mRNA.
ACCESSION   NM_004625
VERSION     NM_004625.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3991)
  AUTHORS   Huang,Q., Xiao,Y., Lan,T., Lu,Y., Huang,L. and Zheng,D.
  TITLE     WNT7A promotes tumorigenesis of head and neck squamous cell
            carcinoma via activating FZD7/JAK1/STAT3 signaling
  JOURNAL   Int J Oral Sci 16 (1), 7 (2024)
   PUBMED   38246919
  REMARK    GeneRIF: WNT7A promotes tumorigenesis of head and neck squamous
            cell carcinoma via activating FZD7/JAK1/STAT3 signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3991)
  AUTHORS   Qi,X., Hu,Q., Elghobashi-Meinhardt,N., Long,T., Chen,H. and Li,X.
  TITLE     Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific
            signaling
  JOURNAL   Cell 186 (23), 5028-5040 (2023)
   PUBMED   37852257
  REMARK    GeneRIF: Molecular basis of Wnt biogenesis, secretion, and
            Wnt7-specific signaling.
REFERENCE   3  (bases 1 to 3991)
  AUTHORS   Kayamori,K., Katsube,K.I., Hirai,H., Harada,H. and Ikeda,T.
  TITLE     Role of Stromal Fibroblast-Induced WNT7A Associated with Cancer
            Cell Migration Through the AKT/CLDN1 Signaling Axis in Oral
            Squamous Cell Carcinoma
  JOURNAL   Lab Invest 103 (10), 100228 (2023)
   PUBMED   37541622
  REMARK    GeneRIF: Role of Stromal Fibroblast-Induced WNT7A Associated with
            Cancer Cell Migration Through the AKT/CLDN1 Signaling Axis in Oral
            Squamous Cell Carcinoma.
REFERENCE   4  (bases 1 to 3991)
  AUTHORS   Shen,Y., Cui,Q., Xiao,L., Wang,L., Li,Q., Zhang,R., Chen,Z. and
            Niu,J.
  TITLE     Down-regulated Wnt7a and GPR124 in early-onset preeclampsia
            placentas reduce invasion and migration of trophoblast cells
  JOURNAL   J Perinat Med 52 (1), 41-49 (2023)
   PUBMED   37694534
  REMARK    GeneRIF: Down-regulated Wnt7a and GPR124 in early-onset
            preeclampsia placentas reduce invasion and migration of trophoblast
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3991)
  AUTHORS   Saw,S.P.L., Zhou,S., Chen,J., Lai,G., Ang,M.K., Chua,K.,
            Kanesvaran,R., Ng,Q.S., Jain,A., Tan,W.L., Rajasekaran,T.,
            Lim,D.W.T., Tan,A., Fong,K.W., Takano,A., Cheng,X.M., Lim,K.H.,
            Koh,T., Ong,B.H., Tan,E.H., Toh,C.K., Skanderup,A.J., Tan,S.H. and
            Tan,D.S.W.
  TITLE     Association of Clinicopathologic and Molecular Tumor Features With
            Recurrence in Resected Early-Stage Epidermal Growth Factor
            Receptor-Positive Non-Small Cell Lung Cancer
  JOURNAL   JAMA Netw Open 4 (11), e2131892 (2021)
   PUBMED   34739062
  REMARK    GeneRIF: Association of Clinicopathologic and Molecular Tumor
            Features With Recurrence in Resected Early-Stage Epidermal Growth
            Factor Receptor-Positive Non-Small Cell Lung Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3991)
  AUTHORS   Parr,B.A. and McMahon,A.P.
  TITLE     Sexually dimorphic development of the mammalian reproductive tract
            requires Wnt-7a
  JOURNAL   Nature 395 (6703), 707-710 (1998)
   PUBMED   9790192
REFERENCE   7  (bases 1 to 3991)
  AUTHORS   Bui,T.D., Lako,M., Lejeune,S., Curtis,A.R., Strachan,T., Lindsay,S.
            and Harris,A.L.
  TITLE     Isolation of a full-length human WNT7A gene implicated in limb
            development and cell transformation, and mapping to chromosome 3p25
  JOURNAL   Gene 189 (1), 25-29 (1997)
   PUBMED   9161407
REFERENCE   8  (bases 1 to 3991)
  AUTHORS   Ikegawa,S., Kumano,Y., Okui,K., Fujiwara,T., Takahashi,E. and
            Nakamura,Y.
  TITLE     Isolation, characterization and chromosomal assignment of the human
            WNT7A gene
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 149-152 (1996)
   PUBMED   8893824
REFERENCE   9  (bases 1 to 3991)
  AUTHORS   Huguet,E.L., McMahon,J.A., McMahon,A.P., Bicknell,R. and
            Harris,A.L.
  TITLE     Differential expression of human Wnt genes 2, 3, 4, and 7B in human
            breast cell lines and normal and disease states of human breast
            tissue
  JOURNAL   Cancer Res 54 (10), 2615-2621 (1994)
   PUBMED   8168088
REFERENCE   10 (bases 1 to 3991)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008811.2 and AC090646.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004625.3.
            
            Summary: This gene is a member of the WNT gene family, which
            consists of structurally related genes that encode secreted
            signaling proteins. These proteins have been implicated in
            oncogenesis and in several developmental processes, including
            regulation of cell fate and patterning during embryogenesis. This
            gene is involved in the development of the anterior-posterior axis
            in the female reproductive tract, and also plays a critical role in
            uterine smooth muscle pattering and maintenance of adult uterine
            function. Mutations in this gene are associated with Fuhrmann and
            Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.246352.1, BC008811.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285018.5/ ENSP00000285018.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1664              BC008811.2         51-1714
            1665-3991           AC090646.2         97705-100031
FEATURES             Location/Qualifiers
     source          1..3991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..3991
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /note="Wnt family member 7A"
                     /db_xref="GeneID:7476"
                     /db_xref="HGNC:HGNC:12786"
                     /db_xref="MIM:601570"
     exon            1..326
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1305
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /note="proto-oncogene Wnt7a protein; protein Wnt-7a;
                     wingless-type MMTV integration site family, member 7A"
                     /codon_start=1
                     /product="protein Wnt-7a precursor"
                     /protein_id="NP_004616.2"
                     /db_xref="CCDS:CCDS2616.1"
                     /db_xref="GeneID:7476"
                     /db_xref="HGNC:HGNC:12786"
                     /db_xref="MIM:601570"
                     /translation="MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGL
                     APRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSR
                     EAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGI
                     GFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTL
                     PQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPN
                     YCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYV
                     KCNTCSERTEMYTCK"
     exon            327..553
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /inference="alignment:Splign:2.1.0"
     exon            554..825
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /inference="alignment:Splign:2.1.0"
     exon            826..3991
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1645..1650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /note="hexamer: ATTAAA"
     polyA_site      1663
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /note="major polyA site"
     regulatory      2028..2033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /note="hexamer: AATAGA"
     regulatory      2044..2049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /note="hexamer: AATAAA"
     polyA_site      2045
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
     polyA_site      2089
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
     regulatory      3248..3253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
                     /note="hexamer: AATAAA"
     polyA_site      3271
                     /gene="WNT7A"
                     /gene_synonym="SANTOS; Wnt-7a"
ORIGIN      
        1 acacttgcac cggtcgctcg cgcgcagccc ggcgtcgccc cacgccgcgc tcgctcctcc
       61 ctccctcctc ccgctccgtg gctcccgtgc tcctggcgag gctcaggcgc ggagcgcgcg
      121 gacgggcgca ccgacagacg gccccgggga cgcctcggct cgcgcctccc gggcgggcta
      181 tgttgattgc cccgccgggg ccggcccgcg ggatcagcac agcccggccc gcggccccgg
      241 cggccaatcg ggactatgaa ccggaaagcg cggcgctgcc tgggccacct ctttctcagc
      301 ctgggcatgg tctacctccg gatcggtggc ttctcctcag tggtagctct gggcgcaagc
      361 atcatctgta acaagatccc aggcctggct cccagacagc gggcgatctg ccagagccgg
      421 cccgacgcca tcatcgtcat aggagaaggc tcacaaatgg gcctggacga gtgtcagttt
      481 cagttccgca atggccgctg gaactgctct gcactgggag agcgcaccgt cttcgggaag
      541 gagctcaaag tggggagccg ggaggctgcg ttcacctacg ccatcattgc cgccggcgtg
      601 gcccacgcca tcacagctgc ctgtacccag ggcaacctga gcgactgtgg ctgcgacaaa
      661 gagaagcaag gccagtacca ccgggacgag ggctggaagt ggggtggctg ctctgccgac
      721 atccgctacg gcatcggctt cgccaaggtc tttgtggatg cccgggagat caagcagaat
      781 gcccggactc tcatgaactt gcacaacaac gaggcaggcc gaaagatcct ggaggagaac
      841 atgaagctgg aatgtaagtg ccacggcgtg tcaggctcgt gcaccaccaa gacgtgctgg
      901 accacactgc cacagtttcg ggagctgggc tacgtgctca aggacaagta caacgaggcc
      961 gttcacgtgg agcctgtgcg tgccagccgc aacaagcggc ccaccttcct gaagatcaag
     1021 aagccactgt cgtaccgcaa gcccatggac acggacctgg tgtacatcga gaagtcgccc
     1081 aactactgcg aggaggaccc ggtgaccggc agtgtgggca cccagggccg cgcctgcaac
     1141 aagacggctc cccaggccag cggctgtgac ctcatgtgct gtgggcgtgg ctacaacacc
     1201 caccagtacg cccgcgtgtg gcagtgcaac tgtaagttcc actggtgctg ctatgtcaag
     1261 tgcaacacgt gcagcgagcg cacggagatg tacacgtgca agtgagcccc gtgtgcacac
     1321 caccctcccg ctgcaagtca gattgctggg aggactggac cgtttccaag ctgcgggctc
     1381 cctggcagga tgctgagctt gtcttttctg ctgaggaggg tacttttcct gggtttcctg
     1441 caggcatccg tgggggaaaa aaaatctctc agagccctca actattctgt tccacaccca
     1501 atgctgctcc accctccccc agacacagcc caggtccctc cgcggctgga gcgaagcctt
     1561 ctgcagcagg aactctggac ccctgggcct catcacagca atatttaaca atttattctg
     1621 ataaaaataa tattaattta tttaattaaa aagaattctt ccacctcgtc gggatccgtt
     1681 ttctgcaatc aaagtggact gcttgctttc ctagcaggat gattttgttg ctaggacaag
     1741 gagccgtgta gaagtgtaca taactattct ttatgcagat atttctacta gctgattttg
     1801 caggtaccca ccttgcagca ctagatgttt aagtacaaga ggagacatct tttatgcata
     1861 tatagatata cacacacaca tttttttttt tttttttgct gtttgctgct acttatccag
     1921 aaatttaagc tggtccagat ttggagacgt tttttccaga gtatgttttc catccttttg
     1981 ccctccccag ttcaaacttc accattagaa aaatccagtt tggaataaat agagaggaaa
     2041 aataataaat tcccagcagt ttccatcttt cggaaagtga gccaccggat aagagagaat
     2101 attttgtaag agactatttt tatatgaata ttttatttat atcgagtcta ctgtatcatt
     2161 ccacggcctg tgcttcttct taattctggt actcacttag gggtaaggag gggcgatgcc
     2221 tggttgtggc gtcaggcccc atggggcccc ttgcacagct ggattcttga gttctgtttg
     2281 ccaagtgggc acaagctgcc cctggatgcc tggggttgag gcatcatctc atccatgtta
     2341 gccgggaaag aaatcaaatc cccagcctca gcctgttaag ctcaggcctt tcaagcaggg
     2401 ccactgagtg gtagcttcga aatgagtcac tgtggtgggt ggtcatcgtg cccctcacag
     2461 ggacttgacc gtcatcctgc agcagaggcc agttcaggga gccccacacc tcaccaagac
     2521 actagccatt gcctgcgtgt cctggaaggt gagatgtagt cctcaggtga ggtgacccaa
     2581 agcagatggg gtgaggggcc gatgagcagc cgggcccagc ggggcttcct ggatatcctg
     2641 ctcccaaggc caagcagcag agagaggttc aagtgaggcc actttgcttt gggtccagct
     2701 acacccagag cctcagccta gaaagctgtc ctccagcagg ctgggggtgt tctaatatgt
     2761 gtccgtttgc atttccggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2821 tgtgtactgt atcttcttag ggacttgagt gtagtcacgt gactttgcgc cttgcagcgc
     2881 ctccgccgta ctcgtgtgtg tatgtgtctg tgtgtttccg tgctacccaa gcgtctgttt
     2941 ctctccgtgt gcctgggaga tcaggtctca ggcatggagc tgcatgcctt tgcatctgct
     3001 gctccccaga gtctctgctt gcatgtgagg gctggtggta tgaggcagac agcagagatt
     3061 gtgtgtgatt gtgttgaacc gccaagagaa ggcacctctg aactctgtcc ccacacccat
     3121 gggtgaaaac cagacacctc tgagaccaca gcacagcccc atggccccac ctgctgggag
     3181 cccttcagta tctaggctgt gtctgactcc tcagtgtcca cactgagcct ggatcacagc
     3241 atgggcaaat aaaagtgact ggatggttgc atggtttctt cccttggaca tttttttcca
     3301 tttttctttt acttgggtgt ctggaggagt gggcatgtga aggggccatg gagtgaatgg
     3361 atggagggat ggatgaatgt gtgagtaggt aggtaggtga atgggtagat gtgtggatgg
     3421 ataagtaggt gggtgggtga atggataaat ggatggatgg gtagatggat ggatgaaggg
     3481 ataaacagat gggtggatgg attgataagt gagcggatga atggatgaat agctaggaaa
     3541 gtgggtgggt ggatgagggt gggttgatga ggtaggtaca cctacagata ggtaagtgag
     3601 cagtttcttg ggagtccaca ggtcacattt tatctttgct ttggaaaacc tagcagatct
     3661 gccatgatca ggatggcttc ccgaccttgc aacccttctg cttctgacct ccttggcacc
     3721 tgggaatggg ggagattctg accagcctcc ccagatgagt gttcaatgat agttacataa
     3781 acacagtctc agaagagtca tccctgtgtc ctccctcact gtgggttccc agctctgggg
     3841 cctgccctct ctcgggtgcc ctgttcagct gtgctctgag ccccagtttc tccacctgtg
     3901 aaatcagaat aacacctacc tcacagggct gttgtgagga tcctcccagt aatgactgta
     3961 tggcactttg agttgcaaag caatggatga a
//
