LOCUS       NM_006522               1719 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Wnt family member 6 (WNT6), mRNA.
ACCESSION   NM_006522
VERSION     NM_006522.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Ramirez,I., Kirschneck,C., Silva-Sousa,A.C., Proff,P., S
            Antunes,L., Gabbardo,M.C., de Oliveira,D.S., Sousa-Neto,M.D.,
            Baratto-Filho,F. and Kuchler,E.C.
  TITLE     The investigation of WNT6 and WNT10A single nucleotide
            polymorphisms as potential biomarkers for dental pulp calcification
            in orthodontic patients
  JOURNAL   PLoS One 18 (8), e0288782 (2023)
   PUBMED   37566620
  REMARK    GeneRIF: The investigation of WNT6 and WNT10A single nucleotide
            polymorphisms as potential biomarkers for dental pulp calcification
            in orthodontic patients.
            Erratum:[PLoS One. 2024 Jun 6;19(6):e0305377. doi:
            10.1371/journal.pone.0305377.. PMID: 38843152]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Bao,H., Wu,W., Li,Y., Zong,Z. and Chen,S.
  TITLE     WNT6 participates in the occurrence and development of ovarian
            cancer by upregulating/activating the typical Wnt pathway and
            Notch1 signaling pathway
  JOURNAL   Gene 846, 146871 (2022)
   PUBMED   36075327
  REMARK    GeneRIF: WNT6 participates in the occurrence and development of
            ovarian cancer by upregulating/activating the typical Wnt pathway
            and Notch1 signaling pathway.
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Fu,H., Tan,X., Ye,L. and Wang,C.
  TITLE     The glycoprotein Wnt6 regulates human dental papilla cells
            differentiation by canonical Wnt signaling pathway
  JOURNAL   Arch Oral Biol 141, 105469 (2022)
   PUBMED   35691114
  REMARK    GeneRIF: The glycoprotein Wnt6 regulates human dental papilla cells
            differentiation by canonical Wnt signaling pathway.
REFERENCE   4  (bases 1 to 1719)
  AUTHORS   Chronopoulou,E., Koika,V., Tsiveriotis,K., Stefanidis,K.,
            Kalogeropoulos,S., Georgopoulos,N., Adonakis,G. and Kaponis,A.
  TITLE     Wnt4, Wnt6 and beta-catenin expression in human placental tissue -
            is there a link with first trimester miscarriage? Results from a
            pilot study
  JOURNAL   Reprod Biol Endocrinol 20 (1), 51 (2022)
   PUBMED   35300692
  REMARK    GeneRIF: Wnt4, Wnt6 and beta-catenin expression in human placental
            tissue - is there a link with first trimester miscarriage? Results
            from a pilot study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1719)
  AUTHORS   Bonnet,C., Oh,D., Mei,H., Robertson,S., Chang,D., Bourges,J.L.,
            Behar-Cohen,F., Zheng,J.J. and Deng,S.X.
  TITLE     Wnt6 plays a complex role in maintaining human limbal
            stem/progenitor cells
  JOURNAL   Sci Rep 11 (1), 20948 (2021)
   PUBMED   34686698
  REMARK    GeneRIF: Wnt6 plays a complex role in maintaining human limbal
            stem/progenitor cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1719)
  AUTHORS   Tanaka,K., Okabayashi,K., Asashima,M., Perrimon,N. and Kadowaki,T.
  TITLE     The evolutionarily conserved porcupine gene family is involved in
            the processing of the Wnt family
  JOURNAL   Eur J Biochem 267 (13), 4300-4311 (2000)
   PUBMED   10866835
REFERENCE   7  (bases 1 to 1719)
  AUTHORS   Rankin,J., Strachan,T., Lako,M. and Lindsay,S.
  TITLE     Partial cloning and assignment of WNT6 to human chromosome band
            2q35 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 50-52 (1999)
   PUBMED   10343101
REFERENCE   8  (bases 1 to 1719)
  AUTHORS   Cadigan,K.M. and Nusse,R.
  TITLE     Wnt signaling: a common theme in animal development
  JOURNAL   Genes Dev 11 (24), 3286-3305 (1997)
   PUBMED   9407023
  REMARK    Review article
REFERENCE   9  (bases 1 to 1719)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
REFERENCE   10 (bases 1 to 1719)
  AUTHORS   Gavin,B.J., McMahon,J.A. and McMahon,A.P.
  TITLE     Expression of multiple novel Wnt-1/int-1-related genes during fetal
            and adult mouse development
  JOURNAL   Genes Dev 4 (12B), 2319-2332 (1990)
   PUBMED   2279700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009974.10, CB960823.1,
            BC004329.1, AB059570.1, AK075522.1 and AC073128.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006522.3.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. It is
            overexpressed in cervical cancer cell line and strongly coexpressed
            with another family member, WNT10A, in colorectal cancer cell line.
            The gene overexpression may play key roles in carcinogenesis. This
            gene and the WNT10A gene are clustered in the chromosome 2q35
            region. The protein encoded by this gene is 97% identical to the
            mouse Wnt6 protein at the amino acid level. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY009401.1, AK075522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233948.4/ ENSP00000233948.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC009974.10        197889-197906
            19-294              CB960823.1         51-326
            295-799             BC004329.1         65-569
            800-1111            AB059570.1         572-883
            1112-1716           BC004329.1         882-1486
            1717-1718           AK075522.1         1583-1584
            1719-1719           AC073128.5         7461-7461
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..1719
                     /gene="WNT6"
                     /note="Wnt family member 6"
                     /db_xref="GeneID:7475"
                     /db_xref="HGNC:HGNC:12785"
                     /db_xref="MIM:604663"
     exon            1..313
                     /gene="WNT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1331
                     /gene="WNT6"
                     /note="protein Wnt-6; wingless-type MMTV integration site
                     family, member 6"
                     /codon_start=1
                     /product="protein Wnt-6 precursor"
                     /protein_id="NP_006513.1"
                     /db_xref="CCDS:CCDS2425.1"
                     /db_xref="GeneID:7475"
                     /db_xref="HGNC:HGNC:12785"
                     /db_xref="MIM:604663"
                     /translation="MLPPLPSRLGLLLLLLLCPAHVGGLWWAVGSPLVMDPTSICRKA
                     RRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRILQQDI
                     RETAFVFAITAAGASHAVTQACSMGELLQCGCQAPRGRAPPRPSGLPGTPGPPGPAGS
                     PEGSAAWEWGGCGDDVDFGDEKSRLFMDARHKRGRGDIRALVQLHNNEAGRLAVRSHT
                     RTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTL
                     KPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESV
                     QLEENCLCRFHWCCVVQCHRCRVRKELSLCL"
     exon            314..534
                     /gene="WNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            535..869
                     /gene="WNT6"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1719
                     /gene="WNT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1698..1703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT6"
                     /note="hexamer: AATAAA"
     polyA_site      1719
                     /gene="WNT6"
                     /note="major polyA site"
ORIGIN      
        1 cttctcccga gcgagctccg caggagacac aggcgctggc tgccccgtcc gctctccgcc
       61 tccgccgcgc cctcctcgcc cgggatgggc ccccccgccg ccgccggatc cctcgcctcc
      121 cggccgccgc cgttgcgctc gccgcgctcg cactgaagcc cgggccctcg cgcgccgcgg
      181 ttcgccccgc agcctcgccc cctgcccacc cgggcggccg tagggcggtc acgatgctgc
      241 cgcccttacc ctcccgcctc gggctgctgc tgctgctgct cctgtgcccg gcgcacgtcg
      301 gcggactgtg gtgggctgtg ggcagcccct tggttatgga ccctaccagc atctgcagga
      361 aggcacggcg gctggccggg cggcaggccg agttgtgcca ggctgagccg gaagtggtgg
      421 cagagctagc tcggggcgcc cggctcgggg tgcgagagtg ccagttccag ttccgcttcc
      481 gccgctggaa ttgctccagc cacagcaagg cctttggacg catcctgcaa caggacattc
      541 gggagacggc cttcgtgttc gccatcactg cggccggcgc cagccacgcc gtcacgcagg
      601 cctgttctat gggcgagctg ctgcagtgcg gctgccaggc gccccgcggg cgggcccctc
      661 cccggccctc cggcctgccc ggcacccccg gaccccctgg ccccgcgggc tccccggaag
      721 gcagcgccgc ctgggagtgg ggaggctgcg gcgacgacgt ggacttcggg gacgagaagt
      781 cgaggctctt tatggacgcg cggcacaagc ggggacgcgg agacatccgc gcgttggtgc
      841 aactgcacaa caacgaggcg ggcaggctgg ccgtgcggag ccacacgcgc accgagtgca
      901 aatgccacgg gctgtcggga tcatgcgcgc tgcgcacctg ctggcagaag ctgcctccat
      961 ttcgcgaggt gggcgcgcgg ctgctggagc gcttccacgg cgcctcacgc gtcatgggca
     1021 ccaacgacgg caaggccctg ctgcccgccg tccgcacgct caagccgccg ggccgagcgg
     1081 acctcctcta cgccgccgat tcgcccgact tctgcgcccc caaccgacgc accggctccc
     1141 ccggcacgcg cggtcgcgcc tgcaatagca gcgccccgga cctcagcggc tgcgacctgc
     1201 tgtgctgcgg ccgcgggcac cgccaggaga gcgtgcagct cgaagagaac tgcctgtgcc
     1261 gcttccactg gtgctgcgta gtacagtgcc accgctgccg tgtgcgcaag gagctcagcc
     1321 tctgcctgtg acccgccgcc cggccgctag actgacttcg cgcagcggtg gctcgcacct
     1381 gtgggacctc agggcaccgg caccgggcgc ctctcgccgc tcgagcccag cctctccctg
     1441 ccaaagccca actcccaggg ctctggaaat ggtgaggcga ggggcttgag aggaacgccc
     1501 acccacgaag gcccagggcg ccagacggcc ccgaaaaggc gctcggggag cgtttaaagg
     1561 acactgtaca ggccctccct ccccttggcc tctaggagga aacagttttt tagactggaa
     1621 aaaagccagt ctaaaggcct ctggatactg ggctccccag aactgctggc cacaggatgg
     1681 tgggtgaggt tagtatcaat aaagatattt aaaccacca
//
