LOCUS       NM_003392               5841 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens Wnt family member 5A (WNT5A), transcript variant 1,
            mRNA.
ACCESSION   NM_003392
VERSION     NM_003392.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5841)
  AUTHORS   Wilkinson,E.J., Raspin,K., Malley,R.C., Donovan,S., Nott,L.M.,
            Holloway,A.F. and Dickinson,J.L.
  TITLE     WNT5A is a putative epi-driver of prostate cancer metastasis to the
            bone
  JOURNAL   Cancer Med 13 (16), e70122 (2024)
   PUBMED   39164966
  REMARK    GeneRIF: WNT5A is a putative epi-driver of prostate cancer
            metastasis to the bone.
REFERENCE   2  (bases 1 to 5841)
  AUTHORS   Ma,J., Gan,L., Chen,H., Chen,L., Hu,Y., Luan,C., Chen,K. and
            Zhang,J.
  TITLE     Upregulated miR-374a-5p drives psoriasis pathogenesis through WIF1
            downregulation and Wnt5a/NF-kappaB activation
  JOURNAL   Cell Signal 119, 111171 (2024)
   PUBMED   38604345
  REMARK    GeneRIF: Upregulated miR-374a-5p drives psoriasis pathogenesis
            through WIF1 downregulation and Wnt5a/NF-kappaB activation.
REFERENCE   3  (bases 1 to 5841)
  AUTHORS   Liu,Y.B., Tan,X.H., Yang,H.H., Yang,J.T., Zhang,C.Y., Jin,L.,
            Yang,N.S., Guan,C.X., Zhou,Y., Liu,S.K. and Xiong,J.B.
  TITLE     Wnt5a-mediated autophagy contributes to the epithelial-mesenchymal
            transition of human bronchial epithelial cells during asthma
  JOURNAL   Mol Med 30 (1), 93 (2024)
   PUBMED   38898476
  REMARK    GeneRIF: Wnt5a-mediated autophagy contributes to the
            epithelial-mesenchymal transition of human bronchial epithelial
            cells during asthma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5841)
  AUTHORS   Strope,A.M., Phillips,C., Khadgi,S., Jenkinson,S.A.,
            Coschigano,K.T. and Malgor,R.
  TITLE     Differential expression of WNT5A long and short isoforms in
            non-muscle-invasive bladder urothelial carcinoma
  JOURNAL   Histol Histopathol 39 (6), 715-727 (2024)
   PUBMED   38445662
  REMARK    GeneRIF: Differential expression of WNT5A long and short isoforms
            in non-muscle-invasive bladder urothelial carcinoma.
REFERENCE   5  (bases 1 to 5841)
  AUTHORS   Van Den Berg,D.J., Sharma,A.K., Bruno,E. and Hoffman,R.
  TITLE     Role of members of the Wnt gene family in human hematopoiesis
  JOURNAL   Blood 92 (9), 3189-3202 (1998)
   PUBMED   9787155
REFERENCE   6  (bases 1 to 5841)
  AUTHORS   He,X., Saint-Jeannet,J.P., Wang,Y., Nathans,J., Dawid,I. and
            Varmus,H.
  TITLE     A member of the Frizzled protein family mediating axis induction by
            Wnt-5A
  JOURNAL   Science 275 (5306), 1652-1654 (1997)
   PUBMED   9054360
REFERENCE   7  (bases 1 to 5841)
  AUTHORS   Danielson,K.G., Pillarisetti,J., Cohen,I.R., Sholehvar,B.,
            Huebner,K., Ng,L.J., Nicholls,J.M., Cheah,K.S. and Iozzo,R.V.
  TITLE     Characterization of the complete genomic structure of the human
            WNT-5A gene, functional analysis of its promoter, chromosomal
            mapping, and expression in early human embryogenesis
  JOURNAL   J Biol Chem 270 (52), 31225-31234 (1995)
   PUBMED   8537388
REFERENCE   8  (bases 1 to 5841)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
REFERENCE   9  (bases 1 to 5841)
  AUTHORS   Clark,C.C., Cohen,I., Eichstetter,I., Cannizzaro,L.A.,
            McPherson,J.D., Wasmuth,J.J. and Iozzo,R.V.
  TITLE     Molecular cloning of the human proto-oncogene Wnt-5A and mapping of
            the gene (WNT5A) to chromosome 3p14-p21
  JOURNAL   Genomics 18 (2), 249-260 (1993)
   PUBMED   8288227
REFERENCE   10 (bases 1 to 5841)
  AUTHORS   Roifman,M., Brunner,H., Lohr,J., Mazzeu,J. and Chitayat,D.
  TITLE     Autosomal Dominant Robinow Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25577943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK090582.1, BC064694.1,
            AC121764.2 and BU742635.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 14, 2020 this sequence version replaced NM_003392.6.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene encodes a member of the WNT family that
            signals through both the canonical and non-canonical WNT pathways.
            This protein is a ligand for the seven transmembrane receptor
            frizzled-5 and the tyrosine kinase orphan receptor 2. This protein
            plays an essential role in regulating developmental pathways during
            embryogenesis. This protein may also play a role in oncogenesis.
            Mutations in this gene are the cause of autosomal dominant Robinow
            syndrome. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ891372.1, BC064694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264634.9/ ENSP00000264634.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK090582.1         337-339
            4-2281              BC064694.1         1-2278
            2282-5425           AC121764.2         138755-141898       c
            5426-5841           BU742635.1         18-433              c
FEATURES             Location/Qualifiers
     source          1..5841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..5841
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /note="Wnt family member 5A"
                     /db_xref="GeneID:7474"
                     /db_xref="HGNC:HGNC:12784"
                     /db_xref="MIM:164975"
     exon            1..327
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1464
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein Wnt-5a; WNT-5A protein; wingless-type
                     MMTV integration site family, member 5A; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="protein Wnt-5a isoform 1 precursor"
                     /protein_id="NP_003383.4"
                     /db_xref="CCDS:CCDS46850.1"
                     /db_xref="GeneID:7474"
                     /db_xref="HGNC:HGNC:12784"
                     /db_xref="MIM:164975"
                     /translation="MKKSIGILSPGVALGMAGSAMSSKFFLVALAIFFSFAQVVIEAN
                     SWWSLGMNNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIK
                     ECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELS
                     TCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILM
                     NLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAM
                     RLNSRGKLVQVNSRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDG
                     CELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK"
     exon            328..461
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            462..712
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            713..1005
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..5841
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3953..3958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /note="hexamer: AATAAA"
     polyA_site      3979
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
     regulatory      5818..5823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /note="hexamer: ATTAAA"
     polyA_site      5841
                     /gene="WNT5A"
                     /gene_synonym="hWNT5A"
                     /note="major polyA site"
ORIGIN      
        1 aacagttgcc tgcgcgccct cgccggaccg gcggctccct agttgcgccc cgaccaggcc
       61 ctgcccttgc tgccggctcg cgcgcgtccg cgccccctcc attcctgggc gcatcccagc
      121 tctgccccaa ctcgggagtc caggcccggg cgccagtgcc cgcttcagct ccggttcact
      181 gcgcccgccg gacgcgcgcc ggaggactcc gcagccctgc tcctgaccgt ccccccaggc
      241 ttaacccggt cgctccgctc ggattcctcg gctgcgctcg ctcgggtggc gacttcctcc
      301 ccgcgccccc tccccctcgc catgaagaag tccattggaa tattaagccc aggagttgct
      361 ttggggatgg ctggaagtgc aatgtcttcc aagttcttcc tagtggcttt ggccatattt
      421 ttctccttcg cccaggttgt aattgaagcc aattcttggt ggtcgctagg tatgaataac
      481 cctgttcaga tgtcagaagt atatattata ggagcacagc ctctctgcag ccaactggca
      541 ggactttctc aaggacagaa gaaactgtgc cacttgtatc aggaccacat gcagtacatc
      601 ggagaaggcg cgaagacagg catcaaagaa tgccagtatc aattccgaca tcgaaggtgg
      661 aactgcagca ctgtggataa cacctctgtt tttggcaggg tgatgcagat aggcagccgc
      721 gagacggcct tcacatacgc ggtgagcgca gcaggggtgg tgaacgccat gagccgggcg
      781 tgccgcgagg gcgagctgtc cacctgcggc tgcagccgcg ccgcgcgccc caaggacctg
      841 ccgcgggact ggctctgggg cggctgcggc gacaacatcg actatggcta ccgctttgcc
      901 aaggagttcg tggacgcccg cgagcgggag cgcatccacg ccaagggctc ctacgagagt
      961 gctcgcatcc tcatgaacct gcacaacaac gaggccggcc gcaggacggt gtacaacctg
     1021 gctgatgtgg cctgcaagtg ccatggggtg tccggctcat gtagcctgaa gacatgctgg
     1081 ctgcagctgg cagacttccg caaggtgggt gatgccctga aggagaagta cgacagcgcg
     1141 gcggccatgc ggctcaacag ccggggcaag ttggtacagg tcaacagccg cttcaactcg
     1201 cccaccacac aagacctggt ctacatcgac cccagccctg actactgcgt gcgcaatgag
     1261 agcaccggct cgctgggcac gcagggccgc ctgtgcaaca agacgtcgga gggcatggat
     1321 ggctgcgagc tcatgtgctg cggccgtggc tacgaccagt tcaagaccgt gcagacggag
     1381 cgctgccact gcaagttcca ctggtgctgc tacgtcaagt gcaagaagtg cacggagatc
     1441 gtggaccagt ttgtgtgcaa gtagtgggtg ccacccagca ctcagccccg ctcccaggac
     1501 ccgcttattt atagaaagta cagtgattct ggtttttggt ttttagaaat attttttatt
     1561 tttccccaag aattgcaacc ggaaccattt tttttcctgt taccatctaa gaactctgtg
     1621 gtttattatt aatattataa ttattatttg gcaataatgg gggtgggaac caagaaaaat
     1681 atttattttg tggatctttg aaaaggtaat acaagacttc ttttgatagt atagaatgaa
     1741 ggggaaataa cacataccct aacttagctg tgtggacatg gtacacatcc agaaggtaaa
     1801 gaaatacatt ttctttttct caaatatgcc atcatatggg atgggtaggt tccagttgaa
     1861 agagggtggt agaaatctat tcacaattca gcttctatga ccaaaatgag ttgtaaattc
     1921 tctggtgcaa gataaaaggt cttgggaaaa caaaacaaaa caaaacaaac ctcccttccc
     1981 cagcagggct gctagcttgc tttctgcatt ttcaaaatga taatttacaa tggaaggaca
     2041 agaatgtcat attctcaagg aaaaaaggta tatcacatgt ctcattctcc tcaaatattc
     2101 catttgcaga cagaccgtca tattctaata gctcatgaaa tttgggcagc agggaggaaa
     2161 gtccccagaa attaaaaaat ttaaaactct tatgtcaaga tgttgatttg aagctgttat
     2221 aagaattagg attccagatt gtaaaaagat ccccaaatga ttctggacac tagatttttt
     2281 tgtttgggga ggttggcttg aacataaatg aaaatatcct gttattttct tagggatact
     2341 tggttagtaa attataatag taaaaataat acatgaatcc cattcacagg ttctcagccc
     2401 aagcaacaag gtaattgcgt gccattcagc actgcaccag agcagacaac ctatttgagg
     2461 aaaaacagtg aaatccacct tcctcttcac actgagccct ctctgattcc tccgtgttgt
     2521 gatgtgatgc tggccacgtt tccaaacggc agctccactg ggtccccttt ggttgtagga
     2581 caggaaatga aacattagga gctctgcttg gaaaacagtt cactacttag ggatttttgt
     2641 ttcctaaaac ttttattttg aggagcagta gttttctatg ttttaatgac agaacttggc
     2701 taatggaatt cacagaggtg ttgcagcgta tcactgttat gatcctgtgt ttagattatc
     2761 cactcatgct tctcctattg tactgcaggt gtaccttaaa actgttccca gtgtacttga
     2821 acagttgcat ttataagggg ggaaatgtgg tttaatggtg cctgatatct caaagtcttt
     2881 tgtacataac atatatatat atatacatat atataaatat aaatataaat atatctcatt
     2941 gcagccagtg atttagattt acagtttact ctggggttat ttctctgtct agagcattgt
     3001 tgtccttcac tgcagtccag ttgggattat tccaaaagtt ttttgagtct tgagcttggg
     3061 ctgtggccct gctgtgatca taccttgagc acgacgaagc aaccttgttt ctgaggaagc
     3121 ttgagttctg actcactgaa atgcgtgttg ggttgaagat atcttttttc ttttctgcct
     3181 cacccctttg tctccaacct ccatttctgt tcactttgtg gagagggcat tacttgttcg
     3241 ttatagacat ggacgttaag agatattcaa aactcagaag catcagcaat gtttctcttt
     3301 tcttagttca ttctgcagaa tggaaaccca tgcctattag aaatgacagt acttattaat
     3361 tgagtcccta aggaatattc agcccactac atagatagct tttttttttt tttttttaat
     3421 aaggacacct ctttccaaac agtgccatca aatatgttct tatctcagac ttacgttgtt
     3481 ttaaaagttt ggaaagatac acatctttca tacccccctt aggcaggttg gctttcatat
     3541 cacctcagcc aactgtggct cttaatttat tgcataatga tattcacatc ccctcagttg
     3601 cagtgaattg tgagcaaaag atcttgaaag caaaaagcac taattagttt aaaatgtcac
     3661 ttttttggtt tttattatac aaaaaccatg aagtactttt tttatttgct aaatcagatt
     3721 gttccttttt agtgactcat gtttatgaag agagttgagt ttaacaatcc tagcttttaa
     3781 aagaaactat ttaatgtaaa atattctaca tgtcattcag atattatgta tatcttctag
     3841 cctttattct gtacttttaa tgtacatatt tctgtcttgc gtgatttgta tatttcactg
     3901 gtttaaaaaa caaacatcga aaggcttatg ccaaatggaa gatagaatat aaaataaaac
     3961 gttacttgta tattggtaag tggtttcaat tgtccttcag ataattcatg tggagatttt
     4021 tggagaaacc atgacggata gtttaggatg actacatgtc aaagtaataa aagagtggtg
     4081 aattttacca aaaccaagct atttggaagc ttcaaaaggt ttctatatgt aatggaacaa
     4141 aaggggaatt ctcttttcct atatatgttc cttacaaaaa aaaaaaaaaa agaaatcaag
     4201 cagatggctt aaagctggtt ataggattgc tcacattctt ttagcattat gcatgtaact
     4261 taattgtttt agagcgtgtt gctgttgtaa catcccagag aagaatgaaa aggcacatgc
     4321 ttttatccgt gaccagattt ttagtccaaa aaaatgtatt tttttgtgtg tttaccactg
     4381 caactattgc acctctctat ttgaatttac tgtggaccat gtgtggtgtc tctatgccct
     4441 ttgaaagcag tttttataaa aagaaagccc gggtctgcag agaatgaaaa ctggttggaa
     4501 actaaaggtt cattgtgtta agtgcaatta atacaagtta ttgtgctttt caaaaatgta
     4561 cacggaaatc tggacagtgc tccacagatt gatacattag cctttgcttt ttctctttcc
     4621 ggataacctt gtaacatatt gaaacctttt aaggatgcca agaatgcatt attccacaaa
     4681 aaaacagcag accaacatat agagtgttta aaatagcatt tctgggcaaa ttcaaactct
     4741 tgtggttcta ggactcacat ctgtttcagt ttttcctcag ttgtatattg accagtgttc
     4801 tttattgcaa aaacatatac ccgatttagc agtgtcagcg tattttttct tctcatcctg
     4861 gagcgtattc aagatcttcc caatacaaga aaattaataa aaaatttata tataggcagc
     4921 agcaaaagag ccatgttcaa aatagtcatt atgggctcaa atagaaagaa gacttttaag
     4981 ttttaatcca gtttatctgt tgagttctgt gagctactga cctcctgaga ctggcactgt
     5041 gtaagtttta gttgcctacc ctagctcttt tctcgtacaa ttttgccaat accaagtttc
     5101 aatttgtttt tacaaaacat tattcaagcc actagaatta tcaaatatga cgctatagca
     5161 gagtaaatac tctgaataag agaccggtac tagctaactc caagagatcg ttagcagcat
     5221 cagtccacaa acacttagtg gcccacaata tatagagaga tagaaaaggt agttataact
     5281 tgaagcatgt atttaatgca aataggcacg aaggcacagg tctaaaatac tacattgtca
     5341 ctgtaagcta tacttttaaa atatttattt tttttaaagt attttctagt cttttctctc
     5401 tctgtggaat ggtgaaagag agatgccgtg ttttgaaagt aagatgatga aatgaatttt
     5461 taattcaaga aacattcaga aacataggaa ttaaaactta gagaaatgat ctaatttccc
     5521 tgttcacaca aactttacac tttaatctga tgattggata ttttatttta gtgaaacatc
     5581 atcttgttag ctaactttaa aaaatggatg tagaatgatt aaaggttggt atgatttttt
     5641 tttaatgtat cagtttgaac ctagaatatt gaattaaaat gctgtctcag tattttaaaa
     5701 gcaaaaaagg aatggaggaa aattgcatct tagaccattt ttatatgcag tgtacaattt
     5761 gctgggctag aaatgagata aagattattt atttttgttc atatcttgta cttttctatt
     5821 aaaatcattt tatgaaatcc a
//
