LOCUS       NM_030761               3968 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens Wnt family member 4 (WNT4), mRNA.
ACCESSION   NM_030761
VERSION     NM_030761.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3968)
  AUTHORS   Meidyana,S., Isfandiary,S. and Primariawan,R.Y.
  TITLE     WNT4 (rs7521902 and rs16826658) polymorphism and its association
            with endometriosis - A systematic review and meta-analysis
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 295, 111-117 (2024)
   PUBMED   38354602
  REMARK    GeneRIF: WNT4 (rs7521902 and rs16826658) polymorphism and its
            association with endometriosis - A systematic review and
            meta-analysis.
REFERENCE   2  (bases 1 to 3968)
  AUTHORS   Sottnik,J.L., Shackleford,M.T., Robinson,S.K., Villagomez,F.R.,
            Bahnassy,S., Oesterreich,S., Hu,J., Madak-Erdogan,Z., Riggins,R.B.,
            Corr,B.R., Cook,L.S., Trevino,L.S., Bitler,B.G. and Sikora,M.J.
  TITLE     WNT4 Regulates Cellular Metabolism via Intracellular Activity at
            the Mitochondria in Breast and Gynecologic Cancers
  JOURNAL   Cancer Res Commun 4 (1), 134-151 (2024)
   PUBMED   38112643
  REMARK    GeneRIF: WNT4 Regulates Cellular Metabolism via Intracellular
            Activity at the Mitochondria in Breast and Gynecologic Cancers.
REFERENCE   3  (bases 1 to 3968)
  AUTHORS   Yuan,Y., Li,Y., Zhao,W., Hu,Y., Zhou,C., Long,T. and Long,L.
  TITLE     WNT4 promotes macrophage polarization via granulosa cell M-CSF and
            reduces granulosa cell apoptosis in endometriosis
  JOURNAL   Cytokine 172, 156400 (2023)
   PUBMED   37839333
  REMARK    GeneRIF: WNT4 promotes macrophage polarization via granulosa cell
            M-CSF and reduces granulosa cell apoptosis in endometriosis.
REFERENCE   4  (bases 1 to 3968)
  AUTHORS   Ragitha,T.S., Sunish,K.S., Gilvaz,S., Daniel,S., Varghese,P.R.,
            Raj,S., Francis,J. and Suresh Kumar,R.
  TITLE     Mutation analysis of WNT4 gene in SRY negative 46,XX DSD patients
            with Mullerian agenesis and/or gonadal dysgenesis- An Indian study
  JOURNAL   Gene 861, 147236 (2023)
   PUBMED   36738897
  REMARK    GeneRIF: Mutation analysis of WNT4 gene in SRY negative 46,XX DSD
            patients with Mullerian agenesis and/or gonadal dysgenesis- An
            Indian study.
REFERENCE   5  (bases 1 to 3968)
  AUTHORS   Chronopoulou,E., Koika,V., Tsiveriotis,K., Stefanidis,K.,
            Kalogeropoulos,S., Georgopoulos,N., Adonakis,G. and Kaponis,A.
  TITLE     Wnt4, Wnt6 and beta-catenin expression in human placental tissue -
            is there a link with first trimester miscarriage? Results from a
            pilot study
  JOURNAL   Reprod Biol Endocrinol 20 (1), 51 (2022)
   PUBMED   35300692
  REMARK    GeneRIF: Wnt4, Wnt6 and beta-catenin expression in human placental
            tissue - is there a link with first trimester miscarriage? Results
            from a pilot study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3968)
  AUTHORS   Vainio,S., Heikkila,M., Kispert,A., Chin,N. and McMahon,A.P.
  TITLE     Female development in mammals is regulated by Wnt-4 signalling
  JOURNAL   Nature 397 (6718), 405-409 (1999)
   PUBMED   9989404
REFERENCE   7  (bases 1 to 3968)
  AUTHORS   Lescher,B., Haenig,B. and Kispert,A.
  TITLE     sFRP-2 is a target of the Wnt-4 signaling pathway in the developing
            metanephric kidney
  JOURNAL   Dev Dyn 213 (4), 440-451 (1998)
   PUBMED   9853965
REFERENCE   8  (bases 1 to 3968)
  AUTHORS   Huguet,E.L., McMahon,J.A., McMahon,A.P., Bicknell,R. and
            Harris,A.L.
  TITLE     Differential expression of human Wnt genes 2, 3, 4, and 7B in human
            breast cell lines and normal and disease states of human breast
            tissue
  JOURNAL   Cancer Res 54 (10), 2615-2621 (1994)
   PUBMED   8168088
REFERENCE   9  (bases 1 to 3968)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
REFERENCE   10 (bases 1 to 3968)
  AUTHORS   Mohnach,L., Fechner,P.Y. and Keegan,C.E.
  TITLE     Nonsyndromic Disorders of Testicular Development Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301714
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445253.13, BC057781.1,
            AF316543.1 and AL031281.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_030761.4.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family, and is
            the first signaling molecule shown to influence the
            sex-determination cascade. It encodes a protein which shows 98%
            amino acid identity to the Wnt4 protein of mouse and rat. This gene
            and a nuclear receptor known to antagonize the testis-determining
            factor play a concerted role in both the control of female
            development and the prevention of testes formation. This gene and
            another two family members, WNT2 and WNT7B, may be associated with
            abnormal proliferation in breast tissue. Mutations in this gene can
            result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358947.1, BC057781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290167.11/ ENSP00000290167.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AL445253.13        3139-3209           c
            72-666              BC057781.1         92-686
            667-1313            AF316543.1         536-1182
            1314-3968           AL031281.6         21922-24576
FEATURES             Location/Qualifiers
     source          1..3968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..3968
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /note="Wnt family member 4"
                     /db_xref="GeneID:54361"
                     /db_xref="HGNC:HGNC:12783"
                     /db_xref="MIM:603490"
     exon            1..252
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1231
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /note="protein Wnt-4; wingless-type MMTV integration site
                     family, member 4"
                     /codon_start=1
                     /product="protein Wnt-4 precursor"
                     /protein_id="NP_110388.2"
                     /db_xref="CCDS:CCDS223.1"
                     /db_xref="GeneID:54361"
                     /db_xref="HGNC:HGNC:12783"
                     /db_xref="MIM:603490"
                     /translation="MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCE
                     KLKGLIQRQVQMCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVV
                     TQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIA
                     YGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVK
                     TCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPS
                     PDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAQVELAERCSCKFHWCC
                     FVKCRQCQRLVELHTCR"
     exon            253..488
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /inference="alignment:Splign:2.1.0"
     exon            489..620
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /inference="alignment:Splign:2.1.0"
     exon            621..763
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /inference="alignment:Splign:2.1.0"
     exon            764..3968
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1554..1559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /note="hexamer: AACAAG"
     polyA_site      1573
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
     regulatory      3948..3953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /note="hexamer: GATAAA"
     polyA_site      3968
                     /gene="WNT4"
                     /gene_synonym="SERKAL; WNT-4"
                     /note="major polyA site"
ORIGIN      
        1 agtctggtcc gcgccgggca gcgggcgcag cagcgggcag gctgccggca ggcacacgga
       61 ggcagagccc cgccgcgcgc gccccggccc gcccgcgggc gcccacctgc agccccgacg
      121 ggaggccccc cgcggccgca gccgctgccc cgggccgggc gcccgcggcg gcaccatgag
      181 tccccgctcg tgcctgcgtt cgctgcgcct cctcgtcttc gccgtcttct cagccgccgc
      241 gagcaactgg ctgtacctgg ccaagctgtc gtcggtgggg agcatctcag aggaggagac
      301 gtgcgagaaa ctcaagggcc tgatccagag gcaggtgcag atgtgcaagc ggaacctgga
      361 agtcatggac tcggtgcgcc gcggtgccca gctggccatt gaggagtgcc agtaccagtt
      421 ccggaaccgg cgctggaact gctccacact cgactccttg cccgtcttcg gcaaggtggt
      481 gacgcaaggg actcgggagg cggccttcgt gtacgccatc tcttcggcag gtgtggcctt
      541 tgcagtgacg cgggcgtgca gcagtgggga gctggagaag tgcggctgtg acaggacagt
      601 gcatggggtc agcccacagg gcttccagtg gtcaggatgc tctgacaaca tcgcctacgg
      661 tgtggccttc tcacagtcgt ttgtggatgt gcgggagaga agcaaggggg cctcgtccag
      721 cagagccctc atgaacctcc acaacaatga ggccggcagg aaggccatcc tgacacacat
      781 gcgggtggaa tgcaagtgcc acggggtgtc aggctcctgt gaggtaaaga cgtgctggcg
      841 agccgtgccg cccttccgcc aggtgggtca cgcactgaag gagaagtttg atggtgccac
      901 tgaggtggag ccacgccgcg tgggctcctc cagggcactg gtgccacgca acgcacagtt
      961 caagccgcac acagatgagg acctggtgta cttggagcct agccccgact tctgtgagca
     1021 ggacatgcgc agcggcgtgc tgggcacgag gggccgcaca tgcaacaaga cgtccaaggc
     1081 catcgacggc tgtgagctgc tgtgctgtgg ccgcggcttc cacacggcgc aggtggagct
     1141 ggctgaacgc tgcagctgca aattccactg gtgctgcttc gtcaagtgcc ggcagtgcca
     1201 gcggctcgtg gagttgcaca cgtgccgatg accgcctgcc tagccctgcg ccggcaacca
     1261 cctagtggcc cagggaaggc cgataattta aacagtctcc caccacctac cccaagagat
     1321 actggttgta ttttttgttc tggtttggtt tttgggtcct catgttattt attgccgaaa
     1381 ccaggcaggc aaccccaagg gcaccaacca gggcctcccc aaagcctggg cctttgtggc
     1441 tgccactgac caaagggacc ttgctcgtgc cgctggctgc ccgcatgtgg ctgccactga
     1501 ccactcagtt gttatctgtg tccgtttttc tacttgcaga cctaaggtgg agtaacaagg
     1561 agtattacca ccacatggct actgaccgtg tcatcgggga agagggggcc ttatggcagg
     1621 gaaaataggt accgacttga tggaagtcac accctctgga aaaaagaact cttaactctc
     1681 cagcacacat acacatggac tcctggcagc ttgagcctag aagccatgtc tctcaaatgc
     1741 cctgagaaag ggaacaagca gataccaggt caagggcacc aggttcattt cagcccttac
     1801 atggacagct agaggttcga tatctgtggg tccttccagg caagaagagg gagatgagag
     1861 caagagacga ctgaagtccc accctagaac ccagcctgcc ccagcctgcc cctgggaaga
     1921 ggaaacttaa ccactcccca gacccaccta ggcaggcata taggctgcca tcctggacca
     1981 gggatcccgg ctgtgccttt gcagtcatgc ccgagtcacc tttcacagcg ctgttcctcc
     2041 atgaaactga aacacacaca cacacacaca cacacacaca cacacacaca cacggacaca
     2101 cacacacacc tgcgagagag agggaggaaa gggctgtgcc tttgcagtca tgcccctgag
     2161 tcacctttca cagcactgtt cctccatgaa actgaaaaag gaaaacacac acacacacac
     2221 ctgcgagagg gagggaggaa agggctgtgc aataaagtcc tctcccatta tcttactcaa
     2281 cacaatttat tgagcaaata ctacgtgttc taggccctgt acaggccatc tcacttgatg
     2341 gccacaacag tcctgggaag cagacaaacc aagaatgcta atgcccatct gacatcagag
     2401 acggcagtgc tccccagacc tctcacagca agctggatgg acaggcaggg ccagaagagt
     2461 cctccagcca agcctcctcc ttggttcttg tacccaaagg tagagaaact gcaggtcttc
     2521 ttgggtctga gcctggggca ggggttctgg ctggacgaaa aggggcaggg aagcagcagg
     2581 agccagagac cacaggctga gctggagccc acatggttcc taagggcaga acaggctctg
     2641 aggaaagatg tgaacagctg gaaggctgac agtgaggtct cagcagtgtg gtgcacccct
     2701 ccccagcaca tccgagtccc tggggtccca ggtaccatag gtactgcaag atttcccaag
     2761 agacagcacc agcaacctgg gcctgaccct gtacaaccgc caaaccatca cgagccccgc
     2821 ccaggcttgt gagaaggaca tgcatggatc aagaccttgc ccttgaccca tctgcttctc
     2881 agatgggctc ccaatcacca gaggaagttg ctgtaagccc actttccaga ctgcccccac
     2941 actggggctc taagtttcag gtcggagatt ttatgctctg tgatccccca cttggggttc
     3001 ccagactcca agctcctggc tcctgtgttc agtggctgaa ttcaacgtcc gagattcgga
     3061 atatgggctc cagcctgcag aaactcttct ccaggcattg tggtttgtgc ctcctagtgt
     3121 tggctccctc atgaaaagag ggtcaacacc cttggccccc agccaagatc tctgctcaat
     3181 gtccatacaa ggaggaagcc aaaaccaagt gaggtgctgg agccacattc aaatgtggtt
     3241 gataatcttg gggcaggcca gctctgatgt ggatgaaagc tgatccaact gtcgccacag
     3301 ctgcccagct gggtccgctg ctcccctggc tggctgttca gctgtctact aagcccaaaa
     3361 aaaatactat gcctcactag cagaggctag acccagaaag agggaacaat gaggacccct
     3421 cccctcccag aggaaagagc tgagccactc tccccatcca gggaacagta ggtccaggct
     3481 ggatgctggt atgatgggaa ctgccctttt cacctgccag ggagttccta aagctgatct
     3541 tcctggggtt ctgaaggttg cgacctaggt taatgagacc aaattctagg aaccactgcc
     3601 caggccaacc accgccagtg ctgcagagat caaagaaatc cacagccaca ggaaaaggag
     3661 cttctttgga catgcccagc tccaaactgt cccaggggga actggcacag cccttacata
     3721 gcccaccccc tcttggcctc accgtggcct ggaaattggc cagagggtcc acatcctgcc
     3781 caaaccactc tcctctcgtc ccaaggcaaa ggtgatgccc tgaggcctag ggctggataa
     3841 agcccagctc tggatgctgc taacccactc tgctgcccca ccccatcctc caatttttat
     3901 actaggctct ttgccattgt gacgtcccat gacatagtct gatgcacgat aaaacaatta
     3961 tttcttta
//
