LOCUS       NM_033131               2996 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Wnt family member 3A (WNT3A), mRNA.
ACCESSION   NM_033131
VERSION     NM_033131.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Zuo,X., Wang,X., Ma,T., Chen,S., Cao,P., Cheng,H., Yang,N., Han,X.,
            Gao,W., Liu,X. and Sun,Y.
  TITLE     TNFRSF19 within the 13q12.12 Risk Locus Functions as a Lung Cancer
            Suppressor by Binding Wnt3a to Inhibit Wnt/beta-Catenin Signaling
  JOURNAL   Mol Cancer Res 22 (3), 227-239 (2024)
   PUBMED   38047807
  REMARK    GeneRIF: TNFRSF19 within the 13q12.12 Risk Locus Functions as a
            Lung Cancer Suppressor by Binding Wnt3a to Inhibit Wnt/beta-Catenin
            Signaling.
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Meng,X. and Zhu,H.
  TITLE     SOX9 Inhibits the Progression of Osteonecrosis of the Femoral Head
            via the Activation of the Wnt/Beta-Catenin Pathway
  JOURNAL   J Invest Surg 36 (1), 2197054 (2023)
   PUBMED   37076124
  REMARK    GeneRIF: SOX9 Inhibits the Progression of Osteonecrosis of the
            Femoral Head via the Activation of the Wnt/Beta-Catenin Pathway.
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Wang,J., Shen,D., Li,S., Li,Q., Zuo,Q., Lu,J., Tang,D., Feng,Y.,
            Yin,P., Chen,C. and Chen,T.
  TITLE     LINC00665 activating Wnt3a/beta-catenin signaling by bond with YBX1
            promotes gastric cancer proliferation and metastasis
  JOURNAL   Cancer Gene Ther 30 (11), 1530-1542 (2023)
   PUBMED   37563362
  REMARK    GeneRIF: LINC00665 activating Wnt3a/beta-catenin signaling by bond
            with YBX1 promotes gastric cancer proliferation and metastasis.
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Bitencourt Reis,C.L., Nakane Matsumoto,M.A., Baratto-Filho,F.,
            Scariot,R., Sasso Stuani,M.B., Lourenco Romano,F., Della
            Coletta,R., Silva Barroso de Oliveira,D., Proff,P., Kirschneck,C.
            and Calvano Kuchler,E.
  TITLE     Impact of genetic variations in the WNT family members and RUNX2 on
            dental and skeletal maturation: a cross-sectional study
  JOURNAL   Head Face Med 19 (1), 26 (2023)
   PUBMED   37400934
  REMARK    GeneRIF: Impact of genetic variations in the WNT family members and
            RUNX2 on dental and skeletal maturation: a cross-sectional study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Gao,L., Sun,Y., Zhang,X., Ma,D., Xie,A., Wang,E., Cheng,L. and
            Liu,S.
  TITLE     Wnt3a-Loaded Extracellular Vesicles Promote Alveolar Epithelial
            Regeneration after Lung Injury
  JOURNAL   Adv Sci (Weinh) 10 (18), e2206606 (2023)
   PUBMED   37072558
  REMARK    GeneRIF: Wnt3a-Loaded Extracellular Vesicles Promote Alveolar
            Epithelial Regeneration after Lung Injury.
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Tanaka,K., Okabayashi,K., Asashima,M., Perrimon,N. and Kadowaki,T.
  TITLE     The evolutionarily conserved porcupine gene family is involved in
            the processing of the Wnt family
  JOURNAL   Eur J Biochem 267 (13), 4300-4311 (2000)
   PUBMED   10866835
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   Lee,C.S., Buttitta,L.A., May,N.R., Kispert,A. and Fan,C.M.
  TITLE     SHH-N upregulates Sfrp2 to mediate its competitive interaction with
            WNT1 and WNT4 in the somitic mesoderm
  JOURNAL   Development 127 (1), 109-118 (2000)
   PUBMED   10654605
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Gazit,A., Yaniv,A., Bafico,A., Pramila,T., Igarashi,M.,
            Kitajewski,J. and Aaronson,S.A.
  TITLE     Human frizzled 1 interacts with transforming Wnts to transduce a
            TCF dependent transcriptional response
  JOURNAL   Oncogene 18 (44), 5959-5966 (1999)
   PUBMED   10557084
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Huguet,E.L., McMahon,J.A., McMahon,A.P., Bicknell,R. and
            Harris,A.L.
  TITLE     Differential expression of human Wnt genes 2, 3, 4, and 7B in human
            breast cell lines and normal and disease states of human breast
            tissue
  JOURNAL   Cancer Res 54 (10), 2615-2621 (1994)
   PUBMED   8168088
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136379.19, DA742143.1,
            AB060284.1, AK056278.1 and CA437424.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033131.3.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. It
            encodes a protein which shows 96% amino acid identity to mouse
            Wnt3A protein, and 84% to human WNT3 protein, another WNT gene
            product. This gene is clustered with WNT14 gene, another family
            member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056278.1, SRR14038193.3009024.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284523.2/ ENSP00000284523.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL136379.19        113908-113931       c
            25-521              DA742143.1         1-497
            522-1681            AB060284.1         396-1555
            1682-2985           AK056278.1         1629-2932
            2986-2996           CA437424.1         17-27               c
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..2996
                     /gene="WNT3A"
                     /note="Wnt family member 3A"
                     /db_xref="GeneID:89780"
                     /db_xref="HGNC:HGNC:15983"
                     /db_xref="MIM:606359"
     exon            1..202
                     /gene="WNT3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1190
                     /gene="WNT3A"
                     /note="protein Wnt-3a; wingless-type MMTV integration site
                     family, member 3A"
                     /codon_start=1
                     /product="protein Wnt-3a precursor"
                     /protein_id="NP_149122.1"
                     /db_xref="CCDS:CCDS1564.1"
                     /db_xref="GeneID:89780"
                     /db_xref="HGNC:HGNC:15983"
                     /db_xref="MIM:606359"
                     /translation="MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCAS
                     IPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVL
                     DKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIE
                     FGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCW
                     WSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEA
                     SPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWC
                     CYVSCQECTRVYDVHTCK"
     exon            203..444
                     /gene="WNT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            445..710
                     /gene="WNT3A"
                     /inference="alignment:Splign:2.1.0"
     exon            711..2996
                     /gene="WNT3A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2996
                     /gene="WNT3A"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacaccc gcgcacccgc ggccgcagga gggcccagcg acgccgccgc gccagctccc
       61 agggcccggc cccccccggc gctcacgctc tcggggcgga ctcccggccc tccgcgccct
      121 ctcgcgcggc gatggcccca ctcggatact tcttactcct ctgcagcctg aagcaggctc
      181 tgggcagcta cccgatctgg tggtcgctgg ctgttgggcc acagtattcc tccctgggct
      241 cgcagcccat cctgtgtgcc agcatcccgg gcctggtccc caagcagctc cgcttctgca
      301 ggaactacgt ggagatcatg cccagcgtgg ccgagggcat caagattggc atccaggagt
      361 gccagcacca gttccgcggc cgccggtgga actgcaccac cgtccacgac agcctggcca
      421 tcttcgggcc cgtgctggac aaagctacca gggagtcggc ctttgtccac gccattgcct
      481 cagccggtgt ggcctttgca gtgacacgct catgtgcaga aggcacggcc gccatctgtg
      541 gctgcagcag ccgccaccag ggctcaccag gcaagggctg gaagtggggt ggctgtagcg
      601 aggacatcga gtttggtggg atggtgtctc gggagttcgc cgacgcccgg gagaaccggc
      661 cagatgcccg ctcagccatg aaccgccaca acaacgaggc tgggcgccag gccatcgcca
      721 gccacatgca cctcaagtgc aagtgccacg ggctgtcggg cagctgcgag gtgaagacat
      781 gctggtggtc gcaacccgac ttccgcgcca tcggtgactt cctcaaggac aagtacgaca
      841 gcgcctcgga gatggtggtg gagaagcacc gggagtcccg cggctgggtg gagaccctgc
      901 ggccgcgcta cacctacttc aaggtgccca cggagcgcga cctggtctac tacgaggcct
      961 cgcccaactt ctgcgagccc aaccctgaga cgggctcctt cggcacgcgc gaccgcacct
     1021 gcaacgtcag ctcgcacggc atcgacggct gcgacctgct gtgctgcggc cgcggccaca
     1081 acgcgcgagc ggagcggcgc cgggagaagt gccgctgcgt gttccactgg tgctgctacg
     1141 tcagctgcca ggagtgcacg cgcgtctacg acgtgcacac ctgcaagtag gcaccggccg
     1201 cggctccccc tggacggggc gggccctgcc tgagggtggg cttttccctg ggtggagcag
     1261 gactcccacc taaacggggc agtactcctc cctgggggcg ggactcctcc ctgggggtgg
     1321 ggctcctacc tgggggcaga actcctacct gaaggcaggg ctcctccctg gagctagtgt
     1381 ctcctctctg gtggctgggc tgctcctgaa tgaggcggag ctccaggatg gggaggggct
     1441 ctgcgttggc ttctccctgg ggacggggct cccctggaca gaggcggggc tacagattgg
     1501 gcggggcttc tcttgggtgg gacagggctt ctcctgcggg ggcgaggccc ctcccagtaa
     1561 gggcgtggct ctgggtgggc ggggcactag gtaggcttct acctgcaggc ggggctcctc
     1621 ctgaaggagg cggggctcta ggatggggca cggctctggg gtaggctgct ccctgagggc
     1681 ggagcgcctc cttaggagtg gggttttatg gtggatgagg cttcttcctg gatggggcag
     1741 agcttctcct gaccagggca aggccccttc cacgggggct gtggctctgg gtgggcgtgg
     1801 cctgcatagg ctccttcctg tgggtggggc ttctctggga ccaggctcca atggggcggg
     1861 gcttctctcc gcgggtggga ctcttccctg ggaaccgccc tcctgattaa ggcgtggctt
     1921 ctgcaggaat cccggctcca gagcaggaaa ttcagcccac cagccacctc atccccaacc
     1981 ccctgtaagg ttccatccac ccctgcgtcg agctgggaag gttccatgaa gcgagtcggg
     2041 tccccaaccc gtgcccctgg gatccgaggg cccctctcca agcgcctggc tttggaatgc
     2101 tccaggcgcg ccgacgcctg tgccacccct tcctcagcct ggggtttgac cacccacctg
     2161 accaggggcc ctacctgggg aaagcctgaa gggcctccca gcccccaacc ccaagaccaa
     2221 gcttagtcct gggagaggac agggacttcg cagaggcaag cgaccgaggc cctcccaaag
     2281 aggcccgccc tgcccgggct cccacaccgt caggtactcc tgccagggaa ctggcctgct
     2341 gcgccccagg ccccgcccgt ctctgctctg ctcagctgcg cccccttctt tgcagctgcc
     2401 cagcccctcc tccctgccct cgggtctccc cacctgcact ccatccagct acaggagaga
     2461 tagaagcctc tcgtcccgtc cctccctttc ctccgcctgt ccacagcccc ttaagggaaa
     2521 ggtaggaaga gaggtccagc cccccaggct gcccagagct gctggtctca tttgggggcg
     2581 ttcgggaggt ttggggggca tcaacccccc gactgtgctg ctcgcgaagg tcccacagcc
     2641 ctgagatggg ccggccccct tcctggcccc tcatggcggg actggagaaa tggtccgctt
     2701 tcctggagcc aatggcccgg cccctcctga ctcatccgcc tggcccggga atgaatgggg
     2761 aggccgctga acccacccgg cccatatccc tggttgcctc atggccagcg cccctcagcc
     2821 tctgccactg tgaaccggct cccaccctca aggtgcgggg agaagaagcg gccaggcggg
     2881 gcgccccaag agcccaaaag agggcacacc gccatcctct gcctcaaatt ctgcgttttt
     2941 ggttttaatg ttatatctga tgctgctata tccactgtcc aacggagtta gacgaa
//
