LOCUS       NM_030753               3287 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens Wnt family member 3 (WNT3), mRNA.
ACCESSION   NM_030753
VERSION     NM_030753.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3287)
  AUTHORS   Bhandari,R., Shaikh,I.I., Bhandari,R. and Chapagain,S.
  TITLE     LINC01023 Promotes the Hepatoblastoma Tumorigenesis via
            miR-378a-5p/WNT3 Axis
  JOURNAL   Mol Cell Biochem 478 (8), 1867-1885 (2023)
   PUBMED   36576714
  REMARK    GeneRIF: LINC01023 Promotes the Hepatoblastoma Tumorigenesis via
            miR-378a-5p/WNT3 Axis.
REFERENCE   2  (bases 1 to 3287)
  AUTHORS   Schule,S., Bristy,E.A., Muhtadi,R., Kaletka,G., Stewart,S.,
            Ostheim,P., Hermann,C., Asang,C., Pleimes,D., Port,M. and Abend,M.
  TITLE     Four Genes Predictive for the Severity of Hematological Damage
            Reveal a Similar Response after X Irradiation and Chemotherapy
  JOURNAL   Radiat Res 199 (2), 115-123 (2023)
   PUBMED   36480042
  REMARK    GeneRIF: Four Genes Predictive for the Severity of Hematological
            Damage Reveal a Similar Response after X Irradiation and
            Chemotherapy.
REFERENCE   3  (bases 1 to 3287)
  AUTHORS   Zhang,L., Sang,M., Li,Y., Li,Y., Yuan,E., Yang,L., Shi,W., Yuan,Y.,
            Yang,B., Yang,P. and Yuan,E.
  TITLE     WNT3 hypomethylation counteracts low activity of the Wnt signaling
            pathway in the placenta of preeclampsia
  JOURNAL   Cell Mol Life Sci 78 (21-22), 6995-7008 (2021)
   PUBMED   34608506
  REMARK    GeneRIF: WNT3 hypomethylation counteracts low activity of the Wnt
            signaling pathway in the placenta of preeclampsia.
REFERENCE   4  (bases 1 to 3287)
  AUTHORS   Michelli,M., Zougros,A., Chatziandreou,I., Michalopoulos,N.V.,
            Lazaris,A.C. and Saetta,A.A.
  TITLE     Concurrent Wnt pathway component expression in breast and
            colorectal cancer
  JOURNAL   Pathol Res Pract 216 (7), 153005 (2020)
   PUBMED   32534708
  REMARK    GeneRIF: Concurrent Wnt pathway component expression in breast and
            colorectal cancer.
REFERENCE   5  (bases 1 to 3287)
  AUTHORS   Xu,Y., Zhang,S., Fu,D. and Lu,D.
  TITLE     Circulating miR-374b-5p negatively regulates osteoblast
            differentiation in the progression of osteoporosis via targeting
            Wnt3 AND Runx2
  JOURNAL   J Biol Regul Homeost Agents 34 (2), 345-355 (2020)
   PUBMED   32548991
  REMARK    GeneRIF: Circulating miR-374b-5p negatively regulates osteoblast
            differentiation in the progression of osteoporosis via targeting
            Wnt3 AND Runx2.
REFERENCE   6  (bases 1 to 3287)
  AUTHORS   Huguet,E.L., McMahon,J.A., McMahon,A.P., Bicknell,R. and
            Harris,A.L.
  TITLE     Differential expression of human Wnt genes 2, 3, 4, and 7B in human
            breast cell lines and normal and disease states of human breast
            tissue
  JOURNAL   Cancer Res 54 (10), 2615-2621 (1994)
   PUBMED   8168088
REFERENCE   7  (bases 1 to 3287)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
REFERENCE   8  (bases 1 to 3287)
  AUTHORS   Roelink,H., Wang,J., Black,D.M., Solomon,E. and Nusse,R.
  TITLE     Molecular cloning and chromosomal localization to 17q21 of the
            human WNT3 gene
  JOURNAL   Genomics 17 (3), 790-792 (1993)
   PUBMED   8244403
REFERENCE   9  (bases 1 to 3287)
  AUTHORS   Niemann,S.
  TITLE     Tetra-Amelia Syndrome - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301453
REFERENCE   10 (bases 1 to 3287)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB462855.1, BC114219.1 and
            CX872929.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_030753.4.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. It
            encodes a protein which shows 98% amino acid identity to mouse Wnt3
            protein, and 84% to human WNT3A protein, another WNT gene product.
            The mouse studies show the requirement of Wnt3 in primary axis
            formation in the mouse. Studies of the gene expression suggest that
            this gene may play a key role in some cases of human breast,
            rectal, lung, and gastric cancer through activation of the
            WNT-beta-catenin-TCF signaling pathway. This gene is clustered with
            WNT15, another family member, in the chromosome 17q21 region.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC114219.1, SRR1803616.121826.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225512.6/ ENSP00000225512.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                DB462855.1         69-145
            78-1551             BC114219.1         1-1474
            1552-1961           CX872929.1         32-441
            1962-3287           BC114219.1         1886-3211
FEATURES             Location/Qualifiers
     source          1..3287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31-q21.32"
     gene            1..3287
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /note="Wnt family member 3"
                     /db_xref="GeneID:7473"
                     /db_xref="HGNC:HGNC:12782"
                     /db_xref="MIM:165330"
     exon            1..175
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1163
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /note="WNT-3 proto-oncogene protein; proto-oncogene Wnt-3;
                     proto-oncogene Int-4 homolog; wingless-type MMTV
                     integration site family, member 3"
                     /codon_start=1
                     /product="proto-oncogene Wnt-3 precursor"
                     /protein_id="NP_110380.1"
                     /db_xref="CCDS:CCDS11505.1"
                     /db_xref="GeneID:7473"
                     /db_xref="HGNC:HGNC:12782"
                     /db_xref="MIM:165330"
                     /translation="MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLL
                     CGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFG
                     PVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSE
                     DADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVK
                     TCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVY
                     YENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIF
                     HWCCYVSCQECIRIYDVHTCK"
     exon            176..417
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /inference="alignment:Splign:2.1.0"
     exon            418..683
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1171
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..3287
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3203..3208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /note="hexamer: AATATA"
     polyA_site      3225
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
     regulatory      3260..3265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /note="hexamer: ATTAAA"
     polyA_site      3287
                     /gene="WNT3"
                     /gene_synonym="INT4; TETAMS"
                     /note="major polyA site"
ORIGIN      
        1 atttccaatc tcaagtggac tttgttccaa ctattggggg cgtcgctccc cctcttcatg
       61 gtcgcgggca aacttcctcc tcggcgcctc ttctaatgga gccccacctg ctcgggctgc
      121 tcctcggcct cctgctcggt ggcaccaggg tcctcgctgg ctacccaatt tggtggtccc
      181 tggccctggg ccagcagtac acatctctgg gctcacagcc cctgctctgc ggctccatcc
      241 caggcctggt ccccaagcaa ctgcgcttct gccgcaatta catcgagatc atgcccagcg
      301 tggccgaggg cgtgaagctg ggcatccagg agtgccagca ccagttccgg ggccgccgct
      361 ggaactgcac caccatagat gacagcctgg ccatctttgg gcccgtcctc gacaaagcca
      421 cccgcgagtc ggccttcgtt cacgccatcg cctcggccgg cgtggccttc gccgtcaccc
      481 gctcctgcgc cgagggcacc tccaccattt gcggctgtga ctcgcatcat aaggggccgc
      541 ctggcgaagg ctggaagtgg ggcggctgca gcgaggacgc tgacttcggc gtgttagtgt
      601 ccagggagtt cgcggatgcg cgcgagaaca ggccggacgc gcgctcggcc atgaacaagc
      661 acaacaacga ggcgggccgc acgactatcc tggaccacat gcacctcaaa tgcaagtgcc
      721 acgggctgtc gggcagctgt gaggtgaaga cctgctggtg ggcgcagcct gacttccgtg
      781 ccatcggtga cttcctcaag gacaagtatg acagcgcctc ggagatggta gtagagaagc
      841 accgtgagtc ccgaggctgg gtggagaccc tccgggccaa gtactcgctc ttcaagccac
      901 ccacggagag ggacctggtc tactacgaga actcccccaa cttttgtgag cccaacccag
      961 agacgggttc ctttggcaca agggaccgga cttgcaatgt cacctcccac ggcatcgatg
     1021 gctgcgatct gctctgctgt ggccggggcc acaacacgag gacggagaag cggaaggaaa
     1081 aatgccactg catcttccac tggtgctgct acgtcagctg ccaggagtgt attcgcatct
     1141 acgacgtgca cacctgcaag tagggcacca gggcgctggg aaggggtgaa gtgtgtggct
     1201 gggcggattc agcgaagtct catgggaagc aggacctaga gccgggcaca gccctcagcg
     1261 tcagacagca aggaactgtc accagccgca cgcgtggtaa atgacccaga cccaactcgc
     1321 ctgtggacgg ggaggctctc cctctctctc atcttacatt tctcacccta ctctggatgg
     1381 tgtgtggttt ttaaagaagg gggctttctt tttagttctc tagggtctga taggaacaga
     1441 cctgaggctt atctttgcac atgttaaaga aaataaaaat gaaaaaaaat ttgactccaa
     1501 cagaacaggc tgggctaatg tgagctctca gcctggcagt caagacatca gcatgggcaa
     1561 ggttctgttt ccaaactgct gcttctggtg acattccaag acgcctggag ggtgggagtc
     1621 aggaagtagg acacacccct gcagtctcct tttcttggtc cactcccatt caaatttgag
     1681 ctaatttctc attctgataa aagccatagg tttagctagg atgaagtggt aggaaggtcc
     1741 gtggcagttg ttagagtagg atttggagtt tggaagaact ggcagctcag ggtggcctgg
     1801 tcagccgttt gaagagcagc catgtgttct tctcagtctc attttctcta taaccctgtt
     1861 ctgcacgagg ggcagtcaga tctcaaaatc tttttctacc attctgcagt ttccaccgtc
     1921 aatgcagttt tttttttgtt tttttgtttt tttttttttt tggtggtagt ggaccttgta
     1981 aataggctat gtaagggggc aagtcttctc tagctcaaat ggcttcctaa ataaataagc
     2041 ggtatcttca gaaggggcca ttcagtcctt cccagccctg ctcacctgca gattctctgt
     2101 acaaataact ccaggtagag cagttggact ccaggtcacc ttagtataag ttagacaaag
     2161 ggtccgtgag ggagtagcca tcaattcctg aaattccaac tttgtgacta gcagatgggg
     2221 aggatgaaaa ccatcccttt gcttcctctc caatacggac ccatcttact gtgtcctttc
     2281 ctctctgggg ccaatgtgag taaacacaga cacagagttc tttcccccag ctcttcctcc
     2341 ctcacctgca tgctgagata gcttccatcc atgcagttcc caaggatctg gattagaagt
     2401 tcaaagggga accagcagtc acctactccc ttaggtgaag catctcacgg ctgagttctc
     2461 cctgaggcat actggtccag ctgagcgtcc tagagaaagc tagcaaaagg gaggcacatg
     2521 gatttcacag tatgaattgg ttcaacaact gtcttaggga gaatcagaaa gaagagatgc
     2581 agcaggggaa tgagcagaac aaagattttt ctttctcccc cttctctctg gggtctacct
     2641 aaccctgacc taaaatacca gggcagcgat ctcccagctg gtgcaggtgg gcttgccaag
     2701 atggtcgtcc aggagcccgc cttcacttct aaatctgctg gccacaagcc ctgctaaaga
     2761 tacacatctc accccctccg ccaagtctga aatgcccctc cccatctcac cttagactga
     2821 aaagttttaa atcatgtcaa ctggataata cttgctttat gtgagaatac ttcagcagaa
     2881 tggatacgaa ttttcaaaac aatcttttca tatctatgta ttctatatta aaagtgataa
     2941 agtcatgttt ctggggcgta ttcaagtagc tgacaagtaa ttatttaata atagtacatg
     3001 agtgcattgt aatgattctc gccgtagtca ggtaatagta tccaaccgaa atttcctacc
     3061 aacctgctgt atccaaagtt ttgtaaaaag ttgtagaagt tgttgatctt tttgatttta
     3121 tattcaaaaa gtctcttttt ataaatatta tttattatac aatgtatata cctttgagtt
     3181 aactaagatt atatattata taaatatata tatatttgga gaaaatatat ttcatcatgc
     3241 agtttttttc tgttaagtca ttaaagagaa ggtaaacaaa cctaaaa
//
