LOCUS       NM_024494              11130 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens Wnt family member 2B (WNT2B), transcript variant
            WNT-2B2, mRNA.
ACCESSION   NM_024494
VERSION     NM_024494.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11130)
  AUTHORS   Lan,L., Huang,C., Liu,D., Cheng,Y., Tang,R., Gu,J., Geng,L.,
            Cheng,Y. and Gong,S.
  TITLE     WNT2B activates macrophages via NF-kappaB signaling pathway in
            inflammatory bowel disease
  JOURNAL   FASEB J 38 (6), e23551 (2024)
   PUBMED   38489235
  REMARK    GeneRIF: WNT2B activates macrophages via NF-kappaB signaling
            pathway in inflammatory bowel disease.
REFERENCE   2  (bases 1 to 11130)
  AUTHORS   O'Connell,A.E., Raveenthiraraj,S., Oliveira,L.F.S., Adegboye,C.,
            Dasuri,V.S., Qi,W., Khetani,R.S., Singh,A., Sundaram,N., Lin,J.,
            Nandivada,P., Rincon-Cruz,L., Goldsmith,J.D., Thiagarajah,J.R.,
            Carlone,D.L., Turner,J.R., Agrawal,P.B., Helmrath,M. and
            Breault,D.T.
  TITLE     WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to
            Increased Inflammatory Cytokine Production
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (2), 101349 (2024)
   PUBMED   38697357
  REMARK    GeneRIF: WNT2B Deficiency Causes Enhanced Susceptibility to Colitis
            Due to Increased Inflammatory Cytokine Production.
REFERENCE   3  (bases 1 to 11130)
  AUTHORS   Cheng,Y.L., Xiao,S.Z., Liu,D.Q., Geng,L.L., Gu,J.B., Tang,R.,
            Lan,L., Zhu,Y., Chen,P.Y., He,Z.H., Gong,S.T. and Cheng,Y.
  TITLE     [Mechanism of intestinal injury induced by WNT2B high-expressed
            fibroblasts in Crohn's disease]
  JOURNAL   Zhonghua Er Ke Za Zhi 61 (7), 606-613 (2023)
   PUBMED   37385803
  REMARK    GeneRIF: [Mechanism of intestinal injury induced by WNT2B
            high-expressed fibroblasts in Crohn's disease].
REFERENCE   4  (bases 1 to 11130)
  AUTHORS   Xiao,S., Cheng,Y., Zhu,Y., Tang,R., Gu,J., Lan,L., He,Z., Liu,D.,
            Geng,L., Cheng,Y. and Gong,S.
  TITLE     [Fibroblasts overpressing WNT2b cause impairment of intestinal
            mucosal barrier]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (2), 206-212 (2023)
   PUBMED   36946039
  REMARK    GeneRIF: [Fibroblasts overpressing WNT2b cause impairment of
            intestinal mucosal barrier].
REFERENCE   5  (bases 1 to 11130)
  AUTHORS   Tang,T., Rector,K., Barnett,C.D. and Mao,C.D.
  TITLE     Upstream open reading frames regulate the expression of the nuclear
            Wnt13 isoforms
  JOURNAL   Biochem Biophys Res Commun 366 (4), 1081-1088 (2008)
   PUBMED   18155664
REFERENCE   6  (bases 1 to 11130)
  AUTHORS   Katoh,M., Kirikoshi,H., Saitoh,T., Sagara,N. and Koike,J.
  TITLE     Alternative splicing of the WNT-2B/WNT-13 gene
  JOURNAL   Biochem Biophys Res Commun 275 (1), 209-216 (2000)
   PUBMED   10944466
REFERENCE   7  (bases 1 to 11130)
  AUTHORS   Van Den Berg,D.J., Sharma,A.K., Bruno,E. and Hoffman,R.
  TITLE     Role of members of the Wnt gene family in human hematopoiesis
  JOURNAL   Blood 92 (9), 3189-3202 (1998)
   PUBMED   9787155
REFERENCE   8  (bases 1 to 11130)
  AUTHORS   Bergstein,I., Eisenberg,L.M., Bhalerao,J., Jenkins,N.A.,
            Copeland,N.G., Osborne,M.P., Bowcock,A.M. and Brown,A.M.
  TITLE     Isolation of two novel WNT genes, WNT14 and WNT15, one of which
            (WNT15) is closely linked to WNT3 on human chromosome 17q21
  JOURNAL   Genomics 46 (3), 450-458 (1997)
   PUBMED   9441749
REFERENCE   9  (bases 1 to 11130)
  AUTHORS   Katoh,M., Hirai,M., Sugimura,T. and Terada,M.
  TITLE     Cloning, expression and chromosomal localization of Wnt-13, a novel
            member of the Wnt gene family
  JOURNAL   Oncogene 13 (4), 873-876 (1996)
   PUBMED   8761309
REFERENCE   10 (bases 1 to 11130)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC141825.1 and AL109932.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024494.2.
            
            Summary: This gene encodes a member of the wingless-type MMTV
            integration site (WNT) family of highly conserved, secreted
            signaling factors. WNT family members function in a variety of
            developmental processes including regulation of cell growth and
            differentiation and are characterized by a WNT-core domain. This
            gene may play a role in human development as well as
            carcinogenesis. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (WNT-2B2) represents the shortest
            transcript and encodes the longest isoform (WNT-2B2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141825.1, SRR1803616.108706.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369684.5/ ENSP00000358698.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2253              BC141825.1         218-2470
            2254-11130          AL109932.15        4107-12983
FEATURES             Location/Qualifiers
     source          1..11130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..11130
                     /gene="WNT2B"
                     /gene_synonym="WNT13"
                     /note="Wnt family member 2B"
                     /db_xref="GeneID:7482"
                     /db_xref="HGNC:HGNC:12781"
                     /db_xref="MIM:601968"
     exon            1..480
                     /gene="WNT2B"
                     /gene_synonym="WNT13"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1474
                     /gene="WNT2B"
                     /gene_synonym="WNT13"
                     /note="isoform WNT-2B2 is encoded by transcript variant
                     WNT-2B2; XWNT2, Xenopus, homolog of; wingless-type MMTV
                     integration site family, member 13; protein Wnt-2b;
                     wingless-type MMTV integration site family, member 2B"
                     /codon_start=1
                     /product="protein Wnt-2b isoform WNT-2B2"
                     /protein_id="NP_078613.1"
                     /db_xref="CCDS:CCDS847.1"
                     /db_xref="GeneID:7482"
                     /db_xref="HGNC:HGNC:12781"
                     /db_xref="MIM:601968"
                     /translation="MLRPGGAEEAAQLPLRRASAPVPVPSPAAPDGSRASARLGLACL
                     LLLLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGARE
                     WIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQ
                     GELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMN
                     LHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVM
                     ATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDG
                     CEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT"
     exon            481..701
                     /gene="WNT2B"
                     /gene_synonym="WNT13"
                     /inference="alignment:Splign:2.1.0"
     exon            702..979
                     /gene="WNT2B"
                     /gene_synonym="WNT13"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1244
                     /gene="WNT2B"
                     /gene_synonym="WNT13"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..11130
                     /gene="WNT2B"
                     /gene_synonym="WNT13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11112..11117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT2B"
                     /gene_synonym="WNT13"
                     /note="hexamer: AGTAAA"
     polyA_site      11130
                     /gene="WNT2B"
                     /gene_synonym="WNT13"
                     /note="major polyA site"
ORIGIN      
        1 gcacactagg cccgcagctc ccttcagcgc cgcagacccc ctgacaccgc acccggtcct
       61 caggcagcgc gccccagacc ccgggttcgg cacgccgtcg tcggcttccg gacatcgcaa
      121 cttgcgcccc tctcggggat cctcctcccg ggctctggac cccaggtgat cctaggtccc
      181 cagccgccgg cgaacaccat ggccccccag gggggtgagg taggagcagc ctgagtaccc
      241 ccagaaggtg ccccgtccac gcccctccgg gctgcgcggc gggagtcttc ggggagctat
      301 gctgagaccg ggtggtgcgg aggaagctgc gcagctcccg cttcggcgcg ccagcgcccc
      361 ggtccctgtg ccgtcgcccg cggcccccga cggctcccgg gcttcggccc gcctaggtct
      421 tgcctgcctt ctgctcctgc tgctgctgac gctgccggcc cgcgtagaca cgtcctggtg
      481 gtacattggg gcactggggg cacgagtgat ctgtgacaat atccctggtt tggtgagccg
      541 gcagcggcag ctgtgccagc gttacccaga catcatgcgt tcagtgggcg agggtgcccg
      601 agaatggatc cgagagtgtc agcaccaatt ccgccaccac cgctggaact gtaccaccct
      661 ggaccgggac cacaccgtct ttggccgtgt catgctcaga agtagccgag aggcagcttt
      721 tgtatatgcc atctcatcag caggggtagt ccacgctatt actcgcgcct gtagccaggg
      781 tgaactgagt gtgtgcagct gtgaccccta cacccgtggc cgacaccatg accagcgtgg
      841 ggactttgac tggggtggct gcagtgacaa catccactac ggtgtccgtt ttgccaaggc
      901 cttcgtggat gccaaggaga agaggcttaa ggatgcccgg gccctcatga acttacataa
      961 taaccgctgt ggtcgcacgg ctgtgcggcg gtttctgaag ctggagtgta agtgccatgg
     1021 cgtgagtggt tcctgtactc tgcgcacctg ctggcgtgca ctctcagatt tccgccgcac
     1081 aggtgattac ctgcggcgac gctatgatgg ggctgtgcag gtgatggcca cccaagatgg
     1141 tgccaacttc accgcagccc gccaaggcta tcgccgtgcc acccggactg atcttgtcta
     1201 ctttgacaac tctccagatt actgtgtctt ggacaaggct gcaggttccc taggcactgc
     1261 aggccgtgtc tgcagcaaga catcaaaagg aacagacggt tgtgaaatca tgtgctgtgg
     1321 ccgagggtac gacacaactc gagtcacccg tgttacccag tgtgagtgca aattccactg
     1381 gtgctgtgct gtacggtgca aggaatgcag aaatactgtg gacgtccata cttgcaaagc
     1441 ccccaagaag gcagagtggc tggaccaaac ctgaacacac agatacctca ctcatccctc
     1501 caattcaagc ctctcaactc aaaagcacaa gatccttgca tgcacacctt cctccaccct
     1561 ccaccctggg ctgctaccgc ttctatttaa ggatgtagag agtaatccat agggaccatg
     1621 gtgtcctggc tggttcctta gccctgggaa ggagttgtca ggggatataa gaaactgagc
     1681 aagctccctg atttcccgct ctggagattt gaagggagag tagaagagat agggggtctt
     1741 tagagtgaaa tgagttgcac taaagtacgt agttgaggct ccttttttct ttcctttgca
     1801 ccagcttccc gatacttctt ggtgtgcaag aggaagggta cctgtagaga gcttcttttt
     1861 gtttctacct ggccaaagtt agatgggaca aagatgaatg gcatgtccct tctctgaagt
     1921 ccgtttgagc agaactacct ggtaccccga aagaaaatct taggctacca cattctatta
     1981 ttgagagcct gagatgttag ccatagtgga caaggttcca ttcacatgct catatgttta
     2041 taaactgtgt tttgtagaag aaaaagaatc ataacaatac aaacacacat tcattctctc
     2101 tttttctctc taccattctc aacctgtatt ggacagcact gcctcttttg cttacttgct
     2161 gcctgttcaa actgaggtgg aatgcagtgg ttcccatgct taacaaatca ttaaaacacc
     2221 ctagaacact cctaggatag attaatgtag taagtctggc taggccttgt gttgcctttt
     2281 tttttttttt ttttttcttt tcttttcttc tcttcccatg cactattctg gaggtttgcc
     2341 aggtttgggg agacatggag taaaagaaag ataggcaact catggatggt gggagagcag
     2401 gtaagcaggt ctgatctcaa gggcccacat gaggcatcag tatatattag gcaggtaggg
     2461 atctctggct ttggtaattc tttatgagag gatcctagcc tttgaagctg ggagcaggag
     2521 tcagtggcta cagtgggaag gagtactgca ggttggggcc aaagtgatac acagcttaga
     2581 aggcagcctt cctccactta ctcaacaaat ctttatttag tgactctcca agtcctagtg
     2641 attattatta ttgttcactc cacatttggc ttaatgggta atgctattac ccattgccta
     2701 actaggtttg cagtagtgga atctccagag atagcaggct tagtaagctg gaggtaggac
     2761 atgaagtccc ccaaaacttg atgtcctatt tttatgtgag ttggacagtg gttatctttt
     2821 gcctgttgat atcttaaagc agcagagtgg tatagaaatt tgcggttatg acagacccgg
     2881 gttaaaaatc acagctgtgc catttgcttt gatattttga gcaaggtagc taaattttct
     2941 gagcttctat tttctcatct gtaaaatgag gatacgtacc tgttcttttt tttctttctt
     3001 tttatttctt ttagagatag ggtctcgctt tgttgcccag gctggagtgc actggcatga
     3061 tcatggctca ctgcagcctc aaattcccag gctcaagcaa tcctcccacc tcagcctccc
     3121 cattagctgg gactacaggg ccatgccatc atgcccagct aatttaaaca tagttttcag
     3181 agatggagct cactatgttg cccaggctgg tcttgaattc ttggtctcaa gcaatcctcc
     3241 cactgcagcc ttccaaagtg ctgggcgtac aagcgcaagc cactgtgccc agctgtcaga
     3301 cgctgagttt taattatgca ccaaactcca gcccgcagat cctcttcacc aaagcccctg
     3361 gctggtctag cccatcatga cttctctagg aacagtcctt ctttaggact ataaagtatt
     3421 aacaaaagtc tgtagattaa ggagcctgca taaagaattc tggatacagg cccctgtctt
     3481 tccaaagttc ctctccaata tcccttgggg tcctcatgtt tttgaagcag cttcactctg
     3541 cacaggcagc aggaggttgg gggagccata gctctgggcc acgggggcag atttatttgg
     3601 atgataggac taatatttgt gtaacctgct gagacctgtg tgggagagtt tagggtggtt
     3661 tttcttttgg tgaggggatt tgctctggtt tcacatccat taacacaaaa catgagctag
     3721 tcagggccct tgtggtctgc ggtaagggga tgcctgtgga gaaatgggcc tgagtgagtc
     3781 aggccaagag aatgtcttcc ttcagaatgg agtcaactgg ataactgatg agccaatggt
     3841 gggattaagg agggggaaat gggaggggaa gagaacagct gacatcttga ggaaagcttt
     3901 ggggtagtgg agaggtaagg gggtcatggt cagtctgaac tcaacaatag ggctgaatga
     3961 atttaccaaa ggaagctgcc ttatattata tgccaggctg ctggggaaag cctcaggtcc
     4021 tggccagccc ctgttctcac aagaacatgc aggttaccac ataaataatg gcatatgcct
     4081 tccataggac gtcaacctga cttaaatcta cctataccct actctctatt ctttggtttt
     4141 tggttctcat ccctgtggaa ggaaatgggc ctcttctggc atctcatgct actctgtgct
     4201 tttccttggg ctccaaattc tagctcataa agatgcaagt tttgcaattt cctataaatg
     4261 gttaagaaaa gagcaagctg tccagagagt gagaagtttg aaaagagagg tgcataagag
     4321 agaaatgatg tccatttgag ccccaccacg gaggttatgt ggtcccaaaa ggaatgatgg
     4381 ccaagcaatt aatttttcct cctagttctt agcttgcttc tgcattgatt ggctttacac
     4441 aactggcatt tagtctgcat tacacaaata gacactaatt tatttggaac aagcagcaaa
     4501 atgagaactt tatttggtgc agtcagggct ccatttagtt ccctcactct gcttctaatc
     4561 accccttctc ccagccctct tctatttgat agaggtctgt ccctcagatc agcaatgtct
     4621 tagcccctct cctctcttcc attccttcct gttggtactc atttcttcta acttttaata
     4681 aacatttagg tataatacat tacagtaagt gctatttaga tacaaactta aaacatacta
     4741 tatattttaa ggatctaaga atcctttaga gaaggcacat gactgaagta cctcagctgc
     4801 gcagcctgta gccagttttt ttaatgtaaa agtaagaatg ccagccttaa cctagccctg
     4861 cagataaaag ctaactttta ttaataccag ccctgaataa tggcactaat ccacactctt
     4921 ccttagagtg atgctggaaa aataaaatca ggggcttcag attaaaaaaa aaaacaaaaa
     4981 acaaaaaaca aaaacaaaca ttgcctggcc ctgagggtct gtttgcaaaa cttcttgtag
     5041 atctaatttc tgaacactca ctgcttcatt tctattcctc ctgttgcagg gagtaatttc
     5101 ttctcctttg tctcacttcc cttatcaaga acaccaacca gtaagtcttt gccaaattct
     5161 cagacccact caggacacga gtctctacat ggcttaacag aagagagata attaggattt
     5221 ttttttcctc agtctttctg aggtttttat ttaaatgcac tcagtggtca tagggcagaa
     5281 gctcaagcta gctggggcga agggaggacg ccagggagag tatgtttctc atccctggga
     5341 ggcattcagc ctagctcctg cagccaaatt acagcaccag agaacaatgt gatgcattcc
     5401 tgggcaggtc ggtgggaccc tgggcgcctg ggccttgtgg agagaggtgc cagacacaga
     5461 gttctccgta agcaatcctg cagagccgcc ccctgggtgc agaaatgaaa tacgggagag
     5521 cttcacatta cacagagacc tgtagctcac acctggttat tgatggcctt ggtggaggcc
     5581 tctgccccga ccctccactt gggaactgcc tgctactacg ggggttgggc atctttgaag
     5641 caatgttgga taacaagaaa gagatgcttc cttttcactc tttgccctcc ctgtcagcct
     5701 gagcacaacc atgaggttac acacacacac acagaggtgt acatatacag acacatagag
     5761 aacttctctc aggctgcata ggagttctgc tcatcctcct ctccccaaca attaaaaaaa
     5821 aaagcaatta gatttcgatc cagtacttca aaaaggatac caatagggtc tggctttaat
     5881 caaggaatat ctacaaagtc acattaccaa cctgcaggca actctttggt ttggggacca
     5941 gaactcctct ggtgggtggt tgggggaagg atgcaggaag ggcatggtga ggagagatca
     6001 gtggtgaaga attaccatca aagcagagtg gctgagactg tataagttcg caaggctggt
     6061 tcatgccaga gatagtgaga tgtgcaccct atgtgctgag aatgatggag cagtctccta
     6121 tgactgcatg gggtataact gccaagccta ctgctcatga cctgtggttg tttttaactc
     6181 ttaactgggt tagaaaactg gagagctttg gattccaggg atgatctcca taagagagaa
     6241 gcactggaaa agaccaagtg gtggctttat tagggtaaat atatcacagt tgctacagtg
     6301 aattgagctt tctcagaagc tattattttc tttgggtgat tggcaggtat agggcaatag
     6361 ccagtggggt gtcagtaata tgccctgtcc ctgacctcaa aggtaaaggg atagaaaaga
     6421 gagggcgttg acaaactcat tttcccactt cccactcatg gcttatatta tctctgagca
     6481 tctcggtggc tattcctcat ttacttaaga tgttttagtc attctggatg tgcaaatgca
     6541 aggcaagcat tctcccactg gccccctaac ggttaactat cctggcttaa aattttcctt
     6601 tgctcacttc cattctatga gtatatcgat ggagcagctg gacattagag ttctttctct
     6661 ttgaccaaag gagccaaaat gcggtgactt gacttcaacc ccaacagccc ctgtaagtag
     6721 ccctggccaa acagaaaggc taagctgaat gaagaaaaaa ggaagacaat ttcatctaca
     6781 gttgtccttt ttgacagctt ccaagggggg tttgcctagg aataacaata ttcataagaa
     6841 gctttttcat atgcaaaatg ctttagcata tatgtaatcc tcacaacaac cctgtgaggt
     6901 aggggttact gtcactttac agatgctgtt cagaaaaatt tggtgatttg tccaaggtca
     6961 catgaacagt gcgtggctca gccagaactc aaacctaggt cttctgactt caaatcctgt
     7021 gtattctcct caaagcctga ggatgcccag ggttgggggc accagagtcc cagcaccttc
     7081 aaaacagaaa ttgatacaaa atgttcaagc cctgtaggag tcccaggaca gccaagagag
     7141 tatatctgag cacagtttac aaaggaacag cctaggccct cctgaacctt atcaaccaat
     7201 ggctcttttg ccatttctgc cactattacc accagtacca tgtgaccact atacaacata
     7261 ttccacattt aaacaactct ggctcctaat tctactcctt ttttcccctt cagattaaca
     7321 ttaaaaattt tatctagtcc ttttgaaatt atgctaaatg tatagacaca gtagaagtag
     7381 tcatgacaga aaattattaa ggctttgaaa atatgtatca gaggccgggt gcagtggctc
     7441 atgcctgtaa tcccagcact ttgggaggcc gaggtggggc agatcacgag gtcaggagat
     7501 tgagaccatc ctggctaaca cggtgaaacc ctgtctctac taaaaataca aaaaaattag
     7561 ccgggcctgg tggcgggcgc ctgtagtccc agctactggg gaggctgagg caggagaatg
     7621 gcgtgaaccc aggaggcaga gcttgcagtg agccaagatg caccactgca ctccagcctg
     7681 ggagacagag cgagactccg tcacaaaaaa aaaaaaaaag aaggtatgta ttagaatttt
     7741 ctttgagatt tcactccttt taaaaatgac gtcaactcct gggttaggaa agcaagatga
     7801 gggaataagt gtcctaagaa actcccatcc caagccagac agatgcctac ccgtggcctg
     7861 gcaaaggtcc tgggatctca agctgatgca agcaatttgt gtacaccaag gcaaggggtc
     7921 tcaatcctgc agagaaaccc atgagatgag gcagacagca gattttcact tgatcaaaca
     7981 cttgctgctc tcaacccctc tttgttttcc catccaaaat ctggacctct gtttaggcgc
     8041 aagacagtga gtaagagcag ctccaaaaga tgacgtatgc aaggggaact cttctgttca
     8101 atcctgtaat gttttctgtt agagacagca taggctacct atcctaatcc tgcaccccaa
     8161 ctgttaagac agaagggaaa agtacaatgt tcatcaatca tagctctggg atgctgcagc
     8221 tccctgacct gggcccctac ttgagctagg agaagaacac ctcatgaaaa cagtctacct
     8281 atagtcagga cttccccaag gcagacttta ttttttggtc catcgatctt ggctctcact
     8341 gttctccctg cttcccaccc ccaactgcct ctgcatgtgg gctcagaagt catcatctaa
     8401 agaattccat tgctcacctc ctgcatagca gcacagcccc atgaggccac acaccagatg
     8461 gaggggataa aagtacgagg tcatggcttc ttgcaagagg ctttttctta aactaaccct
     8521 gactcctgga aaagaggcag agcaggagag tgttgaatga gctgctgatg acagcagctt
     8581 cataggtctt gtgtataaag gaaggaaaaa gctaacttgg ctttccgtgg aaatttacct
     8641 actcccattt tcaggtctac tcctggtctc acatctactt cttgaaggtg tctaagtaga
     8701 atgcagagat tgtcaagcta gagggttaac tccttcccaa ttgtagggat ctattcagca
     8761 ggctgccaca cacatgctga ggtggaggcc aaccctgaac acatgcgctg cttctttagg
     8821 aatgtaacta tgaagtaaaa ggaaacagta aggaaggtga actggaactc tggggaaact
     8881 gaaaaggtca tcaataggcc ttcaaaatat ttgtgtgtaa taagtagaca caagaggctg
     8941 gaggaagatg atcattccta gaataattat gcttactggg tgacaatata cagaagcaac
     9001 aattacaata aaatgaaaca gtttaatgga ctaggaagca gaagtctgag aataaaggaa
     9061 ttaggttaat gagattaagc agagatggca ttccacagga ggtgactttt gagttgaatt
     9121 tttaaaagat agctttatgt gttttatgaa ctgactgagg gcagtcagaa gaaggcattc
     9181 taaatagagg gaactggtat gtgctgaaac ttagaagcag gaatgtacaa gcaatatata
     9241 aggaatttca agcaagtaca cattatatac actggggaat acagagaaat tagaatgctg
     9301 agatcagggc ttaaataatg tgaggtgact gtgtgcacct agactgtcaa atggttcagc
     9361 atcccctata gagccacata gtatcttgat ttatgtcagt aaacatcagg gcacctatgg
     9421 aaaagcacaa ggatgagtcc atttgttaca gacccaggga ctaacagaga tctacactgt
     9481 aaagttcaac aaaatgctac atatcattaa ctacagctcc ttatcatttg agattctggg
     9541 ctaagtaaga gatatcaaat atcctatcca gtactgtgat acattaatgt aggcttacag
     9601 gcccagaacc tggcataaat caagccaaac ccttaagaaa ttagaatgtg aaaagaaaat
     9661 aatttaaaat agaaaataca tgctgctttt cctcactccc aaacttaaaa cttgactggt
     9721 cctacatatt ctacttggta tattgaattt ttgcagctag cagatttatc gtatctgagg
     9781 ccatagtgaa tagaagagct gcaaaagagc tttagagact gcaaaaccag ctcactaata
     9841 aatgaggaac tttattctaa tttactacca ggggctgaag tagcagccaa agaaggagac
     9901 aaattctaac ttcatgatct ctagttaggt gtctattttc ctgcatttgc taaaggtaaa
     9961 aatcgctact tatggggctt ttgtcatact tcttaaccaa acttccctaa cttctgagga
    10021 taaaaaccat aagggcaatc ttattcttcc aaagcagttc cctggtgcca ctttcagaaa
    10081 cagagtattg aactatgggt ctgacccagt gtggcactga gtgtgtgtgt gtttgtgtgt
    10141 ttgtgtgtgt gtgtacactg aataagccaa aacgtgtgcc atattctagg tttctgcttt
    10201 acttaactgg caaaatttgg tgctgtaagg gaggcagcca caaaaccagt gatagcattt
    10261 gttagtatca tcttagttct cttccctccc ctaggtagtt tataaagggt gatttctgaa
    10321 acccttcaca aaagaaaagc tcaagggttt acattcaact gtgacagcac tatgaattca
    10381 ttaagaagca tgtttcaggt tgcactgtaa tttccctatg taatacaaac ccatggaatc
    10441 tgacataagc tgattgctca tgctggttgt tttatttaca tttctgaatg gaaaggattt
    10501 caatactcat aaaatatcta actggcttat ttttcatctg ttctcccaga gaagctatta
    10561 taagataggc atagagacag aagtctcaac ttgtataact ggttaagcaa ccagggaaat
    10621 gttattgctc aaaatgcaat tttaaaaaat tcaatatgga acttgaggcc aaaaaaacag
    10681 aaggttactc tcaatgccat ccaaaagata aaagttaaaa aaaaaaaaaa aaaaaaaggt
    10741 aactatgctc attattttca accaagttct atggaggtgg taccttcaca ggagctcagt
    10801 ggaactgggg tttacttaca tcttttttct gggaacctaa tgttagcaga cacagttgct
    10861 agtttgaaca ggaatgcaga tgaatggatg aaagtgggct ccctaccacc cagaaatatg
    10921 aatgtgcctc cttaccaata tgctacaaat cagacctctg aattagaaga tgccatcatg
    10981 caactaactt actatctgga gatgtgtatt ttgttaacct aggcaaagaa taacaatttc
    11041 tgcttattcc agtaggtgtg acaagctcag agaagtgagc gacaagctag agaagtaata
    11101 attaccaata aagtaaattc caaagccgaa
//
