LOCUS       NM_003391               3856 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Wnt family member 2 (WNT2), transcript variant 1,
            mRNA.
ACCESSION   NM_003391
VERSION     NM_003391.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3856)
  AUTHORS   Zehra,Z., von Bartheld,C.S., Agarwal,A.B., Vasquez-Gross,H.,
            Noorani Siddiqui,S., Azam,M. and Qamar,R.
  TITLE     Exploring WNT2 polymorphisms in comitant strabismus: A genetic
            association study
  JOURNAL   Gene 928, 148797 (2024)
   PUBMED   39068999
  REMARK    GeneRIF: Exploring WNT2 polymorphisms in comitant strabismus: A
            genetic association study.
REFERENCE   2  (bases 1 to 3856)
  AUTHORS   Lin,L., Li,L., Ma,G., Kang,Y., Wang,X. and He,J.
  TITLE     Overexpression of IL-8 and Wnt2 is associated with prognosis of
            gastric cancer
  JOURNAL   Folia Histochem Cytobiol 60 (1), 66-73 (2022)
   PUBMED   35037695
  REMARK    GeneRIF: Overexpression of IL-8 and Wnt2 is associated with
            prognosis of gastric cancer.
REFERENCE   3  (bases 1 to 3856)
  AUTHORS   Chien,Y.L., Chen,Y.C., Chiu,Y.N., Tsai,W.C. and Gau,S.S.
  TITLE     A translational exploration of the effects of WNT2 variants on
            altered cortical structures in autism spectrum disorder
  JOURNAL   J Psychiatry Neurosci 46 (6), E647-E658 (2021)
   PUBMED   34862305
  REMARK    GeneRIF: A translational exploration of the effects of WNT2
            variants on altered cortical structures in autism spectrum
            disorder.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3856)
  AUTHORS   Wrona,A., Sejda,A., Dziadziuszko,R. and Jassem,J.
  TITLE     Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and beta-catenin
            Expression in Operable Non-small Cell Lung Cancer
  JOURNAL   J Histochem Cytochem 69 (11), 711-722 (2021)
   PUBMED   34666560
  REMARK    GeneRIF: Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and
            beta-catenin Expression in Operable Non-small Cell Lung Cancer.
REFERENCE   5  (bases 1 to 3856)
  AUTHORS   Wang,B., Wang,X., Tseng,Y., Huang,M., Luo,F., Zhang,J. and Liu,J.
  TITLE     Distinguishing colorectal adenoma from hyperplastic polyp by WNT2
            expression
  JOURNAL   J Clin Lab Anal 35 (10), e23961 (2021)
   PUBMED   34477243
  REMARK    GeneRIF: Distinguishing colorectal adenoma from hyperplastic polyp
            by WNT2 expression.
REFERENCE   6  (bases 1 to 3856)
  AUTHORS   Bafico,A., Gazit,A., Pramila,T., Finch,P.W., Yaniv,A. and
            Aaronson,S.A.
  TITLE     Interaction of frizzled related protein (FRP) with Wnt ligands and
            the frizzled receptor suggests alternative mechanisms for FRP
            inhibition of Wnt signaling
  JOURNAL   J Biol Chem 274 (23), 16180-16187 (1999)
   PUBMED   10347172
REFERENCE   7  (bases 1 to 3856)
  AUTHORS   Huguet,E.L., McMahon,J.A., McMahon,A.P., Bicknell,R. and
            Harris,A.L.
  TITLE     Differential expression of human Wnt genes 2, 3, 4, and 7B in human
            breast cell lines and normal and disease states of human breast
            tissue
  JOURNAL   Cancer Res 54 (10), 2615-2621 (1994)
   PUBMED   8168088
REFERENCE   8  (bases 1 to 3856)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
REFERENCE   9  (bases 1 to 3856)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
REFERENCE   10 (bases 1 to 3856)
  AUTHORS   Wainwright,B.J., Scambler,P.J., Stanier,P., Watson,E.K., Bell,G.,
            Wicking,C., Estivill,X., Courtney,M., Boue,A., Pedersen,P.S. et al.
  TITLE     Isolation of a human gene with protein sequence similarity to human
            and murine int-1 and the Drosophila segment polarity mutant
            wingless
  JOURNAL   EMBO J 7 (6), 1743-1748 (1988)
   PUBMED   2971536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC078170.1 and AC006326.2.
            
            On May 17, 2019 this sequence version replaced NM_003391.2.
            
            Summary: This gene is a member of the WNT gene family. The WNT gene
            family consists of structurally related genes which encode secreted
            signaling proteins. These proteins have been implicated in
            oncogenesis and in several developmental processes, including
            regulation of cell fate and patterning during embryogenesis.
            Alternatively spliced transcript variants have been identified for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.213744.1,
                                           SRR1803616.104775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265441.8/ ENSP00000265441.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2083              BC078170.1         218-2300
            2084-3856           AC006326.2         13960-15732         c
FEATURES             Location/Qualifiers
     source          1..3856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.2"
     gene            1..3856
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /note="Wnt family member 2"
                     /db_xref="GeneID:7472"
                     /db_xref="HGNC:HGNC:12780"
                     /db_xref="MIM:147870"
     exon            1..152
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1152
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /note="secreted growth factor; Int-1-related protein;
                     protein Wnt-2; int-1-like protein 1; wingless-type MMTV
                     integration site family member 2; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="protein Wnt-2 precursor"
                     /protein_id="NP_003382.1"
                     /db_xref="CCDS:CCDS5771.1"
                     /db_xref="GeneID:7472"
                     /db_xref="HGNC:HGNC:12780"
                     /db_xref="MIM:147870"
                     /translation="MNAPLGGIWLWLPLLLTWLTPEVNSSWWYMRATGGSSRVMCDNV
                     PGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLL
                     RSSRESAFVYAISSAGVVFAITRACSQGEVKSCSCDPKKMGSAKDSKGIFDWGGCSDN
                     IDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLR
                     TCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPD
                     YCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCGCKFHWCCAV
                     RCQDCLEALDVHTCKAPKNADWTTAT"
     exon            153..379
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /inference="alignment:Splign:2.1.0"
     exon            380..657
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /inference="alignment:Splign:2.1.0"
     exon            658..922
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /inference="alignment:Splign:2.1.0"
     exon            923..3856
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /note="hexamer: ATTAAA"
     polyA_site      1795
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /note="major polyA site"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /note="hexamer: AATAAA"
     polyA_site      2083
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /note="hexamer: ATTACA"
     polyA_site      2676
                     /gene="WNT2"
                     /gene_synonym="INT1L1; IRP"
                     /note="major polyA site"
ORIGIN      
        1 gcttctgctc tgggcacgca tggcgcccgc acacggagtc tgacctgatg cagacgcaag
       61 ggggttaata tgaacgcccc tctcggtgga atctggctct ggctccctct gctcttgacc
      121 tggctcaccc ccgaggtcaa ctcttcatgg tggtacatga gagctacagg tggctcctcc
      181 agggtgatgt gcgataatgt gccaggcctg gtgagcagcc agcggcagct gtgtcaccga
      241 catccagatg tgatgcgtgc cattagccag ggcgtggccg agtggacagc agaatgccag
      301 caccagttcc gccagcaccg ctggaattgc aacaccctgg acagggatca cagccttttt
      361 ggcagggtcc tactccgaag tagtcgggaa tctgcctttg tttatgccat ctcctcagct
      421 ggagttgtat ttgccatcac cagggcctgt agccaaggag aagtaaaatc ctgttcctgt
      481 gatccaaaga agatgggaag cgccaaggac agcaaaggca tttttgattg gggtggctgc
      541 agtgataaca ttgactatgg gatcaaattt gcccgcgcat ttgtggatgc aaaggaaagg
      601 aaaggaaagg atgccagagc cctgatgaat cttcacaaca acagagctgg caggaaggct
      661 gtaaagcggt tcttgaaaca agagtgcaag tgccacgggg tgagcggctc atgtactctc
      721 aggacatgct ggctggccat ggccgacttc aggaaaacgg gcgattatct ctggaggaag
      781 tacaatgggg ccatccaggt ggtcatgaac caggatggca caggtttcac tgtggctaac
      841 gagaggttta agaagccaac gaaaaatgac ctcgtgtatt ttgagaattc tccagactac
      901 tgtatcaggg accgagaggc aggctccctg ggtacagcag gccgtgtgtg caacctgact
      961 tcccggggca tggacagctg tgaagtcatg tgctgtggga gaggctacga cacctcccat
     1021 gtcacccgga tgaccaagtg tgggtgtaag ttccactggt gctgcgccgt gcgctgtcag
     1081 gactgcctgg aagctctgga tgtgcacaca tgcaaggccc ccaagaacgc tgactggaca
     1141 accgctacat gaccccagca ggcgtcacca tccaccttcc cttctacaag gactccattg
     1201 gatctgcaag aacactggac ctttgggttc tttctggggg gatatttcct aaggcatgtg
     1261 gcctttatct caacggaagc cccctcttcc tccctggggg ccccaggatg ggggggccac
     1321 acgctgcacc taaagcctac cctattctat ccatctcctg gtgttctgca gtcatctccc
     1381 ctcctggcga gttctctttg gaaatagcat gacaggctgt tcagccggga gggtggtggg
     1441 cccagaccac tgtctccacc caccttgacg tttcttcttt ctagagcagt tggccaagca
     1501 gaaaaaaaag tgtctcaaag gagctttctc aatgtcttcc cacaaatggt cccaattaag
     1561 aaattccata cttctctcag atgggaacag taaagaaagc agaatcaact gcccctgact
     1621 taactttaac ttttgaaaag accaagactt ttgtctgatc aagtggtttt acagctacca
     1681 cccttagggg taattggtaa ttacctggag aagaatggct ttcaataccc ttttaagttt
     1741 aaaatgtgta tttttcaagg catttattgc catattaaaa tctgatgtaa caaggtgggg
     1801 acgtgtgtcc tttggtacta tggtgtgttg tatctttgta agagcaaaag cctcagaaag
     1861 ggattgcttt gcattactgt ccccttgata taaaaaatct ttagggaatg agagttcctt
     1921 ctcacttaga atccgaaggg aattaaaaag aagatgaatg gtctggcaat attctgtaac
     1981 tattgggtga atatggtgga aaataattta gtggatggaa tatcagaagt atatctgtac
     2041 agatcaagaa aaaaagggag aataaaattc ctatctcata ttatgcatgt gacccatgga
     2101 atctcataac tgaaagactt gaaggatgaa aattttgggg atacaagatt ggtgaactaa
     2161 aatgctgaca gagaggtttc cagagctaac tcgtgcctgg ggcggcctta caataagcag
     2221 atgcctgaaa gaagtcggcc acgtccgccg tctgctaatg cccatcaccc ttcaagccca
     2281 gtttaaagac ctgtcatatt taattgtatt tatttgatgc ttacaagatg atgtgatact
     2341 gtagcctaaa gcaaatgaca catagcattg cttataaagt tggtaaccct gctatattat
     2401 attgcaaaca aatcgtaact tggagactat gtttaaggga ctcaactgta attatgggag
     2461 catcagtatg caaatagtgg ttggcttctg ccatcagcca aaagatgaca ttcagggaaa
     2521 atggagaggc tgcctgcacc gtttttttat gttaaatgaa agaaaggtga aatagctact
     2581 tctcgtcttc ttgaaaaatt tggttcttat tctgtatatg acttccttac agtgctacat
     2641 taacaggata tttcattaca tgcatctggt atcaaattat tggttcttcc tcattcttta
     2701 ataccataca gtaaggtcat ttagactgag actcgtacaa aacaacctac tggagtactt
     2761 tgccatagtt aacatttgcc tccagccctc ttaaaaatgt cagaattcat cccctttccc
     2821 tcattcccaa attgttgtct aacttttcca aagtgactct ttcctccttt tattctatgg
     2881 attcggatgg tgggaacagt ggaatgacag tagctgctct gagcttggtg tgaagaaggc
     2941 caggcacatg ggcagctgct cagtcttcag ttaccctgaa ggttggtgtg aattccttca
     3001 tgagagtgcg aaggcacttt catgggggtc ccacagccat cagcccttcc tcctgctgga
     3061 tgaactgtga aatcatcaat ccaggctgtg tttcaaattg gaaaggatct taggagacat
     3121 ctcagcttcc tttagtttgg ggaaattgag accaagagag gcgaagggat tggtgcacat
     3181 atcaggcatt gcccaatgct ccatcacaaa taggaccaca ctcttgagtg tttgagatag
     3241 tgtaggactt tatccattaa atgaaactag cttctcccag aattaactca gtggatttta
     3301 aataatttta gcttccaatg gtgtgtttgc tacttttttt atgcctggta tgtttagatc
     3361 tgacattctt tttatgctga gatatatccc tcctggtaag tagcaagggg acaaggatat
     3421 ccacgtagga acctacataa attgtcctaa tccataaggg agattatggc aaccatcgca
     3481 agtggcagtg ggtcctgcca ctgaggtggg aaaaataaga gaatgaaata ttgctatcgg
     3541 cttttacttc tgaaagagga aatgtctatt gttcgggaaa aaaattacac aacaaatgaa
     3601 ggtaatttta aactcctttg ccttagagct tggtagagga tcagtattcc aggaacctga
     3661 aatacactga aactctcaat tatctgaggc ttttaagggg aatatatggc acaaattagc
     3721 caaaacaaaa taattgggaa atccccttat aaattccctc tttattaaaa tcttactata
     3781 aattgaagtt ttctaggtcc aagataatgt ccattaattt tctacaatat ctgaaaaagt
     3841 ttccacaata ggacat
//
