LOCUS       NM_057168               3150 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens Wnt family member 16 (WNT16), transcript variant 1,
            mRNA.
ACCESSION   NM_057168
VERSION     NM_057168.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3150)
  AUTHORS   Kragl,A., Hannemann,A., Nauck,M., Volker,U., Siggelkow,H.,
            Teumer,A. and Tzvetkov,M.V.
  TITLE     Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel Ultrasound
            Bone Stiffness: Analyses from the General Population and Patients
            Evaluated for Osteoporosis
  JOURNAL   Calcif Tissue Int 113 (5), 540-551 (2023)
   PUBMED   37831088
  REMARK    GeneRIF: Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel
            Ultrasound Bone Stiffness: Analyses from the General Population and
            Patients Evaluated for Osteoporosis.
REFERENCE   2  (bases 1 to 3150)
  AUTHORS   Ye,X. and Liu,X.
  TITLE     Wnt16 signaling in bone homeostasis and osteoarthristis
  JOURNAL   Front Endocrinol (Lausanne) 13, 1095711 (2022)
   PUBMED   36619549
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3150)
  AUTHORS   Chen,J., Zhang,P., Chen,H., Wang,X., He,X., Zhong,J., Zheng,H.,
            Li,X., Jakovlic,I., Zhang,Y., Chen,Y., Shen,B., Deng,C. and Wu,Y.
  TITLE     Whole-genome sequencing identifies rare missense variants of WNT16
            and ERVW-1 causing the systemic lupus erythematosus
  JOURNAL   Genomics 114 (3), 110332 (2022)
   PUBMED   35283196
  REMARK    GeneRIF: Whole-genome sequencing identifies rare missense variants
            of WNT16 and ERVW-1 causing the systemic lupus erythematosus.
REFERENCE   4  (bases 1 to 3150)
  AUTHORS   Li,X., Shi,J., Zhao,W., Huang,X., Cui,L., Liu,L., Jin,X., Li,D.,
            Zhang,X. and Du,M.
  TITLE     WNT16 from decidual stromal cells regulates HTR8/SVneo
            trophoblastic cell function via AKT/beta-catenin pathway
  JOURNAL   Reproduction 163 (5), 241-250 (2022)
   PUBMED   35174787
  REMARK    GeneRIF: WNT16 from decidual stromal cells regulates HTR8/SVneo
            trophoblastic cell function via AKT/beta-catenin pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3150)
  AUTHORS   Jo,S., Weon,S., Nam,B., Jang,M.A., Kang,H., Kim,T.J., Park,Y.S. and
            Kim,T.H.
  TITLE     WNT16 elevation induced cell senescence of osteoblasts in
            ankylosing spondylitis
  JOURNAL   Arthritis Res Ther 23 (1), 301 (2021)
   PUBMED   34879876
  REMARK    GeneRIF: WNT16 elevation induced cell senescence of osteoblasts in
            ankylosing spondylitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3150)
  AUTHORS   Howard,E.W., Been,L.F., Lerner,M., Brackett,D., Lightfoot,S.,
            Bullen,E.C. and Sanghera,D.K.
  TITLE     Carriers of a novel frame-shift insertion in WNT16a possess
            elevated pancreatic expression of TCF7L2
  JOURNAL   BMC Genet 14, 28 (2013)
   PUBMED   23617586
  REMARK    GeneRIF: results suggest synergistic effects of WNT16a insertion
            and the at-risk 'T' allele of TCF7L2 (rs7903146) for elevating the
            expression of TCF7L2 in human pancreas which may affect the
            regulation of downstream target genes involved in the development
            of T2D
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3150)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Comparative genomics on Wnt16 orthologs
  JOURNAL   Oncol Rep 13 (4), 771-775 (2005)
   PUBMED   15756456
  REMARK    GeneRIF: genomic analysis of conserved sequences between human,
            rat, and zebrafish WNT16
REFERENCE   8  (bases 1 to 3150)
  AUTHORS   Fear,M.W., Kelsell,D.P., Spurr,N.K. and Barnes,M.R.
  TITLE     Wnt-16a, a novel Wnt-16 isoform, which shows differential
            expression in adult human tissues
  JOURNAL   Biochem Biophys Res Commun 278 (3), 814-820 (2000)
   PUBMED   11095990
REFERENCE   9  (bases 1 to 3150)
  AUTHORS   McWhirter,J.R., Neuteboom,S.T., Wancewicz,E.V., Monia,B.P.,
            Downing,J.R. and Murre,C.
  TITLE     Oncogenic homeodomain transcription factor E2A-Pbx1 activates a
            novel WNT gene in pre-B acute lymphoblastoid leukemia
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11464-11469 (1999)
   PUBMED   10500199
REFERENCE   10 (bases 1 to 3150)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006364.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_057168.1.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. It
            contains two transcript variants diverging at the 5' termini. These
            two variants are proposed to be the products of separate promoters
            and not to be splice variants from a single promoter. They are
            differentially expressed in normal tissues, one of which (variant
            2) is expressed at significant levels only in the pancreas, whereas
            another one (variant 1) is expressed more ubiquitously with highest
            levels in adult kidney, placenta, brain, heart, and spleen.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs from variant 2 at the
            5' terminus including 5' UTR and the coding region for the
            N-terminus. Isoform 1, encoded by this variant, is 90% identical to
            the mouse Wnt16 protein at the amino acid level.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169963.1, SRR14372080.2115073.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222462.3/ ENSP00000222462.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-388               AC006364.4         66638-67025
            389-639             AC006364.4         67205-67455
            640-926             AC006364.4         69316-69602
            927-3150            AC006364.4         76519-78742
FEATURES             Location/Qualifiers
     source          1..3150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.31"
     gene            1..3150
                     /gene="WNT16"
                     /note="Wnt family member 16"
                     /db_xref="GeneID:51384"
                     /db_xref="HGNC:HGNC:16267"
                     /db_xref="MIM:606267"
     exon            1..388
                     /gene="WNT16"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1391
                     /gene="WNT16"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein Wnt-16; wingless-type MMTV integration
                     site family member 16b; wingless-type MMTV integration
                     site family, member 16"
                     /codon_start=1
                     /product="protein Wnt-16 isoform 1 precursor"
                     /protein_id="NP_476509.1"
                     /db_xref="CCDS:CCDS5781.1"
                     /db_xref="GeneID:51384"
                     /db_xref="HGNC:HGNC:16267"
                     /db_xref="MIM:606267"
                     /translation="MDRAALLGLARLCALWAALLVLFPYGAQGNWMWLGIASFGVPEK
                     LGCANLPLNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTAP
                     MGASPLFGYELSSGTKETAFIYAVMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSAS
                     EGWHWGGCSDDVQYGMWFSRKFLDFPIGNTTGKENKVLLAMNLHNNEAGRQAVAKLMS
                     VDCRCHGVSGSCAVKTCWKTMSSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRK
                     IPIHKDDLLYVNKSPNYCVEDKKLGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVV
                     RHVERCECKFIWCCYVRCRRCESMTDVHTCK"
     exon            389..639
                     /gene="WNT16"
                     /inference="alignment:Splign:2.1.0"
     exon            640..926
                     /gene="WNT16"
                     /inference="alignment:Splign:2.1.0"
     exon            927..3150
                     /gene="WNT16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2944..2949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT16"
                     /note="hexamer: AATAGA"
     polyA_site      2962
                     /gene="WNT16"
                     /note="major polyA site"
     regulatory      3120..3125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT16"
                     /note="hexamer: ATTAAA"
     polyA_site      3150
                     /gene="WNT16"
                     /note="major polyA site"
ORIGIN      
        1 aacagaagtt tctcacctag gaatgcgagg ggcgctcccg catctcctgc acatctccac
       61 ccctgcgcag gaggagatcc ccaggctgct ctctccatct ctcctacagc tccctgcaaa
      121 cgagggggaa gctgctgaga gtccctatca ctgctggcct tttaatgttg tatgcaagga
      181 ggaagagggc gagggataac ttggtgctgg acaactgacc tgcggcccga agggcctctg
      241 gggagggggt gcaaaagagg agcggctggg ctgggggact ccatgcgggg gcgatggaca
      301 gggcggcgct cctgggactg gcccgcttgt gcgcgctgtg ggcagccctg ctcgtgctgt
      361 tcccctacgg agcccaagga aactggatgt ggttgggcat tgcctccttc ggggttccag
      421 agaagctggg ctgcgccaat ttgccgctga acagccgcca gaaggagctg tgcaagagga
      481 aaccgtacct gctgccgagc atccgagagg gcgcccggct gggcattcag gagtgcggga
      541 gccagttcag acacgagaga tggaactgca tgatcaccgc cgccgccact accgccccga
      601 tgggcgccag ccccctcttt ggctacgagc tgagcagcgg caccaaagag acagcattta
      661 tttatgctgt gatggctgca ggcctggtgc attctgtgac caggtcatgc agtgcaggca
      721 acatgacaga gtgttcctgt gacaccacct tgcagaacgg cggctcagca agtgaaggct
      781 ggcactgggg gggctgctcc gatgatgtcc agtatggcat gtggttcagc agaaagttcc
      841 tagatttccc catcggaaac accacgggca aagaaaacaa agtactatta gcaatgaacc
      901 tacataacaa tgaagctgga aggcaggctg tcgccaagtt gatgtcagta gactgccgct
      961 gccacggagt ttccggctcc tgtgctgtga aaacatgctg gaaaaccatg tcttcttttg
     1021 aaaagattgg ccatttgttg aaggataaat atgaaaacag tatccagata tcagacaaaa
     1081 caaagaggaa aatgcgcagg agagaaaaag atcagaggaa aataccaatc cataaggatg
     1141 atctgctcta tgttaataag tctcccaact actgtgtaga agataagaaa ctgggaatcc
     1201 cagggacaca aggcagagaa tgcaaccgta catcagaggg tgcagatggc tgcaacctcc
     1261 tctgctgtgg ccgaggttac aacacccatg tggtcaggca cgtggagagg tgtgagtgta
     1321 agttcatctg gtgctgctat gtccgttgca ggaggtgtga aagcatgact gatgtccaca
     1381 cttgcaagta accactccat ccagccttgg gcaagatgcc tcagcaatat acaatggcat
     1441 tgcaaccaga gaggtgccca tccctgtgca gcgctagtaa agttgactct tgcagtggaa
     1501 tccctagaac cttggacctg agagtttccc ttacctgatc gacatatttt cctttatctg
     1561 atcaacccat caatcatgtg gatttcttgg gattctaatg ttgaaaaggt ttatattcac
     1621 cttttgatga tttggggaat atatattgac atacaaggaa gataatctgt ttcctaagca
     1681 agaaataaca ggaaagatcc cttatgccag gaggcctgcc atactcagga taagatcctt
     1741 gaatatggaa cttagttaca ggactcaata atggtgggtg aacattagtc atttttaaaa
     1801 gacacctctt atagcaataa ggagacatta acatgaatct catttattct ctcagtattt
     1861 taactgaaga aattatactg tttgtgtgtg gatagaagat gttgaaaagt taacataagc
     1921 attgggtgct gacttaccct ttcatgtact tccaaagaaa ggtaatcaaa aagaatcttc
     1981 ttaagtgata taatatccct aaaaaaatga tcattacaga tgtttagtga caaagaatca
     2041 atatgtaaaa agtataatga atgatttaga ttttaagtgc cttttcactg ggagaatctg
     2101 gaaaaacctc cataaggtat atagcaatct ttgatcttta gattcatact tttatcacag
     2161 atcagtttca actgttaaaa acccacctct gagatactgg ggggaggatc ctgaaacatg
     2221 cgggaaaagg agaggtaaac agtggaggta aaaatataat ttcatacatt gtaaagaaaa
     2281 gcacccttta aatgtgtaaa gacagtgttt tgtaaagaat tttgtttaaa aagtttctat
     2341 tttgtaaata cagtacttaa gttatatgat ttatattaaa acatttattg acaaagccta
     2401 agagctaagg cagtaaaatt atctcataaa taatattagc ttattttttt tcatactatt
     2461 aatgctattt ttttggacat cgaagagaat ttaacttagc agttagttat atggatgtgt
     2521 atttcttgct aaaatgacag ttttatatgt tatagattaa aatatgttgc aaaatatcaa
     2581 aaatttgtgt tatttcagca gtaagattaa ttgaattctc ttttcacatt agttatgctt
     2641 aactcataag gttattataa taaattatat tagtaaaagt cttaactgga aaaaagaatc
     2701 taaatcagaa tagtgatcaa tttgtggatt tgatatcctg gatatttatt atattttatg
     2761 taatgctgca tttctatttg aatgttaagt ggtctttctt gtttttaata ttcatgcatg
     2821 tatattcatc atattttaca aggttcctgg taaaaattac agggctctat ttaaggatgt
     2881 attttaatgt aaatgcttat gttttttatg aattgttaaa tatttcagta ttatatagaa
     2941 aaaaatagat ttttaaaatt cagaatggac aaagagaata ttcattttct tattaataag
     3001 ataaagaaat gtttccctgc cccacagtct tcattctatt tctctttaat tttattcact
     3061 gaggcagaga aacaattttt gaaaaagagc aaacccatgg aaaatgtctc agatctaata
     3121 ttaaaatcaa gactaagcat ttaactgtga
//
