LOCUS       NM_004626               1900 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Wnt family member 11 (WNT11), mRNA.
ACCESSION   NM_004626
VERSION     NM_004626.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Odrzywolski,A., Tuysuz,B., Debeer,P., Souche,E., Voet,A.,
            Dimitrov,B., Krzesinska,P., Vermeesch,J.R. and Tylzanowski,P.
  TITLE     Gollop-Wolfgang Complex Is Associated with a Monoallelic Variation
            in WNT11
  JOURNAL   Genes (Basel) 15 (1), 129 (2024)
   PUBMED   38275609
  REMARK    GeneRIF: Gollop-Wolfgang Complex Is Associated with a Monoallelic
            Variation in WNT11.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Ding,G. and Mu-Guo,S.
  TITLE     Inhibition of Wnt11 impairs the osteogenesis and aggravates the
            inflammatory response of human mesenchymal stem cells under
            LPS-induced inflammatory condition
  JOURNAL   Biochem Biophys Res Commun 661, 82-88 (2023)
   PUBMED   37087802
  REMARK    GeneRIF: Inhibition of Wnt11 impairs the osteogenesis and
            aggravates the inflammatory response of human mesenchymal stem
            cells under LPS-induced inflammatory condition.
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Liu,T., Gonzalez De Los Santos,F., Hirsch,M., Wu,Z. and Phan,S.H.
  TITLE     Noncanonical Wnt Signaling Promotes Myofibroblast Differentiation
            in Pulmonary Fibrosis
  JOURNAL   Am J Respir Cell Mol Biol 65 (5), 489-499 (2021)
   PUBMED   34107237
  REMARK    GeneRIF: Noncanonical Wnt Signaling Promotes Myofibroblast
            Differentiation in Pulmonary Fibrosis.
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Zou,Y., Pan,L., Shen,Y., Wang,X., Huang,C., Wang,H., Jin,X.,
            Yin,C., Wang,Y., Jia,J., Qian,J., Zou,Y., Gong,H. and Ge,J.
  TITLE     Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5
            and EGFR signaling under pressure overload
  JOURNAL   Cell Death Dis 12 (10), 877 (2021)
   PUBMED   34564708
  REMARK    GeneRIF: Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk
            of FZD5 and EGFR signaling under pressure overload.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Wang,J., Gong,M., Zuo,S., Xu,J., Paul,C., Li,H., Liu,M., Wang,Y.G.,
            Ashraf,M. and Xu,M.
  TITLE     WNT11-Conditioned Medium Promotes Angiogenesis through the
            Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway
  JOURNAL   Genes (Basel) 11 (11), 1277 (2020)
   PUBMED   33137935
  REMARK    GeneRIF: WNT11-Conditioned Medium Promotes Angiogenesis through the
            Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Koyanagi,M., Haendeler,J., Badorff,C., Brandes,R.P., Hoffmann,J.,
            Pandur,P., Zeiher,A.M., Kuhl,M. and Dimmeler,S.
  TITLE     Non-canonical Wnt signaling enhances differentiation of human
            circulating progenitor cells to cardiomyogenic cells
  JOURNAL   J Biol Chem 280 (17), 16838-16842 (2005)
   PUBMED   15701629
  REMARK    GeneRIF: Wnt11 promotes cardiac differentiation via the
            non-canonical PKC-dependent signaling pathway
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Ouko,L., Ziegler,T.R., Gu,L.H., Eisenberg,L.M. and Yang,V.W.
  TITLE     Wnt11 signaling promotes proliferation, transformation, and
            migration of IEC6 intestinal epithelial cells
  JOURNAL   J Biol Chem 279 (25), 26707-26715 (2004)
   PUBMED   15084607
  REMARK    GeneRIF: Wnt11 stimulates proliferation, migration, cytoskeletal
            rearrangement, and contact-independent growth by a
            beta-catenin-independent mechanism
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Kirikoshi,H., Sekihara,H. and Katoh,M.
  TITLE     Molecular cloning and characterization of human WNT11
  JOURNAL   Int J Mol Med 8 (6), 651-656 (2001)
   PUBMED   11712081
  REMARK    GeneRIF: WNT11 mRNA was up-regulated in four cases of colorectal
            adenocarcinoma, and a case of renal cell carcinoma. Up-regulation
            of WNT11 mRNA might play an important role in human carcinogenesis
            through activation of the WNT signaling pathway.
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Lako,M., Strachan,T., Bullen,P., Wilson,D.I., Robson,S.C. and
            Lindsay,S.
  TITLE     Isolation, characterisation and embryonic expression of WNT11, a
            gene which maps to 11q13.5 and has possible roles in the
            development of skeleton, kidney and lung
  JOURNAL   Gene 219 (1-2), 101-110 (1998)
   PUBMED   9757009
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000785.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_004626.2.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. It
            encodes a protein which shows 97%, 85%, and 63% amino acid identity
            with mouse, chicken, and Xenopus Wnt11 protein, respectively. This
            gene may play roles in the development of skeleton, kidney and
            lung, and is considered to be a plausible candidate gene for High
            Bone Mass Syndrome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y12692.1, AB070218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322563.8/ ENSP00000325526.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AP000785.4         46159-46336         c
            179-414             AP000785.4         36317-36552         c
            415-692             AP000785.4         34401-34678         c
            693-985             AP000785.4         31398-31690         c
            986-1900            AP000785.4         26159-27073         c
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..1900
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /note="Wnt family member 11"
                     /db_xref="GeneID:7481"
                     /db_xref="HGNC:HGNC:12776"
                     /db_xref="MIM:603699"
     exon            1..178
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1160
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /note="protein Wnt-11; wingless-type MMTV integration site
                     family, member 11"
                     /codon_start=1
                     /product="protein Wnt-11 precursor"
                     /protein_id="NP_004617.2"
                     /db_xref="CCDS:CCDS8242.1"
                     /db_xref="GeneID:7481"
                     /db_xref="HGNC:HGNC:12776"
                     /db_xref="MIM:603699"
                     /translation="MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQH
                     CKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLL
                     DLERGTRESAFVYALSAAAISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADN
                     LSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSC
                     SIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYL
                     QSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYH
                     WCCYVTCRRCERTVERYVCK"
     exon            179..414
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /inference="alignment:Splign:2.1.0"
     exon            415..692
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /inference="alignment:Splign:2.1.0"
     exon            693..985
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1900
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1795..1800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /note="hexamer: AATAAA"
     polyA_site      1816
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /note="major polyA site"
     polyA_site      1900
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcggcg tgcaggacca gcggcggccg tgcaggcgga ggacttcggc gcggctcctc
       61 ctgggtgtga ccccgggcgc gcccgccgcg cgacgatgag ggcgcggccg caggtctgcg
      121 aggcgctgct cttcgccctg gcgctccaga ccggcgtgtg ctatggcatc aagtggctgg
      181 cgctgtccaa gacaccatcg gccctggcac tgaaccagac gcaacactgc aagcagctgg
      241 agggtctggt gtctgcacag gtgcagctgt gccgcagcaa cctggagctc atgcacacgg
      301 tggtgcacgc cgcccgcgag gtcatgaagg cctgtcgccg ggcctttgcc gacatgcgct
      361 ggaactgctc ctccattgag ctcgccccca actatttgct tgacctggag agagggaccc
      421 gggagtcggc cttcgtgtat gcgctgtcgg ccgccgccat cagccacgcc atcgcccggg
      481 cctgcacctc cggcgacctg cccggctgct cctgcggccc cgtcccaggt gagccacccg
      541 ggcccgggaa ccgctgggga ggatgtgcgg acaacctcag ctacgggctc ctcatggggg
      601 ccaagttttc cgatgctcct atgaaggtga aaaaaacagg atcccaagcc aataaactga
      661 tgcgtctaca caacagtgaa gtggggagac aggctctgcg cgcctctctg gaaatgaagt
      721 gtaagtgcca tggggtgtct ggctcctgct ccatccgcac ctgctggaag gggctgcagg
      781 agctgcagga tgtggctgct gacctcaaga cccgatacct gtcggccacc aaggtagtgc
      841 accgacccat gggcacccgc aagcacctgg tgcccaagga cctggatatc cggcctgtga
      901 aggactcgga actcgtctat ctgcagagct cacctgactt ctgcatgaag aatgagaagg
      961 tgggctccca cgggacacaa gacaggcagt gcaacaagac atccaacgga agcgacagct
     1021 gcgaccttat gtgctgcggg cgtggctaca acccctacac agaccgcgtg gtcgagcggt
     1081 gccactgtaa gtaccactgg tgctgctacg tcacctgccg caggtgtgag cgtaccgtgg
     1141 agcgctatgt ctgcaagtga ggccctgccc tccgccccac gcaggagcga ggactctgct
     1201 caaggaccct cagcaactgg ggccaggggc ctggagacac tccatggagc tctgcttgtg
     1261 aattccagat gccaggcatg ggaggcggct tgtgctttgc cttcacttgg aagccaccag
     1321 gaacagaagg tctggccacc ctggaaggag ggcaggacat caaaggaaac cgacaagatt
     1381 aaaaataact tggcagcctg aggctctgga gtgcccacag gctggtgtaa ggagcggggc
     1441 ttgggatcgg tgagactgat acagacttga cctttcaggg ccacagagac cagcctccgg
     1501 gaaggggtct gcccgccttc ttcagaatgt tctgcgggac cccctggccc accctggggt
     1561 ctgagcctgc tgggcccacc acatggaatc actagcttgg gttgtaaatg ttttcttttg
     1621 ttttttgctt tttcttcctt tgggatgtgg aagctacaga aatatttata aaacatagct
     1681 ttttctttgg ggtggcactt ctcaattcct ctttatatat tttatatata taaatatata
     1741 tgtatatata taatgatctc tattttaaaa ctagcttttt aagcagctgt atgaaataaa
     1801 tgctgagtga gccccagccc gcccctgcag ttcccggcct cgtcaagtga actcggcaga
     1861 ccctggggct ggcagaggga gctctccagt ttccaggcaa
//
