LOCUS       NM_003394               2246 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Wnt family member 10B (WNT10B), mRNA.
ACCESSION   NM_003394
VERSION     NM_003394.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2246)
  AUTHORS   Pourdashti,S., Faridi,N., Yaghooti,H., Jalali,M.T., Soroush,A. and
            Bathaie,S.Z.
  TITLE     Possible role of WNT10B in increased proliferation and tubule
            formation of human umbilical vein endothelial cell cultures treated
            with hypoxic conditioned medium from human adipocytes
  JOURNAL   Biotech Histochem 97 (3), 168-179 (2022)
   PUBMED   34044678
  REMARK    GeneRIF: Possible role of WNT10B in increased proliferation and
            tubule formation of human umbilical vein endothelial cell cultures
            treated with hypoxic conditioned medium from human adipocytes.
REFERENCE   2  (bases 1 to 2246)
  AUTHORS   Williams,M., Zeng,Y., Chiquet,B., Jacob,H., Kurtis Kasper,F.,
            Harrington,D.A., English,J., Akyalcin,S. and Letra,A.
  TITLE     Functional characterization of ATF1, GREM2 AND WNT10B variants
            associated with tooth agenesis
  JOURNAL   Orthod Craniofac Res 24 (4), 486-493 (2021)
   PUBMED   33369218
  REMARK    GeneRIF: Functional characterization of ATF1, GREM2 AND WNT10B
            variants associated with tooth agenesis.
REFERENCE   3  (bases 1 to 2246)
  AUTHORS   Cassaro,A., Grillo,G., Notaro,M., Gliozzo,J., Esposito,I., Reda,G.,
            Trojani,A., Valentini,G., Di Camillo,B., Cairoli,R. and Beghini,A.
  TITLE     FZD6 triggers Wnt-signalling driven by WNT10BIVS1 expression and
            highlights new targets in T-cell acute lymphoblastic leukemia
  JOURNAL   Hematol Oncol 39 (3), 364-379 (2021)
   PUBMED   33497493
  REMARK    GeneRIF: FZD6 triggers Wnt-signalling driven by WNT10B(IVS1)
            expression and highlights new targets in T-cell acute lymphoblastic
            leukemia.
REFERENCE   4  (bases 1 to 2246)
  AUTHORS   Li,C., Chen,X., Liu,T. and Chen,G.
  TITLE     lncRNA HOTAIRM1 regulates cell proliferation and the metastasis of
            thyroid cancer by targeting Wnt10b
  JOURNAL   Oncol Rep 45 (3), 1083-1093 (2021)
   PUBMED   33650656
  REMARK    GeneRIF: lncRNA HOTAIRM1 regulates cell proliferation and the
            metastasis of thyroid cancer by targeting Wnt10b.
REFERENCE   5  (bases 1 to 2246)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2246)
  AUTHORS   Van Den Berg,D.J., Sharma,A.K., Bruno,E. and Hoffman,R.
  TITLE     Role of members of the Wnt gene family in human hematopoiesis
  JOURNAL   Blood 92 (9), 3189-3202 (1998)
   PUBMED   9787155
REFERENCE   7  (bases 1 to 2246)
  AUTHORS   Bergstein,I., Eisenberg,L.M., Bhalerao,J., Jenkins,N.A.,
            Copeland,N.G., Osborne,M.P., Bowcock,A.M. and Brown,A.M.
  TITLE     Isolation of two novel WNT genes, WNT14 and WNT15, one of which
            (WNT15) is closely linked to WNT3 on human chromosome 17q21
  JOURNAL   Genomics 46 (3), 450-458 (1997)
   PUBMED   9441749
REFERENCE   8  (bases 1 to 2246)
  AUTHORS   Bui,T.D., Rankin,J., Smith,K., Huguet,E.L., Ruben,S., Strachan,T.,
            Harris,A.L. and Lindsay,S.
  TITLE     A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in
            human breast carcinomas
  JOURNAL   Oncogene 14 (10), 1249-1253 (1997)
   PUBMED   9121776
REFERENCE   9  (bases 1 to 2246)
  AUTHORS   Hardiman,G., Kastelein,R.A. and Bazan,J.F.
  TITLE     Isolation, characterization and chromosomal localization of human
            WNT10B
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 278-282 (1997)
   PUBMED   9284937
REFERENCE   10 (bases 1 to 2246)
  AUTHORS   Smolich,B.D., McMahon,J.A., McMahon,A.P. and Papkoff,J.
  TITLE     Wnt family proteins are secreted and associated with the cell
            surface
  JOURNAL   Mol Biol Cell 4 (12), 1267-1275 (1993)
   PUBMED   8167409
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA530656.1, BC096356.1 and
            U81787.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003394.3.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. It may
            be involved in breast cancer, and its protein signaling is likely a
            molecular switch that governs adipogenesis. This protein is 96%
            identical to the mouse Wnt10b protein at the amino acid level. This
            gene is clustered with another family member, WNT1, in the
            chromosome 12q13 region. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U81787.1, SRR1803612.140697.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301061.9/ ENSP00000301061.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               DA530656.1         128-364
            238-2181            BC096356.1         1-1944
            2182-2246           U81787.1           2224-2288
FEATURES             Location/Qualifiers
     source          1..2246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2246
                     /gene="WNT10B"
                     /gene_synonym="SHFM6; STHAG8; WNT-12"
                     /note="Wnt family member 10B"
                     /db_xref="GeneID:7480"
                     /db_xref="HGNC:HGNC:12775"
                     /db_xref="MIM:601906"
     exon            1..281
                     /gene="WNT10B"
                     /gene_synonym="SHFM6; STHAG8; WNT-12"
                     /inference="alignment:Splign:2.1.0"
     exon            282..395
                     /gene="WNT10B"
                     /gene_synonym="SHFM6; STHAG8; WNT-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1491
                     /gene="WNT10B"
                     /gene_synonym="SHFM6; STHAG8; WNT-12"
                     /note="WNT-10B protein; protein Wnt-10b; wingless-type
                     MMTV integration site family, member 10B"
                     /codon_start=1
                     /product="protein Wnt-10b precursor"
                     /protein_id="NP_003385.2"
                     /db_xref="CCDS:CCDS8775.1"
                     /db_xref="GeneID:7480"
                     /db_xref="HGNC:HGNC:12775"
                     /db_xref="MIM:601906"
                     /translation="MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTA
                     NTVCLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGR
                     LPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAK
                     LLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSRE
                     APRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALR
                     ERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGRAC
                     NKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK"
     exon            396..658
                     /gene="WNT10B"
                     /gene_synonym="SHFM6; STHAG8; WNT-12"
                     /inference="alignment:Splign:2.1.0"
     exon            659..1032
                     /gene="WNT10B"
                     /gene_synonym="SHFM6; STHAG8; WNT-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..2246
                     /gene="WNT10B"
                     /gene_synonym="SHFM6; STHAG8; WNT-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2228..2233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT10B"
                     /gene_synonym="SHFM6; STHAG8; WNT-12"
                     /note="hexamer: AATAAA"
     polyA_site      2246
                     /gene="WNT10B"
                     /gene_synonym="SHFM6; STHAG8; WNT-12"
                     /note="major polyA site"
ORIGIN      
        1 agagccaccc tgagctcggt gagagcaaag ccagagcccc cagtcctttg ctcgccggct
       61 tgctagctct ctcgatcact ccctcccttc ctccctccct tcctcccggc ggccgcggcg
      121 gcgctgggga agcggtgaag aggagtggcc cggccctgga agaatgcggc tctgacaagg
      181 ggacagaacc cagcgcagtc tccccacggt ttaagcagca ctagtgaagc ccaggcaacc
      241 caaccgtgcc tgtctcggac cccgcaccca aaccactgga ggtcctgatc gatctgccca
      301 ccggagcctc cgggcttcga catgctggag gagccccggc cgcggcctcc gccctcgggc
      361 ctcgcgggtc tcctgttcct ggcgttgtgc agtcgggctc taagcaatga gattctgggc
      421 ctgaagttgc ctggcgagcc gccgctgacg gccaacaccg tgtgcttgac gctgtccggc
      481 ctgagcaagc ggcagctagg cctgtgcctg cgcaaccccg acgtgacggc gtccgcgctt
      541 cagggtctgc acatcgcggt ccacgagtgt cagcaccagc tgcgcgacca gcgctggaac
      601 tgctccgcgc ttgagggcgg cggccgcctg ccgcaccaca gcgccatcct caagcgcggt
      661 ttccgagaaa gtgctttttc cttctccatg ctggctgctg gggtcatgca cgcagtagcc
      721 acggcctgca gcctgggcaa gctggtgagc tgtggctgtg gctggaaggg cagtggtgag
      781 caggatcggc tgagggccaa actgctgcag ctgcaggcac tgtcccgagg caagagtttc
      841 ccccactctc tgcccagccc tggccctggc tcaagcccca gccctggccc ccaggacaca
      901 tgggaatggg gtggctgtaa ccatgacatg gactttggag agaagttctc tcgggatttc
      961 ttggattcca gggaagctcc ccgggacatc caggcacgaa tgcgaatcca caacaacagg
     1021 gtggggcgcc aggtggtaac tgaaaacctg aagcggaaat gcaagtgtca tggcacatca
     1081 ggcagctgcc agttcaagac atgctggagg gcggccccag agttccgggc agtgggggcg
     1141 gcgttgaggg agcggctggg ccgggccatc ttcattgata cccacaaccg caattctgga
     1201 gccttccagc cccgtctgcg tccccgtcgc ctctcaggag agctggtcta ctttgagaag
     1261 tctcctgact tctgtgagcg agaccccact atgggctccc cagggacaag gggccgggcc
     1321 tgcaacaaga ccagccgcct gttggatggc tgtggcagcc tgtgctgtgg ccgtgggcac
     1381 aacgtgctcc ggcagacacg agttgagcgc tgccattgcc gcttccactg gtgctgctat
     1441 gtgctgtgtg atgagtgcaa ggttacagag tgggtgaatg tgtgtaagtg agggtcagcc
     1501 ttaccttggg gctggggaag aggactgtgt gagaggggcg ccttttcagc cctttgctct
     1561 gatttccttc caaggtcact cttggtccct ggaagcttaa agtatctacc tggaaacagc
     1621 tttaggggtg gtgggggtca ggtggactct gggatgtgta gccttctccc caacaattgg
     1681 agggtcttga ggggaagctg ccacccctct tctgctcctt agacacctga atggactaag
     1741 atgaaatgca ctgtattgct cctcccactt ctcaactcca gagccccttt aaccctgatt
     1801 catactcctt ttggctgggg agtccctata gtttcaccac tcctctccct tgagggataa
     1861 ccccaggcac tgtttggagc cataagatct gtatctagaa agagatcacc cactcctatg
     1921 tactatcccc aaactccttt actgcagcct gggctccctc ttgtgggata atgggagaca
     1981 gtggtagaga ggtttttctt gggaaagaga cagagtgctg aggggcactc tcccctgaat
     2041 cctcagagag ttgtctgtcc aggcccttag ggaagttgtc tccttccatt cagatgttaa
     2101 tggggaccct ccaaaggaag gggttttccc atgactcttg gagcctcttt ttccttcttc
     2161 agcaggaagg gtgggaaggg ataatttatc atactgagac ttgttcttgg ttcctgtttg
     2221 aaactaaaat aaattaagtt actgga
//
