LOCUS       NM_025216               2055 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Wnt family member 10A (WNT10A), mRNA.
ACCESSION   NM_025216
VERSION     NM_025216.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Ma,Y.N., Zou,Y.D., Liu,Z.L., Wu,G.X., Zhou,Y.Z., Luo,C.X.,
            Huang,X.T., Xie,M.L., Xu,S.N. and Li,X.
  TITLE     SENP3 Promotes Mantle Cell Lymphoma Development through Regulating
            Wnt10a Expression
  JOURNAL   Curr Med Sci 44 (1), 134-143 (2024)
   PUBMED   38273178
  REMARK    GeneRIF: SENP3 Promotes Mantle Cell Lymphoma Development through
            Regulating Wnt10a Expression.
REFERENCE   2  (bases 1 to 2055)
  AUTHORS   Liu,Y., Sun,J., Zhang,C., Wu,Y., Ma,S., Li,X., Wu,X. and Gao,Q.
  TITLE     Compound heterozygous WNT10A missense variations exacerbated the
            tooth agenesis caused by hypohidrotic ectodermal dysplasia
  JOURNAL   BMC Oral Health 24 (1), 136 (2024)
   PUBMED   38280992
  REMARK    GeneRIF: Compound heterozygous WNT10A missense variations
            exacerbated the tooth agenesis caused by hypohidrotic ectodermal
            dysplasia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2055)
  AUTHORS   Cesarato,N., Schwieger-Briel,A., Gossmann,Y., Henne,S.K.,
            Hillmann,K., Frommherz,L.H., Wehner,M., Xiong,X., Thiele,H.,
            Oji,V., Milani,D., Tantcheva-Poor,I., Giehl,K., Folster-Holst,R.,
            Teichler,A., Braeckmans,D., Hoeger,P.H., Jones,G., Frank,J.,
            Weibel,L., Blume-Peytavi,U., Hamm,H., Nothen,M.M., Geyer,M.,
            Heilmann-Heimbach,S., Basmanav,F.B. and Betz,R.C.
  TITLE     Short anagen hair syndrome: association with mono- and biallelic
            variants in WNT10A and a genetic overlap with male pattern hair
            loss
  JOURNAL   Br J Dermatol 189 (6), 741-749 (2023)
   PUBMED   37671665
  REMARK    GeneRIF: Short anagen hair syndrome: association with mono- and
            biallelic variants in WNT10A and a genetic overlap with male
            pattern hair loss.
REFERENCE   4  (bases 1 to 2055)
  AUTHORS   Zhao,Y., Hou,Y., Ren,J., Gao,X., Meng,L., Liu,Y., Xing,C. and
            Shen,W.
  TITLE     Phenotypic characteristics of taurodontism and a novel WNT10A
            variant in non-syndromic oligodontia family
  JOURNAL   Arch Oral Biol 154, 105759 (2023)
   PUBMED   37422997
  REMARK    GeneRIF: Phenotypic characteristics of taurodontism and a novel
            WNT10A variant in non-syndromic oligodontia family.
REFERENCE   5  (bases 1 to 2055)
  AUTHORS   Ramirez,I., Kirschneck,C., Silva-Sousa,A.C., Proff,P., S
            Antunes,L., Gabbardo,M.C., de Oliveira,D.S., Sousa-Neto,M.D.,
            Baratto-Filho,F. and Kuchler,E.C.
  TITLE     The investigation of WNT6 and WNT10A single nucleotide
            polymorphisms as potential biomarkers for dental pulp calcification
            in orthodontic patients
  JOURNAL   PLoS One 18 (8), e0288782 (2023)
   PUBMED   37566620
  REMARK    GeneRIF: The investigation of WNT6 and WNT10A single nucleotide
            polymorphisms as potential biomarkers for dental pulp calcification
            in orthodontic patients.
            Erratum:[PLoS One. 2024 Jun 6;19(6):e0305377. doi:
            10.1371/journal.pone.0305377.. PMID: 38843152]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2055)
  AUTHORS   Adaimy,L., Chouery,E., Megarbane,H., Mroueh,S., Delague,V.,
            Nicolas,E., Belguith,H., de Mazancourt,P. and Megarbane,A.
  TITLE     Mutation in WNT10A is associated with an autosomal recessive
            ectodermal dysplasia: the odonto-onycho-dermal dysplasia
  JOURNAL   Am J Hum Genet 81 (4), 821-828 (2007)
   PUBMED   17847007
  REMARK    GeneRIF: c.697G-->T (p.Glu233X) homozygous nonsense mutation in
            exon 3 of the WNT10A gene in an autosomal recessive ectodermal
            dysplasia: odonto-onycho-dermal dysplasia
REFERENCE   7  (bases 1 to 2055)
  AUTHORS   Beaty,T.H., Hetmanski,J.B., Fallin,M.D., Park,J.W., Sull,J.W.,
            McIntosh,I., Liang,K.Y., Vanderkolk,C.A., Redett,R.J.,
            Boyadjiev,S.A., Jabs,E.W., Chong,S.S., Cheah,F.S., Wu-Chou,Y.H.,
            Chen,P.K., Chiu,Y.F., Yeow,V., Ng,I.S., Cheng,J., Huang,S., Ye,X.,
            Wang,H., Ingersoll,R. and Scott,A.F.
  TITLE     Analysis of candidate genes on chromosome 2 in oral cleft
            case-parent trios from three populations
  JOURNAL   Hum Genet 120 (4), 501-518 (2006)
   PUBMED   16953426
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2055)
  AUTHORS   Zhou,S., Eid,K. and Glowacki,J.
  TITLE     Cooperation between TGF-beta and Wnt pathways during chondrocyte
            and adipocyte differentiation of human marrow stromal cells
  JOURNAL   J Bone Miner Res 19 (3), 463-470 (2004)
   PUBMED   15040835
REFERENCE   9  (bases 1 to 2055)
  AUTHORS   Kirikoshi,H., Sekihara,H. and Katoh,M.
  TITLE     WNT10A and WNT6, clustered in human chromosome 2q35 region with
            head-to-tail manner, are strongly coexpressed in SW480 cells
  JOURNAL   Biochem Biophys Res Commun 283 (4), 798-805 (2001)
   PUBMED   11350055
REFERENCE   10 (bases 1 to 2055)
  AUTHORS   Wright,J.T., Grange,D.K. and Fete,M.
  TITLE     Hypohidrotic Ectodermal Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301291
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073128.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_025216.2.
            
            Summary: The WNT gene family consists of structurally related genes
            which encode secreted signaling proteins. These proteins have been
            implicated in oncogenesis and in several developmental processes,
            including regulation of cell fate and patterning during
            embryogenesis. This gene is a member of the WNT gene family. It is
            strongly expressed in the cell lines of promyelocytic leukemia and
            Burkitt's lymphoma. In addition, it and another family member, the
            WNT6 gene, are strongly coexpressed in colorectal cancer cell
            lines. The gene overexpression may play key roles in carcinogenesis
            through activation of the WNT-beta-catenin-TCF signaling pathway.
            This gene and the WNT6 gene are clustered in the chromosome 2q35
            region. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052234.1, AK024363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258411.8/ ENSP00000258411.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AC073128.5         14080-14336
            258-520             AC073128.5         15389-15651
            521-900             AC073128.5         23212-23591
            901-2055            AC073128.5         26002-27156
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2055
                     /gene="WNT10A"
                     /gene_synonym="ECTD16; OODD; SSPS; STHAG4"
                     /note="Wnt family member 10A"
                     /db_xref="GeneID:80326"
                     /db_xref="HGNC:HGNC:13829"
                     /db_xref="MIM:606268"
     exon            1..257
                     /gene="WNT10A"
                     /gene_synonym="ECTD16; OODD; SSPS; STHAG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1398
                     /gene="WNT10A"
                     /gene_synonym="ECTD16; OODD; SSPS; STHAG4"
                     /note="protein Wnt-10a; wingless-type MMTV integration
                     site family, member 10A"
                     /codon_start=1
                     /product="protein Wnt-10a precursor"
                     /protein_id="NP_079492.2"
                     /db_xref="CCDS:CCDS2426.1"
                     /db_xref="GeneID:80326"
                     /db_xref="HGNC:HGNC:13829"
                     /db_xref="MIM:606268"
                     /translation="MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDI
                     LDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRD
                     QRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCD
                     ASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDM
                     GFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTC
                     WQVTPEFRTVGALLRSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPA
                     DLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERC
                     HCRFHWCCFVVCEECRITEWVSVCK"
     exon            258..520
                     /gene="WNT10A"
                     /gene_synonym="ECTD16; OODD; SSPS; STHAG4"
                     /inference="alignment:Splign:2.1.0"
     exon            521..900
                     /gene="WNT10A"
                     /gene_synonym="ECTD16; OODD; SSPS; STHAG4"
                     /inference="alignment:Splign:2.1.0"
     exon            901..2055
                     /gene="WNT10A"
                     /gene_synonym="ECTD16; OODD; SSPS; STHAG4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2038..2043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WNT10A"
                     /gene_synonym="ECTD16; OODD; SSPS; STHAG4"
                     /note="hexamer: AACAAG"
     polyA_site      2055
                     /gene="WNT10A"
                     /gene_synonym="ECTD16; OODD; SSPS; STHAG4"
                     /note="major polyA site"
ORIGIN      
        1 gtctgctccg ggagccctga cccgagtcgg agctgtgtgt cgcagccgcc ccgacccccc
       61 gccgatcatg cgccggcgcc cctggctctc cagtcccact gggctgtgag ccccccactc
      121 ccagcccgtc agggcctgcg cgccatgggc agcgcccacc ctcgcccctg gctgcggctc
      181 cgaccccagc cccagccgcg gccagcgctc tgggtgctcc tgttcttcct actgctgctg
      241 gctgctgcca tgcccaggtc agcacccaat gacattctgg acctccgcct ccccccggag
      301 cccgtgctca atgccaacac agtgtgccta acattgccag gcctgagccg gcggcagatg
      361 gaggtgtgtg tgcgtcaccc tgatgtggct gcctcagcca tacagggcat ccagatcgcc
      421 atccacgaat gccaacacca attcagggac cagcgctgga actgctcaag cctggagact
      481 cgcaacaaga tcccctatga gagtcccatc ttcagcagag gtttccgaga gagcgctttt
      541 gcctacgcca tcgcagcagc tggcgtggtg cacgccgtgt ccaatgcgtg tgccctgggc
      601 aaactgaagg cctgtggctg tgatgcgtcc cggcgagggg acgaggaggc cttccgtagg
      661 aagctgcacc gcttacaact ggatgcactg cagcgtggta agggcctgag ccatggggtc
      721 ccggaacacc cagccctgcc cacagccagc ccaggcctgc aggactcctg ggagtggggc
      781 ggctgcagcc ccgacatggg cttcggggag cgcttttcta aggactttct ggactcccgg
      841 gagcctcaca gagacatcca cgcgagaatg aggcttcaca acaaccgagt tgggaggcag
      901 gcagtgatgg agaacatgcg gcggaagtgc aagtgccacg gcacgtcagg cagctgccag
      961 ctcaagacgt gctggcaggt gacgcccgag ttccgcaccg tgggggcgct gctgcgcagc
     1021 cgcttccacc gcgccacgct catccggccg cacaaccgca acggcggcca gctggagccg
     1081 ggcccagcgg gggcaccctc gccggctccg ggcgctcccg ggccgcgccg acgggccagc
     1141 cccgccgacc tggtctactt cgaaaagtct cccgacttct gcgagcgcga gccgcgcctg
     1201 gactcggcgg gcaccgtggg ccgcctgtgc aacaagagca gcgccggctc ggatggctgc
     1261 ggcagcatgt gctgcggccg cggccacaac atcctgcgcc agacgcgcag cgagcgctgc
     1321 cactgccgct tccactggtg ctgtttcgtg gtctgcgaag agtgccgcat caccgagtgg
     1381 gtcagcgtct gcaagtgagc ggcccggggt cccctgggcc ctgatcgagg tcccctcctg
     1441 gagcctggcc ctctgaggct tacggtcttg gcaaggcagc atcgccttgg ctcttgggaa
     1501 gaggagattg gaccacatga tcttatagga acccctcagc tctgaggtct gtgatcgccg
     1561 gacagtccag gcctgtctga accccaccac tcacttctgt gggctctagg actgactggg
     1621 ttcttcctcc ctccccgaag cccagacagt tcagttgggc tgggggttgc tccacaccct
     1681 aaaacaagcc tcagccaggc aacccgtcag tctgtctcca tcctttcacc ccttccctgg
     1741 agatgggagg tggggaatga atggaagctg acgggcagag agaggaggat taaaaaaaag
     1801 aaatagacat aactgagctg aagtaattcc ataaagggcc cagacagcct cctccaccat
     1861 tcccttcatc attcatttaa caaatattta ttttgcactc tctttgcggc actctggggg
     1921 cggtggggtg cgtgggggtg gcaatgcaag gcactgaggc cacagatgtg agtaagcgag
     1981 acacaacact tgtcctcttg gaggttacat tcttgctggg gggaggcatg ggcaataaac
     2041 aagtaaatat acaaa
//
