LOCUS       NM_024911               2716 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens Wnt ligand secretion mediator (WLS), transcript
            variant 1, mRNA.
ACCESSION   NM_024911
VERSION     NM_024911.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2716)
  AUTHORS   Abdel-Salam,G.M.H., Afifi,H.H., Abdel-Hamid,M.S., Ahmed,N.E.B.,
            Taher,M.B., El-Kamah,G., Thiele,H., Nurnberg,P.N. and Bolz,H.J.
  TITLE     Expanding the phenotypic spectrum and clinical severity associated
            with WLS gene
  JOURNAL   J Hum Genet 68 (9), 607-613 (2023)
   PUBMED   37106064
  REMARK    GeneRIF: Expanding the phenotypic spectrum and clinical severity
            associated with WLS gene.
REFERENCE   2  (bases 1 to 2716)
  AUTHORS   Yu,C., Wang,C., Zhou,W., Zhang,A., Jia,Z., Zheng,B. and Ding,G.
  TITLE     Compound heterozygous variants in WLS gene causes Zaki syndrome
  JOURNAL   Clin Genet 104 (2), 226-229 (2023)
   PUBMED   37005218
  REMARK    GeneRIF: Compound heterozygous variants in WLS gene causes Zaki
            syndrome.
REFERENCE   3  (bases 1 to 2716)
  AUTHORS   Kantaputra,P., Tripuwabhrut,K., Jatooratthawichot,P.,
            Adisornkanj,P., Hatsadaloi,A., Porntrakoolsaree,N., Kaewgaya,M.,
            Olsen,B., Tongsima,S., Ngamphiw,C. and Ketudat Cairns,J.R.
  TITLE     Mutations in the WLS are associated with dental anomalies, torus
            palatinus, and torus mandibularis
  JOURNAL   Eur J Orthod 45 (3), 317-323 (2023)
   PUBMED   36374649
  REMARK    GeneRIF: Mutations in the WLS are associated with dental anomalies,
            torus palatinus, and torus mandibularis.
REFERENCE   4  (bases 1 to 2716)
  AUTHORS   Wolf,L. and Boutros,M.
  TITLE     The role of Evi/Wntless in exporting Wnt proteins
  JOURNAL   Development 150 (3) (2023)
   PUBMED   36763105
  REMARK    GeneRIF: The role of Evi/Wntless in exporting Wnt proteins.
            Review article
REFERENCE   5  (bases 1 to 2716)
  AUTHORS   Xie,Y.K., Luo,H., Zhang,S.X., Chen,X.Y., Guo,R., Qiu,X.Y., Liu,S.,
            Wu,H., Chen,W.B., Zhen,X.H., Ma,Q., Tian,J.L., Li,S., Chen,X.,
            Han,Q., Duan,S., Shen,C., Yang,F. and Xu,Z.Z.
  TITLE     GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain
            via WNT-mediated TRPV1 activation
  JOURNAL   Sci Transl Med 14 (639), eabh2557 (2022)
   PUBMED   35385340
  REMARK    GeneRIF: GPR177 in A-fiber sensory neurons drives diabetic
            neuropathic pain via WNT-mediated TRPV1 activation.
REFERENCE   6  (bases 1 to 2716)
  AUTHORS   Belenkaya,T.Y., Wu,Y., Tang,X., Zhou,B., Cheng,L., Sharma,Y.V.,
            Yan,D., Selva,E.M. and Lin,X.
  TITLE     The retromer complex influences Wnt secretion by recycling wntless
            from endosomes to the trans-Golgi network
  JOURNAL   Dev Cell 14 (1), 120-131 (2008)
   PUBMED   18160348
REFERENCE   7  (bases 1 to 2716)
  AUTHORS   Binnerts,M.E., Kim,K.A., Bright,J.M., Patel,S.M., Tran,K., Zhou,M.,
            Leung,J.M., Liu,Y., Lomas,W.E. 3rd, Dixon,M., Hazell,S.A.,
            Wagle,M., Nie,W.S., Tomasevic,N., Williams,J., Zhan,X., Levy,M.D.,
            Funk,W.D. and Abo,A.
  TITLE     R-Spondin1 regulates Wnt signaling by inhibiting internalization of
            LRP6
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14700-14705 (2007)
   PUBMED   17804805
REFERENCE   8  (bases 1 to 2716)
  AUTHORS   Bartscherer,K., Pelte,N., Ingelfinger,D. and Boutros,M.
  TITLE     Secretion of Wnt ligands requires Evi, a conserved transmembrane
            protein
  JOURNAL   Cell 125 (3), 523-533 (2006)
   PUBMED   16678096
REFERENCE   9  (bases 1 to 2716)
  AUTHORS   Banziger,C., Soldini,D., Schutt,C., Zipperlen,P., Hausmann,G. and
            Basler,K.
  TITLE     Wntless, a conserved membrane protein dedicated to the secretion of
            Wnt proteins from signaling cells
  JOURNAL   Cell 125 (3), 509-522 (2006)
   PUBMED   16678095
REFERENCE   10 (bases 1 to 2716)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ323735.1 and AW137622.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024911.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074984.1, DQ323735.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262348.9/ ENSP00000262348.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2655              DQ323735.1         48-2702
            2656-2716           AW137622.1         17-77               c
FEATURES             Location/Qualifiers
     source          1..2716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..2716
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /note="Wnt ligand secretion mediator"
                     /db_xref="GeneID:79971"
                     /db_xref="HGNC:HGNC:30238"
                     /db_xref="MIM:611514"
     exon            1..330
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1850
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /note="isoform 1 is encoded by transcript variant 1; G
                     protein-coupled receptor 177; integral membrane protein
                     GPR177; putative NFkB activating protein 373; protein
                     evenness interrupted homolog; putative
                     NF-kappa-B-activating protein 373; wntless Wnt ligand
                     secretion mediator"
                     /codon_start=1
                     /product="protein wntless homolog isoform 1"
                     /protein_id="NP_079187.3"
                     /db_xref="CCDS:CCDS642.1"
                     /db_xref="GeneID:79971"
                     /db_xref="HGNC:HGNC:30238"
                     /db_xref="MIM:611514"
                     /translation="MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVS
                     YMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHME
                     MSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKL
                     KCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKD
                     IRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGIS
                     MTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAG
                     YWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLY
                     FLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFF
                     IVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDL
                     GVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE"
     exon            331..603
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            604..728
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            729..890
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1027
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1196
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1294
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1358
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1502
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1586
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1740
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2716
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /note="hexamer: ATTAAA"
     polyA_site      2584
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /note="major polyA site"
     regulatory      2659..2664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
                     /note="hexamer: AATAAA"
     polyA_site      2680
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
     polyA_site      2716
                     /gene="WLS"
                     /gene_synonym="C1orf139; EVI; GPR177; mig-14; MRP; ZKS"
ORIGIN      
        1 acaatcacag ctccgggcat tgggggaacc cgagccggct gcgccggggg aatccgtgcg
       61 ggcgccttcc gtcccggtcc catcctcgcc gcgctccagc acctctgaag ttttgcagcg
      121 cccagaaagg aggcgaggaa ggagggagtg tgtgagagga gggagcaaaa agctcaccct
      181 aaaacattta tttcaaggag aaaagaaaaa gggggggcgc aaaaatggct ggggcaatta
      241 tagaaaacat gagcaccaag aagctgtgca ttgttggtgg gattctgctc gtgttccaaa
      301 tcatcgcctt tctggtggga ggcttgattg ctccagggcc cacaacggca gtgtcctaca
      361 tgtcggtgaa atgtgtggat gcccgtaaga accatcacaa gacaaaatgg ttcgtgcctt
      421 ggggacccaa tcattgtgac aagatccgag acattgaaga ggcaattcca agggaaattg
      481 aagccaatga catcgtgttt tctgttcaca ttcccctccc ccacatggag atgagtcctt
      541 ggttccaatt catgctgttt atcctgcagc tggacattgc cttcaagcta aacaaccaaa
      601 tcagagaaaa tgcagaagtc tccatggacg tttccctggc ttaccgtgat gacgcgtttg
      661 ctgagtggac tgaaatggcc catgaaagag taccacggaa actcaaatgc accttcacat
      721 ctcccaagac tccagagcat gagggccgtt actatgaatg tgatgtcctt cctttcatgg
      781 aaattgggtc tgtggcccat aagttttacc ttttaaacat ccggctgcct gtgaatgaga
      841 agaagaaaat caatgtggga attggggaga taaaggatat ccggttggtg gggatccacc
      901 aaaatggagg cttcaccaag gtgtggtttg ccatgaagac cttccttacg cccagcatct
      961 tcatcattat ggtgtggtat tggaggagga tcaccatgat gtcccgaccc ccagtgcttc
     1021 tggaaaaagt catctttgcc cttgggattt ccatgacctt tatcaatatc ccagtggaat
     1081 ggttttccat cgggtttgac tggacctgga tgctgctgtt tggtgacatc cgacagggca
     1141 tcttctatgc gatgcttctg tccttctgga tcatcttctg tggcgagcac atgatggatc
     1201 agcacgagcg gaaccacatc gcagggtatt ggaagcaagt cggacccatt gccgttggct
     1261 ccttctgcct cttcatattt gacatgtgtg agagaggggt acaactcacg aatcccttct
     1321 acagtatctg gactacagac attggaacag agctggccat ggccttcatc atcgtggctg
     1381 gaatctgcct ctgcctctac ttcctgtttc tatgcttcat ggtatttcag gtgtttcgga
     1441 acatcagtgg gaagcagtcc agcctgccag ctatgagcaa agtccggcgg ctacactatg
     1501 aggggctaat ttttaggttc aagttcctca tgcttatcac cttggcctgc gctgccatga
     1561 ctgtcatctt cttcatcgtt agtcaggtaa cggaaggcca ttggaaatgg ggcggcgtca
     1621 cagtccaagt gaacagtgcc tttttcacag gcatctatgg gatgtggaat ctgtatgtct
     1681 ttgctctgat gttcttgtat gcaccatccc ataaaaacta tggagaagac cagtccaatg
     1741 gcgatctggg tgtccatagt ggggaagaac tccagctcac caccactatc acccatgtgg
     1801 acggacccac tgagatctac aagttgaccc gcaaggaggc ccaggagtag gaggctgcag
     1861 cgcccggctg ggacggtctc tccatacccc agcccctcta actagagtgg ggagcatgcc
     1921 agagagagct caatgtacaa atgaatgcct catggctctt agctgtggtt tcttggacca
     1981 gcggcatgga catttgtcag tttgccttct gacggtagct tttggaggaa gattcctgca
     2041 gccactaatg cattgtgtat gataacaaaa actctggtat gacacatttt ctgtgatcat
     2101 tgttaattag tgacatagta acatctgtag cagctggtta gtaaacctca tgtgggggtg
     2161 gggtgggggt gtattccttg ggggatggtt tgggccgaat ggggagtgga atatttgaca
     2221 tttttcctgt tttaaattct aggatagatt ttaacatcct ttgcggtccc agtccaaggt
     2281 aggctggtgt catagtcttc tcactcctaa tccatgacca ctgttttttt cctatttata
     2341 tcaccaggta gcccactgag ttaatattta agttgtcaat agataagtgt ccctgttttg
     2401 tggcataata taactgaatt tcatgagaag atttattcca ccaggggtat ttcagctttg
     2461 aaaccaaatc tgtgtatcta atactaacca atctgttgga tgtgggtttt aaaaaatgtt
     2521 tgctaaacta cccaagtaag atttactgta ttaaatggcc ttcgggtctg aaaagctttt
     2581 ttaacttctt gcttaaaatg cgttttattt tgataagata cttcaaatag cctccaaaag
     2641 tgtagatcca atcatttaaa taaacctgta tgtatatgca tatgtgtaca tgcatatccc
     2701 ctcctgctaa aactca
//
