LOCUS       NM_001371589            8987 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens WIZ zinc finger (WIZ), transcript variant 3, mRNA.
ACCESSION   NM_001371589 XM_005260004
VERSION     NM_001371589.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8987)
  AUTHORS   Conway,E., Jerman,E., Healy,E., Ito,S., Holoch,D., Oliviero,G.,
            Deevy,O., Glancy,E., Fitzpatrick,D.J., Mucha,M., Watson,A.,
            Rice,A.M., Chammas,P., Huang,C., Pratt-Kelly,I., Koseki,Y.,
            Nakayama,M., Ishikura,T., Streubel,G., Wynne,K., Hokamp,K.,
            McLysaght,A., Ciferri,C., Di Croce,L., Cagney,G., Margueron,R.,
            Koseki,H. and Bracken,A.P.
  TITLE     A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL
            Genes Balance PRC2 Subtype Activities
  JOURNAL   Mol Cell 70 (3), 408-421 (2018)
   PUBMED   29628311
REFERENCE   2  (bases 1 to 8987)
  AUTHORS   Isbel,L., Prokopuk,L., Wu,H., Daxinger,L., Oey,H., Spurling,A.,
            Lawther,A.J., Hale,M.W. and Whitelaw,E.
  TITLE     Wiz binds active promoters and CTCF-binding sites and is required
            for normal behaviour in the mouse
  JOURNAL   Elife 5, e15082 (2016)
   PUBMED   27410475
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8987)
  AUTHORS   Simon,J.M., Parker,J.S., Liu,F., Rothbart,S.B., Ait-Si-Ali,S.,
            Strahl,B.D., Jin,J., Davis,I.J., Mosley,A.L. and Pattenden,S.G.
  TITLE     A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the
            G9a Methyltransferase on Chromatin
  JOURNAL   J Biol Chem 290 (43), 26088-26102 (2015)
   PUBMED   26338712
  REMARK    GeneRIF: Disrupting the association of G9a-GLP with chromatin by
            depleting WIZ resulted in altered gene expression and
            protein-protein interactions that were distinguishable from that of
            small molecule-based inhibition of G9a/GLP
REFERENCE   4  (bases 1 to 8987)
  AUTHORS   Bian,C., Chen,Q. and Yu,X.
  TITLE     The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP
            complex for gene repression
  JOURNAL   Elife 4, e05606 (2015)
   PUBMED   25789554
  REMARK    GeneRIF: Data indicate zinc finger proteins ZNF644 and WIZ as two
            core subunits in the histone-lysine N-methyltransferase G9a/GLP
            complex, and interact with the transcription activation domain of
            G9a and GLP.
            Erratum:[Elife. 2015 Apr 22;4. doi: 10.7554/eLife.08168.. PMID:
            25900010]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8987)
  AUTHORS   Lopez-Contreras,A.J., Ruppen,I., Nieto-Soler,M., Murga,M.,
            Rodriguez-Acebes,S., Remeseiro,S., Rodrigo-Perez,S., Rojas,A.M.,
            Mendez,J., Munoz,J. and Fernandez-Capetillo,O.
  TITLE     A proteomic characterization of factors enriched at nascent DNA
            molecules
  JOURNAL   Cell Rep 3 (4), 1105-1116 (2013)
   PUBMED   23545495
REFERENCE   6  (bases 1 to 8987)
  AUTHORS   Ueda,J., Tachibana,M., Ikura,T. and Shinkai,Y.
  TITLE     Zinc finger protein Wiz links G9a/GLP histone methyltransferases to
            the co-repressor molecule CtBP
  JOURNAL   J Biol Chem 281 (29), 20120-20128 (2006)
   PUBMED   16702210
REFERENCE   7  (bases 1 to 8987)
  AUTHORS   Baust,C., Baillie,G.J. and Mager,D.L.
  TITLE     Insertional polymorphisms of ETn retrotransposons include a
            disruption of the wiz gene in C57BL/6 mice
  JOURNAL   Mamm Genome 13 (8), 423-428 (2002)
   PUBMED   12226707
REFERENCE   8  (bases 1 to 8987)
  AUTHORS   Matsumoto,K., Ishii,N., Yoshida,S., Shiosaka,S., Wanaka,A. and
            Tohyama,M.
  TITLE     Molecular cloning and distinct developmental expression pattern of
            spliced forms of a novel zinc finger gene wiz in the mouse
            cerebellum
  JOURNAL   Brain Res Mol Brain Res 61 (1-2), 179-189 (1998)
   PUBMED   9795207
REFERENCE   9  (bases 1 to 8987)
  AUTHORS   Funke,B., Puech,A., Saint-Jore,B., Pandita,R., Skoultchi,A. and
            Morrow,B.
  TITLE     Isolation and characterization of a human gene containing a nuclear
            localization signal from the critical region for velo-cardio-facial
            syndrome on 22q11
  JOURNAL   Genomics 53 (2), 146-154 (1998)
   PUBMED   9790763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011492.8, AC007059.1 and AC006128.1.
            
            On Jul 18, 2019 this sequence version replaced XM_005260004.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000673675.1/ ENSP00000500993.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC011492.8         5777-5935           c
            160-424             AC011492.8         4082-4346           c
            425-497             AC007059.1         29897-29969         c
            498-2635            AC007059.1         25799-27936         c
            2636-2959           AC007059.1         24027-24350         c
            2960-3130           AC007059.1         18233-18403         c
            3131-3634           AC006128.1         38764-39267         c
            3635-4033           AC006128.1         37288-37686         c
            4034-4585           AC006128.1         36160-36711         c
            4586-5113           AC006128.1         34419-34946         c
            5114-5533           AC006128.1         33791-34210         c
            5534-5729           AC006128.1         33361-33556         c
            5730-8987           AC006128.1         29156-32413         c
FEATURES             Location/Qualifiers
     source          1..8987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..8987
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /note="WIZ zinc finger"
                     /db_xref="GeneID:58525"
                     /db_xref="HGNC:HGNC:30917"
                     /db_xref="MIM:619715"
     exon            1..159
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            160..424
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..5889
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein Wiz; zinc finger protein 803; widely-interspaced
                     zinc finger-containing protein; widely interspaced zinc
                     finger motifs"
                     /codon_start=1
                     /product="protein Wiz isoform 3"
                     /protein_id="NP_001358518.1"
                     /db_xref="CCDS:CCDS92547.1"
                     /db_xref="GeneID:58525"
                     /db_xref="HGNC:HGNC:30917"
                     /db_xref="MIM:619715"
                     /translation="MEGSLAGSLAAPDRPQGPERLPGPAPRENIEGGAEAAEGEGGIF
                     RSTRYLPVTKEGPRDILDGRGGISDGQPHPGLSEALPRVTSATHRISSCCWDGGSLDF
                     RPGSPPPHLLGHFPGTPDGRGPWEHPLVQEAGEGILSERRFEDSVIVRTMKPHAELEG
                     SRRFLHHRGEPRLLEKHAQGRPRFDWLQDEDEQGSPQDAGLHLDLPAQPPPLAPFRRV
                     FVPVEDTPKTLDMAVVGGREDLEDLEGLAQPSEWGLPTSASEVATQTWTVNSEASVER
                     LQPLLPPIRTGPYLCELLEEVAEGVASPDEDEDEEPAVFPCIECSIYFKQKEHLLEHM
                     SQHRRAPGQEPPADLAPLACGECGWAFADPTALEQHRQLHQASREKIIEEIQKLKQVP
                     GDEGREARLQCPKCVFGTNSSRAYVQHAKLHMREPPGQTTKEPFGGSSGAGSPSPEAS
                     ALLYQPYGAAVGLSACVFCGFPAPSESLLREHVRLVHAHPHWEEDGEAYEEDPASQPG
                     TSQDAHACFPDTAVDYFGKAEPSLAPMWRENPAGYDPSLAFGPGCQQLSIRDFPLSKP
                     LLHGTGQRPLGRLAFPSTLASTPYSLQLGRNKSTVHPQGLGERRRPWSEEEEEEEEEE
                     DVVLTSEMDFSPENGVFSPLATPSLIPQAALELKQAFREALQAVEATQGQQQQLRGMV
                     PIVLVAKLGPQVMAAARVPPRLQPEELGLAGAHPLDFLLLDAPLGGPLGLDTLLDGDP
                     AMALKHEERKCPYCPDRFHNGIGLANHVRGHLNRVGVSYNVRHFISAEEVKAIERRFS
                     FQKKKKKVANFDPGTFSLMRCDFCGAGFDTRAGLSSHARAHLRDFGITNWELTVSPIN
                     ILQELLATSAAEQPPSPLGREPGGPPGSFLTSRRPRLPLTVPFPPTWAEDPGPAYGDG
                     LGSEENAMVAMDLGSPSLPKKSLPVPGALEQVASRLSSKVAAEVPHGSKQELQDLKAQ
                     SLTTCEVCGACFETRKGLSSHARSHLRQLGVAESESSGAPIDLLYELVKQKGLPDAHL
                     GLPPGLAKKSSSLKEVVAGAPRPGLLSLAKPLDAPAVNKAIKSPPGFSAKGLGHPPSS
                     PLLKKTPLALAGSPTPKNPEDKSPQLSLSPRPASPKAQWPQSEDEGPLNLTLDSDGGR
                     ELDCQLCGAWFETRKGLSSHARAHLRHLGVSDPDAKGSPIDVLHGLIRRDGVQIRLPP
                     RRGALAHPGRPPPTSAALSLLPPPPPAKKAKLKAAGMASPWGKQDLSAAAAAGIFWAS
                     DVEPSPLNLSSGPEPARDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWYVNGSPID
                     TLREILKRRTQSRPGGPPNPPGPSPKALAKMMGGAGPGSSLEARSPSDLHISPLAKKL
                     PPPPGSPLGHSPTASPPPTARKMFPGLAAPSLPKKLKPEQIRVEIKREMLPGALHGEL
                     HPSEGPWGAPREDMTPLNLSSRAEPVRDIRCEFCGEFFENRKGLSSHARSHLRQMGVT
                     EWSVNGSPIDTLREILKKKSKPCLIKKEPPAGDLAPALAEDGPPTVAPGPVQSPLPLS
                     PLAGRPGKPGAGPAQVPRELSLTPITGAKPSATGYLGSVAAKRPLQEDRLLPAEVKAK
                     TYIQTELPFKAKTLHEKTSHSSTEACCELCGLYFENRKALASHARAHLRQFGVTEWCV
                     NGSPIETLSEWIKHRPQKVGAYRSYIQGGRPFTKKFRSAGHGRDSDKRPSLGLAPGGL
                     AVVGRSAGGEPGPEAGRAADGGERPLAASPPGTVKAEEHQRQNINKFERRQARPPDAS
                     AARGGEDTNDLQQKLEEVRQPPPRVRPVPSLVPRPPQTSLVKFVGNIYTLKCRFCEVE
                     FQGPLSIQEEWVRHLQRHILEMNFSKADPPPEESQAPQAQTAAAEAP"
     exon            425..497
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            498..2635
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2959
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3130
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3634
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..4033
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4585
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            4586..5113
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            5114..5533
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            5534..5729
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     exon            5730..8987
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6849..6854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /note="hexamer: ATTAAA"
     polyA_site      6871
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /note="major polyA site"
     polyA_site      7427
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
     polyA_site      7442
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
     regulatory      8729..8734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /note="hexamer: AGTAAA"
     polyA_site      8760
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
     regulatory      8951..8956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
                     /note="hexamer: AAGAAA"
     polyA_site      8987
                     /gene="WIZ"
                     /gene_synonym="ZNF803"
ORIGIN      
        1 gatttaaagg gacaatgtcc cccgagcggt ggaggcggcg gcggctgcgg aggccgcggc
       61 accggcaccg ggagcggcag cggcggtagc ggcagcgacg gccgcaccaa ggaggggagc
      121 tccgagcccc ggcacctggc cggcggcgcc gcctccccgg cccacaatgc cccgctgagc
      181 cggtgcagca gctgagtgga tccaagcaga gaaaatccga tggaggggtc tctggcaggc
      241 agcctggctg caccagatcg tccccaaggc ccagagagac tgcctggccc ggcgccaagg
      301 gagaacatcg agggtggggc cgaagctgct gagggggaag gtggcatctt ccggtccacc
      361 cgttacctgc ctgtcaccaa ggagggcccc cgagacattc tggatggcag aggtggcatc
      421 tctgacgggc agccccatcc cggcctcagc gaagccctcc cccgtgtcac ctccgccacc
      481 catcggatca gcagctgctg ctgggatgga ggcagcctgg acttccggcc gggctcccca
      541 ccaccccatc tcctgggcca tttcccaggt acccctgatg gccgggggcc ctgggagcac
      601 ccccttgtcc aggaggctgg ggagggcatc ctatctgagc ggagattcga ggactcagtc
      661 attgtgagaa ccatgaaacc ccacgctgag ctagagggct ctagaaggtt cttacaccac
      721 cggggggaac caaggctttt ggagaaacat gcccagggcc gccccaggtt cgactggctc
      781 caagatgagg acgagcaggg atccccccag gacgcagggc tgcacttgga cctgcctgcc
      841 cagccgccac ccctcgcccc cttcaggagg gtgtttgtgc cagtggaaga caccccgaag
      901 acgctggaca tggcggtggt gggtggcaga gaagatctgg aggacctgga ggggctggcc
      961 cagccgtccg agtggggcct acccacgtca gcctcggagg tagccacaca gacctggaca
     1021 gtgaactcgg aggcttctgt ggagcggctg cagccgctac tgcccccgat ccggaccggg
     1081 ccctacctgt gtgagctgct ggaggaggtg gccgaagggg tggccagccc agatgaggac
     1141 gaggacgagg agccggccgt gttcccatgc atcgagtgca gcatctactt caagcagaag
     1201 gagcacctcc tggagcacat gagccagcac cgccgagccc cgggccagga gccccctgcg
     1261 gacctggccc cgctggcctg cggggagtgt ggctgggcct ttgctgaccc cactgccctg
     1321 gagcagcacc ggcagctgca tcaggcctcc cgggagaaga tcattgagga gatccaaaag
     1381 ctgaagcaag ttccaggaga cgagggccgg gaggcacggc tgcagtgccc taagtgtgtc
     1441 tttggcacca attcatccag ggcctatgtg cagcatgcca agctgcacat gcgtgagccc
     1501 ccaggccaga ccaccaaaga gccttttgga ggcagcagcg gggctggcag ccccagccct
     1561 gaggccagcg ccctcctcta tcagccctac ggagctgccg ttggcctcag cgcctgtgtc
     1621 ttctgtggtt tccccgcgcc cagcgagagc ctgctcaggg agcacgtgag gctggtgcat
     1681 gcccatcccc actgggagga ggatggcgag gcttatgagg aagaccctgc cagccagcca
     1741 ggcactagcc aggatgctca cgcctgcttc cctgacactg ctgtggacta ctttggcaaa
     1801 gctgagccgt ccttggcccc catgtggcgg gagaaccctg ctggatacga ccccagcctg
     1861 gcctttggcc caggatgcca gcagctgagc atcagagatt tcccgctgtc aaagccactc
     1921 ctgcatggca cgggccagag gcctctcgga aggctggcct ttccctccac actagcatcc
     1981 accccctact ccttacagct cgggagaaac aaaagcaccg tccacccaca agggctgggg
     2041 gaacggaggc gcccttggag cgaagaggag gaggaggagg aggaggagga ggatgtagtg
     2101 ctgacctccg agatggattt ttcccctgaa aatggggtct tttcacccct agccaccccc
     2161 agcctcatcc cgcaggcggc cctggagctg aagcaggcat tccgagaggc cctgcaggca
     2221 gtagaggcca cccaggggca gcagcagcag ctccgaggga tggtacccat tgtgctcgtg
     2281 gcgaagctgg ggccgcaggt catggcggca gccagggtgc ccccaaggtt gcagcccgag
     2341 gagctggggc tggcaggcgc ccaccccctg gacttcctgc tcctggacgc gccgctgggc
     2401 ggcccgctgg ggctggacac actcctggat ggggatccgg ccatggcact gaagcacgag
     2461 gagcggaaat gcccctactg ccccgatcgc ttccacaacg gcatcggctt ggccaaccac
     2521 gtccggggcc acctgaaccg cgtgggcgtc agctacaatg tgcgccattt catctccgct
     2581 gaggaggtga aggccattga gcgcaggttc tccttccaga agaagaagaa aaaagtggcc
     2641 aactttgacc caggcacctt cagcctgatg cgctgtgact tctgcggggc tggcttcgac
     2701 acacgggccg gcctctccag ccacgcccgg gcccacctac gtgacttcgg tatcaccaac
     2761 tgggagctca ctgtctcacc catcaacatc ctgcaggagc tgctggccac ctctgctgct
     2821 gagcagcccc ccagccccct gggccgagag cctgggggtc cgcctggcag cttcctgacc
     2881 tcccgtcggc cccgcttacc tctcacggtg ccctttccac ccacctgggc tgaggaccct
     2941 gggccagcct atggagatgg cctgggttct gaggaaaacg caatggtggc catggacttg
     3001 ggctctccct cgctccctaa gaagagcctg cctgtccctg gggccctgga gcaggtggcc
     3061 agtcggctga gcagcaaagt ggctgcagag gttcctcatg gcagcaaaca ggagctgcag
     3121 gacctcaagg cccagagcct gaccacctgc gaggtctgcg gtgcctgctt tgagacccga
     3181 aagggcctgt ccagccacgc gcgctcccac ctgcggcagc tgggagtggc agagtcggaa
     3241 agcagcggcg cacccatcga cctcctctac gagcttgtga agcagaaggg tctgcctgac
     3301 gcccaccttg ggctgccccc aggcctggct aagaagtcca gctcactgaa ggaggtggtc
     3361 gccggggccc cccggcccgg cttgctcagc ctggccaagc ccttggatgc ccctgctgtc
     3421 aacaaagcca tcaagtcgcc tcccggcttc tcggccaagg gcctgggcca cccgcccagc
     3481 tctccactcc tcaaaaagac accactggcc ctggcgggct cccctacccc taagaatcct
     3541 gaggacaaga gcccccagct gtccctgagc ccccggccgg cctccccaaa ggcacagtgg
     3601 cctcagtctg aggatgaggg gcccttgaac ctcactttag atagtgacgg gggcagagag
     3661 ctggactgcc agctgtgcgg tgcctggttt gagacccgca agggcctgtc tagccacgcc
     3721 cgtgcccacc tgcgccacct gggcgtcagc gatccggacg ccaagggatc ccccatagac
     3781 gtgctccacg ggctcatcag gagggacggc gtccagatcc gcctcccacc caggcgcggc
     3841 gccctggccc acccggggcg gccgcctccc acctccgcgg ccctctcctt gcttcccccc
     3901 ccaccgccgg ccaagaaggc caagctgaag gccgcgggta tggccagccc ctgggggaag
     3961 caggacctct cggccgccgc agccgccggc attttctggg cctctgatgt ggagccgtct
     4021 cctctcaacc tctcctcagg cccagagcca gcacgagaca tccgctgcga gttctgtggt
     4081 gagttcttcg agaaccgcaa gggcctctcg agccacgcgc gctcccatct gcggcaaatg
     4141 ggcgtgaccg agtggtacgt caatggctcg cccatcgaca cgctgcggga gatcctgaag
     4201 agacggaccc agtctcggcc tggtggacct cccaacccac cagggccaag cccaaaagcc
     4261 ctggccaaga tgatgggcgg cgcaggtcct ggcagctcac tggaagcccg cagcccctcg
     4321 gaccttcaca tctcaccctt ggccaagaag ttgccaccac caccgggcag ccccctgggc
     4381 cactcaccaa ctgcctctcc tcctcctacg gcccgaaaga tgttcccagg cctggctgca
     4441 ccctccttgc ccaagaagct gaagcctgaa caaatacggg tggagatcaa gcgggagatg
     4501 ctgccggggg cccttcatgg ggaactgcac ccatctgagg gtccctgggg ggcaccacgg
     4561 gaagacatga cacccctgaa cctgtcgtcc cgggcagagc cggtgcgcga catccgctgt
     4621 gagttctgcg gcgagttctt cgagaaccgc aagggcctgt cgagtcacgc gcgctcacac
     4681 ctgcggcaga tgggtgtgac cgagtggtcc gtcaatggtt cgcccatcga cacactgcga
     4741 gagatcctca agaagaagtc caagccgtgc ctcatcaaga aggagccacc ggctggagac
     4801 ctggcccctg ccctggctga ggacgggcct cccaccgtgg cccctgggcc cgtgcagtcc
     4861 ccactgccgc tgtcgcccct ggctggccgg ccaggcaaac caggtgcagg gccggcccag
     4921 gttcctcgtg agctcagcct gacgcccatc actggggcca agccctcagc cactggctac
     4981 ctgggctcag tggcagccaa gcggcccctg caggaggacc gcctcctccc agcagaggtc
     5041 aaggccaaga cctacatcca gactgaactg cccttcaagg caaagaccct tcatgagaag
     5101 acctcccact cctccaccga ggcctgctgc gagctgtgtg gcctttactt tgaaaaccgc
     5161 aaggccctgg ccagccacgc acgggcacac ctgcggcagt tcggcgtgac cgagtggtgc
     5221 gtcaatggct cgcccatcga gacactgagc gagtggatca aacaccggcc ccagaaggtg
     5281 ggcgcctacc gcagctacat ccagggcggc cgccccttca ccaagaagtt ccgcagtgcc
     5341 ggccatggcc gtgacagtga caagcggccg tccctggggc tggcacccgg gggcctggcc
     5401 gtggtcggcc gcagtgccgg aggggagcca gggcccgagg ctggccgggc agccgacggt
     5461 ggtgagcggc ctctggcagc cagcccgcca ggcaccgtga aggctgagga gcaccagcgg
     5521 cagaacatca acaaatttga acgccgacaa gcccgccctc cagatgcctc cgcagcccgg
     5581 ggaggcgagg acaccaatga cctacagcag aagctggagg aggtgcggca acccccaccc
     5641 cgagtccggc cagtcccctc cctggtgccc cggccccccc agacatcact tgtcaagttc
     5701 gtgggcaaca tctacaccct caaatgcagg ttctgtgagg tggaattcca gggccccctc
     5761 tccatccagg aagagtgggt gcggcactta cagcggcaca tcctggagat gaacttctcc
     5821 aaagcggacc ccccacctga ggagtcccag gccccgcagg cacagacagc ggcggcagag
     5881 gctccctaac acaaaagcat tccagatccc ctctcgtgcc acctctgtct cctcttcttc
     5941 ctcctctgtg tccttgtccc tcttcctctt tctttccgtt tccaaaggag caagccaaaa
     6001 cctcaaaccg gcgccccttg ggggccgggc acactacagc cagggcgccg ggagccagct
     6061 agctgccctt cccccagccc gaggactctg gggccacagg gtgtcttcct tcagcccatg
     6121 cccacctggt ccagcagggg cagcagccag gtctctgatg gcagccggtc tggtcacagg
     6181 ggaggacagc actcccccgt ctagcagcca ggcagggcga tgtctgccat ccgtggccat
     6241 ttgcaaagac cccaaagacc cctgttctgg ttccctctct cccccatgaa tatcctctca
     6301 cacacatgta catgcgaaca cacacaacac gcacctcgtg agacccggga cctgccccgg
     6361 acccccagtt cctgggttga acgaccacat catgccacgg tgcttgctca ggggaagcca
     6421 cgctccctct gtggggcctg ctggggcctg ggagcccccc actgagccca caatgccacg
     6481 gaaatccttg ttggctgccc ccgagagggg ccttcccagc tgggaagagc tcagagctga
     6541 cagctgcctc ctgccatgtc aaggcccccc aaagagcctc aggggctctg gggccctgga
     6601 gggtggggtt ggggggtggg actctcctcc cccactcctg ctccctctcc cttttcactg
     6661 ttgctttcta tgtatagctc cctagacctt tcactttttt aaaaacgcgt tttgtgtaga
     6721 gaataaggaa cgtggatctt tttattttgc aatcctgggc cagctagaag ccaggagctg
     6781 attgaccttt taactttttt cagtggccac attttggtta tcgatgtacc tagaagtatg
     6841 taaattagat taaatttctc ttctggaaac accctggggc aggcggccag cgtgtgtttt
     6901 tctgtcaagt ggacaggctg gcattggctg gcagccgggg ctgggatcgg ggcctcctct
     6961 gtccagagcg ccatggaggc cctgggtttt ccagttggcc gccaagccga ccagacgcag
     7021 ctggggatga gcccaagttc ccagctgttg gctctttagg ccatggctgg gagggggtct
     7081 ctggctggct ggcaaagcgg ctccagtgag cagatgaacc agggttctgg gcagcctgtc
     7141 tgggaaggga gccaggatca agaagcagtt gaggctagag gagcttatca aaggcaggag
     7201 ctaccagcga gggtgtcagg gacccgttgg gagcatttgg gtgggggcca gtggggttgt
     7261 agagagctgg aactcacctg cttttaatac atgtgacttc tagtgagaca catgcacccc
     7321 tgacccaagg aacatgcggg gaaaagagga gccactggct cctttgcgat gttatttatt
     7381 ttctcgctct gcaaatgttt attgaacatt tctgagattt taagagattt tgttggctgc
     7441 tccttcttgt ttattgcatg tggtttttca gctcatcgtt tttactaaac ggtcaagtgc
     7501 tggagagtgg gaacgacctc atggcgtgtg gacagaaggg gccacctcta cccccagccc
     7561 tgctttctgg gccctcccac catacccctt cctgggaagg agggattaac aggctgcaat
     7621 aacgcccaca agggtggtct tggcccacac gtctgctcct gtggggtcag gacgcacatc
     7681 tcgcctggtg gcagaaggcc gcaaccactt ctctccatcc tgtgctgtgg gtgggtggat
     7741 gtatccagga cttaggaagc agggagagca tcttgtgagc tgactcaaag gtgtttcttc
     7801 ctctttcaac ttttcataag tcagttttta tttttttatt ttattttttg agacagggtc
     7861 tcattttgtt gcccaagctg gagtgcagtg tagggacctc ggctcgctgc agtctctgcc
     7921 tcctgggttc aagtgattct cctgcctcag ccatccaggt agctgggatc acaggcatgc
     7981 accaccaccc ctggcttata tctgtaattt ttgtagagac gggggtttca ccatgttgcc
     8041 cgggctggtc ttgaactcct gagctcaagt gatcagcctc ccaaagtgct gggattacag
     8101 gcgtgagcca ctatgcccgg cccgtaagtc agtttttgaa atataaaagt ggtataggct
     8161 agatgtgaca aaaaacagtc aaatgataca agagcttata aagtcatatg gcaagttcct
     8221 ccccaccaat catgcagtga agtgagggtc atgtgtgtcc ttggaagagt cacctccagt
     8281 tcttgcaggg ggatgttttc ctaaaacttt ctgagcattg ctcttctctg ctcaagccac
     8341 ttcaatacac ctcaggcagc aaagtctcag cttttgagcc gtggtctctg agggtgttgg
     8401 atgtgaacga aatcaaatcg gtacaatgat gactgtggca agtgcgatga aggaacgaac
     8461 ctgcagggcg cagaagacgt gtcctggggc cctgccttgg tttggaagac aggcaggcat
     8521 ccctgaggct gatggggaga tgaaccccga agccagagtg cttatccgtc agatctctgc
     8581 ttcatgtttg gagtttgctc acttaacaca tcagaagtgg ctttgttccg tatggcagca
     8641 agttctgcag aagcctcatt tgggtggggg gagttttatt aaaacagttt atcatggaga
     8701 attccaacta tacaaaagta gagcaaacag taaaatggac tctcatctat ccatcaccaa
     8761 cccatgacca atgtcttcag ctgtcagaga tttatcttat agctccttgc ttcctcctcc
     8821 tctctctacc tgtctgaatt gtgtgaagca catcctggcc ataagatcag ttaacttctt
     8881 agtatttcag tatgtttctc tcaacgttgt aaatgccact attacaccta aagaaatcaa
     8941 caatatcaaa aagaaacagc ataccttaaa aaaagtttta aaacaca
//
