LOCUS       NM_017983               1908 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens WD repeat domain, phosphoinositide interacting 1
            (WIPI1), transcript variant 1, mRNA.
ACCESSION   NM_017983
VERSION     NM_017983.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Sporbeck,K., Haas,M.L., Pastor-Maldonado,C.J., Schussele,D.S.,
            Hunter,C., Takacs,Z., Diogo de Oliveira,A.L., Franz-Wachtel,M.,
            Charsou,C., Pfisterer,S.G., Gubas,A., Haller,P.K., Knorr,R.L.,
            Kaulich,M., Macek,B., Eskelinen,E.L., Simonsen,A. and
            Proikas-Cezanne,T.
  TITLE     The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan
            extension
  JOURNAL   Commun Biol 6 (1), 872 (2023)
   PUBMED   37620393
  REMARK    GeneRIF: The ABL-MYC axis controls WIPI1-enhanced autophagy in
            lifespan extension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Zhao,Y., Li,W.F., Li,Q.J., He,S.W., He,Q.M., Long,L.F., Liu,N. and
            Ma,J.
  TITLE     WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21
            axis and MYC regulation in nasopharyngeal carcinoma
  JOURNAL   Oral Oncol 122, 105576 (2021)
   PUBMED   34689010
  REMARK    GeneRIF: WIPI-1 inhibits metastasis and tumour growth via the
            WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   De Leo,M.G., Berger,P. and Mayer,A.
  TITLE     WIPI1 promotes fission of endosomal transport carriers and
            formation of autophagosomes through distinct mechanisms
  JOURNAL   Autophagy 17 (11), 3644-3670 (2021)
   PUBMED   33685363
  REMARK    GeneRIF: WIPI1 promotes fission of endosomal transport carriers and
            formation of autophagosomes through distinct mechanisms.
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Kojima,W., Yamano,K., Kosako,H., Imai,K., Kikuchi,R., Tanaka,K. and
            Matsuda,N.
  TITLE     Mammalian BCAS3 and C16orf70 associate with the phagophore assembly
            site in response to selective and non-selective autophagy
  JOURNAL   Autophagy 17 (8), 2011-2036 (2021)
   PUBMED   33499712
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Ran,T., Ke,S., Song,X., Ma,T., Xu,Y. and Wang,M.
  TITLE     WIPI1 promotes osteosarcoma cell proliferation by inhibiting CDKN1A
  JOURNAL   Gene 782, 145537 (2021)
   PUBMED   33636294
  REMARK    GeneRIF: WIPI1 promotes osteosarcoma cell proliferation by
            inhibiting CDKN1A.
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   Polson,H.E., de Lartigue,J., Rigden,D.J., Reedijk,M., Urbe,S.,
            Clague,M.J. and Tooze,S.A.
  TITLE     Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores
            and positively regulates LC3 lipidation
  JOURNAL   Autophagy 6 (4), 506-522 (2010)
   PUBMED   20505359
REFERENCE   7  (bases 1 to 1908)
  AUTHORS   Chasman,D.I., Pare,G., Mora,S., Hopewell,J.C., Peloso,G.,
            Clarke,R., Cupples,L.A., Hamsten,A., Kathiresan,S., Malarstig,A.,
            Ordovas,J.M., Ripatti,S., Parker,A.N., Miletich,J.P. and
            Ridker,P.M.
  TITLE     Forty-three loci associated with plasma lipoprotein size,
            concentration, and cholesterol content in genome-wide analysis
  JOURNAL   PLoS Genet 5 (11), e1000730 (2009)
   PUBMED   19936222
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 1908)
  AUTHORS   Proikas-Cezanne,T., Ruckerbauer,S., Stierhof,Y.D., Berg,C. and
            Nordheim,A.
  TITLE     Human WIPI-1 puncta-formation: a novel assay to assess mammalian
            autophagy
  JOURNAL   FEBS Lett 581 (18), 3396-3404 (2007)
   PUBMED   17618624
  REMARK    GeneRIF: Quantification of WIPI-1 puncta should be suitable to
            assay mammalian autophagy
REFERENCE   9  (bases 1 to 1908)
  AUTHORS   Proikas-Cezanne,T., Waddell,S., Gaugel,A., Frickey,T., Lupas,A. and
            Nordheim,A.
  TITLE     WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein
            family, is aberrantly expressed in human cancer and is linked to
            starvation-induced autophagy
  JOURNAL   Oncogene 23 (58), 9314-9325 (2004)
   PUBMED   15602573
  REMARK    GeneRIF: share an evolutionary conserved function in autophagy and
            that autophagic capacity may be compromised in human cancers
REFERENCE   10 (bases 1 to 1908)
  AUTHORS   Jeffries,T.R., Dove,S.K., Michell,R.H. and Parker,P.J.
  TITLE     PtdIns-specific MPR pathway association of a novel WD40 repeat
            protein, WIPI49
  JOURNAL   Mol Biol Cell 15 (6), 2652-2663 (2004)
   PUBMED   15020712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI764142.1, BC039867.2 and AC007780.10.
            
            On Nov 22, 2018 this sequence version replaced NM_017983.6.
            
            Summary: This gene encodes a WD40 repeat protein. Members of the
            WD40 repeat family are key components of many essential biologic
            functions. They regulate the assembly of multiprotein complexes by
            presenting a beta-propeller platform for simultaneous and
            reversible protein-protein interactions. Members of the WIPI
            subfamily of WD40 repeat proteins have a 7-bladed propeller
            structure and contain a conserved motif for interaction with
            phospholipids. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039867.2, SRR11853565.13530.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262139.10/ ENSP00000262139.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BI764142.1         18-82
            66-166              BC039867.2         38-138
            167-167             AC007780.10        128862-128862       c
            168-1908            BC039867.2         140-1880
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..1908
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /note="WD repeat domain, phosphoinositide interacting 1"
                     /db_xref="GeneID:55062"
                     /db_xref="HGNC:HGNC:25471"
                     /db_xref="MIM:609224"
     exon            1..155
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1416
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /note="isoform a is encoded by transcript variant 1; WD
                     repeat domain phosphoinositide-interacting protein 1;
                     WIPI-1 alpha; atg18 protein homolog"
                     /codon_start=1
                     /product="WD repeat domain phosphoinositide-interacting
                     protein 1 isoform a"
                     /protein_id="NP_060453.3"
                     /db_xref="CCDS:CCDS11677.1"
                     /db_xref="GeneID:55062"
                     /db_xref="HGNC:HGNC:25471"
                     /db_xref="MIM:609224"
                     /translation="MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSS
                     VEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYSSN
                     ILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTLLDIPANPTGLCALSINHSNSYLAYP
                     GSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTVIRVFSVPD
                     GQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRPEEPSTWS
                     GYMGKMFMAATNYLPTQVSDMMHQDRAFATARLNFSGQRNICTLSTIQKLPRLLVASS
                     SGHLYMYNLDPQDGGECVLIKTHSLLGSGTTEENKENDLRPSLPQSYAATVARPSASS
                     ASTVPGYSEDGGALRGEVIPEHEFATGPVCLDDENEFPPIILCRGNQKGKTKQS"
     exon            156..238
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            239..408
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            409..505
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            506..603
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            604..696
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            697..767
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            768..875
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1040
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1148
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1267
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1368
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1908
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /note="hexamer: AATAAA"
     polyA_site      1908
                     /gene="WIPI1"
                     /gene_synonym="ATG18; ATG18A; WIPI49"
                     /note="major polyA site"
ORIGIN      
        1 gtggagccgg cgcgggcggg ctgctgaggt ggctgtcgcc ggctccgagc tgcggcttcc
       61 cgggccgagc ccccgatgga ggccgaggcc gcggacgctc ccccgggcgg ggttgagtcg
      121 gcgctcagct gcttctcttt caaccaggac tgcacatccc tagcaactgg aactaaagcc
      181 gggtataagc tgttttctct gagttctgtg gagcagctgg atcaagtcca cggaagcaat
      241 gaaatcccgg acgtctacat cgtggagcgc ctcttctcca gcagcctggt ggtggtagtc
      301 agtcacacaa aaccacggca gatgaacgtg tatcacttca agaaaggcac agagatctgt
      361 aattacagct actccagcaa catcttgtcc ataaggctga accggcaaag gctgctggtt
      421 tgcctagaag agtccattta tattcacaac attaaagaca tgaagctgtt gaagaccctc
      481 ctggatattc ctgcaaaccc aacaggtcta tgtgctctct ctatcaacca ttccaattct
      541 tacctggcct atcctggaag cctgacttca ggggagattg tgctttatga tggaaactcc
      601 ctgaaaacag tctgcactat tgctgcccat gagggaacac tagctgccat caccttcaat
      661 gcctcaggct ccaaactagc aagtgcgtct gaaaaaggca cagtcatccg ggtgttctct
      721 gtccctgatg ggcaaaagct ctatgagttc cggagaggga tgaaaaggta tgtgacaatc
      781 agctctctag tgttcagtat ggattcacaa ttcctctgcg cctccagtaa caccgagacg
      841 gtacacatct tcaagctgga acaggtcacc aacagtcgac cagaagagcc ttcgacctgg
      901 agtggctaca tgggaaagat gtttatggct gctaccaact acctccctac ccaggtgtca
      961 gacatgatgc atcaggacag ggcttttgcc actgcacgct tgaacttctc cggacagagg
     1021 aacatctgta ccctctcaac gatccagaag ttgccacggc tgctagttgc gtcatccagt
     1081 ggacaccttt atatgtacaa tttggatcct caggatggag gagagtgtgt cttaatcaaa
     1141 acccacagct tgcttggctc aggaacaaca gaagagaata aagaaaatga cctcagacct
     1201 tccttacctc agtcttatgc agcgaccgta gccagaccaa gtgcatcttc agcctccacg
     1261 gtgccaggtt attctgagga cggcggggcg ctgcgaggag aagttattcc tgaacatgag
     1321 tttgcgacgg gaccagtgtg tcttgatgat gagaatgagt ttcctcctat aatcttgtgc
     1381 cgtggaaatc agaagggcaa aacgaagcag tcatgatgag aagcacacct cagaaatcag
     1441 gacatccccc ctatcaggtg gttttggaga aaacaaggaa ggcggaagaa tggagtgcaa
     1501 ttgtgtgagc agaaaggggg gcaggaatcc cgggtgctcc actgcttaaa ccacaggacc
     1561 tggttaactc ctcaccaagc ttcccacgac cctggttgcc aatgggcgcg ggagacattg
     1621 tatacacatc atgctattta aaatacgttc aaactatagt gtaaatgcta attaaccata
     1681 ttggtatata accggaattt tatattaaaa ggggcctcct ttttaaatat atgccgtgta
     1741 aaaaatgtac ttataggaac atctctttga attgtatttc ttgtatatta catacttaga
     1801 gagagactct tttagccagg caaagtcttt tttggctgtg gctggaataa atcatttatt
     1861 acttgggagt cccattttgg acactaataa taaaatcatg gcaatgca
//
