LOCUS       NM_133264               7492 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WAS/WASL interacting protein family member 2 (WIPF2),
            mRNA.
ACCESSION   NM_133264
VERSION     NM_133264.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7492)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 7492)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7492)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7492)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7492)
  AUTHORS   Michard,C., Yum,L.K. and Agaisse,H.
  TITLE     WIPF2 promotes Shigella flexneri actin-based motility and
            cell-to-cell spread
  JOURNAL   Cell Microbiol 21 (12), e13098 (2019)
   PUBMED   31414511
  REMARK    GeneRIF: WIPF2 promotes Shigella flexneri actin-based motility and
            cell-to-cell spread.
REFERENCE   6  (bases 1 to 7492)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 7492)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   8  (bases 1 to 7492)
  AUTHORS   Salazar,M.A., Kwiatkowski,A.V., Pellegrini,L., Cestra,G.,
            Butler,M.H., Rossman,K.L., Serna,D.M., Sondek,J., Gertler,F.B. and
            De Camilli,P.
  TITLE     Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl
            homology domains, links dynamin to regulation of the actin
            cytoskeleton
  JOURNAL   J Biol Chem 278 (49), 49031-49043 (2003)
   PUBMED   14506234
REFERENCE   9  (bases 1 to 7492)
  AUTHORS   Aspenstrom,P.
  TITLE     The WASP-binding protein WIRE has a role in the regulation of the
            actin filament system downstream of the platelet-derived growth
            factor receptor
  JOURNAL   Exp Cell Res 279 (1), 21-33 (2002)
   PUBMED   12213210
  REMARK    GeneRIF: The WASP-binding protein WIRE has a role in the regulation
            of the actin filament system downstream of the platelet-derived
            growth factor receptor
REFERENCE   10 (bases 1 to 7492)
  AUTHORS   Kato,M., Miki,H., Kurita,S., Endo,T., Nakagawa,H., Miyamoto,S. and
            Takenawa,T.
  TITLE     WICH, a novel verprolin homology domain-containing protein that
            functions cooperatively with N-WASP in actin-microspike formation
  JOURNAL   Biochem Biophys Res Commun 291 (1), 41-47 (2002)
   PUBMED   11829459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068669.21, CN404607.1, BC065551.1, BC043408.1, AU138315.1,
            BC019706.1, CB240594.1 and AC080112.15.
            
            On Nov 22, 2018 this sequence version replaced NM_133264.4.
            
            Summary: This gene encodes a WASP interacting protein (WIP)-related
            protein. It has been shown that this protein has a role in the
            WASP-mediated organization of the actin cytoskeleton and that this
            protein is a potential link between the activated platelet-derived
            growth factor receptor and the actin polymerization machinery.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.375701.1, BC065551.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323571.9/ ENSP00000320924.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC068669.21        164274-164291
            19-81               CN404607.1         1-63
            82-1619             BC065551.1         1-1538
            1620-3227           BC043408.1         559-2166
            3228-3538           AU138315.1         371-681
            3539-5477           BC019706.1         146-2084
            5478-5543           CB240594.1         143-208
            5544-7492           AC080112.15        139562-141510       c
FEATURES             Location/Qualifiers
     source          1..7492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..7492
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /note="WAS/WASL interacting protein family member 2"
                     /db_xref="GeneID:147179"
                     /db_xref="HGNC:HGNC:30923"
                     /db_xref="MIM:609692"
     exon            1..189
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            190..321
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1581
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /note="WASP-binding protein; WIP-related protein; WIP- and
                     CR16-homologous protein; WASP-interacting protein-related
                     protein"
                     /codon_start=1
                     /product="WAS/WASL-interacting protein family member 2"
                     /protein_id="NP_573571.1"
                     /db_xref="CCDS:CCDS11364.1"
                     /db_xref="GeneID:147179"
                     /db_xref="HGNC:HGNC:30923"
                     /db_xref="MIM:609692"
                     /translation="MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDI
                     CKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQGGVLKLRPVGAKD
                     GSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLS
                     RPNTTSSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLH
                     PGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTNESAPEL
                     PQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAAPPPPPPVIRN
                     GARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPPPLRNGHRDSITTVRSF
                     LDDFESKYSFHPVEDFPAPEEYKHFQRIYPSKTNRAARGAPPLPPILR"
     exon            322..454
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            455..571
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            572..1228
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1438
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1540
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..7492
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6023..6028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /note="hexamer: ATTAAA"
     polyA_site      6048
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /note="major polyA site"
     regulatory      7467..7472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
                     /note="hexamer: AATAAA"
     polyA_site      7492
                     /gene="WIPF2"
                     /gene_synonym="WICH; WIRE"
ORIGIN      
        1 attttgttcg cggacgctgg ggacggtggg agcagatcca tttccgggtt ggcaaaaggg
       61 gcggtggcgg cggcggcggc ggcggcggcg gcggcgacgg cgagaaagag cttgccgggg
      121 ggcgagcagg acaggacgaa gccggagtgt aggcggcaga ggattcgctc ccagagcagc
      181 tgcggccagg tatatgaatg acctaaaggt acaaataaag acggagagag aacagtgcca
      241 actgggagca gggcaagaat gccaattcct cctcccccgc cacccccacc tggtcctcct
      301 ccacctccca catttcatca ggcaaacaca gagcagccca agctgagtag agatgagcag
      361 cggggtcgag gcgccctctt acaggacatt tgcaaaggga ccaagctgaa gaaggtgacc
      421 aacattaatg atcggagtgc tcccatcctc gagaagccga aaggaagcag tggtggctat
      481 ggctctggag gagctgccct gcagcccaag ggaggtctct tccaaggagg agtgctgaag
      541 cttcgacctg tgggagccaa ggatggttca gagaacctag ctggtaagcc agccctgcaa
      601 atccccagtt ctcgagctgc tgccccaagg cctccagtat ctgccgccag cgggcgtcct
      661 caggatgata cagacagcag ccgggcctca ctcccagaac tgccccggat gcagagaccc
      721 tctttaccgg acctctctcg gcctaatacc accagcagta cgggcatgaa gcacagctcc
      781 tctgcccctc ccccaccacc cccagggcgg cgtgccaacg caccccccac acctctgcct
      841 atgcacagca gcaaagcccc cgcctacaac agagagaaac ccttgccacc gacgcctgga
      901 caaaggcttc accctggtcg agagggacct cctgctccac ccccagtcaa accacctcct
      961 tcccctgtga atatcagaac aggaccaagt ggccagtctc tggctcctcc tcctccgcct
     1021 taccgccagc ctcctggggt ccccaatgga ccctctagcc ccactaatga gtcagcccct
     1081 gagctgccac agagacacaa ttctttgcat aggaagacac cagggcctgt cagaggccta
     1141 gcacctcctc cacccacctc ggcctcccca tctttactga gtaataggcc acctccccca
     1201 gcccgagacc ctcccagtcg gggagcagct cctccacccc caccacctgt gatccgaaat
     1261 ggtgccaggg atgctccccc tcccccacca ccataccgaa tgcatgggtc agaacccccg
     1321 agccgaggaa agcccccacc tccaccctca aggacgccag ctgggccacc ccctcctcct
     1381 ccaccgcccc tgaggaatgg ccacagagat tctatcacca ctgtccggtc tttcttggat
     1441 gattttgagt caaagtattc cttccatcca gtagaagact ttcctgctcc agaagaatat
     1501 aaacactttc agaggatata tcccagcaaa acaaaccgag ctgcccgtgg agccccacct
     1561 ctgccaccca ttctcaggtg aagcctggct tggtcccgtt cctcaggaaa aggatggacc
     1621 ttctcttctt ctcagatggt cccttccatt cccctgaaac ctgcatgaga gctcctaaca
     1681 tgtttctcca atgcaatcaa gccctagact ccaaatgtcc tcccagctca cctccatcta
     1741 tgcatctcat ctctggattt ggtgatcaga ctctatattg acagtaggat ctcaaaccct
     1801 gcatccatcc ttcctccagc aagccctgct agccacatga ggaacaagtt tccgtgtctt
     1861 ctgccttcct cttggggaaa ggtgccttgt tgtgatgaat taactcactg ttagggcagg
     1921 gtggagaatg gtactccttc cttctcctgt ccactgtggg ggaagcttgg caggtatatt
     1981 atatttcatc atttaggagg ctggcatgac caggacttat gggtgggagg ggagcatttt
     2041 tagtgaagca agaaaggagt ttgccaagaa gtgatctgtt ttaaaggtca tatttggaga
     2101 aagggcaagg aattgggtct gctttatttt tgggggtatt ttgtttttgt tctcacctgc
     2161 tgccccccca ccccaccacc ccagggataa attggatata aacactaaat actaatcagt
     2221 tgaacttaac atttaataaa aagaaagggt gaaataaact gaagaccatt ttagaactag
     2281 tcagttctct gcagcaaagg gaacaggagc catttgaacc ctctgggacc cctcacccca
     2341 ctgcttcagg gtgctaggct gagggatgtt tttcctcccc cttaccgccc atgcccttga
     2401 aagaaaagtc actttttgtg gagggcatca ttcattcctg attcacaaac cccaaaaacc
     2461 tctggtggga gataggaaga tagggcgtgg gcctgggcct taacctcaat cttgtgtctg
     2521 cctcagtctt ttctgactgg ccctgaagtt gtcagtggct ctttctgtcc ttcagcccct
     2581 ggaaggtgct ccaggataac aaagaagggc aggttgaagc ccctcatgga aggagctggc
     2641 tttgtggggc tgcaaaggac ttttaagtcc tgcctgtact gaagttcaca gcccacctga
     2701 ctgagcagac tcttcctgtt cctttctcta ccacccttgc cttcccagga ctgcacggtt
     2761 taacacagca gagtacagaa gggtgaagaa gtgagcagag gcttatgaag atattcagat
     2821 actcttctat gccaggaagc acaaagactt tgttgagatt tgcctcagtt cagtagatct
     2881 tccttggcag ccagccatag gttgtttctt tgtcttccgg gtcctaaaga gcacagagaa
     2941 aatggaggtc cccagtctag gtaggaagct gattggatga ggacttcttt ttttccgaca
     3001 gcaggatggg gctcttgggc tccacacacc agatgctttg gttttctaca actgttgcta
     3061 tgtgtagagg gtgctcagag cgtggcatga gagcaaggag accatggcta ctctttgaaa
     3121 tggatgggga aaattagctt aaaaatttaa tcacgagatt gcgccactgc actccagcct
     3181 gggcgacaga gccagactcc gtctcaaaaa aaaaaaaaaa aaaaaaattt aatcacacac
     3241 atcacaggct taaactgtct tagagacctt tccagttgat tggatcacag gctagggatc
     3301 tgtgcatggt gccaggtgaa acccaagtct ccccagtgct aggtgaggga gggctcaacg
     3361 ggggtaatgt gtatggggtc tgctgtcctt tgccatcccc tggaccatat taactctggg
     3421 acagaccatg attaggtctg tcaccaaact tttcctaatc attttttatg tatcattctt
     3481 ctttctaatc tgttagcagt tatctcccag aagtatccct agcatcctga agcaaacaga
     3541 actgccgggc gctgtggctt atgcctgtaa tctcagcaat ttgggaggcc gaggcgggcg
     3601 gatcacctga ggtcagaagt tcgagaccag cctgtccaac atggtgaaac cccgtctcca
     3661 ctaaaaacac aaaaattatc tgggcgtggt ggcatgtgcc tgtagtccca gctactgggg
     3721 aggctgaggc aggagaatcg cttgaatcca ggaggtggag gttgcagtga gtggagatgg
     3781 cgccactgcg ctccagcccg ggtgacagag tgaaactcca tctcagaaaa caaacaaacc
     3841 aaacaactga gagagggcat gctagtggag ggaaaaggag agagtacaag agttgatact
     3901 gcatcagagt tccagggcag atactgacaa gtgactgaac tttgactgtg aagtcttccc
     3961 atttattttt gaaatgggag tcgatgcctt ttgtacgtta tcaaagtgtt tttttttttt
     4021 tcctccttta ctcagacata gagcatcaaa atatcacgag taaagccaaa ccccagcttt
     4081 tcactggggc tgatatcttc ctccccatgg cccactgccc cctcatattc cccagcactt
     4141 ggactgtgtc acatgggtat tgattgtata cttgttgtct tggcctcatg caaaaaggcc
     4201 tgggtctaga tctagtcaga tgagtttttt ttagagcatg ttgatgatac aacacctgtt
     4261 taaatgtctg ccttatatgt tatttggtcc cactgttaat aatagattta ttactatgta
     4321 tatttactat tgaagatggg aatgtgatct gcatagttat cagtctattt tgtatgttgt
     4381 aaaaagcttc taatttaggt ttaaggtggg ctggctacaa gagcactaaa actcctcacc
     4441 ttttaaactg ctctttttat ctgcttgtgg gaatgtcgtc tctttcgtgg aagattgggt
     4501 ggtctcatgt tgaggctgtt gcccagtccc attaactccc ttgtcccccc acagaaggaa
     4561 gagacattgc ccagctaagc atcaggaagc tgtgttaaaa gcccttctat gggtttggtt
     4621 ttgtgatgtt tttccctaat gggaaaaacg ttatagttgt ttcttactgc cctgtctggg
     4681 aagcagggca aacctccagg tttttaaatg agctagatgc ccctcttcct cttctctggt
     4741 cactgaacct ggaccaaagc actttgatat tccaggtgtg attttctctg tcatggggat
     4801 ttgctccact gcagagcccc atcattttca cagcgtaggc caacagagtg agaacctagg
     4861 gctaccctag ctgatggatg tgaggctgct gtctacagga gctcatccca gccctgttaa
     4921 ctggcagtgg caaggatact cgtcatcggc cattgcactg gggaactccc tcaccccatg
     4981 gcttcccaac ttgaaaccca gatttacctc cagggagagg tgagaaaaaa attgtaaata
     5041 gacttgctaa agagcaactc agggttgggg tgtgttttaa ttctcctgat cacttgaaat
     5101 aatctgtagg ctgagtgctt atgggggtgg gggagaaggg tgactccagg gtccttccat
     5161 tttgtgaagc tctgggggtg gagtgtgggc atctgaggcc ctatgatggc actacattga
     5221 gctgtctgcc cttccggaaa cccaacctgc aatcaactgc aaatcaaatt cttcacattc
     5281 cagctacagt ctttctttcc ccattgaatc tcagtccctg gccatgtggt caaggtggct
     5341 ttctgttaag ctaccctaat ttcgggaatg ggaggggaga gaggagggcc attacaactc
     5401 tgccttcaag actcatctct taaaaacaaa acgaaacaaa actacaacca ccatcaaaac
     5461 cacacgcaaa aaaaaaaaaa aaaaaaaaaa ggataacttt aaccgaagga agggtttggt
     5521 tccattcaac tccacattca ttgtgccttt acttgcatta gatttctgtg ctttcttcct
     5581 ttccctcttt gaagcaatta aaatcttcct tgataactgc tgtttctttc tactcttgtt
     5641 tctggcaatt tagtgggttc cttctctagt ggtcttaaat ctcattccac tggtggcaag
     5701 atggggccta gccttctttt cacatgtcta atcttttcct ttctcatggt gccctccatg
     5761 gaagtcacag tcaacactga ataaatgact agaatgacac gtgtgcgtgc gcacgcgtgt
     5821 gcgtgtgtgt gttcatctgt ctgcatgtgg atcaatttct tttagaaaat aatttattgt
     5881 atgatttatt ttggagttat attctgatta cagtgctccc tctcccaaat agcattgatt
     5941 ttttcccccc tctaaaatgt ataatctggt ctcaggttgg attctttggt acatttctct
     6001 cttctggatg ccatgcagct taattaaaac cttgcttaaa aacaaaaagt gaaaattgtg
     6061 tactcttgtc tggaataccg cctcaggtgg tggcacagag aggggagaaa acctttgcct
     6121 cataatttgg gtaagtgtag tggtttgatt ccaggtccct tgaaaaagta gatctactga
     6181 attgggcaga ctcatctata gctttctgag ggtcttctct cctcctctcc agctgtattt
     6241 tgaaaattac agttctagtt ggctgggcgc gatggctcat gtctgtaatc ccagcacttt
     6301 gggaggccaa ggcgggtgga tcatttgagg tcaggagttc aagaccagct tggccaacat
     6361 ggtgaaaccc cgtctctact gaaaatacaa aaattaaccg gtgtcatggc gcatgcctgt
     6421 agtcccagct actcgggagg ccgaggcagg aaaatcactt gaacccagga ggcggaggtt
     6481 gcactgagct gagatcatgc cactgcacta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     6541 aaaaaaaatt ctagagttct agttaccctt cctgggagat tctgatggtc cttattttat
     6601 tattattatt attttttttt gagacaggat gttgctgtca tccaggctgg agtgcagtgg
     6661 tgtgatcata gctcaccgca gcctccaact ctcaagctca agtgatcctc ccacctcagc
     6721 ctcccgtgta gctgggacca caggtgtgta ccactatgcc tggctaattt tgaaaatttt
     6781 tttgtaaaga cagggtctcc ctatgttgcc cagactggtc tcaaattcct gggcttaagt
     6841 gattgtccca cctcagcttc tcaaagtgct gggattacag gcatgagcca ccgcacccag
     6901 ccagtcctta ttttatattt ccacctaact cccctttgcc cacgatttca gggaacctag
     6961 gaggcttcct ggccttgtga ccttttcctt gaatctctta taattctttc tacctgtgtt
     7021 gcatggcaga ttctcagatt gaggctaaag aaaagaaggg tggggacaaa gcatacagaa
     7081 tgtgtgtatc tgtttttatg tgggtgttgg ctgtttttcg tcactgcttt ttaagctgaa
     7141 tcttagctgg ttttcttgaa ctttgacttt aggtgtaaaa attcaaccag acattctctc
     7201 cttactgtgg tcagctgaca tcataaccac taaggcttaa tgagcttaac ttgcactttc
     7261 atcactagca aaggtcttga agttatttct cttactgatt cataatgggt gtgtgtatga
     7321 atcactctca cataatttag atataaaaac ctatgaggat gagggaggga ggggaagaaa
     7381 aaaaaggact cctttcattt tcatccgtac ttcccagatg ggctgaatct ccgattattt
     7441 gacccatcat tgttattaat atggttaata aactacctat ttattgattg aa
//
