LOCUS       NM_001375838            1735 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens WAS/WASL interacting protein family member 1 (WIPF1),
            transcript variant 9, mRNA.
ACCESSION   NM_001375838
VERSION     NM_001375838.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1735)
  AUTHORS   Dong,Y., Jin,Q., Sun,M., Qi,D., Qu,H., Wang,X. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer metastasis through WIP-dependent actin
            cytoskeleton-mediated autophagy
  JOURNAL   J Exp Clin Cancer Res 42 (1), 68 (2023)
   PUBMED   36935496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1735)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1735)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1735)
  AUTHORS   Sokolik,C.G., Qassem,N. and Chill,J.H.
  TITLE     The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein
            Interactions: A Structural View
  JOURNAL   Biomolecules 10 (7), 1084 (2020)
   PUBMED   32708183
  REMARK    GeneRIF: The Disordered Cellular Multi-Tasker WIP and Its
            Protein-Protein Interactions: A Structural View.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1735)
  AUTHORS   Yu,W., Hua,Y., Qiu,H., Hao,J., Zou,K., Li,Z., Hu,S., Guo,P.,
            Chen,M., Sui,S., Xiong,Y., Li,F., Lu,J., Guo,W., Luo,G. and Deng,W.
  TITLE     PD-L1 promotes tumor growth and progression by activating WIP and
            beta-catenin signaling pathways and predicts poor prognosis in lung
            cancer
  JOURNAL   Cell Death Dis 11 (7), 506 (2020)
   PUBMED   32632098
  REMARK    GeneRIF: PD-L1 promotes tumor growth and progression by activating
            WIP and beta-catenin signaling pathways and predicts poor prognosis
            in lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1735)
  AUTHORS   Vaduva,G., Martinez-Quiles,N., Anton,I.M., Martin,N.C., Geha,R.S.,
            Hopper,A.K. and Ramesh,N.
  TITLE     The human WASP-interacting protein, WIP, activates the cell
            polarity pathway in yeast
  JOURNAL   J Biol Chem 274 (24), 17103-17108 (1999)
   PUBMED   10358064
REFERENCE   7  (bases 1 to 1735)
  AUTHORS   Stewart,D.M., Tian,L. and Nelson,D.L.
  TITLE     Mutations that cause the Wiskott-Aldrich syndrome impair the
            interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP
            interacting protein
  JOURNAL   J Immunol 162 (8), 5019-5024 (1999)
   PUBMED   10202051
REFERENCE   8  (bases 1 to 1735)
  AUTHORS   Ramesh,N., Anton,I.M., Martinez-Quiles,N. and Geha,R.S.
  TITLE     Waltzing with WASP
  JOURNAL   Trends Cell Biol 9 (1), 15-19 (1999)
   PUBMED   10087612
  REMARK    Review article
REFERENCE   9  (bases 1 to 1735)
  AUTHORS   Anton,I.M., Lu,W., Mayer,B.J., Ramesh,N. and Geha,R.S.
  TITLE     The Wiskott-Aldrich syndrome protein-interacting protein (WIP)
            binds to the adaptor protein Nck
  JOURNAL   J Biol Chem 273 (33), 20992-20995 (1998)
   PUBMED   9694849
REFERENCE   10 (bases 1 to 1735)
  AUTHORS   Ramesh,N., Anton,I.M., Hartwig,J.H. and Geha,R.S.
  TITLE     WIP, a protein associated with wiskott-aldrich syndrome protein,
            induces actin polymerization and redistribution in lymphoid cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14671-14676 (1997)
   PUBMED   9405671
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010894.10.
            
            Summary: This gene encodes a protein that plays an important role
            in the organization of the actin cytoskeleton. The encoded protein
            binds to a region of Wiskott-Aldrich syndrome protein that is
            frequently mutated in Wiskott-Aldrich syndrome, an X-linked
            recessive disorder. Impairment of the interaction between these two
            proteins may contribute to the disease. Two transcript variants
            encoding the same protein have been identified for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (9), as well as variants 7 and 8,
            encodes isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.3399468.1,
                                           SRR1163658.438360.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC010894.10        121379-121439       c
            62-150              AC010894.10        108731-108819       c
            151-280             AC010894.10        104518-104647       c
            281-457             AC010894.10        98412-98588         c
            458-1735            AC010894.10        94377-95654         c
FEATURES             Location/Qualifiers
     source          1..1735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1735
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="WAS/WASL interacting protein family member 1"
                     /db_xref="GeneID:7456"
                     /db_xref="HGNC:HGNC:12736"
                     /db_xref="MIM:602357"
     exon            1..61
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            62..150
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1311
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="isoform c is encoded by transcript variant 9;
                     Wiskott-Aldrich syndrome protein interacting protein;
                     protein PRPL-2; WASP-interacting protein; testicular
                     tissue protein Li 226"
                     /codon_start=1
                     /product="WAS/WASL-interacting protein family member 1
                     isoform c"
                     /protein_id="NP_001362767.1"
                     /db_xref="CCDS:CCDS92900.1"
                     /db_xref="GeneID:7456"
                     /db_xref="HGNC:HGNC:12736"
                     /db_xref="MIM:602357"
                     /translation="MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGK
                     KLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGG
                     LFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG
                     PPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPT
                     PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPS
                     IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL
                     PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGMTRRGVSCFQNPACP
                     NVPIILSVKIV"
     exon            151..280
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            281..457
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            458..1735
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="hexamer: ATTAAA"
     polyA_site      1735
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="major polyA site"
ORIGIN      
        1 acacacttga atgccctgta aatgagaaga agcccttagc ctaatgaagc gataaggtaa
       61 gatttatcag caagactgtt gaacgcataa ctgcccaaga tgcctgtccc tccccctcca
      121 gcacccccgc cgcccccgac gtttgcactg gccaatacag agaagcctac cttgaataag
      181 acagagcagg ctgggagaaa tgctctcctt tctgatatca gcaaagggaa gaaactaaag
      241 aagacggtca ccaatgacag aagtgcacca atactggaca aacctaaagg agctggtgct
      301 ggaggcggtg gtggtggctt tggtggaggc ggcggatttg gcggaggagg tggtggcgga
      361 ggcggtggaa gttttggagg gggcggacct ccaggtctgg gaggattgtt ccaggctgga
      421 atgccgaagc tgagatccac ggccaacagg gataatgatt ctggaggaag ccgaccacca
      481 ttgttgccac cgggaggaag atccacatct gcgaaaccct tttcaccccc aagtggccca
      541 gggaggtttc ctgtgccttc tccaggccac agaagtggtc ccccagagcc tcagaggaac
      601 cgaatgccgc ccccaaggcc cgacgtgggc tcaaagcctg atagcattcc tcctccagta
      661 cctagtactc caagacccat tcaatcaagt ccgcacaacc gggggtcccc accagtgccc
      721 ggaggcccca ggcagcccag ccccgggccc actcctcccc ctttccctgg aaaccgcggc
      781 actgctttgg gaggaggctc aatacgtcag tcccccttga gctcctcctc gcccttctcc
      841 aaccggcctc ccctgccgcc tacccccagc agggccttgg atgacaaacc ccctccacca
      901 cctcctccag tgggcaacag gccctccatc cacagggaag cggttccccc tcctcctcct
      961 cagaacaaca agcctccagt gccttccact ccgcggcctt cggcctcctc acaggcccca
     1021 cctccgccgc cacctcccag caggcccggg ccgcctcctc tgcctccaag ttccagcggc
     1081 aatgacgaaa ccccaagact cccacagcgg aatctgtccc tcagttcgtc cacgcccccg
     1141 ttaccttcgc caggacgttc aggtcctctt cctcccccgc ccagtgagag acccccacct
     1201 ccagtgaggg acccgccagg ccgatcaggt atgacaagac gtggagtgag ttgcttccaa
     1261 aacccagcct gcccaaatgt accaataatc ctgtcagtca agatagtcta acaaaagcag
     1321 gcataagtaa actcagactg ctttgtgctt ttaagtggca cacgacacgt gtgatcgtga
     1381 cctcgtgtaa accccggggg aaagtgggac caatatttct gttggtgttt tagagatgag
     1441 gacactgagt agctaataaa gttaaatggt cacgagctag ttaataaaga agaggcaaga
     1501 actttcatct tccatctctg aagtgtactt gccagtccac taccctgcct ccctagagag
     1561 aatttcggcg gtcttaattg ggaaaataag tccccacctc ccgcaggagg gctctgttat
     1621 tccaacaaga ggggaagttc ttcaagagct aatgaacttc tcctgtactt ctctcttcat
     1681 tcgccaggct ttgaggccat ttccctattc attaaagact aatgtttaaa aagtc
//
