LOCUS       NM_001375835            4238 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens WAS/WASL interacting protein family member 1 (WIPF1),
            transcript variant 6, mRNA.
ACCESSION   NM_001375835
VERSION     NM_001375835.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4238)
  AUTHORS   Dong,Y., Jin,Q., Sun,M., Qi,D., Qu,H., Wang,X. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer metastasis through WIP-dependent actin
            cytoskeleton-mediated autophagy
  JOURNAL   J Exp Clin Cancer Res 42 (1), 68 (2023)
   PUBMED   36935496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4238)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4238)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4238)
  AUTHORS   Sokolik,C.G., Qassem,N. and Chill,J.H.
  TITLE     The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein
            Interactions: A Structural View
  JOURNAL   Biomolecules 10 (7), 1084 (2020)
   PUBMED   32708183
  REMARK    GeneRIF: The Disordered Cellular Multi-Tasker WIP and Its
            Protein-Protein Interactions: A Structural View.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4238)
  AUTHORS   Yu,W., Hua,Y., Qiu,H., Hao,J., Zou,K., Li,Z., Hu,S., Guo,P.,
            Chen,M., Sui,S., Xiong,Y., Li,F., Lu,J., Guo,W., Luo,G. and Deng,W.
  TITLE     PD-L1 promotes tumor growth and progression by activating WIP and
            beta-catenin signaling pathways and predicts poor prognosis in lung
            cancer
  JOURNAL   Cell Death Dis 11 (7), 506 (2020)
   PUBMED   32632098
  REMARK    GeneRIF: PD-L1 promotes tumor growth and progression by activating
            WIP and beta-catenin signaling pathways and predicts poor prognosis
            in lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4238)
  AUTHORS   Vaduva,G., Martinez-Quiles,N., Anton,I.M., Martin,N.C., Geha,R.S.,
            Hopper,A.K. and Ramesh,N.
  TITLE     The human WASP-interacting protein, WIP, activates the cell
            polarity pathway in yeast
  JOURNAL   J Biol Chem 274 (24), 17103-17108 (1999)
   PUBMED   10358064
REFERENCE   7  (bases 1 to 4238)
  AUTHORS   Stewart,D.M., Tian,L. and Nelson,D.L.
  TITLE     Mutations that cause the Wiskott-Aldrich syndrome impair the
            interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP
            interacting protein
  JOURNAL   J Immunol 162 (8), 5019-5024 (1999)
   PUBMED   10202051
REFERENCE   8  (bases 1 to 4238)
  AUTHORS   Ramesh,N., Anton,I.M., Martinez-Quiles,N. and Geha,R.S.
  TITLE     Waltzing with WASP
  JOURNAL   Trends Cell Biol 9 (1), 15-19 (1999)
   PUBMED   10087612
  REMARK    Review article
REFERENCE   9  (bases 1 to 4238)
  AUTHORS   Anton,I.M., Lu,W., Mayer,B.J., Ramesh,N. and Geha,R.S.
  TITLE     The Wiskott-Aldrich syndrome protein-interacting protein (WIP)
            binds to the adaptor protein Nck
  JOURNAL   J Biol Chem 273 (33), 20992-20995 (1998)
   PUBMED   9694849
REFERENCE   10 (bases 1 to 4238)
  AUTHORS   Ramesh,N., Anton,I.M., Hartwig,J.H. and Geha,R.S.
  TITLE     WIP, a protein associated with wiskott-aldrich syndrome protein,
            induces actin polymerization and redistribution in lymphoid cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14671-14676 (1997)
   PUBMED   9405671
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104595.6 and AC010894.10.
            
            Summary: This gene encodes a protein that plays an important role
            in the organization of the actin cytoskeleton. The encoded protein
            binds to a region of Wiskott-Aldrich syndrome protein that is
            frequently mutated in Wiskott-Aldrich syndrome, an X-linked
            recessive disorder. Impairment of the interaction between these two
            proteins may contribute to the disease. Two transcript variants
            encoding the same protein have been identified for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (6) encodes the longest isoform
            (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX640870.1, SRR14038192.4127577.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC104595.6         26319-26458         c
            141-229             AC010894.10        108731-108819       c
            230-359             AC010894.10        104518-104647       c
            360-536             AC010894.10        98412-98588         c
            537-1307            AC010894.10        94884-95654         c
            1308-1520           AC010894.10        91069-91281         c
            1521-1634           AC010894.10        90278-90391         c
            1635-1686           AC010894.10        85759-85810         c
            1687-4238           AC010894.10        82782-85333         c
FEATURES             Location/Qualifiers
     source          1..4238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..4238
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="WAS/WASL interacting protein family member 1"
                     /db_xref="GeneID:7456"
                     /db_xref="HGNC:HGNC:12736"
                     /db_xref="MIM:602357"
     exon            1..140
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            141..229
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1711
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="isoform b is encoded by transcript variant 6;
                     Wiskott-Aldrich syndrome protein interacting protein;
                     protein PRPL-2; WASP-interacting protein; testicular
                     tissue protein Li 226"
                     /codon_start=1
                     /product="WAS/WASL-interacting protein family member 1
                     isoform b"
                     /protein_id="NP_001362764.1"
                     /db_xref="CCDS:CCDS92901.1"
                     /db_xref="GeneID:7456"
                     /db_xref="HGNC:HGNC:12736"
                     /db_xref="MIM:602357"
                     /translation="MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGK
                     KLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGG
                     LFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG
                     PPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPT
                     PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPS
                     IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL
                     PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTS
                     RALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEW
                     ESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPRPPKQA
                     AE"
     exon            230..359
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            360..536
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            537..1307
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1520
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1634
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1686
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..4238
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4219..4224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="hexamer: AATAAA"
     polyA_site      4238
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="major polyA site"
ORIGIN      
        1 gttcccggat ggtcgcagcc tcccggcgct gagcgctttt cctgcccgcc cggctcagcc
       61 ctgcggaccc cgggagaagt ttcccagaaa aaatgcccag cgcggcgcgg ggctgcggag
      121 tcgtccggag ccgctgcgcg atttatcagc aagactgttg aacgcataac tgcccaagat
      181 gcctgtccct ccccctccag cacccccgcc gcccccgacg tttgcactgg ccaatacaga
      241 gaagcctacc ttgaataaga cagagcaggc tgggagaaat gctctccttt ctgatatcag
      301 caaagggaag aaactaaaga agacggtcac caatgacaga agtgcaccaa tactggacaa
      361 acctaaagga gctggtgctg gaggcggtgg tggtggcttt ggtggaggcg gcggatttgg
      421 cggaggaggt ggtggcggag gcggtggaag ttttggaggg ggcggacctc caggtctggg
      481 aggattgttc caggctggaa tgccgaagct gagatccacg gccaacaggg ataatgattc
      541 tggaggaagc cgaccaccat tgttgccacc gggaggaaga tccacatctg cgaaaccctt
      601 ttcaccccca agtggcccag ggaggtttcc tgtgccttct ccaggccaca gaagtggtcc
      661 cccagagcct cagaggaacc gaatgccgcc cccaaggccc gacgtgggct caaagcctga
      721 tagcattcct cctccagtac ctagtactcc aagacccatt caatcaagtc cgcacaaccg
      781 ggggtcccca ccagtgcccg gaggccccag gcagcccagc cccgggccca ctcctccccc
      841 tttccctgga aaccgcggca ctgctttggg aggaggctca atacgtcagt cccccttgag
      901 ctcctcctcg cccttctcca accggcctcc cctgccgcct acccccagca gggccttgga
      961 tgacaaaccc cctccaccac ctcctccagt gggcaacagg ccctccatcc acagggaagc
     1021 ggttccccct cctcctcctc agaacaacaa gcctccagtg ccttccactc cgcggccttc
     1081 ggcctcctca caggccccac ctccgccgcc acctcccagc aggcccgggc cgcctcctct
     1141 gcctccaagt tccagcggca atgacgaaac cccaagactc ccacagcgga atctgtccct
     1201 cagttcgtcc acgcccccgt taccttcgcc aggacgttca ggtcctcttc ctcccccgcc
     1261 cagtgagaga cccccacctc cagtgaggga cccgccaggc cgatcaggcc ccctcccacc
     1321 acctcctcca gtaagcagaa acggcagcac atctcgggcc ctgcctgcta cccctcagtt
     1381 gccatccagg agtggagtag acagtcccag gagtggaccc aggcctcccc ttcctcctga
     1441 taggcccagt gctggggcac ctcccccacc tccaccatca acatctatta gaaatggctt
     1501 ccaagactct ccatgtgaag atgagtggga aagcagattc tacttccatc cgatttccga
     1561 tttgccacct ccagagccat atgtacaaac gaccaaaagt tatcccagca aactggcaag
     1621 aaacgaaagc cggagtggat ccaaccgaag agaaaggggt gctccaccac tccctcccat
     1681 cccgagacca cctaagcaag ctgctgagta agggctcact ggaaacttgc agtcacagga
     1741 tgtccaatct ttggcagtcc gagcttggct ctaggacaga gctgtccaat agaaatataa
     1801 tgtgagcccc atatacaatt tttacatttc taatatattt taaacaagtg aagttaatat
     1861 gcatccaaaa tatttcaacc tgtaatcaac ataaaatttt aatgagatat tttatattat
     1921 tttttggtac tgaatcttca aaatccagag tgtattttac acttaccgca catctccatt
     1981 cagactagtc acatttttaa gtgctcagta gccacatgtg gctggtggct actggattag
     2041 acagcacgag tctggaagat ggaagctagt gcagaaacct cttgtttaaa aaacaaaaaa
     2101 ggcaagatgg gcttgagcga ttcaagaggc aactaaaaat aaaattagga cccagcacct
     2161 tgtttgacac acagtttgac cttcgatttt cctcccttaa cttccctctt cccttaatat
     2221 ctgtatacaa gtgttgcttc aaagtaccaa ggtcagaaat tgattgagta cggtttacta
     2281 aagtcatgtg gaataaagcc attggaaaca aatggaaagc ctgtcgggac ttctgggctc
     2341 agaaccagct ggctcacgca ctccacttgt cagctggact tctgccttgt gaaatggaag
     2401 cagcctttgt tcctttctgg ctgagcaagc tcctgaggct gggagagact aggaaggctt
     2461 ggtaggaggg gaaaaaagtc aggaaaatat atcaaatcag aaacatggaa gaagaaggga
     2521 accgatttga gttggtgggc aaaactctaa aaatctaaat ctgatgctta tgtaagggtt
     2581 gagcgaatta gggagattgc tagtggaaat tggagggaat ttgttttgca tcatttgtct
     2641 aggatctatg caaatatagc tccactaaag gaccataggg aagagccagc cttgcctttt
     2701 cttatatgat tttgtttaca aaattttact gggactttta aatctagcta tagagttggg
     2761 aaaaaatatt tccacttaga tattttacat ggttttgttt aaaattacca ttacttgttt
     2821 tttaaaaaca catgaccaca tatgtatatg tatatctacc taaacattgt atcatggttt
     2881 cagtatgtta ttcatgtatt actgggagat gctaccaaga aaccaaccca aagaaaattc
     2941 tgaaaaatac atttctattt atagaataaa tgtttcattt atataaaagc aaaagaactt
     3001 agagttctaa taaatgggat gtctaataaa ttatgaagtt actgatttga atatattata
     3061 tttctataac ttccttgcca aagtcctgat ttagtacatt agagaacctg tgtttcctct
     3121 ctcctctacc attcatctct cttccataca gtcatttggg ctttttactc aaagagaatc
     3181 aagaaataat aaggtataac aagcttggca aagtgttggc tttttaaaaa aaaatttttt
     3241 taatctctag cagtttggta atttagcagc atcatttatt tgggattctt ttatctgatt
     3301 tcaacagtga aaaacatccc tatgataaag cctaatgacc catttcacaa aagatggaat
     3361 ttgcccttcc tagaaaatat gacggagaaa agtctgactc agagaaagtg ggtctgaatt
     3421 ttataagggg tagtaagaat tggacaattc ctttgcatat ctgaacttgg caggtaccgt
     3481 tctaaatctg aaacagggtg atagctcaaa gttgccattc atccagaata gattgtttta
     3541 gaatgtagtg tttaagtgac tgtttcatta atacacctac accctttctt tgaaagtttg
     3601 caacctaatt gcatctaaaa ctatgaataa gttctgtggt aaaatcttaa actatggaaa
     3661 attacaaaaa tgaatttttc ttccctgaaa tcagagctta catgtgtgtt tttttataac
     3721 attttcagat aaatgtattc aacatgtaat acagtatttt aacattcacc tcttatttta
     3781 tattgaaatg tattacagta ttaaaactca gtgttcagta tttatttcac tatgcatttt
     3841 atttagtaaa agccaggaga aatgtttaat ccaatggtgc cttactttgt gatttaaaag
     3901 aaatcaactt ttttttatgt ctaagtagta gattatttgc atatttgtaa aaactgttag
     3961 gtctttatat tttaaagtgt aataccagtt ttgttatttt agtagcagaa atgggatgat
     4021 tgttaaagtt ccccaaaaat gttggcatga aattaatttt tccctcctta tagtcaagga
     4081 ccgtagagga agaaaaactt ttttttcata ccatgcacta tgtaaacaga cacattttgc
     4141 tatctgtgtc atcaggatag tgtaagtggt agggtagaga ctaccctaga catctgcatc
     4201 tttgtaagtt agccagacaa taaagaaaag cagaatga
//
