LOCUS       NM_001375834            4727 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens WAS/WASL interacting protein family member 1 (WIPF1),
            transcript variant 5, mRNA.
ACCESSION   NM_001375834 XM_011511780
VERSION     NM_001375834.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4727)
  AUTHORS   Dong,Y., Jin,Q., Sun,M., Qi,D., Qu,H., Wang,X. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer metastasis through WIP-dependent actin
            cytoskeleton-mediated autophagy
  JOURNAL   J Exp Clin Cancer Res 42 (1), 68 (2023)
   PUBMED   36935496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4727)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4727)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4727)
  AUTHORS   Sokolik,C.G., Qassem,N. and Chill,J.H.
  TITLE     The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein
            Interactions: A Structural View
  JOURNAL   Biomolecules 10 (7), 1084 (2020)
   PUBMED   32708183
  REMARK    GeneRIF: The Disordered Cellular Multi-Tasker WIP and Its
            Protein-Protein Interactions: A Structural View.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4727)
  AUTHORS   Yu,W., Hua,Y., Qiu,H., Hao,J., Zou,K., Li,Z., Hu,S., Guo,P.,
            Chen,M., Sui,S., Xiong,Y., Li,F., Lu,J., Guo,W., Luo,G. and Deng,W.
  TITLE     PD-L1 promotes tumor growth and progression by activating WIP and
            beta-catenin signaling pathways and predicts poor prognosis in lung
            cancer
  JOURNAL   Cell Death Dis 11 (7), 506 (2020)
   PUBMED   32632098
  REMARK    GeneRIF: PD-L1 promotes tumor growth and progression by activating
            WIP and beta-catenin signaling pathways and predicts poor prognosis
            in lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4727)
  AUTHORS   Vaduva,G., Martinez-Quiles,N., Anton,I.M., Martin,N.C., Geha,R.S.,
            Hopper,A.K. and Ramesh,N.
  TITLE     The human WASP-interacting protein, WIP, activates the cell
            polarity pathway in yeast
  JOURNAL   J Biol Chem 274 (24), 17103-17108 (1999)
   PUBMED   10358064
REFERENCE   7  (bases 1 to 4727)
  AUTHORS   Stewart,D.M., Tian,L. and Nelson,D.L.
  TITLE     Mutations that cause the Wiskott-Aldrich syndrome impair the
            interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP
            interacting protein
  JOURNAL   J Immunol 162 (8), 5019-5024 (1999)
   PUBMED   10202051
REFERENCE   8  (bases 1 to 4727)
  AUTHORS   Ramesh,N., Anton,I.M., Martinez-Quiles,N. and Geha,R.S.
  TITLE     Waltzing with WASP
  JOURNAL   Trends Cell Biol 9 (1), 15-19 (1999)
   PUBMED   10087612
  REMARK    Review article
REFERENCE   9  (bases 1 to 4727)
  AUTHORS   Anton,I.M., Lu,W., Mayer,B.J., Ramesh,N. and Geha,R.S.
  TITLE     The Wiskott-Aldrich syndrome protein-interacting protein (WIP)
            binds to the adaptor protein Nck
  JOURNAL   J Biol Chem 273 (33), 20992-20995 (1998)
   PUBMED   9694849
REFERENCE   10 (bases 1 to 4727)
  AUTHORS   Ramesh,N., Anton,I.M., Hartwig,J.H. and Geha,R.S.
  TITLE     WIP, a protein associated with wiskott-aldrich syndrome protein,
            induces actin polymerization and redistribution in lymphoid cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14671-14676 (1997)
   PUBMED   9405671
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010894.10.
            
            On Nov 5, 2019 this sequence version replaced XM_011511780.3.
            
            Summary: This gene encodes a protein that plays an important role
            in the organization of the actin cytoskeleton. The encoded protein
            binds to a region of Wiskott-Aldrich syndrome protein that is
            frequently mutated in Wiskott-Aldrich syndrome, an X-linked
            recessive disorder. Impairment of the interaction between these two
            proteins may contribute to the disease. Two transcript variants
            encoding the same protein have been identified for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (5), as well as variants 1-4,
            encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.810258.1,
                                           SRR14038197.1513463.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000679041.1/ ENSP00000503603.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AC010894.10        120809-121012       c
            205-293             AC010894.10        108731-108819       c
            294-423             AC010894.10        104518-104647       c
            424-600             AC010894.10        98412-98588         c
            601-1371            AC010894.10        94884-95654         c
            1372-1584           AC010894.10        91069-91281         c
            1585-1698           AC010894.10        90278-90391         c
            1699-4727           AC010894.10        82782-85810         c
FEATURES             Location/Qualifiers
     source          1..4727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..4727
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="WAS/WASL interacting protein family member 1"
                     /db_xref="GeneID:7456"
                     /db_xref="HGNC:HGNC:12736"
                     /db_xref="MIM:602357"
     exon            1..204
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            205..293
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1754
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="isoform a is encoded by transcript variant 5;
                     Wiskott-Aldrich syndrome protein interacting protein;
                     protein PRPL-2; WASP-interacting protein; testicular
                     tissue protein Li 226"
                     /codon_start=1
                     /product="WAS/WASL-interacting protein family member 1
                     isoform a"
                     /protein_id="NP_001362763.1"
                     /db_xref="CCDS:CCDS2260.1"
                     /db_xref="GeneID:7456"
                     /db_xref="HGNC:HGNC:12736"
                     /db_xref="MIM:602357"
                     /translation="MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGK
                     KLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGG
                     LFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG
                     PPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPT
                     PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPS
                     IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL
                     PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTS
                     RALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEW
                     ESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR"
     exon            294..423
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            424..600
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            601..1371
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1584
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1698
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..4727
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4708..4713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="hexamer: AATAAA"
     polyA_site      4727
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="major polyA site"
ORIGIN      
        1 acagaaggac gtctgcctct gactcagtat gtcacattta acaagaggcc agagcttgtc
       61 caaaatggct gtccaaaaac gaccccacac ttgcgttaga agatgatacc tttttcaggg
      121 acagttttct ctcttggctc ctgtcccgct ggccctctgt ctgcctgtgt ccctgaccat
      181 ggctccctgc agtacccttt aacgatttat cagcaagact gttgaacgca taactgccca
      241 agatgcctgt ccctccccct ccagcacccc cgccgccccc gacgtttgca ctggccaata
      301 cagagaagcc taccttgaat aagacagagc aggctgggag aaatgctctc ctttctgata
      361 tcagcaaagg gaagaaacta aagaagacgg tcaccaatga cagaagtgca ccaatactgg
      421 acaaacctaa aggagctggt gctggaggcg gtggtggtgg ctttggtgga ggcggcggat
      481 ttggcggagg aggtggtggc ggaggcggtg gaagttttgg agggggcgga cctccaggtc
      541 tgggaggatt gttccaggct ggaatgccga agctgagatc cacggccaac agggataatg
      601 attctggagg aagccgacca ccattgttgc caccgggagg aagatccaca tctgcgaaac
      661 ccttttcacc cccaagtggc ccagggaggt ttcctgtgcc ttctccaggc cacagaagtg
      721 gtcccccaga gcctcagagg aaccgaatgc cgcccccaag gcccgacgtg ggctcaaagc
      781 ctgatagcat tcctcctcca gtacctagta ctccaagacc cattcaatca agtccgcaca
      841 accgggggtc cccaccagtg cccggaggcc ccaggcagcc cagccccggg cccactcctc
      901 cccctttccc tggaaaccgc ggcactgctt tgggaggagg ctcaatacgt cagtccccct
      961 tgagctcctc ctcgcccttc tccaaccggc ctcccctgcc gcctaccccc agcagggcct
     1021 tggatgacaa accccctcca ccacctcctc cagtgggcaa caggccctcc atccacaggg
     1081 aagcggttcc ccctcctcct cctcagaaca acaagcctcc agtgccttcc actccgcggc
     1141 cttcggcctc ctcacaggcc ccacctccgc cgccacctcc cagcaggccc gggccgcctc
     1201 ctctgcctcc aagttccagc ggcaatgacg aaaccccaag actcccacag cggaatctgt
     1261 ccctcagttc gtccacgccc ccgttacctt cgccaggacg ttcaggtcct cttcctcccc
     1321 cgcccagtga gagaccccca cctccagtga gggacccgcc aggccgatca ggccccctcc
     1381 caccacctcc tccagtaagc agaaacggca gcacatctcg ggccctgcct gctacccctc
     1441 agttgccatc caggagtgga gtagacagtc ccaggagtgg acccaggcct ccccttcctc
     1501 ctgataggcc cagtgctggg gcacctcccc cacctccacc atcaacatct attagaaatg
     1561 gcttccaaga ctctccatgt gaagatgagt gggaaagcag attctacttc catccgattt
     1621 ccgatttgcc acctccagag ccatatgtac aaacgaccaa aagttatccc agcaaactgg
     1681 caagaaacga aagccggagt ggatccaacc gaagagaaag gggtgctcca ccactccctc
     1741 ccatcccgag gtgatctttg cctgctcttc tctacccaag ctcaagagct gcttctgttg
     1801 ctatctaaga actgcatacc ctcctccctg cttcttccct tgtgcctcat gtatgggcag
     1861 gaggaaaggt gggaggggga gtgggaatat gcgtgtgtgg gtgggaatcg gtaagaaatg
     1921 cacctagctt ttcatattgt gtttattctc caggctattg cttgcttcag ctgcagcctg
     1981 cctgtgctgg ctgctggggt cgataggctt ttgtcgtaat aggcagagat gacttgcatc
     2041 ccagctttcc accaaccaaa ttcaaacatt cactgcttat ttgttacaga ctgtaattat
     2101 taaagtccct gagagctgtt ttctcccgtt cctttttcgc atgcttggcc tcctctctgt
     2161 ttctatgaac cacagaccac ctaagcaagc tgctgagtaa gggctcactg gaaacttgca
     2221 gtcacaggat gtccaatctt tggcagtccg agcttggctc taggacagag ctgtccaata
     2281 gaaatataat gtgagcccca tatacaattt ttacatttct aatatatttt aaacaagtga
     2341 agttaatatg catccaaaat atttcaacct gtaatcaaca taaaatttta atgagatatt
     2401 ttatattatt ttttggtact gaatcttcaa aatccagagt gtattttaca cttaccgcac
     2461 atctccattc agactagtca catttttaag tgctcagtag ccacatgtgg ctggtggcta
     2521 ctggattaga cagcacgagt ctggaagatg gaagctagtg cagaaacctc ttgtttaaaa
     2581 aacaaaaaag gcaagatggg cttgagcgat tcaagaggca actaaaaata aaattaggac
     2641 ccagcacctt gtttgacaca cagtttgacc ttcgattttc ctcccttaac ttccctcttc
     2701 ccttaatatc tgtatacaag tgttgcttca aagtaccaag gtcagaaatt gattgagtac
     2761 ggtttactaa agtcatgtgg aataaagcca ttggaaacaa atggaaagcc tgtcgggact
     2821 tctgggctca gaaccagctg gctcacgcac tccacttgtc agctggactt ctgccttgtg
     2881 aaatggaagc agcctttgtt cctttctggc tgagcaagct cctgaggctg ggagagacta
     2941 ggaaggcttg gtaggagggg aaaaaagtca ggaaaatata tcaaatcaga aacatggaag
     3001 aagaagggaa ccgatttgag ttggtgggca aaactctaaa aatctaaatc tgatgcttat
     3061 gtaagggttg agcgaattag ggagattgct agtggaaatt ggagggaatt tgttttgcat
     3121 catttgtcta ggatctatgc aaatatagct ccactaaagg accataggga agagccagcc
     3181 ttgccttttc ttatatgatt ttgtttacaa aattttactg ggacttttaa atctagctat
     3241 agagttggga aaaaatattt ccacttagat attttacatg gttttgttta aaattaccat
     3301 tacttgtttt ttaaaaacac atgaccacat atgtatatgt atatctacct aaacattgta
     3361 tcatggtttc agtatgttat tcatgtatta ctgggagatg ctaccaagaa accaacccaa
     3421 agaaaattct gaaaaataca tttctattta tagaataaat gtttcattta tataaaagca
     3481 aaagaactta gagttctaat aaatgggatg tctaataaat tatgaagtta ctgatttgaa
     3541 tatattatat ttctataact tccttgccaa agtcctgatt tagtacatta gagaacctgt
     3601 gtttcctctc tcctctacca ttcatctctc ttccatacag tcatttgggc tttttactca
     3661 aagagaatca agaaataata aggtataaca agcttggcaa agtgttggct ttttaaaaaa
     3721 aaattttttt aatctctagc agtttggtaa tttagcagca tcatttattt gggattcttt
     3781 tatctgattt caacagtgaa aaacatccct atgataaagc ctaatgaccc atttcacaaa
     3841 agatggaatt tgcccttcct agaaaatatg acggagaaaa gtctgactca gagaaagtgg
     3901 gtctgaattt tataaggggt agtaagaatt ggacaattcc tttgcatatc tgaacttggc
     3961 aggtaccgtt ctaaatctga aacagggtga tagctcaaag ttgccattca tccagaatag
     4021 attgttttag aatgtagtgt ttaagtgact gtttcattaa tacacctaca ccctttcttt
     4081 gaaagtttgc aacctaattg catctaaaac tatgaataag ttctgtggta aaatcttaaa
     4141 ctatggaaaa ttacaaaaat gaatttttct tccctgaaat cagagcttac atgtgtgttt
     4201 ttttataaca ttttcagata aatgtattca acatgtaata cagtatttta acattcacct
     4261 cttattttat attgaaatgt attacagtat taaaactcag tgttcagtat ttatttcact
     4321 atgcatttta tttagtaaaa gccaggagaa atgtttaatc caatggtgcc ttactttgtg
     4381 atttaaaaga aatcaacttt tttttatgtc taagtagtag attatttgca tatttgtaaa
     4441 aactgttagg tctttatatt ttaaagtgta ataccagttt tgttatttta gtagcagaaa
     4501 tgggatgatt gttaaagttc cccaaaaatg ttggcatgaa attaattttt ccctccttat
     4561 agtcaaggac cgtagaggaa gaaaaacttt tttttcatac catgcactat gtaaacagac
     4621 acattttgct atctgtgtca tcaggatagt gtaagtggta gggtagagac taccctagac
     4681 atctgcatct ttgtaagtta gccagacaat aaagaaaagc agaatga
//
