LOCUS       NM_001375832            4814 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens WAS/WASL interacting protein family member 1 (WIPF1),
            transcript variant 3, mRNA.
ACCESSION   NM_001375832
VERSION     NM_001375832.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4814)
  AUTHORS   Dong,Y., Jin,Q., Sun,M., Qi,D., Qu,H., Wang,X. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer metastasis through WIP-dependent actin
            cytoskeleton-mediated autophagy
  JOURNAL   J Exp Clin Cancer Res 42 (1), 68 (2023)
   PUBMED   36935496
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4814)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4814)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4814)
  AUTHORS   Sokolik,C.G., Qassem,N. and Chill,J.H.
  TITLE     The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein
            Interactions: A Structural View
  JOURNAL   Biomolecules 10 (7), 1084 (2020)
   PUBMED   32708183
  REMARK    GeneRIF: The Disordered Cellular Multi-Tasker WIP and Its
            Protein-Protein Interactions: A Structural View.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4814)
  AUTHORS   Yu,W., Hua,Y., Qiu,H., Hao,J., Zou,K., Li,Z., Hu,S., Guo,P.,
            Chen,M., Sui,S., Xiong,Y., Li,F., Lu,J., Guo,W., Luo,G. and Deng,W.
  TITLE     PD-L1 promotes tumor growth and progression by activating WIP and
            beta-catenin signaling pathways and predicts poor prognosis in lung
            cancer
  JOURNAL   Cell Death Dis 11 (7), 506 (2020)
   PUBMED   32632098
  REMARK    GeneRIF: PD-L1 promotes tumor growth and progression by activating
            WIP and beta-catenin signaling pathways and predicts poor prognosis
            in lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4814)
  AUTHORS   Vaduva,G., Martinez-Quiles,N., Anton,I.M., Martin,N.C., Geha,R.S.,
            Hopper,A.K. and Ramesh,N.
  TITLE     The human WASP-interacting protein, WIP, activates the cell
            polarity pathway in yeast
  JOURNAL   J Biol Chem 274 (24), 17103-17108 (1999)
   PUBMED   10358064
REFERENCE   7  (bases 1 to 4814)
  AUTHORS   Stewart,D.M., Tian,L. and Nelson,D.L.
  TITLE     Mutations that cause the Wiskott-Aldrich syndrome impair the
            interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP
            interacting protein
  JOURNAL   J Immunol 162 (8), 5019-5024 (1999)
   PUBMED   10202051
REFERENCE   8  (bases 1 to 4814)
  AUTHORS   Ramesh,N., Anton,I.M., Martinez-Quiles,N. and Geha,R.S.
  TITLE     Waltzing with WASP
  JOURNAL   Trends Cell Biol 9 (1), 15-19 (1999)
   PUBMED   10087612
  REMARK    Review article
REFERENCE   9  (bases 1 to 4814)
  AUTHORS   Anton,I.M., Lu,W., Mayer,B.J., Ramesh,N. and Geha,R.S.
  TITLE     The Wiskott-Aldrich syndrome protein-interacting protein (WIP)
            binds to the adaptor protein Nck
  JOURNAL   J Biol Chem 273 (33), 20992-20995 (1998)
   PUBMED   9694849
REFERENCE   10 (bases 1 to 4814)
  AUTHORS   Ramesh,N., Anton,I.M., Hartwig,J.H. and Geha,R.S.
  TITLE     WIP, a protein associated with wiskott-aldrich syndrome protein,
            induces actin polymerization and redistribution in lymphoid cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14671-14676 (1997)
   PUBMED   9405671
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010894.10.
            
            Summary: This gene encodes a protein that plays an important role
            in the organization of the actin cytoskeleton. The encoded protein
            binds to a region of Wiskott-Aldrich syndrome protein that is
            frequently mutated in Wiskott-Aldrich syndrome, an X-linked
            recessive disorder. Impairment of the interaction between these two
            proteins may contribute to the disease. Two transcript variants
            encoding the same protein have been identified for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3), as well as variants 1, 2, 4,
            and 5, encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.423778.1,
                                           SRR14038192.3304504.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC010894.10        157726-157813       c
            89-291              AC010894.10        152874-153076       c
            292-380             AC010894.10        108731-108819       c
            381-510             AC010894.10        104518-104647       c
            511-687             AC010894.10        98412-98588         c
            688-1458            AC010894.10        94884-95654         c
            1459-1671           AC010894.10        91069-91281         c
            1672-1785           AC010894.10        90278-90391         c
            1786-4814           AC010894.10        82782-85810         c
FEATURES             Location/Qualifiers
     source          1..4814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..4814
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="WAS/WASL interacting protein family member 1"
                     /db_xref="GeneID:7456"
                     /db_xref="HGNC:HGNC:12736"
                     /db_xref="MIM:602357"
     exon            1..88
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            89..291
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            292..380
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..1841
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="isoform a is encoded by transcript variant 3;
                     Wiskott-Aldrich syndrome protein interacting protein;
                     protein PRPL-2; WASP-interacting protein; testicular
                     tissue protein Li 226"
                     /codon_start=1
                     /product="WAS/WASL-interacting protein family member 1
                     isoform a"
                     /protein_id="NP_001362761.1"
                     /db_xref="CCDS:CCDS2260.1"
                     /db_xref="GeneID:7456"
                     /db_xref="HGNC:HGNC:12736"
                     /db_xref="MIM:602357"
                     /translation="MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGK
                     KLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGG
                     LFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG
                     PPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPT
                     PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPS
                     IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL
                     PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTS
                     RALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEW
                     ESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR"
     exon            381..510
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            511..687
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            688..1458
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1671
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1785
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..4814
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4795..4800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="hexamer: AATAAA"
     polyA_site      4814
                     /gene="WIPF1"
                     /gene_synonym="PRPL-2; WAS2; WASPIP; WIP"
                     /note="major polyA site"
ORIGIN      
        1 gtcacatgca acatttacag gaaactggct agaagacagc aggggaactc gagaagttgg
       61 ttgttttcag cagattaaaa caatacaggc caacaatgga tagatttggt cgtccttgaa
      121 gcatttagag acctgtagaa tgaacttaac ttctgaaaac tgggtgcggg gccaatagag
      181 gggctgctca atacctcacc agcctgctac gcggaaggct agatggaggg ctgctaaagg
      241 aagagaactg ctgttccacc tccgcctcct ccctgcagtg tggcttctta gatttatcag
      301 caagactgtt gaacgcataa ctgcccaaga tgcctgtccc tccccctcca gcacccccgc
      361 cgcccccgac gtttgcactg gccaatacag agaagcctac cttgaataag acagagcagg
      421 ctgggagaaa tgctctcctt tctgatatca gcaaagggaa gaaactaaag aagacggtca
      481 ccaatgacag aagtgcacca atactggaca aacctaaagg agctggtgct ggaggcggtg
      541 gtggtggctt tggtggaggc ggcggatttg gcggaggagg tggtggcgga ggcggtggaa
      601 gttttggagg gggcggacct ccaggtctgg gaggattgtt ccaggctgga atgccgaagc
      661 tgagatccac ggccaacagg gataatgatt ctggaggaag ccgaccacca ttgttgccac
      721 cgggaggaag atccacatct gcgaaaccct tttcaccccc aagtggccca gggaggtttc
      781 ctgtgccttc tccaggccac agaagtggtc ccccagagcc tcagaggaac cgaatgccgc
      841 ccccaaggcc cgacgtgggc tcaaagcctg atagcattcc tcctccagta cctagtactc
      901 caagacccat tcaatcaagt ccgcacaacc gggggtcccc accagtgccc ggaggcccca
      961 ggcagcccag ccccgggccc actcctcccc ctttccctgg aaaccgcggc actgctttgg
     1021 gaggaggctc aatacgtcag tcccccttga gctcctcctc gcccttctcc aaccggcctc
     1081 ccctgccgcc tacccccagc agggccttgg atgacaaacc ccctccacca cctcctccag
     1141 tgggcaacag gccctccatc cacagggaag cggttccccc tcctcctcct cagaacaaca
     1201 agcctccagt gccttccact ccgcggcctt cggcctcctc acaggcccca cctccgccgc
     1261 cacctcccag caggcccggg ccgcctcctc tgcctccaag ttccagcggc aatgacgaaa
     1321 ccccaagact cccacagcgg aatctgtccc tcagttcgtc cacgcccccg ttaccttcgc
     1381 caggacgttc aggtcctctt cctcccccgc ccagtgagag acccccacct ccagtgaggg
     1441 acccgccagg ccgatcaggc cccctcccac cacctcctcc agtaagcaga aacggcagca
     1501 catctcgggc cctgcctgct acccctcagt tgccatccag gagtggagta gacagtccca
     1561 ggagtggacc caggcctccc cttcctcctg ataggcccag tgctggggca cctcccccac
     1621 ctccaccatc aacatctatt agaaatggct tccaagactc tccatgtgaa gatgagtggg
     1681 aaagcagatt ctacttccat ccgatttccg atttgccacc tccagagcca tatgtacaaa
     1741 cgaccaaaag ttatcccagc aaactggcaa gaaacgaaag ccggagtgga tccaaccgaa
     1801 gagaaagggg tgctccacca ctccctccca tcccgaggtg atctttgcct gctcttctct
     1861 acccaagctc aagagctgct tctgttgcta tctaagaact gcataccctc ctccctgctt
     1921 cttcccttgt gcctcatgta tgggcaggag gaaaggtggg agggggagtg ggaatatgcg
     1981 tgtgtgggtg ggaatcggta agaaatgcac ctagcttttc atattgtgtt tattctccag
     2041 gctattgctt gcttcagctg cagcctgcct gtgctggctg ctggggtcga taggcttttg
     2101 tcgtaatagg cagagatgac ttgcatccca gctttccacc aaccaaattc aaacattcac
     2161 tgcttatttg ttacagactg taattattaa agtccctgag agctgttttc tcccgttcct
     2221 ttttcgcatg cttggcctcc tctctgtttc tatgaaccac agaccaccta agcaagctgc
     2281 tgagtaaggg ctcactggaa acttgcagtc acaggatgtc caatctttgg cagtccgagc
     2341 ttggctctag gacagagctg tccaatagaa atataatgtg agccccatat acaattttta
     2401 catttctaat atattttaaa caagtgaagt taatatgcat ccaaaatatt tcaacctgta
     2461 atcaacataa aattttaatg agatatttta tattattttt tggtactgaa tcttcaaaat
     2521 ccagagtgta ttttacactt accgcacatc tccattcaga ctagtcacat ttttaagtgc
     2581 tcagtagcca catgtggctg gtggctactg gattagacag cacgagtctg gaagatggaa
     2641 gctagtgcag aaacctcttg tttaaaaaac aaaaaaggca agatgggctt gagcgattca
     2701 agaggcaact aaaaataaaa ttaggaccca gcaccttgtt tgacacacag tttgaccttc
     2761 gattttcctc ccttaacttc cctcttccct taatatctgt atacaagtgt tgcttcaaag
     2821 taccaaggtc agaaattgat tgagtacggt ttactaaagt catgtggaat aaagccattg
     2881 gaaacaaatg gaaagcctgt cgggacttct gggctcagaa ccagctggct cacgcactcc
     2941 acttgtcagc tggacttctg ccttgtgaaa tggaagcagc ctttgttcct ttctggctga
     3001 gcaagctcct gaggctggga gagactagga aggcttggta ggaggggaaa aaagtcagga
     3061 aaatatatca aatcagaaac atggaagaag aagggaaccg atttgagttg gtgggcaaaa
     3121 ctctaaaaat ctaaatctga tgcttatgta agggttgagc gaattaggga gattgctagt
     3181 ggaaattgga gggaatttgt tttgcatcat ttgtctagga tctatgcaaa tatagctcca
     3241 ctaaaggacc atagggaaga gccagccttg ccttttctta tatgattttg tttacaaaat
     3301 tttactggga cttttaaatc tagctataga gttgggaaaa aatatttcca cttagatatt
     3361 ttacatggtt ttgtttaaaa ttaccattac ttgtttttta aaaacacatg accacatatg
     3421 tatatgtata tctacctaaa cattgtatca tggtttcagt atgttattca tgtattactg
     3481 ggagatgcta ccaagaaacc aacccaaaga aaattctgaa aaatacattt ctatttatag
     3541 aataaatgtt tcatttatat aaaagcaaaa gaacttagag ttctaataaa tgggatgtct
     3601 aataaattat gaagttactg atttgaatat attatatttc tataacttcc ttgccaaagt
     3661 cctgatttag tacattagag aacctgtgtt tcctctctcc tctaccattc atctctcttc
     3721 catacagtca tttgggcttt ttactcaaag agaatcaaga aataataagg tataacaagc
     3781 ttggcaaagt gttggctttt taaaaaaaaa tttttttaat ctctagcagt ttggtaattt
     3841 agcagcatca tttatttggg attcttttat ctgatttcaa cagtgaaaaa catccctatg
     3901 ataaagccta atgacccatt tcacaaaaga tggaatttgc ccttcctaga aaatatgacg
     3961 gagaaaagtc tgactcagag aaagtgggtc tgaattttat aaggggtagt aagaattgga
     4021 caattccttt gcatatctga acttggcagg taccgttcta aatctgaaac agggtgatag
     4081 ctcaaagttg ccattcatcc agaatagatt gttttagaat gtagtgttta agtgactgtt
     4141 tcattaatac acctacaccc tttctttgaa agtttgcaac ctaattgcat ctaaaactat
     4201 gaataagttc tgtggtaaaa tcttaaacta tggaaaatta caaaaatgaa tttttcttcc
     4261 ctgaaatcag agcttacatg tgtgtttttt tataacattt tcagataaat gtattcaaca
     4321 tgtaatacag tattttaaca ttcacctctt attttatatt gaaatgtatt acagtattaa
     4381 aactcagtgt tcagtattta tttcactatg cattttattt agtaaaagcc aggagaaatg
     4441 tttaatccaa tggtgcctta ctttgtgatt taaaagaaat caactttttt ttatgtctaa
     4501 gtagtagatt atttgcatat ttgtaaaaac tgttaggtct ttatatttta aagtgtaata
     4561 ccagttttgt tattttagta gcagaaatgg gatgattgtt aaagttcccc aaaaatgttg
     4621 gcatgaaatt aatttttccc tccttatagt caaggaccgt agaggaagaa aaactttttt
     4681 ttcataccat gcactatgta aacagacaca ttttgctatc tgtgtcatca ggatagtgta
     4741 agtggtaggg tagagactac cctagacatc tgcatctttg taagttagcc agacaataaa
     4801 gaaaagcaga atga
//
