LOCUS       NM_007191               1977 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens WNT inhibitory factor 1 (WIF1), mRNA.
ACCESSION   NM_007191
VERSION     NM_007191.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Ma,J., Gan,L., Chen,H., Chen,L., Hu,Y., Luan,C., Chen,K. and
            Zhang,J.
  TITLE     Upregulated miR-374a-5p drives psoriasis pathogenesis through WIF1
            downregulation and Wnt5a/NF-kappaB activation
  JOURNAL   Cell Signal 119, 111171 (2024)
   PUBMED   38604345
  REMARK    GeneRIF: Upregulated miR-374a-5p drives psoriasis pathogenesis
            through WIF1 downregulation and Wnt5a/NF-kappaB activation.
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Katabi,N., Sukhadia,P., DiNapoli,S.E., Weinreb,I., Hahn,E.,
            Ghossein,R. and Xu,B.
  TITLE     Expanding the histological spectrum of salivary gland neoplasms
            with HMGA2::WIF1 fusion emphasising their malignant potential: a
            report of eight cases
  JOURNAL   Histopathology 84 (2), 387-398 (2024)
   PUBMED   37849332
  REMARK    GeneRIF: Expanding the histological spectrum of salivary gland
            neoplasms with HMGA2::WIF1 fusion emphasising their malignant
            potential: a report of eight cases.
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Wang,Y., Yuan,S., Ma,J., Liu,H., Huang,L., Zhang,F. and Wang,X.
  TITLE     WIF1 was downregulated in cervical cancer due to promoter
            methylation
  JOURNAL   Acta Biochim Pol 70 (2), 419-423 (2023)
   PUBMED   37306343
  REMARK    GeneRIF: WIF1 was downregulated in cervical cancer due to promoter
            methylation.
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Kerekes,K., Trexler,M., Banyai,L. and Patthy,L.
  TITLE     Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic
            Hedgehog
  JOURNAL   Cells 10 (12), 3496 (2021)
   PUBMED   34944004
  REMARK    GeneRIF: Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity
            of Sonic Hedgehog.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Overs,A., Flammang,M., Hervouet,E., Bermont,L., Pretet,J.L.,
            Christophe,B. and Selmani,Z.
  TITLE     The detection of specific hypermethylated WIF1 and NPY genes in
            circulating DNA by crystal digital PCRtrade mark is a powerful new
            tool for colorectal cancer diagnosis and screening
  JOURNAL   BMC Cancer 21 (1), 1092 (2021)
   PUBMED   34627187
  REMARK    GeneRIF: The detection of specific hypermethylated WIF1 and NPY
            genes in circulating DNA by crystal digital PCR is a powerful new
            tool for colorectal cancer diagnosis and screening.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Lin,Y.C., You,L., Xu,Z., He,B., Mikami,I., Thung,E., Chou,J.,
            Kuchenbecker,K., Kim,J., Raz,D., Yang,C.T., Chen,J.K. and
            Jablons,D.M.
  TITLE     Wnt signaling activation and WIF-1 silencing in nasopharyngeal
            cancer cell lines
  JOURNAL   Biochem Biophys Res Commun 341 (2), 635-640 (2006)
   PUBMED   16427602
  REMARK    GeneRIF: aberrant Wnt signaling is a common event in NPC
            carcinogenesis linked with WIF-1 silencing
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Taniguchi,H., Yamamoto,H., Hirata,T., Miyamoto,N., Oki,M.,
            Nosho,K., Adachi,Y., Endo,T., Imai,K. and Shinomura,Y.
  TITLE     Frequent epigenetic inactivation of Wnt inhibitory factor-1 in
            human gastrointestinal cancers
  JOURNAL   Oncogene 24 (53), 7946-7952 (2005)
   PUBMED   16007117
  REMARK    GeneRIF: WIF-1 silencing due to promoter hypermethylation is an
            important mechanism underlying aberrant activation of the Wnt
            signaling pathway in carcinogenesis of the digestive organs
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Esufali,S. and Bapat,B.
  TITLE     Cross-talk between Rac1 GTPase and dysregulated Wnt signaling
            pathway leads to cellular redistribution of beta-catenin and
            TCF/LEF-mediated transcriptional activation
  JOURNAL   Oncogene 23 (50), 8260-8271 (2004)
   PUBMED   15377999
  REMARK    GeneRIF: novel mechanism of Wnt pathway regulation whereby
            activation of Rac1 amplifies signaling activity of
            stabilized/mutated beta-catenin by promoting accumulation in
            nucleus, and synergizing with beta-catenin to augment
            TCF/LEF-dependent gene transcription
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Reguart,N., He,B., Xu,Z., You,L., Lee,A.Y., Mazieres,J., Mikami,I.,
            Batra,S., Rosell,R., McCormick,F. and Jablons,D.M.
  TITLE     Cloning and characterization of the promoter of human Wnt
            inhibitory factor-1
  JOURNAL   Biochem Biophys Res Commun 323 (1), 229-234 (2004)
   PUBMED   15351726
  REMARK    GeneRIF: the methylation-status of the CpG island within the
            functional WIF-1 promoter region is an important key in Wnt
            activation in human cancer
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Hsieh,J.C., Kodjabachian,L., Rebbert,M.L., Rattner,A.,
            Smallwood,P.M., Samos,C.H., Nusse,R., Dawid,I.B. and Nathans,J.
  TITLE     A new secreted protein that binds to Wnt proteins and inhibits
            their activities
  JOURNAL   Nature 398 (6726), 431-436 (1999)
   PUBMED   10201374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC315426.1, BX647427.1,
            AY358344.1 and DB560069.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007191.4.
            
            Summary: The protein encoded by this gene functions to inhibit WNT
            proteins, which are extracellular signaling molecules that play a
            role in embryonic development. This protein contains a WNT
            inhibitory factor (WIF) domain and five epidermal growth factor
            (EGF)-like domains, and is thought to be involved in mesoderm
            segmentation. This gene functions as a tumor suppressor gene, and
            has been found to be epigenetically silenced in various cancers.
            [provided by RefSeq, Jun 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.120575.1,
                                           SRR3476690.886186.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286574.9/ ENSP00000286574.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                DC315426.1         267-336
            71-547              BX647427.1         1-477
            548-1973            AY358344.1         579-2004
            1974-1977           DB560069.1         422-425
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.3"
     gene            1..1977
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /note="WNT inhibitory factor 1"
                     /db_xref="GeneID:11197"
                     /db_xref="HGNC:HGNC:18081"
                     /db_xref="MIM:605186"
     exon            1..262
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1254
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /codon_start=1
                     /product="wnt inhibitory factor 1 precursor"
                     /protein_id="NP_009122.2"
                     /db_xref="CCDS:CCDS8971.1"
                     /db_xref="GeneID:11197"
                     /db_xref="HGNC:HGNC:18081"
                     /db_xref="MIM:605186"
                     /translation="MARRSAFPAAALWLWSILLCLLALRAEAGPPQEESLYLWIDAHQ
                     ARVLIGFEEDILIVSEGKMAPFTHDFRKAQQRMPAIPVNIHSMNFTWQAAGQAEYFYE
                     FLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVDVIVMNSE
                     GNTILQTPQNAIFFKTCQQAECPGGCRNGGFCNERRICECPDGFHGPHCEKALCTPRC
                     MNGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCICPPGLEGEQCEIS
                     KCPQPCRNGGKCIGKSKCKCSKGYQGDLCSKPVCEPGCGAHGTCHEPNKCQCQEGWHG
                     RHCNKRYEASLIHALRPAGAQLRQHTPSLKKAEERRDPPESNYIW"
     exon            263..402
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..511
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..652
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..748
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..844
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..940
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1036
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1132
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1977
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /note="hexamer: AATAAA"
     polyA_site      1977
                     /gene="WIF1"
                     /gene_synonym="WIF-1"
                     /note="major polyA site"
ORIGIN      
        1 aaacgggaac agccctggct gagggagctg cagcgcagca gagtatctga cggcgccagg
       61 ttgcgtaggt gcggcacgag gagttttccc ggcagcgagg aggtcctgag cagcatggcc
      121 cggaggagcg ccttccctgc cgccgcgctc tggctctgga gcatcctcct gtgcctgctg
      181 gcactgcggg cggaggccgg gccgccgcag gaggagagcc tgtacctatg gatcgatgct
      241 caccaggcaa gagtactcat aggatttgaa gaagatatcc tgattgtttc agaggggaaa
      301 atggcacctt ttacacatga tttcagaaaa gcacaacaga gaatgccagc tattcctgtc
      361 aatatccatt ccatgaattt tacctggcaa gctgcagggc aggcagaata cttctatgaa
      421 ttcctgtcct tgcgctccct ggataaaggc atcatggcag atccaaccgt caatgtccct
      481 ctgctgggaa cagtgcctca caaggcatca gttgttcaag ttggtttccc atgtcttgga
      541 aaacaggatg gggtggcagc atttgaagtg gatgtgattg ttatgaattc tgaaggcaac
      601 accattctcc aaacacctca aaatgctatc ttctttaaaa catgtcaaca agctgagtgc
      661 ccaggcgggt gccgaaatgg aggcttttgt aatgaaagac gcatctgcga gtgtcctgat
      721 gggttccacg gacctcactg tgagaaagcc ctttgtaccc cacgatgtat gaatggtgga
      781 ctttgtgtga ctcctggttt ctgcatctgc ccacctggat tctatggagt gaactgtgac
      841 aaagcaaact gctcaaccac ctgctttaat ggagggacct gtttctaccc tggaaaatgt
      901 atttgccctc caggactaga gggagagcag tgtgaaatca gcaaatgccc acaaccctgt
      961 cgaaatggag gtaaatgcat tggtaaaagc aaatgtaagt gttccaaagg ttaccaggga
     1021 gacctctgtt caaagcctgt ctgcgagcct ggctgtggtg cacatggaac ctgccatgaa
     1081 cccaacaaat gccaatgtca agaaggttgg catggaagac actgcaataa aaggtacgaa
     1141 gccagcctca tacatgccct gaggccagca ggcgcccagc tcaggcagca cacgccttca
     1201 cttaaaaagg ccgaggagcg gcgggatcca cctgaatcca attacatctg gtgaactccg
     1261 acatctgaaa cgttttaagt tacaccaagt tcatagcctt tgttaacctt tcatgtgttg
     1321 aatgttcaaa taatgttcat tacacttaag aatactggcc tgaattttat tagcttcatt
     1381 ataaatcact gagctgatat ttactcttcc ttttaagttt tctaagtacg tctgtagcat
     1441 gatggtatag attttcttgt ttcagtgctt tgggacagat tttatattat gtcaattgat
     1501 caggttaaaa ttttcagtgt gtagttggca gatattttca aaattacaat gcatttatgg
     1561 tgtctggggg caggggaaca tcagaaaggt taaattgggc aaaaatgcgt aagtcacaag
     1621 aatttggatg gtgcagttaa tgttgaagtt acagcatttc agattttatt gtcagatatt
     1681 tagatgtttg ttacattttt aaaaattgct cttaattttt aaactctcaa tacaatatat
     1741 tttgacctta ccattattcc agagattcag tattaaaaaa aaaaaaatta cactgtggta
     1801 gtggcattta aacaatataa tatattctaa acacaatgaa atagggaata taatgtatga
     1861 actttttgca ttggcttgaa gcaatataat atattgtaaa caaaacacag ctcttaccta
     1921 ataaacattt tatactgttt gtatgtataa aataaaggtg ctgctttagt tttctga
//
