LOCUS       NM_001080435            5101 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens WASP homolog associated with actin, golgi membranes
            and microtubules (WHAMM), mRNA.
ACCESSION   NM_001080435 XM_058720
VERSION     NM_001080435.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5101)
  AUTHORS   Coulter,A.M., Cortes,V., Theodore,C.J., Cianciolo,R.E.,
            Korstanje,R. and Campellone,K.G.
  TITLE     WHAMM functions in kidney reabsorption and polymerizes actin to
            promote autophagosomal membrane closure and cargo sequestration
  JOURNAL   Mol Biol Cell 35 (6), ar80 (2024)
   PUBMED   38598293
  REMARK    GeneRIF: WHAMM functions in kidney reabsorption and polymerizes
            actin to promote autophagosomal membrane closure and cargo
            sequestration.
REFERENCE   2  (bases 1 to 5101)
  AUTHORS   Seervai,R.N.H., Grimm,S.L., Jangid,R.K., Tripathi,D.N., Coarfa,C.
            and Walker,C.L.
  TITLE     An actin-WHAMM interaction linking SETD2 and autophagy
  JOURNAL   Biochem Biophys Res Commun 558, 202-208 (2021)
   PUBMED   33036756
  REMARK    GeneRIF: An actin-WHAMM interaction linking SETD2 and autophagy.
REFERENCE   3  (bases 1 to 5101)
  AUTHORS   King,V.L., Leclair,N.K., Coulter,A.M. and Campellone,K.G.
  TITLE     The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3
            complex-mediated intrinsic pathway of apoptosis
  JOURNAL   PLoS Genet 17 (4), e1009512 (2021)
   PUBMED   33872315
  REMARK    GeneRIF: The actin nucleation factors JMY and WHAMM enable a rapid
            Arp2/3 complex-mediated intrinsic pathway of apoptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5101)
  AUTHORS   Dai,A., Yu,L. and Wang,H.W.
  TITLE     WHAMM initiates autolysosome tubulation by promoting actin
            polymerization on autolysosomes
  JOURNAL   Nat Commun 10 (1), 3699 (2019)
   PUBMED   31420534
  REMARK    GeneRIF: WHAMM is required for autophagic lysosome reformation.
            WHAMM works as an actin nucleation promoting factor which promotes
            assembly of an actin scaffold on the surface of the autolysosome to
            promote autolysosome tabulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5101)
  AUTHORS   Kast,D.J., Zajac,A.L., Holzbaur,E.L., Ostap,E.M. and Dominguez,R.
  TITLE     WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome
            Biogenesis through an Actin Comet Tail Mechanism
  JOURNAL   Curr Biol 25 (13), 1791-1797 (2015)
   PUBMED   26096974
  REMARK    GeneRIF: WHAMM directs the Arp2/3 complex to the endoplasmic
            reticulum for autophagosome biogenesis through an actin comet tail
            mechanism.
REFERENCE   6  (bases 1 to 5101)
  AUTHORS   Gad,A.K., Nehru,V., Ruusala,A. and Aspenstrom,P.
  TITLE     RhoD regulates cytoskeletal dynamics via the actin
            nucleation-promoting factor WASp homologue associated with actin
            Golgi membranes and microtubules
  JOURNAL   Mol Biol Cell 23 (24), 4807-4819 (2012)
   PUBMED   23087206
  REMARK    GeneRIF: Data show that RhoD binds the actin nucleation-promoting
            factor WHAMM (WASp homologue associated with actin Golgi membranes
            and microtubules), as well as the related filamin A-binding protein
            FILIP1.
REFERENCE   7  (bases 1 to 5101)
  AUTHORS   Shen,Q.T., Hsiue,P.P., Sindelar,C.V., Welch,M.D., Campellone,K.G.
            and Wang,H.W.
  TITLE     Structural insights into WHAMM-mediated cytoskeletal coordination
            during membrane remodeling
  JOURNAL   J Cell Biol 199 (1), 111-124 (2012)
   PUBMED   23027905
  REMARK    GeneRIF: results give rise to a model whereby distinct MT-bound and
            actin-nucleating populations of WHAMM collaborate during membrane
            tubulation
REFERENCE   8  (bases 1 to 5101)
  AUTHORS   Disanza,A. and Scita,G.
  TITLE     Cytoskeletal regulation: coordinating actin and microtubule
            dynamics in membrane trafficking
  JOURNAL   Curr Biol 18 (18), R873-R875 (2008)
   PUBMED   18812086
REFERENCE   9  (bases 1 to 5101)
  AUTHORS   Campellone,K.G., Webb,N.J., Znameroski,E.A. and Welch,M.D.
  TITLE     WHAMM is an Arp2/3 complex activator that binds microtubules and
            functions in ER to Golgi transport
  JOURNAL   Cell 134 (1), 148-161 (2008)
   PUBMED   18614018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK126887.1, AB075851.1,
            AI377476.1 and AC044907.16.
            
            On Nov 22, 2018 this sequence version replaced NM_001080435.2.
            
            Summary: This gene encodes a protein that plays a role in actin
            nucleation, Golgi membrane association and microtubule binding. The
            encoded protein is a nucleation-promoting factor that regulates the
            Actin-related protein 2/3 complex. The activated complex initiates
            growth of new actin filaments by binding to existing actin
            filaments. The encoded protein also functions in regulation of
            transport from the endoplasmic reticulum to the Golgi complex and
            in maintenance of the Golgi complex near the centrosome. Four
            pseudogenes of this gene are present on the same arm of chromosome
            15 as this gene. [provided by RefSeq, Aug 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126887.1, AB075851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286760.5/ ENSP00000286760.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK126887.1         2-15
            15-3651             AB075851.1         1-3637
            3652-3697           AI377476.1         163-208             c
            3698-3698           AC044907.16        113583-113583
            3699-3854           AI377476.1         6-161               c
            3855-5101           AC044907.16        113740-114986
FEATURES             Location/Qualifiers
     source          1..5101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..5101
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /note="WASP homolog associated with actin, golgi membranes
                     and microtubules"
                     /db_xref="GeneID:123720"
                     /db_xref="HGNC:HGNC:30493"
                     /db_xref="MIM:612393"
     exon            1..708
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2529
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /note="WH2 domain-containing protein 1; WAS protein
                     homology region 2 domain-containing protein 1; WAS protein
                     homolog associated with actin, golgi membranes and
                     microtubules"
                     /codon_start=1
                     /product="WASP homolog-associated protein with actin,
                     membranes and microtubules"
                     /protein_id="NP_001073904.1"
                     /db_xref="CCDS:CCDS45333.1"
                     /db_xref="GeneID:123720"
                     /db_xref="HGNC:HGNC:30493"
                     /db_xref="MIM:612393"
                     /translation="MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVT
                     CHDRTAQQRRLREGARLGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLE
                     RCFPRLPPELDVGGGGAWGLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGC
                     GGATVRDALFPAEGGAADCESPREFRERALRARWVEADARLRQVIQGHGKANTMVALM
                     NVYQEEDEAYQELVTVATMFFQYLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVA
                     LEKEAEEWTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQAAWATAIP
                     RLEKLQLMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYEI
                     QLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGL
                     QDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSR
                     QHHSIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPN
                     LPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPV
                     GDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKD
                     DQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVRPPHASIN
                     EHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKAALQRIKRVSADSEED
                     SDEQDPGQWDG"
     exon            709..882
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1033
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1203
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1369
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1557
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1644
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1740
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2221
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..5101
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3631..3636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /note="hexamer: AATAAA"
     polyA_site      3652
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /note="major polyA site"
     regulatory      3815..3820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /note="hexamer: AATAAA"
     polyA_site      3848
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
     regulatory      5082..5087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /note="hexamer: AATAAA"
     polyA_site      5101
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
ORIGIN      
        1 ctagcgaaaa atgatttggc tcggactgtc ccgtgacagg cggtgcgagg aggccaggcc
       61 cgcgcccgcc gagccctagg gccgctgctg ccgacagcca tggaggacga gcagcctgac
      121 agcctggagg gctgggtgcc ggtccgggag ggcctcttcg ccgagcccga gaggcaccgg
      181 ctgcgcttcc tggtggcctg gaacggcgcg gagggcaagt tcgctgtgac ttgtcacgac
      241 cgtaccgcgc agcagcggcg gctgcgcgag ggggcccggt tggggcccga gcccgagccc
      301 aagcctgagg ccgccgtctc cccgtccagc tgggccggcc tgctctcggc cgcggggctc
      361 cgcggcgcgc accggcagtt ggcggcgctg tggccgcctc tggagcgctg cttcccgcgg
      421 ctgccgccgg agctggacgt gggcggcggc ggggcctggg gtctggggct cgggctgtgg
      481 gcgctgctgt ggccgacgcg cgcgggtccc ggcgaggcgg cgctgcagga gctgtgcggg
      541 cagctggaac gctatctggg cgcggcggcc gacggctgcg gcggcgccac agtgcgcgac
      601 gcactcttcc cggctgaggg cggcgcggcc gactgcgaaa gcccgcgcga gttccgggag
      661 cgggccttgc gcgcgcggtg ggtcgaggcg gacgcgcggc tgcgccaggt tattcaagga
      721 cacggaaaag ccaacaccat ggtagcatta atgaacgttt accaagagga agatgaagca
      781 taccaggaat tggttaccgt ggcaaccatg ttcttccagt acttattgca gccatttagg
      841 gctatgcgag aagttgcaac tttatgtaag cttgatattt tgaagtcttt ggatgaggat
      901 gacctaggtc ctagaagggt agttgccctg gagaaagaag ctgaagaatg gaccagacgg
      961 gctgaagaag ctgtcgtctc tattcaggat atcacagtga attattttaa ggagacagta
     1021 aaagcattag caggaatgca gaaagaaatg gaacaggatg cgaagagatt tggtcaggct
     1081 gcctgggcca cagcaattcc caggttggaa aaacttcagc taatgctagc tcgagagact
     1141 ctgcaactca tgagagcgaa agagttgtgt ttaaatcaca aaagagctga aattcaggga
     1201 aagatggaag atcttccaga acaagaaaaa aatacaaatg ttgtagatga attagaaata
     1261 caattttatg aaattcaatt agaactatat gaagttaaat ttgagatatt aaaaaacgaa
     1321 gaaatactgc ttactacaca gttggactct cttaaaagac ttataaaaga aaaacaagat
     1381 gaagttgtct attacgatcc atgtgaaaat ccagaggaac ttaaagtcat tgactgtgtg
     1441 gtggggctgc aggatgataa gaatttggaa gtgaaagaac tcagaaggca gtgccagcag
     1501 ctggagtcta aacggggcag gatctgtgcc aaaagagcct ctctccggag tagaaaggat
     1561 cagtgcaaag aaaatcatcg gttcagattg caacaggctg aagaaagcat aagatactct
     1621 cgtcagcatc acagtattca gatgaaaaga gacaagataa aagaagagga gcaaaagaaa
     1681 aaagaatgga tcaaccaaga acgtcaaaaa acactccaac gattgagatc atttaaagat
     1741 aaacgcctag ctcaatctgt ccgaaacacc tctggctcag aacctgtggc tccaaacctg
     1801 ccaagtgatc tttcccagca gatgtgcttg ccagcttccc acgcggtgtc agtaattcac
     1861 ccgtcctcta ggaaaactag aggtgttccc ctatcggaag ctggtaatgt gaaaagcccc
     1921 aagtgtcaaa actgtcatgg aaatatccct gtccaggttt ttgttccagt tggtgatcaa
     1981 acacattcca aatccagtga ggaattgtca ctgccaccac ctcctcctcc tccaccacca
     2041 ccaccgccgc caccgccgcc cccaccccct cctctccgtg ctctgtcctc atcctctcaa
     2101 gctgcaactc atcagaactt aggcttccgg gctccagtga aagatgacca gccacgtcct
     2161 ctagtgtgcg aatcacctgc tgagcgacca cgtgactcct tggaaagttt ttcatgtcca
     2221 ggatctatgg atgaagtgtt ggcctcctta aggcatggca gagctcctct ccggaaggtg
     2281 gaagtgccgg cggtgcgccc tccccacgcc tcaatcaatg agcacattct ggctgccata
     2341 aggcaagggg tcaaactgaa gaaagttcac cctgatcttg gcccaaaccc cagcagcaaa
     2401 ccaaccagca acagacgcac cagtgacctt gagaggagca tcaaggctgc gctccagaga
     2461 atcaagaggg tgtctgctga ctctgaggag gacagtgatg agcaggaccc tggccagtgg
     2521 gatggttagg ctcaagtttg acaaaggcac ctgccacagt aggcttgaat aaagtgggtg
     2581 agtcttagac ctatcgaaaa gcatactaac agggtgctga tagatgggcc acataacacc
     2641 ccggaagatc agcagggcct tgtgtaggct gctgcagcat tttttttttt tttctttttt
     2701 gagatggagt ctcactctgt cgcccaggct ggggtgcagt ggcgccatct cggctcaccg
     2761 caagctccgc ttcccaggct ggggtgcagt ggtgcgatct tggctcactg caagctccgc
     2821 ctcctgggtt cacgccattc tcctgcctca gcctcccgag tagctgggac tacaggcgcc
     2881 accaccttgc ccaactaatt ttttgtattt tttagtagag acgaggtttc accgtgttag
     2941 ccaggatggt ctcgatcttc tgacctcgtg atccgcctgc ctcagactcc caaagtgctg
     3001 ggattacagg tgtgagccac cacgcccagc cttttttttt tctttctttt gagacagaat
     3061 ctctctgtca tccaggctag agtgcagtgg cacgatcttg gcttactgca acctccacct
     3121 cccaggttca agcaattctc tgtctcagcc tcccgagtag ctgggattac aggcatgcac
     3181 caccacgcct ggctaatttt tgtatattta agtagagaca aggtttcgct atgttggcca
     3241 ggctggtctt gaactcctga cctcgtgatc cacctgcctt ggccacccaa agtgttggga
     3301 ttataggcat gagccaccgt gcctggctga tgctggagct tttatgtgac atggtgactc
     3361 ttaaaactgg ggagggacgt agagatgaga gtttcacaca ccagcccata ggtgggatgt
     3421 caagacccat cggaagtgtc gctggcctaa gagaagagca cttatttctc accatggctg
     3481 atctagaatt gttccctgat tctgaaagaa gtttacacta cactggtaag cagtactatt
     3541 agactactga ctgtggcctt ctgtgcatat ggaataatga tttctcagat ttgtaggctt
     3601 gaatgtgaat gttattttat cagtaatcag aataaattgc ttatattcag gagttatttt
     3661 aaatatttaa atgaaattta ttttaggcac caagcactac ataaactcat aataactatt
     3721 tgcaatgcat tagcatcact cacggggtaa tgaaaacata ccttagctgc tgtaaaagca
     3781 aagtcttccg tgtccgggtg ggctgaaagt ttttaataaa attttagcta aacatttgtt
     3841 taagtgaata ctaaggatgg agcaatagtg ttattttcct caggaactga agtctcatgc
     3901 tgaagtattt tctccttaaa attaaatttt taaaatcagg gaaggggaag ggactgatgc
     3961 aaagcagtcc gttcatttct cagactgcga gcatccctac taacctcatc accctcactc
     4021 tggtgatatt actcctgggt ctccacagaa caaaaggaac gcacctcgtt tacaaagaaa
     4081 gtcctgattg atatagaaca gaaatcttcc tacttcagtt tttttgtttt tttttttgag
     4141 acagagtctt gctctgtcaa ccaggctgga gtgcggtggc acgatctcag ctcactgcaa
     4201 cctctgcctc ctgggttcaa gtgattctcc tgcctcagcc tctcgagtag ctgggactac
     4261 aggcgtgtgc caccacaccc agctaatttt tatattttta gtagagatgg ggtttcacca
     4321 tgttggcagg atggtctcga tctcttgacc tcgtgatcct cccaccttgg cctcccaaat
     4381 gctgggggtt acaggcgtga gccaccacac ctggccttcc agtgtcttaa ctaactggta
     4441 cacagcagcc tgaggggcct cagttggcac agctgggagg ggcgtgagtc cctttcagca
     4501 gctgcagcct gggtctccct ctgtggcatg gccactgcca ggtttcccag ccactgccag
     4561 gttgcccacg ggtctgtcat gtgtgctacc ttttcagaat gcaaatccaa ctcctgtgta
     4621 tgaatgaatg tgcctcactg tgctggccca ggcctgatgg gccaagccct gactctgcac
     4681 tggcccctgt acctgccgct cccacccagg ttcccagggg tgttccagtg ggggacgcaa
     4741 cctgcgggct actcgctggg catcaggtcc agatcccaga gacaggtcca gtggctgtgg
     4801 cccaggcctc cttccccacc acagacaggc caggctcagc atcaaacttc ctagggaaag
     4861 aatttggaat tgaaaaagta gcaaaatcac aactttgtgg gacttttctt atgcatattt
     4921 tgcagtttgg cattgtttgt aattacgtat ttataatttc agtattttga gataccagcg
     4981 agcttaatca ggctaaaata attctcagaa tttgctttct aagggctgcc aaacacaaga
     5041 ggcctttgaa aaaaggatcc ttttcaaaag aacgttctca caataaaaat tcctggccca
     5101 a
//
