LOCUS       NM_147198                675 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens WAP four-disulfide core domain 9 (WFDC9), mRNA.
ACCESSION   NM_147198
VERSION     NM_147198.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 675)
  AUTHORS   Ferreira,Z., Seixas,S., Andres,A.M., Kretzschmar,W.W.,
            Mullikin,J.C., Cherukuri,P.F., Cruz,P., Swanson,W.J., Clark,A.G.,
            Green,E.D. and Hurle,B.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Reproduction and immunity-driven natural selection in the human
            WFDC locus
  JOURNAL   Mol Biol Evol 30 (4), 938-950 (2013)
   PUBMED   23292442
REFERENCE   2  (bases 1 to 675)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   3  (bases 1 to 675)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     A locus on human chromosome 20 contains several genes expressing
            protease inhibitor domains with homology to whey acidic protein
  JOURNAL   Biochem J 368 (Pt 1), 233-242 (2002)
   PUBMED   12206714
REFERENCE   4  (bases 1 to 675)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031671.12, AY047610.1 and AW269752.1.
            
            On May 17, 2019 this sequence version replaced NM_147198.3.
            
            Summary: The WAP-type four-disulfide core (WFDC) domain, or WAP
            signature motif, contains eight cysteines forming four disulfide
            bonds at the core of the protein, and functions as a protease
            inhibitor in many members of the WFDC domain family. This gene
            encodes a protein which contains a WFDC domain, and is thus a
            member of the WFDC domain family. This gene and several other gene
            family members are clustered at 20q13.12. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY047610.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2161674
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326000.2/ ENSP00000320532.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL031671.12        50595-50610         c
            17-672              AY047610.1         1-656
            673-675             AW269752.1         10-12               c
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..675
                     /gene="WFDC9"
                     /gene_synonym="dJ688G8.2; WAP9"
                     /note="WAP four-disulfide core domain 9"
                     /db_xref="GeneID:259240"
                     /db_xref="HGNC:HGNC:20380"
     exon            1..82
                     /gene="WFDC9"
                     /gene_synonym="dJ688G8.2; WAP9"
                     /inference="alignment:Splign:2.1.0"
     exon            83..176
                     /gene="WFDC9"
                     /gene_synonym="dJ688G8.2; WAP9"
                     /inference="alignment:Splign:2.1.0"
     exon            177..325
                     /gene="WFDC9"
                     /gene_synonym="dJ688G8.2; WAP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..504
                     /gene="WFDC9"
                     /gene_synonym="dJ688G8.2; WAP9"
                     /note="protein WFDC9"
                     /codon_start=1
                     /product="protein WFDC9 precursor"
                     /protein_id="NP_671731.1"
                     /db_xref="CCDS:CCDS13362.1"
                     /db_xref="GeneID:259240"
                     /db_xref="HGNC:HGNC:20380"
                     /translation="MKPWILLLVMFISGVVMLLPVLGSFWNKDPFLDMIRETEQCWVQ
                     PPYKYCEKRCTKIMTCVRPNHTCCWTYCGNICLDNEEPLKSMLNP"
     exon            326..473
                     /gene="WFDC9"
                     /gene_synonym="dJ688G8.2; WAP9"
                     /inference="alignment:Splign:2.1.0"
     exon            474..675
                     /gene="WFDC9"
                     /gene_synonym="dJ688G8.2; WAP9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacaccagga cgcaagacaa gtggggcatc tgtaggggcc acagtgagct ctcaatgatc
       61 atctgtagtg gcagcaaaag agttcgagcc ccacttcaaa caacttcata ataaaaggcc
      121 agacaaaaga gctgtcagcc agttactaca gacactcaat gcagacacct tcagagtatt
      181 gggaaaagac ttgccttctg ccagaactta acccaaatac acacagagag caccatgaag
      241 ccctggattc ttctactcgt catgttcatc tctggagttg tgatgcttct gcctgtgctg
      301 ggaagcttct ggaacaaaga tccctttcta gatatgataa gagaaactga gcagtgctgg
      361 gtacagcctc catataagta ctgtgagaaa aggtgtacta aaataatgac ttgtgtacgt
      421 ccaaatcata catgctgctg gacctactgt ggaaacatct gcttagacaa cgaagagccc
      481 cttaaatcaa tgctaaaccc ctagattcta ttggccgatc actactgtgg gctgaaggat
      541 gaccatctgg tctaagaaga gtgctgccta cttccttctt gggacaccca ctggctctag
      601 ctggtaacct ttctgctatt tccttgacct ctttaccctg aagcttttgt caaataaact
      661 gctacatcaa cctga
//
