LOCUS       NM_080827                607 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WAP four-disulfide core domain 6 (WFDC6), mRNA.
ACCESSION   NM_080827
VERSION     NM_080827.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 607)
  AUTHORS   Ferreira,Z., Seixas,S., Andres,A.M., Kretzschmar,W.W.,
            Mullikin,J.C., Cherukuri,P.F., Cruz,P., Swanson,W.J., Clark,A.G.,
            Green,E.D. and Hurle,B.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Reproduction and immunity-driven natural selection in the human
            WFDC locus
  JOURNAL   Mol Biol Evol 30 (4), 938-950 (2013)
   PUBMED   23292442
REFERENCE   3  (bases 1 to 607)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   4  (bases 1 to 607)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     A locus on human chromosome 20 contains several genes expressing
            protease inhibitor domains with homology to whey acidic protein
  JOURNAL   Biochem J 368 (Pt 1), 233-242 (2002)
   PUBMED   12206714
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF411861.1 and AL031663.2.
            
            On Jun 2, 2019 this sequence version replaced NM_080827.1.
            
            Summary: This gene encodes a member of the WAP-type four-disulfide
            core (WFDC) domain family. The WFDC domain, or WAP signature motif,
            contains eight cysteines forming four disulfide bonds at the core
            of the protein, and functions as a protease inhibitor. Most WFDC
            gene members are localized to chromosome 20q12-q13 in two clusters:
            centromeric and telomeric. This gene belongs to the telomeric
            cluster. Read-through transcription exists between this gene and
            the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz
            and WAP domains 1) gene. [provided by RefSeq, Nov 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF411861.1, GQ472217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372670.8/ ENSP00000361755.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-606               AF411861.1         14-619
            607-607             AL031663.2         97947-97947         c
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..607
                     /gene="WFDC6"
                     /gene_synonym="C20orf171; dJ461P17.11; HEL-S-295; WAP6"
                     /note="WAP four-disulfide core domain 6"
                     /db_xref="GeneID:140870"
                     /db_xref="HGNC:HGNC:16164"
     exon            1..166
                     /gene="WFDC6"
                     /gene_synonym="C20orf171; dJ461P17.11; HEL-S-295; WAP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..336
                     /gene="WFDC6"
                     /gene_synonym="C20orf171; dJ461P17.11; HEL-S-295; WAP6"
                     /note="protease inhibitor WAP6; WAP four-disulfide core
                     domain protein 6; epididymis secretory protein Li 295;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 6
                     precursor"
                     /protein_id="NP_543017.1"
                     /db_xref="CCDS:CCDS13358.1"
                     /db_xref="GeneID:140870"
                     /db_xref="HGNC:HGNC:16164"
                     /translation="MGLSGLLPILVPFILLGDIQEPGHAEGILGKPCPKIKVECEVEE
                     IDQCTKPRDCPENMKCCPFSRGKKCLDFRKVSLTLYHKEELE"
     exon            167..297
                     /gene="WFDC6"
                     /gene_synonym="C20orf171; dJ461P17.11; HEL-S-295; WAP6"
                     /inference="alignment:Splign:2.1.0"
     exon            298..607
                     /gene="WFDC6"
                     /gene_synonym="C20orf171; dJ461P17.11; HEL-S-295; WAP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      584..589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WFDC6"
                     /gene_synonym="C20orf171; dJ461P17.11; HEL-S-295; WAP6"
                     /note="hexamer: AATAAA"
     polyA_site      607
                     /gene="WFDC6"
                     /gene_synonym="C20orf171; dJ461P17.11; HEL-S-295; WAP6"
                     /note="major polyA site"
ORIGIN      
        1 caaagtgcag atgtaggagc tgctgaggag cagttcttag ttttggtgcc atcaaccagg
       61 ccagtacttc ctaaaatggg actctcagga cttctgccaa tcctggtacc attcatcctt
      121 ttgggggaca tccaggaacc tgggcacgct gaaggcatcc ttggcaagcc gtgtcccaaa
      181 atcaaagtgg aatgcgaagt ggaagaaata gaccagtgta ccaaacccag agattgccca
      241 gaaaacatga agtgttgccc gttcagccgt ggaaagaaat gtttagactt cagaaaggtc
      301 agccttactt tataccataa ggaggagctt gaataacctc caggatttgg ctcataatcc
      361 aggcctctct ccacgtgtgc ctgattgatg ctccaaattg gcttccacgg gccaaacctt
      421 ggctgttcca gaaactgaac cccaggaatt gcttacacac tttcttccag cgtagcatct
      481 cttcaaacac aatgctcttc cccttgacca cttctcagta tgaaactcta tgtcttcaac
      541 tttcagaccc cccatttatt tgtatgaagg cttcagttgc cttaataaag tgctctgtgg
      601 ggtccga
//
