LOCUS       NM_172005               1350 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens WAP four-disulfide core domain 13 (WFDC13), mRNA.
ACCESSION   NM_172005
VERSION     NM_172005.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Ferreira,Z., Seixas,S., Andres,A.M., Kretzschmar,W.W.,
            Mullikin,J.C., Cherukuri,P.F., Cruz,P., Swanson,W.J., Clark,A.G.,
            Green,E.D. and Hurle,B.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Reproduction and immunity-driven natural selection in the human
            WFDC locus
  JOURNAL   Mol Biol Evol 30 (4), 938-950 (2013)
   PUBMED   23292442
REFERENCE   3  (bases 1 to 1350)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   4  (bases 1 to 1350)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     A locus on human chromosome 20 contains several genes expressing
            protease inhibitor domains with homology to whey acidic protein
  JOURNAL   Biochem J 368 (Pt 1), 233-242 (2002)
   PUBMED   12206714
REFERENCE   5  (bases 1 to 1350)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF454505.1.
            
            On Nov 22, 2018 this sequence version replaced NM_172005.1.
            
            Summary: This gene encodes a member of the WAP-type four-disulfide
            core (WFDC) domain family. The WFDC domain, or WAP signature motif,
            contains eight cysteines forming four disulfide bonds at the core
            of the protein, and functions as a protease inhibitor. Most WFDC
            gene members are localized to chromosome 20q12-q13 in two clusters:
            centromeric and telomeric. This gene belongs to the telomeric
            cluster. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF454505.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2144335
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305479.3/ ENSP00000302938.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1350              AF454505.1         23-1372
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1350
                     /gene="WFDC13"
                     /gene_synonym="C20orf138; dJ601O1.3; WAP13"
                     /note="WAP four-disulfide core domain 13"
                     /db_xref="GeneID:164237"
                     /db_xref="HGNC:HGNC:16131"
     exon            1..174
                     /gene="WFDC13"
                     /gene_synonym="C20orf138; dJ601O1.3; WAP13"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..368
                     /gene="WFDC13"
                     /gene_synonym="C20orf138; dJ601O1.3; WAP13"
                     /note="protease inhibitor WAP13; protein WFDC13; WAP
                     four-disulfide core domain protein 13"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 13
                     precursor"
                     /protein_id="NP_742002.1"
                     /db_xref="CCDS:CCDS13367.1"
                     /db_xref="GeneID:164237"
                     /db_xref="HGNC:HGNC:16131"
                     /translation="MKPVLPLQFLVVFCLALQLVPGSPKQRVLKYILEPPPCISAPEN
                     CTHLCTMQEDCEKGFQCCSSFCGIVCSSETFQKRNRIKHKGSEVIMPAN"
     exon            175..325
                     /gene="WFDC13"
                     /gene_synonym="C20orf138; dJ601O1.3; WAP13"
                     /inference="alignment:Splign:2.1.0"
     exon            326..390
                     /gene="WFDC13"
                     /gene_synonym="C20orf138; dJ601O1.3; WAP13"
                     /inference="alignment:Splign:2.1.0"
     exon            391..1350
                     /gene="WFDC13"
                     /gene_synonym="C20orf138; dJ601O1.3; WAP13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1326..1331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WFDC13"
                     /gene_synonym="C20orf138; dJ601O1.3; WAP13"
                     /note="hexamer: AATAAA"
     polyA_site      1350
                     /gene="WFDC13"
                     /gene_synonym="C20orf138; dJ601O1.3; WAP13"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcctt ctcttctcct cacagcagtg cctggtcaaa cccagcaacc cttggccaga
       61 acttactcac ccatcccact gacaccatga agcctgtgct gcctctccag ttcctggtgg
      121 tgttctgcct agcactgcag ctggtgcctg ggagtcccaa gcagcgtgtt ctgaagtata
      181 tcttggaacc tccaccctgc atatcagcac ctgaaaactg tactcacctg tgtacaatgc
      241 aggaagattg cgagaaagga tttcagtgct gttcctcctt ctgtgggata gtctgttcat
      301 cagaaacatt tcaaaagcgc aacagaatca aacacaaggg ctcagaagtc atcatgcctg
      361 ccaactgagg catatttcct agatcatttt gcctctacga tgttttttct tggtccacct
      421 ttaggaaggt attgagaagc aagaaactgg aggcccaata tctaacctgc aaatcgtttt
      481 tgagtttggc aataaaggct aatctaccat aaaactcttg aagcttaagc tttaggtcaa
      541 cacttgcaag agccccttcc aaagctcagc acagtttcct cctgggatga ggagaggaat
      601 cagaaacccc actttggcat agagacaagc agcactgttc cagtccaggg atgctgtgtg
      661 tgccctggtg gtggtcttaa ggacctacca catcaacatc tggacaaccc tcactgatta
      721 cctgcccttg gttgcactca tcaggctaat tgatcccata tttaacctca aggagaaata
      781 tcaaccagac actgcatggc aacctccttg gggccagcct tcaaggcttc atggccatat
      841 catgaaccca ggacaggcac agtgggggtg gtgaggacct gatagagttg gatcagtgac
      901 taagaggctg caataaggtg ccatgaaatc aaaatcaaag ggctagaact ctccaaggtc
      961 ttgcccccgg catgtagcac cacctgagcc agaaactgca gaggacatga cagtgtggca
     1021 ttactgataa gttatggaaa tggaaataat ctttcctaaa ctaccaataa taactttaaa
     1081 tttttgatca accatgctag agcaaagatt gaattatcct tctgttctct ctacagaaat
     1141 gatataaaaa ctatagtcat aagaagagac aatcaaaaat aatcagccat aaaatattaa
     1201 aaaggtatta taaaggtatt taaaataata ataataaagt gttattttcc tgggattcat
     1261 gatatttgat atattcgtaa gcttttgtta agtttgtaat ttgttgcaat ttctttttca
     1321 tttcaaataa atattcactt acgtgtctaa
//
