LOCUS       NM_080869                775 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens WAP four-disulfide core domain 12 (WFDC12), mRNA.
ACCESSION   NM_080869
VERSION     NM_080869.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 775)
  AUTHORS   Zhuang,Y., Wang,L., Ji,C., Sun,Y. and Shao,F.
  TITLE     Construction of a novel pyrotosis-related prognostic model of
            esophageal square cell carcinoma and determination of the
            anti-tumor effect of WFDC12
  JOURNAL   Funct Integr Genomics 23 (2), 177 (2023)
   PUBMED   37225895
  REMARK    GeneRIF: Construction of a novel pyrotosis-related prognostic model
            of esophageal square cell carcinoma and determination of the
            anti-tumor effect of WFDC12.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 775)
  AUTHORS   Li,G., Gu,L., Zhao,F., Hu,Y., Wang,X., Zeng,F., Yu,J., Yue,C.,
            Zhou,P., Li,Y., Feng,Y., Hu,J., Huang,N., Wu,W., Cui,K., Li,W. and
            Li,J.
  TITLE     WFDC12-overexpressing contributes to the development of atopic
            dermatitis via accelerating ALOX12/15 metabolism and PAF
            accumulation
  JOURNAL   Cell Death Dis 14 (3), 185 (2023)
   PUBMED   36882395
  REMARK    GeneRIF: WFDC12-overexpressing contributes to the development of
            atopic dermatitis via accelerating ALOX12/15 metabolism and PAF
            accumulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 775)
  AUTHORS   Kalinina,P., Vorstandlechner,V., Buchberger,M., Eckhart,L.,
            Lengauer,B., Golabi,B., Laggner,M., Hiess,M., Sterniczky,B.,
            Fodinger,D., Petrova,E., Elbe-Burger,A., Beer,L., Hovnanian,A.,
            Tschachler,E. and Mildner,M.
  TITLE     The Whey Acidic Protein WFDC12 Is Specifically Expressed in
            Terminally Differentiated Keratinocytes and Regulates Epidermal
            Serine Protease Activity
  JOURNAL   J Invest Dermatol 141 (5), 1198-1206 (2021)
   PUBMED   33157095
  REMARK    GeneRIF: The Whey Acidic Protein WFDC12 Is Specifically Expressed
            in Terminally Differentiated Keratinocytes and Regulates Epidermal
            Serine Protease Activity.
REFERENCE   4  (bases 1 to 775)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 775)
  AUTHORS   Ferreira,Z., Seixas,S., Andres,A.M., Kretzschmar,W.W.,
            Mullikin,J.C., Cherukuri,P.F., Cruz,P., Swanson,W.J., Clark,A.G.,
            Green,E.D. and Hurle,B.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Reproduction and immunity-driven natural selection in the human
            WFDC locus
  JOURNAL   Mol Biol Evol 30 (4), 938-950 (2013)
   PUBMED   23292442
REFERENCE   6  (bases 1 to 775)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   7  (bases 1 to 775)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 775)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     A locus on human chromosome 20 contains several genes expressing
            protease inhibitor domains with homology to whey acidic protein
  JOURNAL   Biochem J 368 (Pt 1), 233-242 (2002)
   PUBMED   12206714
REFERENCE   9  (bases 1 to 775)
  AUTHORS   Lundwall,A. and Clauss,A.
  TITLE     Identification of a novel protease inhibitor gene that is highly
            expressed in the prostate
  JOURNAL   Biochem Biophys Res Commun 290 (1), 452-456 (2002)
   PUBMED   11779191
  REMARK    GeneRIF: The size is 774 bp and it gives rise to a polypeptide of
            111 amino acid residues that is homologous to elafin and similar
            WAP-type protease inhibitors.
REFERENCE   10 (bases 1 to 775)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY037803.1 and Z93016.2.
            
            On Nov 23, 2018 this sequence version replaced NM_080869.1.
            
            Summary: This gene encodes a member of the WAP-type four-disulfide
            core (WFDC) domain family. The WFDC domain, or WAP signature motif,
            contains eight cysteines forming four disulfide bonds at the core
            of the protein, and functions as a protease inhibitor. Most WFDC
            gene members are localized to chromosome 20q12-q13 in two clusters:
            centromeric and telomeric. This gene belongs to the centromeric
            cluster. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY037803.1, CU447765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372785.3/ ENSP00000361871.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-774               AY037803.1         1-774
            775-775             Z93016.2           124209-124209       c
FEATURES             Location/Qualifiers
     source          1..775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..775
                     /gene="WFDC12"
                     /gene_synonym="C20orf122; dJ211D12.4; SWAM2; WAP2"
                     /note="WAP four-disulfide core domain 12"
                     /db_xref="GeneID:128488"
                     /db_xref="HGNC:HGNC:16115"
                     /db_xref="MIM:609872"
     exon            1..97
                     /gene="WFDC12"
                     /gene_synonym="C20orf122; dJ211D12.4; SWAM2; WAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..354
                     /gene="WFDC12"
                     /gene_synonym="C20orf122; dJ211D12.4; SWAM2; WAP2"
                     /note="whey acidic protein 2; protease inhibitor WAP2; WAP
                     four-disulfide core domain protein 12; single WAP motif
                     protein 2; putative protease inhibitor WAP12"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 12
                     precursor"
                     /protein_id="NP_543145.1"
                     /db_xref="CCDS:CCDS13343.1"
                     /db_xref="GeneID:128488"
                     /db_xref="HGNC:HGNC:16115"
                     /db_xref="MIM:609872"
                     /translation="MGSSSFLVLMVSLVLVTLVAVEGVKEGIEKAGVCPADNVRCFKS
                     DPPQCHTDQDCLGERKCCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGWEAKCPG
                     SSSTRCPQK"
     exon            98..256
                     /gene="WFDC12"
                     /gene_synonym="C20orf122; dJ211D12.4; SWAM2; WAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..775
                     /gene="WFDC12"
                     /gene_synonym="C20orf122; dJ211D12.4; SWAM2; WAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      750..755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WFDC12"
                     /gene_synonym="C20orf122; dJ211D12.4; SWAM2; WAP2"
                     /note="hexamer: AATAAA"
     polyA_site      775
                     /gene="WFDC12"
                     /gene_synonym="C20orf122; dJ211D12.4; SWAM2; WAP2"
                     /note="major polyA site"
ORIGIN      
        1 aagcacctgc ctggcaacat ggggtccagc agcttcttgg tcctcatggt gtctctcgtt
       61 cttgtgaccc tggtggctgt ggaaggagtt aaagagggta tagagaaagc aggggtttgc
      121 ccagctgaca acgtacgctg cttcaagtcc gatcctcccc agtgtcacac agaccaggac
      181 tgtctggggg aaaggaagtg ttgttacctg cactgtggct tcaagtgtgt gattcctgtg
      241 aaggaactgg aagaaggagg aaacaaggat gaagatgtgt caaggccata ccctgagcca
      301 ggatgggagg ccaagtgtcc aggctcctcc tctaccaggt gtcctcagaa atgatgctgg
      361 gtcctttcta cctctggggg tcactctcac ttggcacctg cccctgaggg tcctgagact
      421 tggaatatgg aagaagcaat acccaacccc accaaagaaa acctgagctt gaagtccttt
      481 tccccaaaaa gagggaagag tcacaaaaag tccagacccc agggacggta ctttccctct
      541 ctacctggtg ctcctcccta atgctcatga atggacccct catgaatgaa accagtgccc
      601 ttataagaga ccccaaagag ctgccttgcc cttctgcaat gtgtgatcac agctagaagg
      661 cactgtcaga gaagagaaac tggtcctcac cagatgctga atctgctggt gccttgatct
      721 tggacttccc agcctctaga actgtaagaa ataaatattt gctgtttata atcca
//
