LOCUS       NM_147197                615 bp    mRNA    linear   PRI 31-MAY-2024
DEFINITION  Homo sapiens WAP four-disulfide core domain 11 (WFDC11), mRNA.
ACCESSION   NM_147197
VERSION     NM_147197.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 615)
  AUTHORS   Ferreira,Z., Seixas,S., Andres,A.M., Kretzschmar,W.W.,
            Mullikin,J.C., Cherukuri,P.F., Cruz,P., Swanson,W.J., Clark,A.G.,
            Green,E.D. and Hurle,B.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Reproduction and immunity-driven natural selection in the human
            WFDC locus
  JOURNAL   Mol Biol Evol 30 (4), 938-950 (2013)
   PUBMED   23292442
REFERENCE   2  (bases 1 to 615)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   3  (bases 1 to 615)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     A locus on human chromosome 20 contains several genes expressing
            protease inhibitor domains with homology to whey acidic protein
  JOURNAL   Biochem J 368 (Pt 1), 233-242 (2002)
   PUBMED   12206714
REFERENCE   4  (bases 1 to 615)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031671.12.
            
            On Jun 10, 2003 this sequence version replaced NM_147197.1.
            
            Summary: This gene encodes a member of the WAP-type four-disulfide
            core (WFDC) domain family. The WFDC domain, or WAP signature motif,
            contains eight cysteines forming four disulfide bonds at the core
            of the protein, and functions as a protease inhibitor. Most WFDC
            gene members are localized to chromosome 20q12-q13 in two clusters:
            centromeric and telomeric. This gene belongs to the telomeric
            cluster. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY047609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324384.4/ ENSP00000318753.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AL031671.12        89504-89565         c
            63-144              AL031671.12        86414-86495         c
            145-295             AL031671.12        69827-69977         c
            296-438             AL031671.12        68583-68725         c
            439-615             AL031671.12        67889-68065         c
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..615
                     /gene="WFDC11"
                     /gene_synonym="WAP11"
                     /note="WAP four-disulfide core domain 11"
                     /db_xref="GeneID:259239"
                     /db_xref="HGNC:HGNC:20478"
     exon            1..62
                     /gene="WFDC11"
                     /gene_synonym="WAP11"
                     /inference="alignment:Splign:2.1.0"
     exon            63..144
                     /gene="WFDC11"
                     /gene_synonym="WAP11"
                     /inference="alignment:Splign:2.1.0"
     exon            145..295
                     /gene="WFDC11"
                     /gene_synonym="WAP11"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..459
                     /gene="WFDC11"
                     /gene_synonym="WAP11"
                     /note="protease inhibitor WAP11; protein WFDC11"
                     /codon_start=1
                     /product="protein WFDC11 precursor"
                     /protein_id="NP_671730.1"
                     /db_xref="CCDS:CCDS13364.1"
                     /db_xref="GeneID:259239"
                     /db_xref="HGNC:HGNC:20478"
                     /translation="MVSLMKLWIPMLMTFFCTVLLSVLGEMRKKRYDRKELLLEECWG
                     KPNVKECTNKCSKAFRCKDKNYTCCWTYCGNICWINVETSGDY"
     exon            296..438
                     /gene="WFDC11"
                     /gene_synonym="WAP11"
                     /inference="alignment:Splign:2.1.0"
     exon            439..615
                     /gene="WFDC11"
                     /gene_synonym="WAP11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      596..601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WFDC11"
                     /gene_synonym="WAP11"
                     /note="hexamer: AATAAA"
     polyA_site      615
                     /gene="WFDC11"
                     /gene_synonym="WAP11"
                     /note="major polyA site"
ORIGIN      
        1 ttctttatat gtctggtaga atttggctgt gaatccatct ggtccagggc cttttctggt
       61 tggggctcca tggttcctag aggcaaggaa gaagagccac cagtcaaata ggtttcagca
      121 cctccaactc caacatcttc aaagcagcga ctgggaagaa aaataatcct tctgacaaca
      181 catattcaga cacatatggt cagcctcatg aagctctgga tacccatgct catgacattc
      241 ttctgtacgg tgctactgtc tgtgctggga gaaatgagga agaaaagata tgacaggaag
      301 gaattgttac ttgaagaatg ctggggaaag ccaaatgtca aagaatgtac caataagtgt
      361 tctaaagcct ttagatgtaa agacaaaaat tacacatgct gctggaccta ttgtggaaac
      421 atctgctgga taaacgtcga aaccagtgga gattactaaa accgtagctt cccaccaggc
      481 tgccacctgt gtgggctggg aaatgtttaa gaggtctcat agtagtaccc tgtggctact
      541 tttaggaaca ccagtctatt tttactgaga gctggacaac agcaaacact tgacaaataa
      601 acttatttac cagta
//
