LOCUS       NM_080753                493 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens WAP four-disulfide core domain 10A (WFDC10A), mRNA.
ACCESSION   NM_080753
VERSION     NM_080753.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Ferreira,Z., Seixas,S., Andres,A.M., Kretzschmar,W.W.,
            Mullikin,J.C., Cherukuri,P.F., Cruz,P., Swanson,W.J., Clark,A.G.,
            Green,E.D. and Hurle,B.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Reproduction and immunity-driven natural selection in the human
            WFDC locus
  JOURNAL   Mol Biol Evol 30 (4), 938-950 (2013)
   PUBMED   23292442
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   3  (bases 1 to 493)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     A locus on human chromosome 20 contains several genes expressing
            protease inhibitor domains with homology to whey acidic protein
  JOURNAL   Biochem J 368 (Pt 1), 233-242 (2002)
   PUBMED   12206714
REFERENCE   4  (bases 1 to 493)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031671.12.
            
            On Nov 26, 2018 this sequence version replaced NM_080753.2.
            
            Summary: This gene encodes a member of the WAP-type four-disulfide
            core (WFDC) domain family. The WFDC domain, or WAP signature motif,
            contains eight cysteines forming four disulfide bonds at the core
            of the protein, and functions as a protease inhibitor. Most WFDC
            gene members are localized to chromosome 20q12-q13 in two clusters:
            centromeric and telomeric. This gene belongs to the telomeric
            cluster. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX380556.2, AY038182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2161674
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372643.4/ ENSP00000361726.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AL031671.12        49065-49230
            167-493             AL031671.12        50196-50522
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..493
                     /gene="WFDC10A"
                     /gene_synonym="C20orf146; dJ688G8.3; WAP10"
                     /note="WAP four-disulfide core domain 10A"
                     /db_xref="GeneID:140832"
                     /db_xref="HGNC:HGNC:16139"
     exon            1..166
                     /gene="WFDC10A"
                     /gene_synonym="C20orf146; dJ688G8.3; WAP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..315
                     /gene="WFDC10A"
                     /gene_synonym="C20orf146; dJ688G8.3; WAP10"
                     /note="WAP four-disulfide core domain protein 10A;
                     putative protease inhibitor WAP10A"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 10A
                     precursor"
                     /protein_id="NP_542791.1"
                     /db_xref="CCDS:CCDS13363.1"
                     /db_xref="GeneID:140832"
                     /db_xref="HGNC:HGNC:16139"
                     /translation="MAPQTLLPVLVLCVLLLQAQGGYRDKKRMQKTQLSPEIKVCQQQ
                     PKLYLCKHLCESHRDCQANNICCSTYCGNVCMSIL"
     exon            167..493
                     /gene="WFDC10A"
                     /gene_synonym="C20orf146; dJ688G8.3; WAP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      468..473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WFDC10A"
                     /gene_synonym="C20orf146; dJ688G8.3; WAP10"
                     /note="hexamer: AATAAA"
     polyA_site      493
                     /gene="WFDC10A"
                     /gene_synonym="C20orf146; dJ688G8.3; WAP10"
                     /note="major polyA site"
ORIGIN      
        1 actctccgta gacagctctg cagggaagtc tgtgacaacc tggccagaca tagggctcac
       61 gatctgatca gagtcatggc accccagact ctgctgcctg tcctggttct ctgtgtgctg
      121 ctgctgcagg cccagggagg ataccgtgac aagaagagga tgcagaaaac acagctatcc
      181 ccagaaatca aagtctgcca gcagcagcct aaactatatc tatgcaaaca cttatgtgaa
      241 tctcaccgag attgtcaagc aaataacata tgctgttcta cctactgtgg gaatgtttgc
      301 atgagcatcc tgtgagtggg agagtgggct gggatgtgca tcctgcttcc caactcctct
      361 atccaagact gtgcccacat ccgaagcaca aggacctcaa gtcaccagca taagaacatc
      421 aacaggaatg ccgccctctc tactgtctga accccttgtc cctgtcaaat aaaccagaac
      481 aaatgcccag gga
//
