LOCUS       NM_001105558            3061 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens WEE2 oocyte meiosis inhibiting kinase (WEE2), mRNA.
ACCESSION   NM_001105558
VERSION     NM_001105558.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Guo,H., Wu,H., Yan,Z., Yin,M., Wu,L. and Li,B.
  TITLE     Novel WEE2 homozygous mutations c.1346C>T and c.949A>T identified
            in primary infertile women due to unexplained fertilization failure
  JOURNAL   Clin Genet 104 (6), 700-704 (2023)
   PUBMED   37772619
  REMARK    GeneRIF: Novel WEE2 homozygous mutations c.1346C>T and c.949A>T
            identified in primary infertile women due to unexplained
            fertilization failure.
REFERENCE   2  (bases 1 to 3061)
  AUTHORS   Wang,A., Huang,S., Liu,M., Wang,B., Wu,F., Zhu,D. and Zhao,X.
  TITLE     Clinical exome sequencing identifies novel compound heterozygous
            mutations of the WEE2 gene in primary infertile women with
            fertilization failure
  JOURNAL   Gynecol Endocrinol 37 (12), 1096-1101 (2021)
   PUBMED   33904356
  REMARK    GeneRIF: Clinical exome sequencing identifies novel compound
            heterozygous mutations of the WEE2 gene in primary infertile women
            with fertilization failure.
REFERENCE   3  (bases 1 to 3061)
  AUTHORS   Jin,J., Tong,X., Zhang,Y.L., Yang,W., Ma,Y., Ren,P., Zhou,F. and
            Zhang,S.
  TITLE     Novel WEE2 compound heterozygous mutations identified in patients
            with fertilization failure or poor fertilization
  JOURNAL   J Assist Reprod Genet 38 (11), 2861-2869 (2021)
   PUBMED   34476630
  REMARK    GeneRIF: Novel WEE2 compound heterozygous mutations identified in
            patients with fertilization failure or poor fertilization.
REFERENCE   4  (bases 1 to 3061)
  AUTHORS   Zhou,X., Zhu,L., Hou,M., Wu,Y., Li,Z., Wang,J., Liu,Z., Zhang,D.,
            Jin,L. and Zhang,X.
  TITLE     Novel compound heterozygous mutations in WEE2 causes female
            infertility and fertilization failure
  JOURNAL   J Assist Reprod Genet 36 (9), 1957-1962 (2019)
   PUBMED   31428887
  REMARK    GeneRIF: Novel compound heterozygous mutations c.598C>T
            (p.Arg200Ter) and c.1319G>C (p.Trp440Ser) in WEE2 gene in a female
            whose oocytes could not form pronucleus after intracytoplasmic
            sperm injection. Mutations in WEE2 gene affect the normal function
            of WEE2 proteins and cause fertilization failure.
REFERENCE   5  (bases 1 to 3061)
  AUTHORS   Zhao,S., Chen,T., Yu,M., Bian,Y., Cao,Y., Ning,Y., Su,S., Zhang,J.
            and Zhao,S.
  TITLE     Novel WEE2 gene variants identified in patients with fertilization
            failure and female infertility
  JOURNAL   Fertil Steril 111 (3), 519-526 (2019)
   PUBMED   30827524
  REMARK    GeneRIF: Novel variants found in WEE2, which is autosomal-recessive
            inherited, may be related to recurrent pronucleus formation failure
            and female infertility.
            Erratum:[Fertil Steril. 2019 May;111(5):1032. doi:
            10.1016/j.fertnstert.2019.03.029.. PMID: 31029236]
REFERENCE   6  (bases 1 to 3061)
  AUTHORS   Zhu,J.Y., Cuellar,R.A., Berndt,N., Lee,H.E., Olesen,S.H.,
            Martin,M.P., Jensen,J.T., Georg,G.I. and Schonbrunn,E.
  TITLE     Structural Basis of Wee Kinases Functionality and Inactivation by
            Diverse Small Molecule Inhibitors
  JOURNAL   J Med Chem 60 (18), 7863-7875 (2017)
   PUBMED   28792760
REFERENCE   7  (bases 1 to 3061)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   8  (bases 1 to 3061)
  AUTHORS   Liu,C., Liu,Y., Liu,Y., Wu,D., Luan,Z., Wang,E. and Yu,B.
  TITLE     Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M
            transition in one-cell stage mouse embryos
  JOURNAL   Mol Med Rep 7 (6), 1929-1937 (2013)
   PUBMED   23616086
REFERENCE   9  (bases 1 to 3061)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 3061)
  AUTHORS   Nakanishi,M., Ando,H., Watanabe,N., Kitamura,K., Ito,K.,
            Okayama,H., Miyamoto,T., Agui,T. and Sasaki,M.
  TITLE     Identification and characterization of human Wee1B, a new member of
            the Wee1 family of Cdk-inhibitory kinases
  JOURNAL   Genes Cells 5 (10), 839-847 (2000)
   PUBMED   11029659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131218.1, BM790836.1, BG402079.1 and AC004918.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131218.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397541.6/ ENSP00000380675.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1197              AK131218.1         1-1197
            1198-1549           BM790836.1         117-468
            1550-1990           AK131218.1         1550-1990
            1991-2138           BG402079.1         340-487
            2139-3061           AC004918.1         98937-99859
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3061
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /note="WEE2 oocyte meiosis inhibiting kinase"
                     /db_xref="GeneID:494551"
                     /db_xref="HGNC:HGNC:19684"
                     /db_xref="MIM:614084"
     exon            1..748
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..2110
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /EC_number="2.7.10.2"
                     /note="wee1B kinase; wee1-like protein kinase 1B; WEE1
                     homolog 2"
                     /codon_start=1
                     /product="wee1-like protein kinase 2"
                     /protein_id="NP_001099028.1"
                     /db_xref="CCDS:CCDS43660.1"
                     /db_xref="GeneID:494551"
                     /db_xref="HGNC:HGNC:19684"
                     /db_xref="MIM:614084"
                     /translation="MDDKDIDKELRQKLNFSYCEETEIEGQKKVEESREASSQTPEKG
                     EVQDSEAKGTPPWTPLSNVHELDTSSEKDKESPDQILRTPVSHPLKCPETPAQPDSRS
                     KLLPSDSPSTPKTMLSRLVISPTGKLPSRGPKHLKLTPAPLKDEMTSLALVNINPFTP
                     ESYKKLFLQSGGKRKIRGDLEEAGPEEGKGGLPAKRCVLRETNMASRYEKEFLEVEKI
                     GVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYY
                     SSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSS
                     MVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKV
                     EEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGNFPD
                     VPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKTEELQQQLNLEKFKTA
                     TLERELREAQQAQSPQGYTHHGDTGVSGTHTGSRSTKRLVGGKSARSSSFTSGEREPL
                     H"
     exon            749..945
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            946..991
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1164
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1286
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1433
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1541
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1627
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1798
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1941
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2084
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..3061
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3039..3044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /note="hexamer: AATAAA"
     polyA_site      3061
                     /gene="WEE2"
                     /gene_synonym="OOMD5; OZEMA5; WEE1B"
                     /note="major polyA site"
ORIGIN      
        1 aatttctttt caatattagc ttattcccaa attggctaat gggtattttt aaagccatgc
       61 taaattaaag gaattcaatt ttctcactag tatttggtaa cacatgggag actatgtgtc
      121 atatccagaa gagttctgta catgaactgc atttaattgc tccgagagtc actggagctt
      181 tctttaatca gaatggaaat caggataagc tgaggtctta tagattggtg gtacttaagg
      241 cagaaaatta acaccgtgtt ttgtagctgt tagttggtag agggaaattc aggctaccgt
      301 cgcgaaacct gcaggttaag ttattttctc ctccctgctt ctgtaggttc acagcgttcc
      361 cttctgatag agctttttgt ctgtgttgta aagctctttg gctgagatgg atgacaaaga
      421 tattgacaaa gaactaaggc agaaattaaa cttttcctat tgtgaggaga ctgagattga
      481 agggcagaag aaagtagaag aaagcaggga ggcttcgagc caaaccccag agaagggtga
      541 agtgcaggat tcagaggcaa agggtacacc accttggact ccccttagca acgtgcatga
      601 gctcgacaca tcttcggaaa aagacaaaga aagtccagat cagattttga ggactccagt
      661 gtcacaccct ctcaaatgtc ctgagacacc agcccaacca gacagcagga gcaagctgct
      721 gcccagtgac agcccctcta ctcccaaaac catgctgagc cggttggtga tttctccaac
      781 agggaagctt ccttccagag gccctaagca tttgaagctc acacctgctc ccctcaagga
      841 tgagatgacc tcattggctc tggtcaatat taatcccttc actccagagt cctataaaaa
      901 attatttctt caatctggtg gcaagaggaa aataagagga gatcttgagg aagctggtcc
      961 agaggaaggc aagggagggc tgcctgccaa gagatgtgtt ttacgagaaa ccaacatggc
     1021 ttcccgctat gaaaaagaat tcttggaggt tgaaaaaatt ggggttggcg aatttggtac
     1081 agtctacaag tgcattaaga ggctggatgg atgtgtttat gcaataaagc gctctatgaa
     1141 aacttttaca gaattatcaa atgagaattc ggctttgcat gaagtttatg ctcacgcagt
     1201 gcttgggcat cacccccatg tggtacgtta ctattcctca tgggcagaag atgaccacat
     1261 gatcattcag aatgaatact gcaatggtgg gagtttgcaa gctgctatat ctgaaaacac
     1321 taagtctggc aatcattttg aagagccaaa actcaaggac atccttctac agatttccct
     1381 tggccttaat tacatccaca actctagcat ggtacacctg gacatcaaac ctagtaatat
     1441 attcatttgt cacaagatgc aaagtgaatc ctctggagtc atagaagaag ttgaaaatga
     1501 agctgattgg tttctctctg ccaatgtgat gtataaaatt ggtgacctgg gccacgcaac
     1561 atcaataaac aaacccaaag tggaagaagg agatagtcgc ttcctggcta atgagatttt
     1621 gcaagaggat taccggcacc ttcccaaagc agacatattt gccttgggat taacaattgc
     1681 agtggctgca ggagcagagt cattgcccac caatggtgct gcatggcacc atatccgcaa
     1741 gggtaacttt ccggacgttc ctcaggagct ctcagaaagc ttttccagtc tgctcaagaa
     1801 catgatccaa cctgatgccg aacagagacc ttctgcagca gctctggcca gaaatacagt
     1861 tctccggcct tccctgggaa aaacagaaga gctccaacag cagctgaatt tggaaaagtt
     1921 caagactgcc acactggaaa gggaactgag agaagcccag caggcccagt caccccaggg
     1981 atatacccat catggtgaca ctggggtctc tgggacccac acaggatcaa gaagcacaaa
     2041 acgcctggtg ggaggaaaga gtgcaaggtc ttcaagcttt acctcaggag agcgtgagcc
     2101 tctgcattaa aggaagaaaa ggaaaacagc ccttggtttg gcctatggat tacgaggttg
     2161 ctgttgctga ttccccacca aagatcccag ggactcgttg tacatagaaa ggaatagaat
     2221 ttagtttaga gttgaagtca cagcttacag aaaatgtgcc tggatttcca cagcgcttcc
     2281 caggttatat gatgctgttc ctaagagaga attcccagct tctttgagga agtgggtctc
     2341 ctaatgtata ccctttctga tattgtattt attaaataaa tggtttcacc attatgtgag
     2401 gtgggtaaaa gttagactgc atgcaacttg gacatctctg agctggttgt taacttgcag
     2461 aacaaaaatg ctgtggggag aggcttcagg gaaaacttga tgtgcctgtg gttgttctcc
     2521 atctatttgc cctgcctctc ttgctgttct ggttggtttg atattctggg tctcaccaat
     2581 ttctcttgat ttttgtgaga atttggcttt gtttcctgtt ttttaaaatc atattttatc
     2641 taaatccttt ttctgtacac atttttaaag gaagagaata ctgtattttt aaataaaggt
     2701 ttttatcttg tccaaagcct aattacaggt aaaatatcct ttgtaaaatg taactaacaa
     2761 agaatgagaa atttatgtcg gagaacattt tatgaataaa agggtaagag aattgagtgg
     2821 gtcagtagta acaggtcttg gtggcaagtc tcagcttcac agttccaaca gttaatgatg
     2881 gtcaggatct gctagaaaat tatgttggtc ataaaggtat ttgataagct ctgtttgtgt
     2941 catcttagtg aatgcaacct gttaatgata atggcttttt cgctgcttga ttttcttctt
     3001 ttcctcattt ttaaaagcta attaagtttt tttaattgaa taaaccctaa tactattctt
     3061 t
//
