LOCUS       NM_001276252            4706 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens WD and tetratricopeptide repeats 1 (WDTC1), transcript
            variant 1, mRNA.
ACCESSION   NM_001276252
VERSION     NM_001276252.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4706)
  AUTHORS   Wang,X., Cai,Q., Ping,J., Diaz-Zabala,H., Xia,Y. and Guo,X.
  TITLE     The putative oncogenic role of WDTC1 in colorectal cancer
  JOURNAL   Carcinogenesis 43 (6), 594-600 (2022)
   PUBMED   35238908
  REMARK    GeneRIF: The putative oncogenic role of WDTC1 in colorectal cancer.
REFERENCE   2  (bases 1 to 4706)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4706)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4706)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4706)
  AUTHORS   Groh,B.S., Yan,F., Smith,M.D., Yu,Y., Chen,X. and Xiong,Y.
  TITLE     The antiobesity factor WDTC1 suppresses adipogenesis via the
            CRL4WDTC1 E3 ligase
  JOURNAL   EMBO Rep 17 (5), 638-647 (2016)
   PUBMED   27113764
  REMARK    GeneRIF: Our results identify a biochemical role for WDTC1 and
            extend the functional range of the CRL4 complex to the suppression
            of fat accumulation.
REFERENCE   6  (bases 1 to 4706)
  AUTHORS   Li,T., Robert,E.I., van Breugel,P.C., Strubin,M. and Zheng,N.
  TITLE     A promiscuous alpha-helical motif anchors viral hijackers and
            substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery
  JOURNAL   Nat Struct Mol Biol 17 (1), 105-111 (2010)
   PUBMED   19966799
REFERENCE   7  (bases 1 to 4706)
  AUTHORS   Lai,C.Q., Parnell,L.D., Arnett,D.K., Garcia-Bailo,B., Tsai,M.Y.,
            Kabagambe,E.K., Straka,R.J., Province,M.A., An,P., Borecki,I.B.,
            Tucker,K.L. and Ordovas,J.M.
  TITLE     WDTC1, the ortholog of Drosophila adipose gene, associates with
            human obesity, modulated by MUFA intake
  JOURNAL   Obesity (Silver Spring) 17 (3), 593-600 (2009)
   PUBMED   19238144
  REMARK    GeneRIF: WDTC1 variation may be an important risk factor
            contributing to obesity in both Puerto Rican and white populations.
            GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 4706)
  AUTHORS   Angers,S., Li,T., Yi,X., MacCoss,M.J., Moon,R.T. and Zheng,N.
  TITLE     Molecular architecture and assembly of the DDB1-CUL4A ubiquitin
            ligase machinery
  JOURNAL   Nature 443 (7111), 590-593 (2006)
   PUBMED   16964240
REFERENCE   9  (bases 1 to 4706)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 4706)
  AUTHORS   Hader,T., Muller,S., Aguilera,M., Eulenberg,K.G., Steuernagel,A.,
            Ciossek,T., Kuhnlein,R.P., Lemaire,L., Fritsch,R., Dohrmann,C.,
            Vetter,I.R., Jackle,H., Doane,W.W. and Bronner,G.
  TITLE     Control of triglyceride storage by a WD40/TPR-domain protein
  JOURNAL   EMBO Rep 4 (5), 511-516 (2003)
   PUBMED   12717455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB072151.1, BC032523.1, AK315564.1, HY218382.1 and FO393419.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001276252.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315564.1, ERR3218372.514239.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319394.8/ ENSP00000317971.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DB072151.1         95-130
            37-237              BC032523.1         16-216
            238-2016            AK315564.1         238-2016
            2017-4314           BC032523.1         1993-4290
            4315-4703           HY218382.1         1-389               c
            4704-4706           FO393419.1         152607-152609       c
FEATURES             Location/Qualifiers
     source          1..4706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..4706
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /note="WD and tetratricopeptide repeats 1"
                     /db_xref="GeneID:23038"
                     /db_xref="HGNC:HGNC:29175"
                     /db_xref="MIM:619763"
     exon            1..320
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            321..467
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..2453
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /note="isoform a is encoded by transcript variant 1; DDB1
                     and CUL4 associated factor 9; adipose homolog; WD and
                     tetratricopeptide repeats protein 1"
                     /codon_start=1
                     /product="WD and tetratricopeptide repeats protein 1
                     isoform a"
                     /protein_id="NP_001263181.1"
                     /db_xref="CCDS:CCDS60044.1"
                     /db_xref="GeneID:23038"
                     /db_xref="HGNC:HGNC:29175"
                     /db_xref="MIM:619763"
                     /translation="MAKVNITRDLIRRQIKERGALSFERRYHVTDPFIRRLGLEAELQ
                     GHSGCVNCLEWNEKGDLLASGSDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHA
                     GDRILITGAADSKVHVHDLTVKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIR
                     QYDLRENSKHSEVLIDLTEYCGQLVEAKCLTVNPQDNNCLAVGASGPFVRLYDIRMIH
                     NHRKSMKQSPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLPDYNNRLRVLVATYVTF
                     SPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSSGEVQNGKMSTNGVSNGVSN
                     GLHLHSNGFRLPESRGHVSPQVELPPYLERVKQQANEAFACQQWTQAIQLYSKAVQRA
                     PHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVA
                     EALECLDDFKGKFPEQAHSSACDALGRDITAALFSKNDGEEKKGPGGGAPVRLRSTSR
                     KDSISEDEMVLRERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWE
                     KETTNLVRVLQGDESIVNCLQPHPSYCFLATSGIDPVVRLWNPRPESEDLTGRVVEDM
                     EGASQANQRRMNADPLEVMLLNMGYRITGLSSGGAGASDDEDSSEGQVQCRPS"
     exon            468..551
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            552..598
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            599..710
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            711..898
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1081
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1176
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1292
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1368
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1477
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1651
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1887
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2062
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2255
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..4706
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4293..4298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /note="hexamer: ATTAAA"
     polyA_site      4312
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /note="major polyA site"
     regulatory      4554..4559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /note="hexamer: AGTAAA"
     polyA_site      4574
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
     regulatory      4612..4617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /note="hexamer: AATATA"
     polyA_site      4633
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
     regulatory      4656..4661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
                     /note="hexamer: TATAAA"
     polyA_site      4675
                     /gene="WDTC1"
                     /gene_synonym="ADP; DCAF9"
ORIGIN      
        1 gggcttctcc tgggtcccca gacagctgga ggagataaac agaggaggag gagggagggg
       61 agtgcgtgtg tgagagcgcg cgagggagtg tgagtgtgtg tgagcgcggg tgtgaggcgg
      121 tgcgcagggg cgggcggagg cgctgtccgg ccccggccag gcgccgggcg gggagcatgg
      181 gaaggggcta gaactgctcg agccccccag ccccctcccc gggatccgcg ccccccttcc
      241 cgggagaggg gccgcccccc ccggacggac atgggctcct gaagttgcgc cgctgccggt
      301 cgggggaaga gacctgacag gtaattaaat gtgtattttg tggacctggg cttggctgga
      361 atgctcaggg gtcctgaaga tcctattata gcttccttct gttgaaccat taagaaaaga
      421 tggcgaaagt caacataact agagacctca tccgtaggca gatcaaggag cggggtgccc
      481 tgagctttga gcggcgctac catgtcactg acccctttat ccggcggctg ggcctggaag
      541 cagagctgca gggtcactca ggatgtgtca actgtctgga gtggaatgag aaaggagact
      601 tgctggcctc tggttccgat gaccagcaca cgattgtgtg ggacccgctg caccacaaga
      661 agctgctctc catgcacacg ggacacaccg caaatatctt ctctgtcaag ttcctgcctc
      721 acgctgggga ccgcatcttg atcacggggg cagccgactc taaggtgcat gtgcacgacc
      781 tgacagtaaa ggagaccatc cacatgtttg gagaccacac aaaccgggtg aagcgcatcg
      841 ccacagcgcc catgtggccc aacacattct ggagtgctgc tgaggatggg cttatccgcc
      901 agtatgacct tcgagagaac agcaaacact cggaggtgct gattgacctg acagagtact
      961 gtggccagct ggtggaggcc aagtgcctca ctgtcaaccc ccaggacaac aactgcctgg
     1021 cagttggggc cagcgggccc ttcgtgaggc tctatgacat ccgcatgatc cataaccaca
     1081 gaaagagcat gaagcagagc ccttcagcgg gtgtgcacac cttctgtgac cggcagaaac
     1141 cccttccgga cggtgcagcc cagtattacg tagcaggtca cctgccagtg aagcttcctg
     1201 actacaacaa ccgtttgaga gtgctggttg ccacctatgt gaccttcagc cccaatggca
     1261 cagagctact agtcaacatg gggggggaac aggtctattt gtttgacttg acttacaagc
     1321 agcggccgta caccttcctc ttgcctagaa aatgccactc ctcgggggaa gtccagaatg
     1381 gcaagatgtc caccaacggt gtgtccaacg gtgtgtccaa tggcctgcac cttcatagca
     1441 atggcttccg gctgccggag agtaggggac atgtcagccc ccaagtagag ctaccaccat
     1501 acctggagcg tgtgaaacag caagccaatg aggcttttgc ctgccagcag tggacccaag
     1561 ccattcagct ttacagcaag gctgtgcaga gggcccctca caatgccatg ctttatggaa
     1621 accgagcagc agcctacatg aagcgcaagt gggatggtga ccactatgat gccctgaggg
     1681 actgcctcaa ggccatctcc ctaaacccat gccacctgaa ggcacacttt cgcctggccc
     1741 gctgcctctt tgagctcaag tatgtggctg aagccctgga gtgcctggac gacttcaaag
     1801 ggaaatttcc ggagcaggcc cacagcagcg cttgtgatgc attgggccgc gacatcacag
     1861 ctgccctctt ctctaaaaat gatggtgagg agaagaaggg acctggtggc ggcgccccag
     1921 tccgcctccg cagcacgagc cgcaaggact ccatctcaga ggatgaaatg gtgctgcggg
     1981 agcgaagcta cgactatcag ttccgctact gcggccactg caacaccacc acggatatca
     2041 aagaggccaa tttctttggc agcaacgctc agtatatcgt cagtggctct gacgatggct
     2101 ccttcttcat ctgggaaaag gagaccacca acctggtccg tgtgctccaa ggggatgagt
     2161 ccattgtcaa ctgcctgcag ccacacccca gctactgctt cctggccacc agtggcatcg
     2221 atcctgttgt gcggctctgg aacccccgac cagagagtga agacctcaca ggccgagtcg
     2281 tggaagatat ggagggtgct tcacaggcca accagcggcg catgaatgca gacccgttgg
     2341 aggtgatgct gctcaacatg ggctaccgga tcacgggcct gagcagtggg ggtgccgggg
     2401 cctctgatga tgaggacagc tctgagggcc aggtgcagtg ccggcccagc tagaccctcc
     2461 agccctggtc cccagcccct gctactggct ggaccctctg ccctgggcag gaggtcaggg
     2521 gattctgttt tggtttgtct tccccaccac cctttttttt catttcccct gttttgtttg
     2581 ttagtttggc gttaggggtg gaggttgcta caacttgctg gctttcggac tctgggctga
     2641 ttgtcccctg actatcccca gccctgaaaa aaagagcagg aggggacacc cctccatatg
     2701 ccccccccca tctcctgctt tcatgtccct ggagggctct ggcctgcctc aaaacccctt
     2761 ctgcctcagg tggggaggaa caagctgaac tgtcttcagg gactgtcctg ccctttagct
     2821 ggcagcagca ggaggagtgg gattcccaat tggtaagggc tcgccttggc ctgttgccac
     2881 tcttgctccc tagcctgcaa ggctagctcc cctgtggtct tcaggaaagg ttttgaaaaa
     2941 ggatgggtcc caccctccct ccagagccac cagtgttaga gcggagccca aaggaaggat
     3001 gggagccctg gagtgggcaa gaccaggcca cctgctgagg tcgctgtgga gcaccctcgc
     3061 tcctctcctg gctactagct ctggccctgc acctactctc actggccacc tctggaggct
     3121 ctgcctttcc caagggccct ggcagagggt ggggcactgc accttacccc acccatccat
     3181 gccagcactt ctgcactacg gccattctcc tcttgggcgc tcctcagcct cactgtgacc
     3241 tttctgccag agctcccagc caggcctact ctgctgaggt ggcgcttcct gctaagggcc
     3301 cttctctgcc ctttctgccc tccttcccat cccacatgct gagccgccac aaagaccaaa
     3361 gaagtgatgg cttttctctg tcccctgctg ctctgagggg agaggggtgg gtctcctgag
     3421 ccactcagat gggaaagtcc cttactcggc ccctccctcc ccagcagccc caagctttac
     3481 actggatgca gcgatcaacc caccactcac caggcctctc ctcccctctg cccccggctc
     3541 ttagctccag ctgctccagg tagttggttc atccttcccc ctctctccct ccctgcttcc
     3601 ccttcagtgc ttacttggct ccagccctcc agctgcagcc cctggggaaa agcagcctcc
     3661 cttctcctct ccctccactc cctcgctccc tccctcagcc cctgtctctg ccaggtgcct
     3721 cctctcagtc aggcttcaga gcagccctgg agacaggagg gccatgttaa aagctttttc
     3781 acagttttaa gaagacaagt ggagggtgag gatagtggtg gggggtctgg caccatctca
     3841 ttgctttaat cccagcaaca caggtggcag cttctccccc ttccttccca ccccagtccc
     3901 tcttcccacc cctctcttct agcttggtaa tgaagtatat ttattggtga aggaaacagc
     3961 tgctgctgct tctcctgctg ctgggacctg ctcccctgtc tcttctccgt gacctttctc
     4021 tagccaggga gaagggagag caggagtatt ggggctgggc cctggggccc aaggaccagc
     4081 tgggtcccct ttgctttctt gtgttccagc cacctgccat ttcctccctg cctcccaccc
     4141 tccctccctg ccccctgtcc tgcttcccac cccctgcctg cccagcctgg gccctgcagt
     4201 gtggagagac acataagcct tactgtcctc tgggggcagg agccgagcct ttttgttgct
     4261 ccgctcccag gagagtgagg gtgacgcaat tgattaaaac cattttgttc taggtgtggc
     4321 tggtggcatt tgtggggtgc agatgggtct tggaaccaaa gtgagggcac ctggtccctc
     4381 acctctgtag ctctatgact tagtaaccac acctctactg gacagaatga ggcctgcctt
     4441 gaagggtcac cgtgagcagc ggccacccag cccagcaggg ctgagtgcag agcccagctc
     4501 tcatggctgt gatttgtaat catcagcttt cactctctgg ctgttttctc atcagtaaaa
     4561 taagggactt ggaatcttag tggtttttca aaccatttta cattgtgacc caatatacac
     4621 atgattactt gtagatatgt gtgtgtgtat atatatataa aaaaaatgaa caaaagtttt
     4681 acacaataat atttaccctt gctaca
//
