LOCUS       NM_001128212            1811 bp    mRNA    linear   PRI 26-APR-2024
DEFINITION  Homo sapiens WD repeat, sterile alpha motif and U-box domain
            containing 1 (WDSUB1), transcript variant 2, mRNA.
ACCESSION   NM_001128212
VERSION     NM_001128212.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1811)
  AUTHORS   Marin,I.
  TITLE     Ancient origin of animal U-box ubiquitin ligases
  JOURNAL   BMC Evol Biol 10, 331 (2010)
   PUBMED   20979629
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR000438.1, AK093494.1, AL040518.1 and CB240898.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001128212.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.877563.1,
                                           SRR18074968.4119548.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359774.9/ ENSP00000352820.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               DR000438.1         104-569
            467-1102            AK093494.1         471-1106
            1103-1234           AL040518.1         583-714
            1235-1811           CB240898.1         16-592              c
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..1811
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /note="WD repeat, sterile alpha motif and U-box domain
                     containing 1"
                     /db_xref="GeneID:151525"
                     /db_xref="HGNC:HGNC:26697"
                     /db_xref="MIM:620802"
     exon            1..121
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..543
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1576
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /note="isoform 1 is encoded by transcript variant 2; WD
                     repeat, SAM and U-box domain-containing protein 1"
                     /codon_start=1
                     /product="WD repeat, SAM and U-box domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_001121684.1"
                     /db_xref="CCDS:CCDS2208.1"
                     /db_xref="GeneID:151525"
                     /db_xref="HGNC:HGNC:26697"
                     /db_xref="MIM:620802"
                     /translation="MVKLIHTLADHGDDVNCCAFSFSLLATCSLDKTIRLYSLRDFTE
                     LPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRV
                     CQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSC
                     GDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWI
                     VSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT
                     LTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSE
                     EDVSTWLCAQDLKDLVGIFKMNNIDGKELLNLTKESLADDLKIESLGLRSKVLRKIEE
                     LRTKVKSLSSGIPDEFICPITRELMKDPVIASDGYSYEKEAMENWISKKKRTSPMTNL
                     VLPSAVLTPNRTLKMAINRWLETHQK"
     exon            544..728
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..821
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..915
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..949
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..990
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1097
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1277
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1418
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1811
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /note="hexamer: AATAAA"
     polyA_site      1811
                     /gene="WDSUB1"
                     /gene_synonym="UBOX6; WDSAM1"
                     /note="major polyA site"
ORIGIN      
        1 ctgttccctc tgctctgggt ctccgccggc gcccgccccg ccagcctcac ctgcgcggca
       61 cgtgacccgc accgcccgtg ggcaccttga aggcggatcc cgcgcgcccc cgctcctgca
      121 ggctgttttt cttcaaataa agaacatggt gaaactgatt cacacattag ctgatcatgg
      181 tgacgatgtc aactgctgtg ccttctcctt ttccctcttg gctacttgct ccttggacaa
      241 aacaattcgc ctgtactcgt tacgtgactt tactgaactg ccacattctc cattgaagtt
      301 tcatacctat gctgtccact gctgctgttt ctccccttca ggacatattt tggcatcgtg
      361 ttcaacagat ggtaccactg tcctatggaa tactgaaaat ggacagatgc tggcagtgat
      421 ggaacagcct agtggcagcc ctgtgagggt ttgccagttt tccccagact ccacgtgttt
      481 ggcatcaggg gcagctgatg gaactgtggt tttgtggaat gcacagtcat acaaattata
      541 tagatgtggt agtgttaaag atggctcctt ggcggcatgt gcattttctc ctaatggaag
      601 cttctttgtc actggctcct catgtggtga tttaacagtg tgggatgata aaatgaggtg
      661 tctgcatagt gaaaaagcac atgatcttgg aattacctgc tgcgattttt cttcacagcc
      721 agtttctgat ggagaacaag gtcttcagtt ttttcgactg gcatcatgtg gtcaggattg
      781 ccaagtcaaa atttggattg tttcttttac ccatatctta ggttttgaat taaaatataa
      841 aagtacactg agtgggcact gtgctcctgt tctggcttgt gctttttccc atgatgggca
      901 gatgctagtc tcagggtcag tggataagtc tgtcatagta tatgatacta atactgagaa
      961 tatacttcac acattgactc agcacaccag gtatgtcaca acttgtgctt ttgcacctaa
     1021 taccctttta cttgctactg gttcaatgga caaaacagtg aacatctggc aatttgacct
     1081 ggaaacactt tgccaagcaa ggcgcacaga acatcagctg aagcaattta ccgaagattg
     1141 gtcagaggag gatgtctcaa catggctttg tgcacaagat ttaaaagatc ttgttggtat
     1201 tttcaagatg aataacattg atggaaaaga actgttgaat cttacaaaag aaagtctggc
     1261 tgatgatttg aaaattgaat ctctaggact gcgtagtaaa gtgctgagga aaattgaaga
     1321 gctcaggacc aaggttaaat ccctttcttc aggaattcct gatgaattta tatgtccaat
     1381 aactagagaa cttatgaaag atccggtcat cgcatcagat ggctattcat atgaaaagga
     1441 agcaatggaa aattggatca gcaaaaagaa acgtacaagt cccatgacaa atcttgttct
     1501 tccttcagcg gtacttacac caaataggac tctgaaaatg gccatcaata gatggctgga
     1561 gacacaccaa aagtaaaatt gttgatattg tattatttat attttcagtg atctcatttg
     1621 aatgatttat aggtaaatac taatcagaca ttattaaaag caaaacagga aaaaggtaaa
     1681 cttcttaaat ttagttacct ataaaaattg tcaattttca ttctttaaaa aacacatgga
     1741 cttactataa aagccttttt gtactagtga aaagaatctt cagctatata gaaataaagt
     1801 tatactttaa a
//
