LOCUS       NM_020212               2395 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens WD repeat domain 93 (WDR93), transcript variant 1,
            mRNA.
ACCESSION   NM_020212 XM_031368
VERSION     NM_020212.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2395)
  AUTHORS   Alazami,A.M., Patel,N., Shamseldin,H.E., Anazi,S., Al-Dosari,M.S.,
            Alzahrani,F., Hijazi,H., Alshammari,M., Aldahmesh,M.A., Salih,M.A.,
            Faqeih,E., Alhashem,A., Bashiri,F.A., Al-Owain,M., Kentab,A.Y.,
            Sogaty,S., Al Tala,S., Temsah,M.H., Tulbah,M., Aljelaify,R.F.,
            Alshahwan,S.A., Seidahmed,M.Z., Alhadid,A.A., Aldhalaan,H.,
            AlQallaf,F., Kurdi,W., Alfadhel,M., Babay,Z., Alsogheer,M.,
            Kaya,N., Al-Hassnan,Z.N., Abdel-Salam,G.M., Al-Sannaa,N., Al
            Mutairi,F., El Khashab,H.Y., Bohlega,S., Jia,X., Nguyen,H.C.,
            Hammami,R., Adly,N., Mohamed,J.Y., Abdulwahab,F., Ibrahim,N.,
            Naim,E.A., Al-Younes,B., Meyer,B.F., Hashem,M., Shaheen,R.,
            Xiong,Y., Abouelhoda,M., Aldeeri,A.A., Monies,D.M. and
            Alkuraya,F.S.
  TITLE     Accelerating novel candidate gene discovery in neurogenetic
            disorders via whole-exome sequencing of prescreened multiplex
            consanguineous families
  JOURNAL   Cell Rep 10 (2), 148-161 (2015)
   PUBMED   25558065
REFERENCE   2  (bases 1 to 2395)
  AUTHORS   Brown,J.M., Dipetrillo,C.G., Smith,E.F. and Witman,G.B.
  TITLE     A FAP46 mutant provides new insights into the function and assembly
            of the C1d complex of the ciliary central apparatus
  JOURNAL   J Cell Sci 125 (Pt 16), 3904-3913 (2012)
   PUBMED   22573824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064626.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020212.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268130.12/ ENSP00000268130.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2395              BC064626.1         15-2409
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..2395
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /note="WD repeat domain 93"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
     exon            1..47
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            48..390
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2148
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 93"
                     /codon_start=1
                     /product="WD repeat-containing protein 93 isoform 1"
                     /protein_id="NP_064597.1"
                     /db_xref="CCDS:CCDS32326.1"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
                     /translation="MSFPRGSQTQKIKHPIGTRKGPLEVPPPTEKDWPKDDEQDHVLV
                     DPDEELDSLPQPYRMINKLVNLLFDQSWEIIEERNALREAESSQIQPTVYPPLGEIQL
                     NKMPNCMAVSQDYVFIGGAKGFSIYNLYSAKQIYAWEKLKVDVTSIWATDLGNEILIA
                     PVDEMGIIRLFYFYKEGLYLVKAINEVDDTSKQTTCIKMEISQGGDFAAFLLQGAGDI
                     WLDVYKLPKETWLKKLEHPQLTSNPKKKVRQPQLNSLGPISADPLEMDANVSFKGDIK
                     LSLPVYIMKIKPPKPVTGTTFKSPLEVFAKIKDCYGLGSGQNHFIKDSQWEQQAEIFN
                     ASYKKYLDREWEEEPLSTATFYFLLPSCLFAMPPEVKGPSGMACVLGIHWTRSHNFFL
                     YSLNRTLKDKADPEGVWPCAAPIAVSQLSCSSSYLVLACEDGVLTLWDLAKGFPLGVA
                     ALPQGCFCQSIHFLKYFSVHKGQNMYPEGQVKSQMKCVVLCTDASLHLVEASGTQGPT
                     ISVLVERPVKHLDKTICAVAPVPALPGMVLIFSKNGSVCLMDVAKREIICAFAPPGAF
                     PLEVPWKPVFAVSPDHPCFLLRGDYSHETASTDDAGIQYSVFYFNFEACPLLENISKN
                     CTIPQRDLDNMAFPQALPLEKRCERFLQKSYRKLEKNPEKEEEHWARLQRYSLSLQRE
                     NFKK"
     exon            391..583
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            584..648
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            649..727
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            728..843
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            844..882
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            883..967
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1139
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1210
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1297
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1417
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1631
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1695
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1852
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2048
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2395
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2371..2376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /note="hexamer: AATAAA"
     polyA_site      2395
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /note="major polyA site"
ORIGIN      
        1 aagccggaag ttgtggttac caaggcgacg caacgccgcc cggccagctt ttcagtttca
       61 tagaggttcc cagtgccacc ttctgtgatg tcattcccaa gaggaagtca gacccagaaa
      121 ataaagcacc ccattggtac acgaaaggga ccattggagg tgccaccccc aacagagaag
      181 gactggccta aagacgatga acaggatcat gtcctcgtgg atccagatga ggagctggat
      241 tccttgcctc agccttatcg aatgatcaac aagctggtga accttctgtt tgaccagtct
      301 tgggaaatta ttgaagagag aaacgcactg agggaagctg agagcagcca gatccagccc
      361 accgtctacc ctccacttgg agaaatccag ctcaacaaaa tgccaaattg tatggctgtt
      421 tcccaagact atgtgtttat tggaggagcc aaaggattct caatttataa tctgtacagt
      481 gctaaacaaa tatatgcgtg ggagaagctt aaggttgatg tcacttccat ctgggccaca
      541 gatttaggga atgaaatact cattgctcct gtggatgaaa tgggtatcat tagactcttt
      601 tatttttata aggaaggact ttacctagtc aaagccatca atgaagtgga tgataccagc
      661 aagcaaacta cctgtataaa gatggagatc tctcaaggag gggactttgc agccttcctc
      721 ctacaaggag ccggagatat ttggctggat gtgtataaat tgcccaagga gacttggctc
      781 aagaaactag agcaccccca actcacttca aatccaaaga aaaaagtcag acagccgcaa
      841 ctgaactccc ttggtcccat ttctgcagat cctttagaaa tggatgcaaa tgttagtttt
      901 aaaggagaca ttaaattgag tcttccagtt tacataatga agatcaaacc acctaagcct
      961 gttacaggca ccacattcaa aagccccctg gaagtctttg caaagatcaa ggactgctac
     1021 ggactgggct ccgggcagaa tcatttcatc aaggacagtc agtgggagca gcaagctgag
     1081 atcttcaacg cttcctacaa gaagtaccta gatagggagt gggaggaaga gccactcagt
     1141 acggccacct tctatttcct tcttcctagc tgcctatttg caatgccacc ggaagtcaag
     1201 ggcccctcag gaatggcctg tgtccttggt atacactgga ccagaagtca caatttcttc
     1261 ctgtattcac taaaccgaac tctaaaggat aaagctgacc ccgagggtgt gtggccctgt
     1321 gctgcgccca ttgcagtctc tcagctcagc tgctcctcct cctacctggt gctggcctgc
     1381 gaggatggtg tgctcacgct gtgggacctg gccaaaggat tccctcttgg ggtcgctgct
     1441 cttcctcagg gatgtttctg ccaaagcatt cacttcctaa aatatttctc ggtccacaaa
     1501 ggacagaata tgtatcctga aggtcaagtg aaatcccaaa tgaaatgtgt ggtgctgtgc
     1561 acagacgcct ccctccatct ggtggaggct agcgggaccc aaggacccac catcagtgtg
     1621 cttgttgaga ggcctgtaaa gcacctggat aaaaccatct gtgccgtggc cccagtccca
     1681 gccttacctg gcatggtgct catcttttcc aagaatggct ctgtgtgcct tatggatgtg
     1741 gccaagcgtg aaatcatctg tgcctttgcc cctccgggag cctttcctct ggaggtcccc
     1801 tggaagccag tgtttgctgt gtctccagac catccatgtt tcctgctccg aggagactat
     1861 tcacatgaaa ctgcgtccac cgacgatgct ggaatccaat attctgtttt ctattttaat
     1921 tttgaggcct gcccactcct ggaaaatatc tcaaaaaatt gtaccattcc tcaaagggac
     1981 ttggataaca tggccttccc ccaagcactg ccactggaga agagatgtga gcgtttcctc
     2041 cagaagagct atcggaagct ggagaagaac ccagagaagg aggaggagca ctgggcccgg
     2101 cttcagaggt actccttgtc gctccagaga gagaacttca agaagtgagg ctgccaccgc
     2161 cctgggatct ctgaaaagga ggtttcagcc acgaggcagc tgctcccagg acactgaggc
     2221 caagagaaat gtaacagagc cacagctcca caggcctgca ctcggagtct ggggcctctg
     2281 cagagccagc aaggggaaaa gtataatctg ggggaccttc aaccactaag cctcttgtca
     2341 gagccctcag gcaggcagat gtgtcaccca aataaacagt gatattgtct ccaga
//
