LOCUS       NM_014149               4580 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens WD repeat domain 91 (WDR91), transcript variant 3,
            mRNA.
ACCESSION   NM_014149
VERSION     NM_014149.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4580)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4580)
  AUTHORS   Liu,K., Xing,R., Jian,Y., Gao,Z., Ma,X., Sun,X., Li,Y., Xu,M.,
            Wang,X., Jing,Y., Guo,W. and Yang,C.
  TITLE     WDR91 is a Rab7 effector required for neuronal development
  JOURNAL   J Cell Biol 216 (10), 3307-3321 (2017)
   PUBMED   28860274
  REMARK    GeneRIF: WDR91 serves as a Rab7 effector that is essential for
            neuronal development by facilitating endosome conversion in the
            endosome-lysosome pathway.
REFERENCE   3  (bases 1 to 4580)
  AUTHORS   Liu,X., Li,Y., Wang,X., Xing,R., Liu,K., Gan,Q., Tang,C., Gao,Z.,
            Jian,Y., Luo,S., Guo,W. and Yang,C.
  TITLE     The BEACH-containing protein WDR81 coordinates p62 and LC3C to
            promote aggrephagy
  JOURNAL   J Cell Biol 216 (5), 1301-1320 (2017)
   PUBMED   28404643
REFERENCE   4  (bases 1 to 4580)
  AUTHORS   Rapiteanu,R., Davis,L.J., Williamson,J.C., Timms,R.T., Paul
            Luzio,J. and Lehner,P.J.
  TITLE     A Genetic Screen Identifies a Critical Role for the WDR81-WDR91
            Complex in the Trafficking and Degradation of Tetherin
  JOURNAL   Traffic 17 (8), 940-958 (2016)
   PUBMED   27126989
  REMARK    GeneRIF: suggest a role for the WDR81-WDR91 complex in the fusion
            of endolysosomal compartments and the absence of WDR81 leads to
            impaired receptor trafficking and degradation
REFERENCE   5  (bases 1 to 4580)
  AUTHORS   Liu,K., Jian,Y., Sun,X., Yang,C., Gao,Z., Zhang,Z., Liu,X., Li,Y.,
            Xu,J., Jing,Y., Mitani,S., He,S. and Yang,C.
  TITLE     Negative regulation of phosphatidylinositol 3-phosphate levels in
            early-to-late endosome conversion
  JOURNAL   J Cell Biol 212 (2), 181-198 (2016)
   PUBMED   26783301
  REMARK    Erratum:[J Cell Biol. 2016 Mar 14;212(6):739. doi:
            10.1083/jcb.20150608103012016c.. PMID: 26975852]
REFERENCE   6  (bases 1 to 4580)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009542.2, BC017246.2 and AC083862.2.
            
            On Nov 23, 2018 this sequence version replaced NM_014149.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.161036.1,
                                           SRR1803617.108882.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354475.5/ ENSP00000346466.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC009542.2         57634-57656         c
            24-2637             BC017246.2         1-2614
            2638-4580           AC083862.2         158512-160454       c
FEATURES             Location/Qualifiers
     source          1..4580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..4580
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /note="WD repeat domain 91"
                     /db_xref="GeneID:29062"
                     /db_xref="HGNC:HGNC:24997"
                     /db_xref="MIM:616303"
     exon            1..147
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2268
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /note="isoform 3 is encoded by transcript variant 3; WD
                     repeat-containing protein 91"
                     /codon_start=1
                     /product="WD repeat-containing protein 91 isoform 3"
                     /protein_id="NP_054868.3"
                     /db_xref="CCDS:CCDS34758.1"
                     /db_xref="GeneID:29062"
                     /db_xref="HGNC:HGNC:24997"
                     /db_xref="MIM:616303"
                     /translation="MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDK
                     IVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTIHKLKTSLFRFYLVYTIQT
                     NRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIVSLH
                     NFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQPEE
                     EEALVQHKLPPYVSNMDRLGDSELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRL
                     SPAQGPPQPQSSAKKESFGGQGTKGKDPTSGAKDGKSLLSGLATGESGWSQHRQRRLQ
                     DHGKERKELFSTTTSQCAEKKPEASGPEAEPCPELHTEPVEPLTRASSAGPEGGGVRP
                     EQPFIVLGQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISK
                     SPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDNMPRILSLACSPNGA
                     SFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTKTMKQQLQFSLDPEPIAIN
                     CTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWRAHYGEVYSVEFSYDENTVYSIGE
                     DGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYML
                     TCSATGGVIYKLGGDEKVLESCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLT
                     TLLAHKA"
     exon            148..327
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..535
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..618
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..749
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..915
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1074
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1268
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1419
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1514
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1683
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1792
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1905
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2103
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..4580
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2652
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /note="major polyA site"
     regulatory      3162..3167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /note="hexamer: AATAAT"
     polyA_site      3187
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
     regulatory      4560..4565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /note="hexamer: AATAAA"
     polyA_site      4580
                     /gene="WDR91"
                     /gene_synonym="HSPC049; SORF-1; SORF1"
                     /note="major polyA site"
ORIGIN      
        1 acccctaaag acgctagcgc tgcgatggcg gaggccgtgg agcgcactga cgagctggtc
       61 cgggagtacc tgctcttccg cgggttcacg cacacactgc ggcagctgga cgccgagatc
      121 aaggcggaca aggagaaggg gttccgggtg gataagattg tggaccagct gcagcagtta
      181 atgcaggtgt atgacttggc tgcccttcgg gattattgga gctacttgga gcgtcggctc
      241 ttcagccgct tggaggatat atacagaccc acaatccaca agctgaaaac cagcctgttt
      301 cgattttatc ttgtctacac aatccagaca aacagaaatg acaaggctca ggagttcttt
      361 gcaaagcagg ccacggaact ccagaaccag gctgagtgga aggattggtt tgtcctgccc
      421 ttcctgccat ccccggacac caaccccacc tttgctacct acttttctcg acagtgggct
      481 gacaccttca ttgtgtccct gcacaacttc ctgagcgtcc tgtttcagtg catgccagtc
      541 cctgtgatcc tgaactttga tgcggagtgt cagaggacta accaggttca agaagaaaat
      601 gaagttctgc gtcagaagct ttttgcattg caagctgaaa tccaccgact gaagaaagag
      661 gagcaacagc cagaagagga agaggccttg gtccaacaca aattgcctcc ttatgtctcc
      721 aacatggacc gcctggggga ctcggaactt gccatggtgt gcagccaaag gaatgcctcc
      781 ctctcccagt cacctcgtgt gggcttcctg tcctcgctgc tgcctcagag taagaagagc
      841 ccctcaaggt tgtcgcctgc tcagggccct cctcaacctc agagctcggc caagaaagag
      901 tccttcggtg gtcagggcac caagggaaag gacccgacgt ccggagccaa ggatgggaag
      961 agcctcctca gcgggctggc cactggggag tccggttggt cacagcaccg gcagcggcgc
     1021 ctgcaggacc atggcaagga gaggaaggag cttttctcca caaccacttc ccagtgtgca
     1081 gagaagaaac cagaagccag tggcccagag gctgagccct gcccagagct ccacacggag
     1141 ccagtggagc cactgactcg ggcatcctcg gcaggccctg agggtggagg agtccgcccc
     1201 gagcagccct ttattgtgct gggacaggag gagtacgggg aacaccactc atccatcatg
     1261 cactgcagag tggactgctc tgggaggaga gtcgccagct tagacgtaga tggggtcatc
     1321 aaagtgtggt ccttcaaccc catcatgcag accaaagcat cctccatttc caaatcaccg
     1381 ctgctgtctt tggaatgggc caccaaacgg gacagactgc tcttgctggg cagtggtgtg
     1441 ggaacagtgc gtctctatga cacggaagcc aagaagaatc tctgtgaaat caatatcaac
     1501 gacaacatgc ccagaatcct gtctcttgcg tgcagcccca acggggcctc tttcgtctgt
     1561 tcggcagcag ctccgagcct cacttcccag gtggacttct cagcaccaga catcggcagc
     1621 aagggcatga accaggttcc tggcaggctg ctgctgtggg acacgaaaac catgaagcag
     1681 cagctccagt tctccctgga tccagaaccc attgctatca actgtacagc cttcaatcac
     1741 aacgggaacc tgctggtcac aggggcagct gatggcgtca tccggctgtt tgacatgcag
     1801 cagcatgagt gcgcgatgag ctggagggcc cactacgggg aggtctactc tgtggagttc
     1861 agctatgatg agaacaccgt gtacagcatc ggcgaggacg ggaagttcat ccagtggaac
     1921 atccacaaga gtggcctcaa ggtatccgag tacagcctcc cctcagatgc cacgggcccc
     1981 tttgtgctgt ctggatacag cggctacaag caggttcaag tccccagggg ccgactcttc
     2041 gcttttgact cggagggaaa ttacatgctg acatgttctg ccacaggcgg cgtcatctac
     2101 aagctgggtg gcgatgagaa ggttctggag agctgcttga gcctaggtgg ccaccgagcc
     2161 cctgtggtca ccgtggactg gagcactgcc atggactgtg ggacctgcct caccgcctcc
     2221 atggatggca agatcaagct gaccaccctc ctggcccata aagcctgatg acttgcccca
     2281 agggccaccc gaggaagcag tattatctgc ggtgggggga ggagatatag gacaggaaaa
     2341 ccacgtgctc cactccagct ccctgccagt gcagtgactc tgcagggaaa gactggcaag
     2401 gaggctcagg tgcttccatc tgtggtgact ggaatgggac ccacgtggag taggtgacat
     2461 atgcttccca gagactggta ttgtggctgt gccaggagta catgtgagac tatgggagga
     2521 aagctccgga agaaggagaa acattgcagt ggctactgtg ttggcccagt agaaattgac
     2581 agtattttgt atatatgtgc ccatttatct ttttcttttt taaaaaaaga gaatactctt
     2641 gtggtcccct gatgtctctt tctaggatgt gtgtcacttt gcttcagtga cagccctccc
     2701 acccagcctg gctctgctgg ccctgaactg aacctctcca ggctctcctg ttgctttgcc
     2761 atggagccag gtcagctctc tgtctgttct gctgggtaac aaggtttggc agttcctgtt
     2821 tctctgggct taagtcaagg ccacagaatt ctttttcttc cctgaaagct ggcagctttt
     2881 gttacagaag attctcagga tgaaggcagg ggctgaggcc tctgctactg gctgcccctt
     2941 tccatccagt ggctgctgtt tcccaagaca ggctaagcgt ttcttatctg aaatgcttgg
     3001 gacaggagtg ttacagattt tggatttttt cagactttgg aatatttgca tatatacata
     3061 atgaggtatc ttggtaggtc tcatgtctaa acatgaaatt cattcatgtt ttatatatac
     3121 cttatacatg tagcctgaag gtaactctat acagtatttt aaataatttt gtacatgaaa
     3181 caaagtattg attgtggtca ggtgtggtat tttccacttg tggtgtcatg ttggtgctca
     3241 cagttttggg gctgggcacg gtggctcacg tctgtaatcc cagcactttg ggaggccaag
     3301 gtgggtggat cacttaaggt caggagcttg agaccagcct ggccaacatg gtgaaacccc
     3361 atctctacta aaaataccaa aattagccag gcatggtggc aggtgcctat aatcccagct
     3421 actctggagg ctggggcagg agaatcactt gagcccagga ggcggaggtt gcagtgagcc
     3481 gagatcacgc cactgggaga acccaactca aaaaaaaaaa aagttttggg ttatggagca
     3541 tttttgattt tggatctttg ggttaaggac gctcaacctg tacctttttc atttggtggc
     3601 tcctctcatt cctccaactg aacatctttg tggaaagatg atggctgcct gcacccactg
     3661 ctggcgaatg gtgagaaggt agagcaaggg ggccaagttg ctgctggtgg gcacctgggg
     3721 ttcaggccgg cccaactgtg gctgagccga tctgtagctg agctgagtgt caaccagctg
     3781 tgtccacacc ctgcctgagg cctgccctct cctccctggc tggggtggga ccttgaagag
     3841 gcatatcttc ccactaggtg aggaggaaca agagcctcac tccccttctc cctcttgcct
     3901 ttcacagctg aggcagagct tatgggagga gtcactatgg gagtgatgga cctgggcttt
     3961 ggtctccagt gtttggcagg ggcgacctta tcactgagct ggggaaggca gctgccatga
     4021 gtcattttaa gtctctgagc tccagcccag ttctaggggc acaaggctgg agtagggata
     4081 ctcctagtta cctgcttgag gaaaagcacg aagaaattgg taccaaagtc ttggctttgt
     4141 tctgggagtt gagggaaaag tagggaggta tttaagtggc ttgattatga gaaaacacca
     4201 gagacagtag taaatagtta tttaccgatt tttacccatt tctaccctgg taatcctccc
     4261 tgcaaatgaa gaaaaccaag acttctttat ttattatctt tccccatctg tattgaaaca
     4321 gtgatcttac ttatctcacc cagtgattct gtaggacatt taaaaagtgg tcatgggttt
     4381 cattggagtg agaatggtat taacgtttcc tcttgtcatc tcaaagtttt ctctcccctt
     4441 aataccatct ctacagcttg ctgagatgct ttaaggatca cagagacaca aagaaaattt
     4501 gaaccctacg cttctcccat cccacttctt actccatccc gggtgagcgc tcgtcctcaa
     4561 ataaagcatg ttggaacttc
//
