LOCUS       NM_145294               5540 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens WD repeat domain 90 (WDR90), mRNA.
ACCESSION   NM_145294
VERSION     NM_145294.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5540)
  AUTHORS   Steib,E., Laporte,M.H., Gambarotto,D., Olieric,N., Zheng,C.,
            Borgers,S., Olieric,V., Le Guennec,M., Koll,F., Tassin,A.M.,
            Steinmetz,M.O., Guichard,P. and Hamel,V.
  TITLE     WDR90 is a centriolar microtubule wall protein important for
            centriole architecture integrity
  JOURNAL   Elife 9, e57205 (2020)
   PUBMED   32946374
  REMARK    GeneRIF: WDR90 is a centriolar microtubule wall protein important
            for centriole architecture integrity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5540)
  AUTHORS   Valera-Perez,A., Tyrkalska,S.D., Viana,C., Rojas-Fernandez,A.,
            Pelegrin,P., Garcia-Moreno,D., Perez-Oliva,A.B. and Mulero,V.
  TITLE     WDR90 is a new component of the NLRC4 inflammasome involved in
            Salmonella Typhimurium resistance
  JOURNAL   Dev Comp Immunol 100, 103428 (2019)
   PUBMED   31276698
  REMARK    GeneRIF: Study describes WD repeat containing protein 90 (WDR90) as
            a new inflammasome component. Reconstitution experiments of the
            human inflammasome in HEK293cells demonstrated that WDR90 was able
            to physically interact with and to alter the cellular distribution
            of NLRC4, but not of NLRP3 and AIM2.
REFERENCE   3  (bases 1 to 5540)
  AUTHORS   Hamel,V., Steib,E., Hamelin,R., Armand,F., Borgers,S.,
            Fluckiger,I., Busso,C., Olieric,N., Sorzano,C.O.S., Steinmetz,M.O.,
            Guichard,P. and Gonczy,P.
  TITLE     Identification of Chlamydomonas Central Core Centriolar Proteins
            Reveals a Role for Human WDR90 in Ciliogenesis
  JOURNAL   Curr Biol 27 (16), 2486-2498 (2017)
   PUBMED   28781053
  REMARK    GeneRIF: This study identified POB15 and POC16 as two proteins of
            the central core region, the distribution of which correlates with
            that of tubulin glutamylation; POB15 is an inner barrel protein
            within this region. Two poc16 mutants exhibit flagellar defects,
            indicating that POC16 is important for flagellum biogenesis. Human
            WDR90 is required for ciliogenesis, echoing the findings in
            Chlamydomonas.
REFERENCE   4  (bases 1 to 5540)
  AUTHORS   Chen,Z., Tang,H., Qayyum,R., Schick,U.M., Nalls,M.A., Handsaker,R.,
            Li,J., Lu,Y., Yanek,L.R., Keating,B., Meng,Y., van Rooij,F.J.,
            Okada,Y., Kubo,M., Rasmussen-Torvik,L., Keller,M.F., Lange,L.,
            Evans,M., Bottinger,E.P., Linderman,M.D., Ruderfer,D.M.,
            Hakonarson,H., Papanicolaou,G., Zonderman,A.B., Gottesman,O.,
            Thomson,C., Ziv,E., Singleton,A.B., Loos,R.J., Sleiman,P.M.,
            Ganesh,S., McCarroll,S., Becker,D.M., Wilson,J.G., Lettre,G. and
            Reiner,A.P.
  CONSRTM   BioBank Japan Project; CHARGE Consortium
  TITLE     Genome-wide association analysis of red blood cell traits in
            African Americans: the COGENT Network
  JOURNAL   Hum Mol Genet 22 (12), 2529-2538 (2013)
   PUBMED   23446634
REFERENCE   5  (bases 1 to 5540)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK091062.1, AB067511.1, AK126622.1, AK092719.1 and Z92544.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145294.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293879.9/ ENSP00000293879.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1489              AK091062.1         3-1491
            1490-2018           AB067511.1         3109-3637
            2019-4363           AK126622.1         660-3004
            4364-5539           AK092719.1         1082-2257
            5540-5540           Z92544.1           25663-25663         c
FEATURES             Location/Qualifiers
     source          1..5540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..5540
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /note="WD repeat domain 90"
                     /db_xref="GeneID:197335"
                     /db_xref="HGNC:HGNC:26960"
                     /db_xref="MIM:618290"
     exon            1..62
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..5299
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /codon_start=1
                     /product="WD repeat-containing protein 90"
                     /protein_id="NP_660337.3"
                     /db_xref="CCDS:CCDS42092.1"
                     /db_xref="GeneID:197335"
                     /db_xref="HGNC:HGNC:26960"
                     /db_xref="MIM:618290"
                     /translation="MARAWQHPFLNVFRHFRVDEWKRSAKQGDVAVVTDKTLKGAVYR
                     IRGSVSAANYIQLPKSSTQSLGLTGRYLYVLFRPLPSKHFVIHLDVSSKDNQVIRVSF
                     SNLFKEFKSTATWLQFPLVLEARTPQRDLVGLAPSGARWTCLQLDLQDVLLVYLNRCY
                     GHLKSIRLCASLLVRNLYTSDLCFEPAISGAQWAKLPVTPMPREMAFPVPKGESWHDR
                     YIHVRFPSESLKVPSKPIEKSCSPPEAVLLGPGPQPLPCPVASSKPVRFSVSPVVQTP
                     SPTASGRAALAPRPFPEVSLSQERSDASNADGPGFHSLEPWAQLEASDIHTAAAGTHV
                     LTHESAEVPVARTGSCEGFLPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVI
                     VVLLVDTGEQRFFLGHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFR
                     SPMHVVCSLSFSDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQ
                     AFRVTFFDETRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFTDLAFKQARDGCP
                     EPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISS
                     LSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHL
                     GFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTS
                     SEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRL
                     LFSSCSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRC
                     TVTVMGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHLLVSTSSNRVVVLDA
                     VSGRIIRELPGVHPEPCPSLTLSEDARFLLIAAGRTIKVWDYATQASPGPQVYIGHSE
                     PVQAVAFSPDQQQVLSAGDAVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASR
                     ASELPRQQVPKPCQASPPRLGVCARPPEGGDGARDTRNSGAPRTTYLASCKAFTPARV
                     SCSPHSAKGTCPPPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDL
                     HSGAQQHWSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFP
                     HSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPWDA
                     GELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSS
                     GQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKG
                     SGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRS
                     KVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPE
                     QQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVS
                     HPCTGTTFRVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLR
                     NHCELVDWLSFPMPATTETQGHLPPSLAAFCPWDGALLMYVGPGVYKEVIIYNLCQKQ
                     VVEKIPLPFFAMSLSLSPGTHLLAVGFAECMLRLVDCAMGTAQDFAGHDNAVHLCRFT
                     PSARLLFTAARNEILVWEVPGL"
     exon            63..154
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            155..331
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            332..440
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            441..611
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            612..720
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            721..788
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            789..892
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1105
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1174
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1285
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1431
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1489
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1608
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1770
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1901
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2018
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2254
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2394
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2525
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2656
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2818
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2947
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3063
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3104
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3236
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3340
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3443
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3565
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3725
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3916
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4085
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..4197
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4363
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4486
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            4487..4661
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            4662..4792
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            4793..4936
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            4937..5056
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            5057..5141
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     exon            5142..5540
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5518..5523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /note="hexamer: AATAAA"
     polyA_site      5540
                     /gene="WDR90"
                     /gene_synonym="C16orf15; C16orf16; C16orf17; C16orf18;
                     C16orf19; POC16"
                     /note="major polyA site"
ORIGIN      
        1 actctgcgct gggcgcgcgg aggcctaggc gggaagctcg agcggcggcg ccatggcccg
       61 agcgtggcag cacccgttcc tcaacgtctt cagacacttc cgggtggacg agtggaagcg
      121 ctccgccaag cagggggacg tggccgtggt cacggacaag accctgaagg gcgccgtgta
      181 tcgcattcgg ggctcagtct ctgccgccaa ctacatccag ctccctaaga gcagcaccca
      241 gtctctgggg ctgacgggac gatacctgta tgtgctcttt cggcccctgc ccagcaagca
      301 cttcgtcatc cacctcgatg tgtcctccaa ggacaaccaa gtcatccgtg tgtctttctc
      361 caacctcttc aaggagttta agtctacggc cacgtggctc cagtttccct tggtcctgga
      421 ggccaggaca cctcagagag atctggtggg tttggccccc tccggagccc gctggacctg
      481 cctgcagctc gatctgcagg acgttctcct ggtctacctg aaccggtgct acggccatct
      541 caagagcatc aggctgtgcg ccagcctgct ggtcaggaac ctgtacacca gtgacctgtg
      601 ctttgagcct gccatctctg gggcccagtg ggcaaagctg cccgtgactc ctatgcctcg
      661 ggaaatggca ttccctgtgc ccaagggaga gagctggcat gaccgctaca tccacgtccg
      721 gtttccaagt gagagcttga aagtgccttc caagccgatt gagaagagct gttcccctcc
      781 tgaggcagtc ctcctggggc cggggccaca gcctctccct tgcccggtgg cctccagcaa
      841 acctgtgcgg ttcagtgtgt ctccagtggt ccagacgccc agccccacag cctccggccg
      901 ggccgccttg gcacccaggc ccttcccgga ggtcagcctg tcccaagagc gctcagacgc
      961 ctccaacgcg gatggccccg gtttccatag ccttgagccc tgggcccagc tggaggcctc
     1021 tgacatccac acggctgctg ccggcaccca cgtgttgact cacgagtcgg ctgaggtgcc
     1081 cgtggcccgc accggctcct gcgaaggctt cctcccagac ccagtcctga ggctcaaggg
     1141 cgtcatcggc tttgggggcc acggcaccag acaggccctg tggaccccag acggggcggc
     1201 tgtcgtgtac ccctgccatg cggtcatcgt cgtcctgctc gtggacacgg gggagcagcg
     1261 cttcttcctt ggccacacag acaaggtctc cgccctggcg ctggatggca gcagctcact
     1321 attggcctcg gcccaggcaa gggcccctag tgtgatgcgg ctctgggact tccagaccgg
     1381 gcggtgcttg tgcctgttcc ggagcccaat gcacgttgtc tgctctctca gcttctctga
     1441 cagcggggcc cttctctgcg gggttggcaa ggaccaccac gggaggacga tggtggtggc
     1501 ctggggcacc ggccaggtgg gcctcggtgg cgaggtggtc gttctggcaa aggcgcacac
     1561 tgactttgac gtccaggcct tccgggtcac cttttttgat gaaaccagga tggcgtcgtg
     1621 cgggcagggc agtgtgcggc tctggcggct gcgtggcggg gtgctgcgtt cctgccccgt
     1681 ggacttaggg gagcaccacg cgctgcagtt caccgacctg gccttcaagc aggcccggga
     1741 cggctgcccg gagccctcgg ctgccatgct cttcgtgtgc agccgcagtg gccacatctt
     1801 ggagattgac tgtcagcgca tggtcgtgcg gcatgcccgc cgcctgctcc ccacacggac
     1861 tccaggcggt ccccacccac agaagcagac cttcagctca ggccccggca ttgccatcag
     1921 cagcctcagc gtctccccgg ccatgtgtgc tgtgggctct gaggacggct tcttgcggct
     1981 ctggcccctg gacttctcct cggtgctcct ggaggcagag cacgagggcc ccgtcagctc
     2041 agtctgtgtc agccccgatg gcctccgtgt gctgtctgcc acctcctcgg gccacctggg
     2101 cttcctggac acgctgtccc gggtgtacca catgctggct cgctcccaca ccgccccggt
     2161 gttggccctc gccatggagc agaggcgggg acagctggcc accgtgtccc aggaccgtac
     2221 cgtccgcatc tgggacctgg ccaccctgca gcagctatac gacttcacat catcagagga
     2281 cgccccgtgc gctgtcacct tccaccccac aaggccaacc tttttctgtg gctttagcag
     2341 tggggccgtg cgctccttca gcctggaggc cgctgaggtc ctggtggaac acacgtgcca
     2401 ccgaggagct gtcaccggcc tgaccgccac ccctgacggc cgcctgctct tcagctcctg
     2461 ctcccagggc tccctggccc agtacagctg tgcggacccc cagtggcatg tcctccgagt
     2521 ggcagcggac atggtatgcc cggatgcccc cgcgagcccc agcgccctgg cagtcagcag
     2581 ggatggccgc ctgctggcct ttgtgggacc ctccaggtgc acagtgacag tcatgggctc
     2641 ggcctccctt gatgagctgc tgcgagttga catcggcact ctggacctgg ccagcagccg
     2701 cctggactca gccatggctg tgtgctttgg ccctgcagct ctgggccacc tgctggtgtc
     2761 cacctcgtcc aacagagtcg tggtgctgga tgctgtgtcg ggccgcatca tccgggagct
     2821 gcccggtgtc caccctgagc cctgcccctc cttgacgctc agtgaggacg cccgcttcct
     2881 gctgattgcc gccggccgga ccatcaaggt gtgggactac gccacacagg ccagcccagg
     2941 cccccaggtg tacatcggcc actcggaacc cgtgcaggct gtggccttct ctcctgacca
     3001 gcagcaggtc ctcagcgcag gggacgccgt cttcctctgg gatgtcctgg cccctactga
     3061 gagcgaccaa agcttccccg gggccccccc agcctgcaag acaggcccgg gcgcaggacc
     3121 gctggaggac gcagcgtcca gggccagcga gctcccccgg cagcaggtcc ccaagccatg
     3181 tcaggcatct ccaccacggc tgggcgtctg tgccaggcct cccgaaggtg gcgatggcgc
     3241 cagggacacc aggaattcgg gggccccacg caccacctac ctggcttcct gcaaggcctt
     3301 cacgcctgcc agggtcagct gcagccccca ctctgccaag ggcacttgcc cgcctcccgc
     3361 cagcggtggg tggctgcgtc tgaaggctgt cgtcggttac agcgggaatg ggcgggccaa
     3421 catggtctgg aggccggaca caggcttctt tgcctacacg tgcggccgcc tggtggtggt
     3481 ggaggacctg cactctggcg cccagcagca ctggtccggc cactctgcgg agatctccac
     3541 gctggccctc agccacagtg cccaggtcct ggcctctgcc tcgggccgaa gcagcacgac
     3601 cgcccattgt cagatccgcg tctgggacgt gtctggcggc ctctgccagc atctcatttt
     3661 cccccatagc accaccgtgc tggccctggc cttctcacca gatgacaggc ttcttgtcac
     3721 actgggggac cacgatggcc gcaccctcgc cctgtggggc acggccacct atgacctcgt
     3781 gtcctccacc cgcctcccgg agccggtgca tggtgtggcc ttcaacccct gggacgccgg
     3841 cgagctcacc tgtgtgggcc agggcactgt caccttctgg ctccttcagc agcgtggggc
     3901 agacatcagc cttcaggtgc gtcgagagcc agtcccagag gcagtggggg ctggagagct
     3961 gacctcgctc tgctacgggg cacctcccct gctctattgt ggcaccagct ctggccaggt
     4021 ctgtgtctgg gacacgcgtg ccggccgctg cttcttgtcc tgggaggcgg atgacggtgg
     4081 cattgggctg ttgctgttct cgggttctcg attggtcagc ggcagcagca cggggcggct
     4141 gcgcctgtgg gccgtggggg ctgtgtcgga gctgaggtgc aagggctcag gcgccagttc
     4201 tgtgttcatg gaacacgagc tggtgctgga cggggctgtg gtgagtgcca gcttcgatga
     4261 cagcgtggac atgggcgtcg tgggcaccac ggcgggcacg ctgtggtttg tcagctgggc
     4321 cgagggcacc agcacacgtc tcatcagtgg ccacaggagc aaggtgaacg aggtggtctt
     4381 cagccccggg gagtcccact gcgccacatg cagtgaggat gggagtgtgc gggtgtgggc
     4441 cttggccagc atggagcttg tgatccagtt ccaggtgctg aaccagagct gcctctgcct
     4501 ggcatggagc cccccgtgct gtggccgccc tgagcagcag cggctagcgg ctggctacgg
     4561 tgacggctcc ctgcgcatct tcagcgtctc ccgcacggcc atggagctca agatgcaccc
     4621 ccacccggtg gcgctgacca ctgttgcctt ctccaccgat ggtcagactg tcctctctgg
     4681 agacaaggat gggctcgtgg ctgtgagcca cccctgcaca gggacaacct tccgtgtgct
     4741 gagtgaccac cagggcgccc caatctctac catctgtgtc acgtgcaaag agtgtgaaga
     4801 cttaggggtg gagggcacag acctatggct ggctgccagt ggggaccagc gggtcagcgt
     4861 ctgggcctcc gactggctgc ggaaccactg tgagcttgtg gactggttga gtttcccaat
     4921 gcctgccacc acggagactc agggccacct gccaccctcc ctcgctgcct tctgcccttg
     4981 ggatggggcg ctcctgatgt acgtgggccc cggtgtttac aaggaggtga tcatctacaa
     5041 cctctgccag aagcaggtgg tggagaagat accactgccc ttttttgcca tgtccctgag
     5101 cctgtccccc gggacccacc tcctggctgt tggctttgct gagtgcatgc tgaggctggt
     5161 agactgtgcc atggggactg cccaagactt tgccggccac gacaacgcag tgcacctgtg
     5221 caggtttaca ccgtccgcca ggctgctctt cacggccgcc cgcaacgaga tccttgtgtg
     5281 ggaggtcccc ggcctctgag atgcagcagg gactgtggtg gtgggcatca cgcctggtca
     5341 tgccaggcac ctggacacag gcttggcaga ggcgccaggt tgtcaatggc ctcatgctgg
     5401 gacaggccag gattcacgta aatcgcctgg agcaagctgt tgtaaatttg gcgccctgtg
     5461 aatactttca tacctgttgc ccttttgcct aagaaatctt taatgtttct atcttgtaat
     5521 aaacatgggc atttattgca
//
